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FR2763944B1 - Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases - Google Patents

Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases

Info

Publication number
FR2763944B1
FR2763944B1 FR9706814A FR9706814A FR2763944B1 FR 2763944 B1 FR2763944 B1 FR 2763944B1 FR 9706814 A FR9706814 A FR 9706814A FR 9706814 A FR9706814 A FR 9706814A FR 2763944 B1 FR2763944 B1 FR 2763944B1
Authority
FR
France
Prior art keywords
drugs
processes
preparation
protease inhibitors
coumarin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9706814A
Other languages
English (en)
Other versions
FR2763944A1 (fr
Inventor
Ravaux Michele Reboud
Lionel Pochet
Caroline Doucet
Bernard Pirotte
Nicole Hoggetto
Jacques Delarge
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR9706814A priority Critical patent/FR2763944B1/fr
Priority to US09/445,177 priority patent/US6355658B1/en
Priority to JP50170799A priority patent/JP2002503241A/ja
Priority to EP98928394A priority patent/EP0988298A1/fr
Priority to PCT/FR1998/001087 priority patent/WO1998055472A1/fr
Publication of FR2763944A1 publication Critical patent/FR2763944A1/fr
Application granted granted Critical
Publication of FR2763944B1 publication Critical patent/FR2763944B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR9706814A 1997-06-03 1997-06-03 Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases Expired - Fee Related FR2763944B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR9706814A FR2763944B1 (fr) 1997-06-03 1997-06-03 Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
US09/445,177 US6355658B1 (en) 1997-06-03 1998-05-29 Coumarin derivatives, methods of preparation and application as medicines
JP50170799A JP2002503241A (ja) 1997-06-03 1998-05-29 クマリン誘導体、それらの製造方法及び医薬品としてのそれらの用途
EP98928394A EP0988298A1 (fr) 1997-06-03 1998-05-29 Derives de coumarines, leurs procedes de preparation et leur application comme medicaments
PCT/FR1998/001087 WO1998055472A1 (fr) 1997-06-03 1998-05-29 Derives de coumarines, leurs procedes de preparation et leur application comme medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9706814A FR2763944B1 (fr) 1997-06-03 1997-06-03 Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases

Publications (2)

Publication Number Publication Date
FR2763944A1 FR2763944A1 (fr) 1998-12-04
FR2763944B1 true FR2763944B1 (fr) 2000-12-15

Family

ID=9507531

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9706814A Expired - Fee Related FR2763944B1 (fr) 1997-06-03 1997-06-03 Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases

Country Status (5)

Country Link
US (1) US6355658B1 (fr)
EP (1) EP0988298A1 (fr)
JP (1) JP2002503241A (fr)
FR (1) FR2763944B1 (fr)
WO (1) WO1998055472A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1506359A (zh) * 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
CN100471583C (zh) * 2003-06-27 2009-03-25 雷克蒂塞尔公司 用于生产一种包括被喷射的聚亚胺酯层的模制物品的方法
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
GB0607389D0 (en) * 2006-04-12 2006-05-24 Novartis Ag Organic compounds
US8569378B2 (en) * 2007-07-20 2013-10-29 Toshiyuki Sakai p27 protein inducer
EP2545916A1 (fr) * 2011-07-15 2013-01-16 Universite Pierre Et Marie Curie - Paris 6 Utilisation de dérivés de coumarine pour la préparation de médicaments prévus pour traiter des maladies cutanées
EP2548973A1 (fr) 2011-07-20 2013-01-23 Centre National de la Recherche Scientifique Nouvelle composition de souche d'actinomycète et son utilisation
US10421756B2 (en) 2015-07-06 2019-09-24 Rodin Therapeutics, Inc. Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase
RS62639B1 (sr) 2015-07-06 2021-12-31 Alkermes Inc Hetero-halo inhibitori histonskih deacetilaza
MD3570834T2 (ro) 2017-01-11 2022-04-30 Alkermes Inc Inhibitori biciclici ai histon deacetilazei
JP7152471B2 (ja) 2017-08-07 2022-10-12 ロダン・セラピューティクス，インコーポレーテッド ヒストン脱アセチル化酵素の二環阻害剤
WO2023213728A1 (fr) 2022-05-03 2023-11-09 Université de Liège Esters d'aryle substitués d'acide coumarine-3-carboxylique et leur utilisation en tant qu'inhibiteurs de protéases de cellules hôte
EP4571417A1 (fr) * 2023-12-14 2025-06-18 Arkema France Procédé de durcissement de composés éthyléniquement insaturés avec des photo-initiateurs de thioester de coumarine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683720A (en) * 1949-12-15 1954-07-13 Endo Products Inc Process for the preparation of 6-nitro-coumarin-3-carboxylic acid
GB772215A (en) * 1954-06-23 1957-04-10 Cilag Ltd Process for the production of new di-acylated tartaric acids
JPS5692261A (en) * 1979-12-26 1981-07-25 Nippon Chemiphar Co Ltd Novel cyclohexanecarboxylic derivative and its preparation
JPS59204173A (ja) * 1983-04-28 1984-11-19 Kowa Co ベンゾイルピペラジンエステル類
US4665070A (en) * 1985-06-25 1987-05-12 Syntex (U.S.A.) Inc. 2-oxy-4H-3,1-benzoxazin-4-ones and pharmaceutical use
JPS6445400A (en) * 1988-04-21 1989-02-17 Green Cross Corp Human urinary trypsin inhibitor derivative and production thereof
NL8900943A (nl) * 1989-04-14 1990-11-01 Euro Biopharm Technology B V Protease inhibitor.
JP2999841B2 (ja) * 1991-04-03 2000-01-17 三井化学株式会社 発光スクリーン用樹脂組成物
CA2068636A1 (fr) * 1991-05-16 1992-11-17 Kyozo Hayashi Composes aromatiques a fonction amide, leur production et leur utilisation
JPH05169853A (ja) * 1991-12-26 1993-07-09 Mitsui Toatsu Chem Inc 感熱転写記録用色素、感熱転写記録用インキ組成物、及び転写シート
EP0552108B1 (fr) * 1992-01-17 1999-11-10 Lakowicz, Joseph R. Essai fluoro-immunologique impliquant un transfert d'énergie par phase-modulation
JPH06145164A (ja) * 1992-11-04 1994-05-24 Mitsui Toatsu Chem Inc 紫外線吸収剤およびそれに適したベンゾピラン誘導体ならびに該紫外線吸収剤を含有してなる熱可塑性樹脂組成物および成形体
ATE211765T1 (de) * 1994-10-28 2002-01-15 Vitaleech Bioscience N V Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen

Also Published As

Publication number Publication date
EP0988298A1 (fr) 2000-03-29
US6355658B1 (en) 2002-03-12
JP2002503241A (ja) 2002-01-29
WO1998055472A1 (fr) 1998-12-10
FR2763944A1 (fr) 1998-12-04

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20120309