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FR2761576B1 - Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee - Google Patents

Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee

Info

Publication number
FR2761576B1
FR2761576B1 FR9704125A FR9704125A FR2761576B1 FR 2761576 B1 FR2761576 B1 FR 2761576B1 FR 9704125 A FR9704125 A FR 9704125A FR 9704125 A FR9704125 A FR 9704125A FR 2761576 B1 FR2761576 B1 FR 2761576B1
Authority
FR
France
Prior art keywords
insulin
suppressed
expression
transgenic animal
gene coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9704125A
Other languages
English (en)
Other versions
FR2761576A1 (fr
Inventor
Jacques Jami
Danielle Bucchini
Rajiv Lochan Joshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9704125A priority Critical patent/FR2761576B1/fr
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to AU70546/98A priority patent/AU741340B2/en
Priority to US09/402,316 priority patent/US20020188961A1/en
Priority to CA002284833A priority patent/CA2284833A1/fr
Priority to EP98917293A priority patent/EP0972018A1/fr
Priority to PCT/FR1998/000667 priority patent/WO1998045422A1/fr
Priority to JP54244598A priority patent/JP2001524819A/ja
Publication of FR2761576A1 publication Critical patent/FR2761576A1/fr
Application granted granted Critical
Publication of FR2761576B1 publication Critical patent/FR2761576B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FR9704125A 1997-04-04 1997-04-04 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee Expired - Fee Related FR2761576B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9704125A FR2761576B1 (fr) 1997-04-04 1997-04-04 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
US09/402,316 US20020188961A1 (en) 1997-04-04 1998-04-02 Non human transgenic animal in which the expression of the gene coding for insulin is deleted
CA002284833A CA2284833A1 (fr) 1997-04-04 1998-04-02 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
EP98917293A EP0972018A1 (fr) 1997-04-04 1998-04-02 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
AU70546/98A AU741340B2 (en) 1997-04-04 1998-04-02 Non human transgenic animal in which the expression of the gene coding for insulin is deleted
PCT/FR1998/000667 WO1998045422A1 (fr) 1997-04-04 1998-04-02 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee
JP54244598A JP2001524819A (ja) 1997-04-04 1998-04-02 インスリンをコードする遺伝子の発現が抑制されている非ヒト・トランスジェニック動物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9704125A FR2761576B1 (fr) 1997-04-04 1997-04-04 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee

Publications (2)

Publication Number Publication Date
FR2761576A1 FR2761576A1 (fr) 1998-10-09
FR2761576B1 true FR2761576B1 (fr) 2002-08-30

Family

ID=9505525

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9704125A Expired - Fee Related FR2761576B1 (fr) 1997-04-04 1997-04-04 Animal transgenique non humain dans lequel l'expression du gene codant pour l'insuline est supprimee

Country Status (7)

Country Link
US (1) US20020188961A1 (fr)
EP (1) EP0972018A1 (fr)
JP (1) JP2001524819A (fr)
AU (1) AU741340B2 (fr)
CA (1) CA2284833A1 (fr)
FR (1) FR2761576B1 (fr)
WO (1) WO1998045422A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033781B1 (en) 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
WO2001096551A2 (fr) * 2000-06-14 2001-12-20 Diversa Corporation Ingenierie cellulaire complete par mutagenese d'une partie substantielle d'un genome de depart, par combinaison de mutations et eventuellement repetition
KR101497160B1 (ko) 2006-08-11 2015-02-27 유니버시티 오브 제네바 단백질 발현 또는 억제를 위한 시스템, 방법 및 장치
US8782653B2 (en) * 2010-03-26 2014-07-15 Virtualmetrix, Inc. Fine grain performance resource management of computer systems

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003791D0 (en) * 1990-02-20 1990-04-18 Ludwig Inst Cancer Res Transgenic animals,cell lines therefrom,and their use
WO1994023760A1 (fr) * 1993-04-14 1994-10-27 The United States Of America As Represented By The Secretary Of The Navy Modele d'animal transgenique pour maladies autoimmunes
JPH09500526A (ja) * 1993-06-14 1997-01-21 ベーアーエスエフ アクツィエンゲゼルシャフト テトラサイクリン反応性プロモーターによる真核細胞の遺伝子発現の厳密な制御
KR100268714B1 (ko) * 1994-11-21 2000-10-16 서정선 당뇨병 발생 유전자 이식 마우스
AU720662B2 (en) * 1995-04-07 2000-06-08 Albert Einstein College Of Medicine Of Yeshiva University Recombinant B-cell and uses thereof
US6087129A (en) * 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines

Also Published As

Publication number Publication date
EP0972018A1 (fr) 2000-01-19
WO1998045422A1 (fr) 1998-10-15
US20020188961A1 (en) 2002-12-12
AU741340B2 (en) 2001-11-29
FR2761576A1 (fr) 1998-10-09
JP2001524819A (ja) 2001-12-04
AU7054698A (en) 1998-10-30
CA2284833A1 (fr) 1998-10-15

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Legal Events

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ST Notification of lapse