[go: up one dir, main page]

FR2719049B1 - Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules. - Google Patents

Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules.

Info

Publication number
FR2719049B1
FR2719049B1 FR9404895A FR9404895A FR2719049B1 FR 2719049 B1 FR2719049 B1 FR 2719049B1 FR 9404895 A FR9404895 A FR 9404895A FR 9404895 A FR9404895 A FR 9404895A FR 2719049 B1 FR2719049 B1 FR 2719049B1
Authority
FR
France
Prior art keywords
kpr
hiv
inhibit
entry
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9404895A
Other languages
English (en)
Other versions
FR2719049A1 (fr
Inventor
Ara Hovanessian
Christian Callebaut
Bernard Krust
Etienne Jacotot
Sylviane Muller
Jean-Paul Briand
Gilles Guichard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Pasteur
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Pasteur filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR9404895A priority Critical patent/FR2719049B1/fr
Priority to EP95918043A priority patent/EP0756603A1/fr
Priority to PCT/FR1995/000528 priority patent/WO1995029190A1/fr
Priority to AU24125/95A priority patent/AU2412595A/en
Priority to JP7527406A priority patent/JPH10502337A/ja
Priority to CA002188470A priority patent/CA2188470A1/fr
Publication of FR2719049A1 publication Critical patent/FR2719049A1/fr
Application granted granted Critical
Publication of FR2719049B1 publication Critical patent/FR2719049B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR9404895A 1994-04-22 1994-04-22 Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules. Expired - Fee Related FR2719049B1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
FR9404895A FR2719049B1 (fr) 1994-04-22 1994-04-22 Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules.
EP95918043A EP0756603A1 (fr) 1994-04-22 1995-04-21 Multirepresentation d'un analogue peptidique du substrat de la dppiv, notamment de type kpr, afin d'inhiber l'entree du hiv dans les cellules
PCT/FR1995/000528 WO1995029190A1 (fr) 1994-04-22 1995-04-21 Multirepresentation d'un analogue peptidique du substrat de la dppiv, notamment de type kpr, afin d'inhiber l'entree du hiv dans les cellules
AU24125/95A AU2412595A (en) 1994-04-22 1995-04-21 Multirepresentation of a peptide analogue of the dppiv substrate, especially of the kpr type, to inhibit the entry of hiv in cells
JP7527406A JPH10502337A (ja) 1994-04-22 1995-04-21 Ｈｉｖの細胞侵入を阻害するための、 ｄｐｐｉｖの基質であるペプチド類縁体、特にｋｐｒ型の該類縁体の複合提示
CA002188470A CA2188470A1 (fr) 1994-04-22 1995-04-21 Multirepresentation d'un analogue peptidique du substrat de la dppiv, notamment de type kpr, afin d'inhiber l'entree du hiv dans les cellules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404895A FR2719049B1 (fr) 1994-04-22 1994-04-22 Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules.

Publications (2)

Publication Number Publication Date
FR2719049A1 FR2719049A1 (fr) 1995-10-27
FR2719049B1 true FR2719049B1 (fr) 1996-06-14

Family

ID=9462438

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9404895A Expired - Fee Related FR2719049B1 (fr) 1994-04-22 1994-04-22 Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules.

Country Status (6)

Country Link
EP (1) EP0756603A1 (fr)
JP (1) JPH10502337A (fr)
AU (1) AU2412595A (fr)
CA (1) CA2188470A1 (fr)
FR (1) FR2719049B1 (fr)
WO (1) WO1995029190A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6825169B1 (en) 1991-10-22 2004-11-30 Trustees Of Tufts College Inhibitors of dipeptidyl-aminopeptidase type IV
US5965532A (en) * 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6011155A (en) * 1996-11-07 2000-01-04 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
CA2284084A1 (fr) * 1997-03-12 1998-09-17 Institut Pasteur Recepteur membranaire pour retrovirus de vih, utilisations therapeutiques et diagnostiques
US6100234A (en) 1997-05-07 2000-08-08 Tufts University Treatment of HIV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
BR9813233A (pt) 1997-09-29 2000-08-22 Point Therapeutics Inc Estimulação de células hematopoéticas in vitro
AU770319C (en) 1998-05-04 2004-11-25 Point Therapeutics, Inc. Hematopoietic stimulation
KR100704814B1 (ko) 1998-06-05 2007-04-10 포인트 써러퓨틱스, 인크. 시클릭 보로프롤린 화합물
US6979697B1 (en) 1998-08-21 2005-12-27 Point Therapeutics, Inc. Regulation of substrate activity
CO5150173A1 (es) * 1998-12-10 2002-04-29 Novartis Ag Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
US6172081B1 (en) 1999-06-24 2001-01-09 Novartis Ag Tetrahydroisoquinoline 3-carboxamide derivatives
US6110949A (en) * 1999-06-24 2000-08-29 Novartis Ag N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6617340B1 (en) 1999-07-29 2003-09-09 Novartis Ag N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
ES2296979T3 (es) 2001-06-27 2008-05-01 Smithkline Beecham Corporation Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
KR20080002998A (ko) * 2005-04-22 2008-01-04 가부시키가이샤 쿠레디아쟈판 아미노산 잔기 또는 펩티드 잔기를 갖는 화합물 및 그 제조방법
CN101193909A (zh) * 2005-05-23 2008-06-04 创新生命化学日本株式会社 具有光敏化作用的化合物、光电极及光敏化型太阳电池
WO2007061077A1 (fr) * 2005-11-25 2007-05-31 Credia Japan Co., Ltd. Vehicule pour utilisation dans l'introduction d'acide nucleique, kit pour utilisation dans l'introduction d'acide nucleique, et procede pour l'introduction d'acide nucleique dans une cellule
FR2900341B1 (fr) * 2006-04-27 2012-09-14 Centre Nat Rech Scient Utilisation de ligands synthetiques multivalents de la nucleoline de surface pour le traitement du cancer
BRPI0822661A2 (pt) 2008-05-22 2015-06-30 Centre Nat Rech Scient Compostos oticamente puros para eficiência terapêutica melhorada
BR112013008026A2 (pt) 2010-10-04 2016-06-21 Centre Nat Rech Scient composições que compreendem ligantes sintéticos multivalentes de nucleolina de superfície e glicosaminaglicanos

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2707170A1 (fr) * 1993-06-04 1995-01-13 Pasteur Institut Expression des récepteurs CD4 et CD26 dans des cellules recombinantes, inhibiteurs du récepteur CD26.
IL110929A0 (en) * 1993-09-13 1994-11-28 Armel Sa Multiple branch peptide constructions and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2719049A1 (fr) 1995-10-27
EP0756603A1 (fr) 1997-02-05
CA2188470A1 (fr) 1995-11-02
WO1995029190A1 (fr) 1995-11-02
AU2412595A (en) 1995-11-16
JPH10502337A (ja) 1998-03-03

Similar Documents

Publication Publication Date Title
FR2719049B1 (fr) Multireprésentation d'un analogue peptidique du substrat de la DPPIV, notamment de type KPR, afin d'inhiber l'entrée du HIV dans les cellules.
DK96589A (da) Dispenser af pumpetypen og til at holde i haanden
AU617088B2 (en) Peptides involved in the pathogenesis of hiv infection
ATE201964T1 (de) Karamellen enthaltend ein süssungsmittel
DE69635904D1 (de) Sauerstoffentfernende zusammensetzungen mit geringer wanderung
AU6924796A (en) 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis c
GB9929781D0 (en) Improvements in or relating to the cleansing of surfaces
EP0626450A3 (fr) Protéines de fusion contenant l'enzyme conjugant l'ubiquitine (E2).
USD376912S (en) Bathing brush
DE69129809D1 (de) Aprotininanaloga
AUPM310493A0 (en) Improvements in relation to row cultivators
AU6285390A (en) Improvements in or relating to i.c. engines
IT1302934B1 (it) Composizione per migliorare l'aspetto di getti cementizi.
USD318092S (en) Water filter or similar article
ATE183201T1 (de) Vielfältig verzweigte peptidkonstruktion zur bekämpfung von hiv
IT8620026A1 (it) Tripeptide ad attivita' immunostimolante
DK320589D0 (da) Fremgangsmaade til hindring af vaekst af aerobe fungi i vandige carbonhydrider
Mosello et al. Chemistry of atmospheric deposition and freshwater acidification: Research in Italy.
ES2015076B3 (es) Estructura de recubrimiento destinada principalmente a ser colocada en una conduccion o analoga, depositada sobre un fondo submarino.
IT8620027A1 (it) Tripeptide ad attivita' immunostimolante
IT8819783A0 (it) L_piroglutamil_l_cisteina, dipeptide ad elevata attivita'anticatarattogena e composizioni farmaceutiche che lo contengono.
AU3953889A (en) Improvements in and relating to the prestressing of concrete articles or structures
DE3782199D1 (de) Biologisch aktive peptide tan-866.
AU3355189A (en) Improvements in or relating to arrays of filamentary form
Ruehm et al. On the age structure and species composition of pre-imago populations of simuliids on artificial substrates in dependence of length of time of exposure.

Legal Events

Date Code Title Description
ST Notification of lapse