FR2753370A1 - INSTALLATION FOR THE AUTOMATIC DELIVERY OF PHARMACEUTICAL PRODUCTS IN SEPARATE BATCHES, INDIVIDUALIZED, FROM INFORMATION RELATING TO MEDICAL PRESCRIPTIONS - Google Patents

Abstract

The installation comprises in particular a vertical store (11) with horizontal racks (12) containing a particular type of drug or pharmaceutical product packaged in a strip (13), and a handling head (4) movable by at least one motor assembly opposite of the store (11) to be positioned selectively facing the racks (12) so that a gripping member (7) is placed in the axis of the packaging (13) to grip it by its end and by a backward movement, arranging the packaging portion corresponding to the desired number of doses of medicament behind a plane (C), in which a cutting member (8) separates said packaging portion from the rest of the packaging. The installation is remarkable in that the head (4) is provided with a support (33) on which rests a container (10), in which are deposited, by the gripping member (7), the portions of 'packaging which correspond to the drug doses of the same prescription.

Description

INSTALLATION FOR THE AUTOMATIC DISPENSATION OF PHAR PRODUCTS
SEPARATE BATCH MACEUTICS, INDIVIDUALIZED, FROM INFORMATION RELATING TO MEDICAL PRESCRIPTIONS.

 The present invention relates to an installation for the automatic dispensing of drugs or other pharmaceutical products, intended to equip hospital centers or other care centers, allowing the preparation, in a particularly safe and rapid manner, of individualized batches of drugs or pharmaceutical products, response to medical prescriptions issued by practitioners to patients undergoing treatment in the hospital center.

 An apparatus is already known for the automatic distribution of drugs in batches according to medical prescriptions, comprising several vertical racks spaced in pairs from each other and divided into horizontal compartments. Each compartment receives a packaging in the form of a strip, carrying in a line, spaced from one another, pills or capsules. The racks are arranged in groups of four and each group is associated with a vertically movable carriage in a controlled manner to be positioned selectively opposite the compartments.

This mobile carriage includes, for each rack in the group, an extraction device with clamps with controlled clamping and displacements, capable of coming into clamping on the end of the pill packaging of the selected compartment and by retraction, of extracting from the compartment the packaging fraction corresponding to the desired number of pills and exposing this packaging fraction to a cutting device it has. After separation of the exposed part of the pill package, the latter falls on a conveyor belt, to be conveyed to a receiving tray.

Subsequently, this tray is transferred to a control station where an operator checks that the composition of the tray matches the medical prescription.

 The disadvantage of such an apparatus resides in the fact that the packaging portions in the form of a strip, following their fall, can rebound on the conveyor belt and come out of the latter to be housed, for example, in the interval between two adjoining racks. In addition, such a device can only be used for the distribution of objects that are not very fragile to shocks such as pills and capsules and is not suitable for the distribution of products packaged in glass bottles or other fragile materials.

 Another drawback lies in the multiplication of the carriages and therefore in the multiplication of the means for monitoring and controlling the vertical movement of the latter and of the means for monitoring and controlling the extraction and cutting members carried by the carriages.

 Another drawback of this equipment lies in the impossibility of checking the identity of the pharmaceutical products seized by the extraction forceps.

 The object of the present invention is to solve the aforementioned drawbacks by implementing an installation for the automatic dispensing in individualized batches of pharmaceutical products composed from medical prescription instructions, which can distribute both pharmaceutical products in fragile packaging and those in impact resistant packaging, without risk of loss and with prior control of the identity of the products to be distributed, which avoids the use of a person to verify the conformity of the lots with the orders and deviates from this makes the risks associated with human error.

 To this end, the installation according to the invention, for the automatic dispensing of drugs or more generally of pharmaceutical products in separate, individualized batches, on the basis of information relating to medical prescriptions, comprises a vertical magazine, comprising a vertical rear face. , formed by juxtaposition of horizontal compartments each containing a packaging in the form of a strip provided with aligned cells, spaced apart from each other in a constant step and each containing one or more unit dose (s) of the same medicine or pharmaceutical product, each compartment being intended to contain a particular type of medicine or pharmaceutical product distinct from that contained in each of the other compartments. The installation further comprises a manipulation head with controlled movements, movable by at least one motor member facing the vertical rear face of the magazine to be positioned selectively facing the lockers so that the gripping member which it has is disposed in the axis of the packaging in the form of a strip, from the corresponding compartment to grasp the end of this packaging and by backward movement, extract from this compartment the packaging portion corresponding to the desired number of doses of medicine and place this packaging portion behind a geometric plane (C) or cutting plane, parallel to the vertical rear face of the magazine, along which a cutting member which the handling head has then makes a cut to separate said portion from packaging in the form of a band from the rest of the packaging. The installation also comprises a storage unit for semi-rigid containers nesting in each other according to at least one vertical stack, in each of which an individualized batch of drugs corresponding to a medical prescription, is intended to be formed, said medical prescription being entered on the keyboard of a computer terminal and delivered to a command and control unit which in particular controls the movements of the handling head, the movements of the gripping member and the movements of the cutting member and activates the cutting members for the separation of the packaging portion when the length of the packaging portion extracted from the rack and disposed behind the geometric plane (C) is compatible with the drug dosage required by the order .

 The installation as defined above is essentially characterized in that the handling head, under the gripping member, is provided with a support on which rests a container previously extracted from the stack of containers, in which are deposited, by the gripping member, the packaging portions in the form of a strip, separated from the rest of the packaging by the cutting member, the said packaging portions corresponding to the medicinal or pharmaceutical doses of the same prescription.

 The container is thus kept at a short distance from the gripping member so that, following the fall of the medicinal or pharmaceutical products in the container, no deterioration of the latter is possible. Furthermore, the low drop height cannot in any way be the source of significant rebounds, so that no loss of medication or pharmaceutical product during the preparation of the batch is to be feared.

 According to another characteristic of the invention, each container, substantially of rectangular shape, is made of a synthetic material capable of absorbing shocks and consequently, limiting rebound.

According to another characteristic of the invention, the container is provided with a continuous annular rim by which it is held on the support which ensures its centering relative to the gripping member equipping the handling head, said rim being formed by four segments of opposite edges two by two, running respectively on the four sides of its opening
According to another characteristic of the invention, the handling head is movable pa ralièlement to the rear vertical face of the store both horizontally and vertically, by two motor assemblies, controlled by the command and control unit and arranged according to a kinematic chain said to be open, the handling head being fixed to the terminal motor element of said chain. In addition, the store lockers are arranged in juxtaposed horizontal lines and juxtaposed vertical columns. Thus by the use of a single handling head it is possible to access all the drugs present in the store which brings a significant simplification compared to the use of several trolleys as described above. Furthermore, this provision avoids the multiplicity of control and command means, which is always a potential source of failures.

 According to another characteristic of the invention, the dorsal zone of each package in the form of a strip for drug or pharmaceutical product, in line with each cell, comprises an identification marking of the pharmaceutical product or drug contained in the cell, and the head of handling is equipped with a means of reading the identification marking, this means of reading, provided with a sensitive reading element facing which the back of the packaging is arranged, is electrically connected to the control unit and of order for verification by this unit, before separation of the packaging portion, of the concordance between the prescribed drugs and those of the seized packaging. In this way, any poor distribution of medication is avoided.

 After completion of the batch according to the prescribed prescription, the container with its batch of medicine is ready for distribution to the patient. To automate the preparation phase for distribution to patients, the installation according to another of its characteristics, provides a means of evacuating the containers with formed batches, to a delivery zone, controlled by the command and control unit. , and a manipulator device controlled by the control and command unit intended to receive each container from the delivery area, and store it in one of the compartments of a transport and distribution trolley, this compartment, preferably, being assigned an address corresponding to the geographic location of the patient in the care center.

 According to yet another characteristic, the installation according to the invention, upstream of the evacuation means, is equipped with a station for printing identification labels and affixing them to the containers, controlled by the command and control unit, to which is brought, by the handling head after formation of a batch of medicaments, the corresponding container for affixing the label printed on one of the blanks of the latter, said identification label comprising in clear and in code form for example the patient's first and last name, date of birth, geographic location in the care center, date of completion of the batch, order number of the latter, practitioner's name and the date of the order.

 Before distribution of the container by means of evacuation, the inscriptions carried by the label affixed on the container, must be checked to ensure in particular their readability and their consistency with the data of the prescription which has just been carried out. . Thus the invention according to another of its aspects, provides for the use on the one hand, of a means of reading the label electrically connected to the control and command unit and operating, before delivery of the container corresponding to the means of evacuation, a reading of the coded inscriptions carried on the label, the result of this reading being compared, by the control and command unit, with the data relating to the batch of medicines or pharmaceutical products which has just been formed in the container, and on the other hand, a means of extracting the containers, controlled by the control and command unit, said extraction means being activated by the control and command unit to extract of the means of evacuation or of the delivery zone, the container, the coded inscriptions of which its label is either illegible, or absent, or relating to another batch than that which has just been formed in the container. Thanks to these means, any risk of poor distribution of medicines is still ruled out.

 According to yet another characteristic of the invention, the installation is equipped with a drug deconditioning machine, the latter being in the form of a tablet or capsule and being packaged in a package in the form of a thermoformed, quadrangular plate, in which are practiced in rows and columns, cells of the drugs, blocked by a perforable sealing sheet under the effect of mechanical pressure.

According to another characteristic of the invention, the installation is equipped with a machine for packaging drugs or pharmaceutical products in a package consisting on the one hand:
a thermoformed strip comprising, at constant pitch along a row, cells intended to receive unit doses of medicaments or pharmaceutical products, and on either side of the row of cells, two longitudinal edges,
- And secondly, a cell sealing sheet, fixed to said strip by heat sealing.

 Finally, according to another characteristic, the installation according to the invention is equipped with a machine for thermoforming the strip of the packaging for packaging drugs.

Other advantages and characteristics of the installation according to the invention will appear on reading the description of a preferred embodiment given by way of indicative example with reference to the appended drawings in which:
FIG. 1 shows in perspective a drug package in the form of a strip,
FIG. 2 shows in perspective a container in which a batch of medicament is intended to be formed,
FIG. 3 is a top view of an installation according to the invention,
FIG. 4 is a front view of the installation according to the invention,
FIG. 5 is a side view in section of the handling head, the gripping member being in the waiting position,
FIG. 6 is a side view in section of the handling head, the gripping member being in the position for gripping a package,
FIG. 7 is a side view in section of the handling head, the cutting member being activated to separate a portion of packaging,
FIG. 8 is a side view in section of the handling head, before opening of the clamping jaws of the gripping member,
FIG. 9 is a side view of the handling head, the container support being in an overflow position relative to said head,
FIG. 10 is a sectional view of the terminal motor assembly ensuring the displacement of the handling head along a vertical axis,
FIG. 11 is a sectional view of the first motor assembly ensuring the displacement of the handling head along a horizontal axis,
FIG. 12 is a view in longitudinal section of the container storage unit,
FIG. 13 is a partial section view of the store,
FIG. 14 is a view of the upstream end of the discharge means on which the label reading means and the transfer means appear, the latter being in the gripping position,
FIG. 15 shows the transfer means in the erasing position,
FIG. 16 is a front view of the first means of extracting the containers,
FIG. 17 is a view in longitudinal section of a second means for extracting the containers,
FIG. 18 is a view in longitudinal section along a vertical plane, of the delivery zone,
FIG. 19 is a view of the manipulator device and of the motor assemblies ensuring its movement, the terminal motor assembly being shown in section,
FIG. 20 is a sectional view, in detail, of the first motor assembly ensuring the displacement of the manipulator device,
FIG. 21 is a front view of the manipulator device,
FIG. 22 is a view in longitudinal section of the manipulator device,
FIG. 23 is a top view of the original packaging of the drugs,
FIG. 24 is a cross-sectional view of the original packaging,
- Figure 25 is a top view in cutaway of the drug deconditioning machine, - Figure 26 is a sectional view along a vertical plane of a drug deconditioning machine, - Figure 27 shows the second means of gripping the deconditioning machine,
FIG. 28 is a view in longitudinal section of a medication packaging machine,
FIG. 29 is a partial section view showing the guide path of the packaging machine as well as the step-by-step advance mechanism,
FIG. 30 is a partial top view of the chassis of the step-by-step advance mechanism,
FIG. 31 shows a side view of a pusher device,
FIG. 32 is a view in longitudinal section of the filling station of the packaging machine,
- Figure 33 is a longitudinal sectional view of the machine for thermoforming a strip with cells.

 In Figure 1 is shown a package 13, for the packaging of medicament in the form of tablet, capsule, cachet, ampoule, etc., arranged for example in unit dosage doses in cells 131 or cavities formed with spacing apart others according to a constant pitch in a strip 13A receiving a closure sheet 132 covering and closing the cells 131. This closure sheet constitutes the dorsal zone of the packaging 13, and comprises on its external face, in line with each cell 131, in plain text and in the form of a bar code of the identification markings of the medicament contained in the cell. On either side of the cell row, the strip 13A is provided with two longitudinal, marginal edges 133. The closure sheet is fixed by heat sealing to the strip 13A and this all around each cell. The cells of packaging 13 may contain pharmaceutical products such as syringes, dressings, disinfection solutions in vials and more generally any type of product which can be used by an infirmary to provide care.

 In FIG. 2 is shown a container 10. This semi-rigid container, substantially of parallelepiped shape, is made of a synthetic material capable of absorbing shocks and is provided with a continuous annular rim 101, formed by four segments of rims opposite two to two, running respectively on the four sides of the opening of said container, this opening being delimited by the upper edges of four inclined sides 102, forming an inverted pyramid trunk, and connected to a bottom wall 103.

In FIG. 3 is represented, seen from above, an installation according to the invention, for the automatic dispensing of drugs and more generally of pharmaceutical products in individualized batches, according to the indications of medical prescriptions prescribed to patients by the practitioners of a care center and recorded in the memory circuits of a control and command unit 1 after input using the keyboard 2 of a computer terminal 3 electrically connected to said unit. The installation includes, in addition to the control and command unit 1 ,:
a handling head 4 controlled by the control and command unit 1, movable in a vertical geometric plane P by two motor assemblies 5 and 6 both controlled by the control and command unit 1, arranged in kinematic chain open, said head being provided with a gripping member 7 and a cutting member 8,
a unit 9 for storing containers 10 and for delivering the containers individually, opposite which the handling head 4 is positioned to receive an empty container 10 intended to contain a batch of medication, said unit being controlled by the control unit and order,
- A drug store 11 disposed adjacent to the container storage unit, comprising a vertical rear face parallel to the vertical plane P, formed by juxtaposition of horizontal compartments 12, arranged in horizontal lines and in vertical columns, intended to contain each a drug conditioned in unit dosage doses in a package 13 in the form of an elongated strip, face which is moved and selectively positioned the handling head 4 so that first the gripping member 7 that comprises said head 4, grips the packaging 13 corresponding to drugs, extracted by recoil movement, the packaging portion corresponding to the prescribed dosage dose and then the cutting member 8 separates from the rest of the packaging, this packaging portion which is then deposited in the container 10,
a station 14 for printing and placing an identification label 15, controlled by the control and command unit 1, to which is brought by the handling head 4, after formation of the batch of medicine, the container 10 corresponding to affix on one of the blanks of the latter a label 15 which may include in clear and in the form of a code, for example a bar code, at least the surname and first name of the patient, his date of birth his geographical location in the center of care, the date of completion of the batch, the serial number of the latter and possibly in clear and in the form of a code for example a bar code, the name of the practitioner and the date of the prescription,
a means of evacuation 16 from the containers 10 with lots formed towards a delivery zone 17, said evacuation means being controlled by the control and command unit 1, and developing perpendicular to the plane P from an adjoining upstream end to the storage unit 9 of the containers 10 and to the printing and laying station 14, towards a downstream end adjoining the delivery zone 17,
a reading means 18 comprising in particular a bar code reader positioned at the upstream end of the discharge means for reading the label of the container before distribution of the latter to the discharge means 16, said reading means being electrically connected to the control and command unit 1, which compares the result of this reading, with the data relating to the prescription which has just been formed in the container,
a means 19 for extracting the containers 10, controlled by the control and command unit 1, and activated by this unit to extract from the evacuation means 16, before it reaches the delivery zone 17, the container, the batch of which must be completed manually, said extraction means being transverse to the discharge means 16 and being intended to convey the container to a manual processing zone,
a means 19A for extracting the containers 10, controlled by the control and command unit 1, and activated by this unit to extract from the evacuation means 16, or from the delivery zone 17, the container whose inscriptions coded that has its label are either illegible, absent, or relating to another order than that which has just been formed in the container, said extraction means being transverse to the discharge means 16 or to the delivery zone 17 ,
- And a manipulator device 20 controlled by the control and command unit 1 for receiving from the delivery area 17 each container 10, and storing it in the locker of a transport and distribution trolley, not shown.

 The handling head 4, according to the preferred embodiment, is carried by a plate 21, vertical, perpendicular to the geometric plane P, fixed to the terminal motor assembly 5.

The terminal motor assembly 5 ensures the displacement and the vertical positioning of the handling head and comprises a frame formed by a hollow beam 22, of square cross section, one of the two walls perpendicular to the geometric plane P, is provided with a median longitudinal slot 23. The motor assembly further comprises a movement transmission belt 24, mounted in the hollow beam 22, in tension between an upper driving pulley and a lower driven pulley, with axes of rotation horizontal and parallel to the plane from the slot in the hollow beam.

The axis of the driving pulley is coupled to the output shaft of a controlled electric motor 25, supplied with electric energy by means of an electric power circuit controlled by the control and command unit 1. This electric motor 25 is fixed by its carcass to the upper part of the hollow beam. The transmission belt 24, by one of its strands, is arranged opposite the slot 23 of the hollow beam 22 to receive in fixing, by any known means, the support plate 21. The electric servo motor is associated with a mechanism brake controlled by the control and command unit 1, so as to ensure, when it is deactivated, the blocking in rotation of the driving pulley and consequently, the blocking in vertical translation of the head 4.

The motor assembly 5, as described, is displaceable along a horizontal axis in the vertical geometric plane P, by the first motor assembly 6 which therefore ensures, along this plane P, the displacement and the horizontal positioning of the handling head 4 .

To guide the motor assembly 5 in translation during its movement, the hollow beam 22 is provided at its lower and upper ends with two roller slides 26, mounted respectively in a lower horizontal guide rail 27 and in a upper horizontal guide rail 28. These guide rails are parallel to the geometric plane P and are rigidly fixed to a support structure 29 in the form of a frame and constituted essentially by the assembly of two vertical uprights with two horizontal beams. This support structure 29, through the opening that the uprights and side members determine, is arranged behind the magazine 11, behind the storage unit 9 for the containers 10 and behind the upstream end of the discharge means 16 , the handling head as for it being brought to evolve in this opening. The lower and upper guide rails 27, 28 are fixed respectively to the lower and upper longitudinal members of the support structure 29.

 According to the preferred embodiment, the motor assembly 6 acts directly on the lower and upper slides 26 to move the assembly 5. For this reason, each guide rail 27 and 28 is in the form of a hollow beam, of square cross section, provided, in its vertical wall facing the assembly S, with a longitudinal slot 30 in the plane of which is engaged in guiding the corresponding slide 26. In each hollow beam 26 and 27, the motor assembly 6 is equipped with an endless belt 31, of movement transmission, mounted in tension between a driving pulley and a driven pulley. These two pulleys are both mounted in rotation in the corresponding beam, about vertical axes of rotation and parallel to the plane of the slot 30. The belt 31 by one of its strands is disposed opposite the slot 30. At this strand is fixed by any known means, the corresponding slide 26. The driving pulley, mounted in the hollow beam 27, and the driving pulley mounted in the hollow beam 28, are coupled to one another by a vertical shaft for transmitting movement and torque. One of these two pulleys, preferably the pulley mounted in the beam 28, is coupled to the output shaft of a controlled electric motor 32 of the assembly 6, supplied with electric energy by a electric power circuit controlled by the control and command unit 1. This electric motor 32 is fixed by its carcass to the hollow beam 28. Advantageously the servo electric motor 32 is associated with a brake mechanism controlled by the control and command 1, so as to ensure, when it is deactivated, the blocking in rotation of the driving pulleys and therefore the blocking in horizontal translation of the assembly 5. Thus it is understood that by controlling the power circuits of the servo motors 25 and 32, the control and command unit 1 moves the head 4 along a vertical axis and along a horizontal axis and its positioning, ie opposite the unit 9 for storing and delivering containers 10 , either opposite one of the compartments 12 of the store 11, or opposite the printing and labeling station 14, 15 or opposite the upstream end of the discharge means 16.

 According to the preferred embodiment, the handling head 4 comprises, on a frame integral with the plate 21, the gripping member 7, the cutting member 8 and a horizontal support 33, positioned at a lower height level by relative to that according to which the gripping member is positioned 7. This support 33 is intended to receive and support, under the gripping member, a container 10 previously extracted from the storage unit 9.

 The frame of the handling head is formed essentially by two vertical metal blanks 34, parallel, perpendicular to the geometric plane P, spaced from one another and joined to one another by a vertical spacer wall before 35 and by a lower horizontal spacer wall 36, set back relative to the front of the frame. The handling head 4 is carried by one of its blanks 34, by the plate 21. The organ

 The gripping member 7 extends perpendicular to the plane P and is disposed on the wall 36 midway between the vertical sides 34. The gripping member 7 comprises two horizontal flat gripping nozzles 37 mounted one above on the other, intended to come into clamping on the end of the packaging 13 of medicament, one of which is fixed and the other mobile and actuated in clamping and in loosening by a motor member such as a double-acting pneumatic cylinder 38 controlled by the control and command unit 1, via a two-way three-port type solenoid valve, connected to a source of compressed air, the rod of this jack being fixed to the movable spout. The gripping spouts 37 and the pneumatic cylinder 38 are carried by the same element 39, fixed at the end of the rod 40 of an electric cylinder 41, provided with a nut integral with the rod, immobilized in rotation and free in translation and a fixed screw in translation, mobile in rotation, in screwing relation with the nut and coupled to the rotary output shaft of a controlled electric motor 42, controlled by the control and command unit 1 via a power interface. By activation of the electric motor 42 is ensured the displacement in translation of the clamping jaws 37, pneumatic cylinder 38 and support element 39 between a rear or erasing position in which the clamping jaws 37 are behind the geometric plane of section C and a position for gripping the package 13 according to which the clamping jaws 37 are in front of the section plane C and on either side of the end of the package to be extracted from the corresponding rack. By activating the pneumatic cylinder 38, the jaws 37 are brought into clamping on the end of the package 13 and by reversing the direction of the polarity of the supply voltage of the servo motor 42, the package is pulled back.

By controlling the slave motor 42, the control unit 1 can control the length of the packaging behind the cutting plane C and deactivate the motor as soon as the value of this length is compatible with the desired dosage dose. Subsequently, the cutting member 8 is activated to separate the packaging portion behind the cutting plane C, from the rest of the packaging and finally the pneumatic cylinder 38 is deactivated by the command and control unit. 1 so that the packaging portion is released from the grip of the clamping jaws 37 and can fall into the container 10 carried by the support 33.

 The handling head 4 is equipped with a means 43 for reading the identification marking. This reading means, provided with a sensitive reading element opposite which the back of the package 13 is placed, is electrically connected to the control and command unit 1 for verification by this unit, before separation by sectioning the packaging portion, the concordance between the prescribed drugs and those of the packaging 13 seized.

 According to the preferred embodiment, the cutting member 8 comprises according to the cutting plane C, an upper cutting blade 44, stationary, fixed to the front spacer wall 35, oriented so that its cutting edge, while developing in the cutting plane C, is turned downwards and a lower cutting blade 45, movable, oriented so that its cutting edge, while developing in the cutting plane, is turned upwards. To the movable cutting blade 45 are fixed two vertical guide columns46, each slidably engaged in a vertical bore formed in the front spacer wall 35. Above this wall, the columns are joined to one another by a horizontal connecting bar 47 fixed to each of the upper ends of said columns. This rod is fixed by any known means, the rod of a double-acting pneumatic cylinder 48. This cylinder is fixed by its body to the front spacer wall 35. This pneumatic cylinder 48 is controlled by the control unit and control 1, via a two-way three-port type solenoid valve, connected to a source of compressed air. The activation of the pneumatic cylinder 48 generates the deployment of the rod of this cylinder and consequently, the upward movement of the movable cutting blade 45, which leads to a cut. To prevent this cutting movement if a cell 131 of the packaging 13 is positioned in the cutting plane C, a detection means is provided, arranged on either side of the path of the packaging in the handling head 4 and on the other hand along the geometric plane C of cut. This detection means is capable of detecting the intervals between the cells 131 of the package 13 and is electrically connected to the command and control unit 1, the activation of the cutting member, ie of the jack tire 48 being performed by the command and control unit 1 only if in particular the signal emitted by the detection means is representative of the detection of an interval between two cells.

Two other conditions for activating cutting are that the packaging portion behind the cutting plane C corresponds to the required drug dose and that the concordance between the prescribed drugs and those of the packaging 13 seized, is established by the control and command unit 1.

 According to the preferred embodiment, the detection means is carried by two protrusions of the front spacer wall 35. These protrusions are arranged opposite one another and both protrude downwards. The detection means is for example constituted by a source 49 of emission of a light ray, carried by one of the two prominence and by a photoelectric cell 50 carried by the other prominence and turned opposite the source 49 in kind of being struck by the light ray.

 The support 33 of the container 10 which the handling head 4, 4 comprises, is actuated in horizontal translation along an axis perpendicular to the plane P, by a drive member 51 fixed to the spacer wall 36 controlled by the command and control unit 1, between a first position or erasing position in the handling head 4, according to which the container 10 which it carries is held under the gripping member 7 to receive from the latter the cut packaging portions and a second position, or overflow position with respect to said head 4, according to which it is in the reception position of an empty container from the storage or delivery unit by means of evacuation, from a container 10 with formed batch.

 The support 33 intended to receive each container 10 is constituted by a U-shaped bracket, ho rizontal, comprising two lateral branches parallel to each other, perpendicular to the geometric plane P and joined to each other by a core parallel to plane P. The container rests by its peripheral rim on the branches and on the core of the stirrup. The drive member 51 preferably consists of a double-acting pneumatic cylinder, fixed by the end of its rod to the central zone of the core of the stirrup and by its body, using a flange, to the underside of the spacer wall 36. This pneumatic cylinder is controlled by a solenoid valve connected to a source of compressed air. The solenoid valve is of the two-way, three-port type and is controlled by the control and command unit 1. The support 33 is further equipped with two horizontal columns, for guiding in translation, each of these columns being slidably engaged in a guide bore made in a guide block integral with the spacer wall 36.

 To receive an empty container for the preparation of an individualized batch from the data relating to a prescription, the handling head is positioned opposite the storage unit 9 and the support 33 is arranged according to the position of overflow with respect to said head 4, in the storage unit to receive a container 10.

 According to the preferred embodiment, the semi-rigid container storage unit 9 10 comprises a horizontal circular plate 52 supporting at least one vertical magazine 53 in which a stack of containers is formed 10. These containers are arranged in the interlocking into each other. The tray 52 is provided at a distance from its center, in the axis of the magazine 53, through a light 54 in which is engaged the lower container of the container stack. This stack of containers is supported on the plate 52 by pressing the peripheral rim of the lower container on the marginal zone of the upper mouth of the through lumen 54.

 The unit 9 further comprises a means 55 for gripping the containers in the container stack and for delivering the containers individually to the handling head, more precisely to the support 33, said means being activated and deactivated by the control unit and 1. This gripping and delivery means 55 is arranged on a support structure, under the plate 52, in line with the stack of containers, so that the last container in the stack can be grasped. The gripping means 55 can be moved along a vertical axis from bottom to top and from top to bottom by a motor member 56 controlled by the control and command unit 1.

 According to a preferred embodiment, the tray 52 is provided with several magazines 53 and in the axis of each of them, of a through lumen 54, each magazine always receiving a stack of containers, the lower container of which engages in the through lumen and abuts, by its peripheral rim, against the marginal zone of the upper mouth of the through lumen 54 to support the container stack. The plate 52 is mounted on a guide bearing in rotation along its vertical axis of symmetry so as to be able to have, by rotation, in line with the gripping and delivery means 55, a new container stack after exhaustion of the previous stack. To maintain the corresponding container stack in the axis of the gripping means, the plate cooperates with means for indexing its angular position constituted in this case, with a finger engaged in a radial orifice of the plate.

 Judiciously, the value of the thickness of the plate 52, at least at the level of the through lumen 54, is less than the value of the height of each container and the lower container of the container stack, by its body, comes to protrude under the underside of the tray. Under the plate 52, in the zone for gripping the container 10 by the gripping means 55, is disposed a detection means electrically connected to the command and control unit. This detection means delivers to said unit a fault signal in the absence of a container protruding under the plate, this signal being representative of the exhaustion of the container stack. The command and control unit 1, in response to this signal, activates a warning means so that the plate is changed angular position and a new container stack is placed in line with the gripping means.

 The gripping and delivery means 55 is constituted by a suction cup, the internal conduit of which is connected by means of a valve controlled by the command and control unit, either to a vacuum source or to the atmosphere. , said suction cup, being applied by the drive member against the bottom wall of the container, and the internal duct of said suction cup, at the end of the downward travel of the drive member being subjected to atmospheric pressure via the valve .

 The drive member 56 is constituted by a double-acting pneumatic cylinder supplied with compressed air by means of a two-way three-way solenoid valve controlled by the control and command unit 1. The suction cup is carried by the rod of the cylinder . The body of this cylinder is fixed to the support structure.

The positioning of the lower container on the support 33 is carried out as follows:
- The support 33, in the overflow position relative to the head 4, is, by its lateral branches, arranged on either side of the rectilinear trajectory of the gripping means and then the motor member 56 is activated from the bottom towards the top to bring the gripping means to the level of the lower container. Then, the gripping means is activated to grasp the lower container of the container stack after which the drive member 56 is activated in the top-down direction to extract the container from said stack and position it at the end. down stroke on the support 33. Thereafter, the gripping means is deactivated and the support 33 is returned to the erasing position in the handling head in order to bring the container 10 which it carries to a position suitable for receive the batch of medicine which is composed step by step by the handling head 4 which is moved for this purpose, opposite the store 1 1 and positioned in turn opposite the preselected lockers containing the drugs making up the batch to be produced.

 The horizontal compartments 12 of the magazine develop perpendicular to the vertical plane P and each comprise an opening for delivering the drug packaging 13 arranged opposite the plane P and a loading opening for the packaging 13 arranged opposite, these two openings being axially aligned. The package 13, by its longitudinal edges 133, is positioned and maintained in the corresponding rack 12 by bearing on two horizontal lips 57, opposite, longitudinal, formed in the rack 12. Preferably, the packages 13 are positioned in their lockers 12 respectively so that the outer face of the closure sheet 132 is turned upward, the means for reading the inscriptions carried by the closure sheet associated with the head 4 being mounted above the trajectory of the packaging. in the head 4. Because of this arrangement, the distance between the lips 57 is greater than the value of the width of the cell row 131 so that the latter can be positioned in the interval between said lips.

 After completion of the batch of medicament, the container 10 is transported by the handling head 4 to the station 14 for printing and affixing of label 15. This station is arranged near the storage unit for the containers 10 and for the upstream end of the discharge means 16. This station is provided with a telescopic arm 58 retracted or deployed by a motor member controlled by the control and command unit 1, this arm carrying at its free end a head of affixing 59 of the labels 15 on the containers 10 and more precisely on the sides of the latter. To avoid deformation of the container when the label is affixed, the handling head 4 is provided with a pressure plate engaged in the container to come opposite the side intended to receive the identification label.

 After affixing the label 15, the container is transported to the discharge means 16. This discharge means is constituted by a conveyor formed by two endless bands, spaced from one another and arranged in tension between the same driven roller and the same driving roller coupled to a motor member controlled by the command and control unit. The upstream end of the belt conveyor is located adjacent to the container storage unit.

The delivery zone 17 is preferably formed by the end section of the discharge means 16 and extends over a distance of a few tens of centimeters.

Preferably, a transfer means 60 is provided, piloted by the command and control unit 1, said transfer means being intended to grip the container 10 carried by the support 33 and to deposit it on the upstream end of the means evacuation 16.

 The transfer means 60 is disposed between the strips of the discharge means 16 and comprises a gripping member 61 activated and deactivated by the monitoring and control unit 1, vertically movable by a motor member 62 controlled by the handling unit control and command 1, between an erasing position according to which it is arranged according to a level of height lower than that of the upper face of the upper strand of each endless band, and a gripping position according to which it is arranged according to a height level higher than that of the upper face of the endless bands and identical to that of the bottom wall 103 of the container 10 carried by the container support 33. This support 33, for delivering to the transfer means 60 the container which it carries is arranged in its overflow position and above the transfer means. To transfer the container from this position to a position for laying on the discharge means, the drive member 62 of the transfer means 60 is first activated by the control and command unit so as to bring the member 61 in the gripping position of the container and said member as soon as it reaches this position is activated by the control unit to grip the container by its bottom wall 103.

Then, the support 33, by activation of its motor member 51 is returned to the erasing position in the handling head 4, the gripping member 61 remaining in engagement with the bottom wall 103 of the container. By activation of the drive member 62 of the transfer means, in the direction from top to bottom, the container is deposited on the endless belts of the transport means, after which the gripping member is deactivated so that the container is released and driven by the conveyor belt 16 to the delivery area 17.

 The gripping member 61 of the transfer means is constituted by a suction cup intended to cooperate in gripping with the bottom wall 103 of the container. The internal duct of the suction cup is connected via a solenoid valve controlled by the command and control unit, either to a vacuum source for gripping the container or to the atmosphere to release the container. The drive member 62 is constituted by a double-acting pneumatic cylinder connected to a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The suction cup 61 is mounted at the end of the cylinder rod 62. This cylinder is fixed by its body to the chassis of the discharge means 16.

 Before placing the container on the discharge means, the label which has one of the sides of the container is read by the reading means 18 which is electrically connected to the control and command unit and comprises on a suitable support a barcode reader. By reading this label it becomes possible to recognize the containers whose batch must be completed manually and must, for this purpose, be removed from the discharge means 16 or from the delivery zone 17, by the extraction means 19 so to be evacuated to a manual processing area.

 The extraction means 19, controlled by the control and command unit 1, comprises on the one hand, at a distance from the delivery zone 17, a stop 63 actuated by a motor member 64 controlled by the control unit and control, between a position of withdrawal relative to the path of the container on the discharge means and a position of stopping the container, and on the other hand, upstream of the stop 63, a push device 65, movable perpendicular to the trajectory of the container towards zone 17, actuated by a motor member 66 controlled by the control and command unit 1. The push device 65, when its motor member 66 is activated by the control and command unit , pushes the container 10 laterally, extract it from the discharge means 16 and place it on the upstream end of an endless belt conveyor 67 which discharges the container to a manual processing zone.

 Each motor member 64, 66 is constituted by a single or double-acting pneumatic cylinder associated with a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The stop 63 is fixed at the end of the cylinder rod 64, and the cylinder body is fixed to the frame of the discharge means 16. The stop 63 is movable vertically between the two endless bands of the discharge means. The pusher device 65 is fixed at the end of the rod of the jack 66. By its body this jack is fixed to a support structure.

 Immediately upstream of the delivery zone 17 and downstream of the stop 63, a second movable stop 68 is arranged, actuated by a motor member 69 controlled by the control and command unit, between a position of withdrawal relative to the trajectory of the container 10 on the discharge means 16 and a stop position of the container 10, said stop 68 being maintained in the stop position as long as a container is present on the delivery zone 17 and as long as this container has not been evacuated from this area by the handling device to be introduced into one of the compartments of the transport cart.

 The drive member 69 is constituted by a single or double-acting pneumatic cylinder associated with a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The stop 68 is mounted for fixing on the rod of the jack 69. This jack, by its body, is fixed to the chassis of the evacuation means. The stop 68 is movable vertically between the two endless bands of the discharge means.

 As said previously, if the label 15 is absent or illegible or if the data written on the label relates to another batch than that which has just been formed, the corresponding container is removed either from the discharge means 16, or of the delivery zone 17 by the extraction means 19A. Preferably, the discharge means 19A is associated with the delivery zone 17.

The extraction means 19A at a distance from the downstream end of the discharge means 16, is provided with a movable stop 63A actuated by a motor member 64A piloted by the control and command unit, between a withdrawal position relative to the trajectory of the container 10 on the delivery zone 17 and a position for stopping the container 10 on this zone. Upstream of the stop 63A, the discharge means is provided with a pusher device 65A movable perpendicular to the trajectory of the container over the area 17, actuated by a motor member 66A controlled by the control and command unit 1. The push device 65A, when its motor member 66A is activated by the control and command unit 1, pushes the container 10,1 laterally to extract it from the delivery zone 17 and place it on the upstream end of a 67A endless belt conveyor which drains the container to a waste or manual processing area.

The stop 63A is vertically movable between the two endless bands of the discharge means.

The drive member 64A is constituted by a single or double-acting pneumatic cylinder associated with a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The stop 63A is fixed at the end of the rod of the cylinder 64A, and the body of this cylinder is fixed to the frame of the evacuation means.

The drive member 66A is constituted by a single or double-acting pneumatic cylinder associated with a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The pusher device 65A is fixed at the end of the cylinder rod 66A. By its body this jack is fixed to an appropriate support structure.

 At the upstream end of the delivery zone 17 is provided a means 70 for reading the label of the container. This reading means, of the bar code reader type, is mounted on a suitable support and is electrically connected to the control and command unit 1. This means 70 reads the coded inscriptions carried on the label 15 and transmits in the form of electrical signals, the result of this reading to the control and command unit 1. Depending on the result of the reading, the control and command unit 1 determines the location in the transport trolley , of the rack intended to receive from the manipulator device 20, the corresponding container.

 The reading means 70 of the label 15 is turned towards the downstream end of the evacuation device 16. In addition, before placing the container 10 on the upstream end of the evacuation device 16 and after reading the label 15 by the reading means 18, the transfer device 60 makes the container 10 undergo a quarter turn along a vertical axis so that the label which it carries is oriented towards the upstream end of said discharge means 16.

 The delivery zone 17, formed as said above by the downstream section of the discharge device 16, comprises, mounted between the endless bands, upstream of the stop 63A, a station 71A for turning the container, provided with a tray horizontal container support, first actuated in vertical translation by a drive member 71 between a lower erasing position, according to which it is arranged at a height level lower than that of the upper strand of each endless belt and an upper position . Then, the horizontal plate is actuated in rotation according to a half-turn always by this motor member and this along a vertical axis.

After rotation, the horizontal plate is returned to its original position and the container placed on the endless belts of the evacuation device. The motor member of the turning device is controlled by the control and command unit 1. The presence of this turning device is justified by the fact that the carts intended for the transport of the containers, in order to save space, are arranged in two parallel rows spaced from each other in the interval between which, the manipulator device evolves on the one hand and by the fact that the labels of the containers once stored in the racks of the trolley must be visible from the on the other hand. Thus after reading the label by the means 70 and determining the allocation of the container, the control and command unit activates or does not activate the motor member of the turning device.

 The stop 63A is systematically arranged by its motor member in the stopped position when the container has to undergo a U-turn. This stop keeps the container above the horizontal plate of the turning means.

 The manipulator device 20, for receiving each container from the delivery zone, is positioned in the axis of the discharge means 16 opposite the downstream end of the latter. Each container is introduced into the manipulator device under the effect of the pushing of the endless bands of the discharge means 16. Preferably, to complete the introduction of the container 10 into the manipulator device, the delivery zone 17, downstream of the turning device is equipped with a pushing mechanism. This pushing mechanism is constituted for example by a finger 89 carried by a motor member 90 for actuating in horizontal translation between the endless belts, from an initial position immediately located downstream of the turning device, towards a final position corresponding to the 'downstream end of the discharge means 16. During its movement towards the final position the finger acts in pushing on the container which completes the introduction of the latter into the manipulator device 20. This finger is mounted articulated in a yoke 91 carried by the drive member, the latter being offset laterally relative to the rectilinear path of the finger. The finger 89 is angularly biased by a spring towards a projecting position relative to the plane containing the upper strand of each strip in order to be able to act in thrust on the container 10. In the initial position, the finger is engaged under a plate 92 to be held in the erasing position relative to the trajectory of the containers. The drive member 90 is constituted by a single or double-acting pneumatic cylinder connected to a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The yoke 91 is fixed at the end of the rod of the cylinder. This cylinder, by its body, is fixed to the structure of the discharge means 16.

 The manipulator device 20 can be moved in a vertical plane P 'parallel to the plane P both horizontally and vertically, by two motor assemblies 72, 73, controlled by the command and control unit and arranged according to a so-called open kinematic chain, the device manipulator 20 being fixed to the terminal drive element 72 of said kinematic chain.

 The terminal motor assembly 72 ensures the displacement and the vertical positioning of the manipulator device 20 and comprises a frame formed by a hollow beam 75 of square cross section, one of the two vertical walls perpendicular to the plane P ', is provided with a median longitudinal slot 76. The motor assembly 72 further comprises a movement transmission belt 77 mounted in the hollow beam 75, in tension between an upper driving pulley and a lower driven pulley. The axes of rotation of these pulleys are horizontal and parallel to the plane of the slot of the hollow beam. The axis of the driving pulley is coupled with the output shaft of a controlled electric motor 78, supplied with electric energy by means of an electric power circuit controlled by the control and command unit 1. This electric motor 78 is fixed by its carcass to the lower part of the hollow beam 75. The transmission belt 77, by one of its strands, is arranged opposite the slot 76 to receive in fixing by any known means, the manipulator device 20. The servo electric motor 78 is associated with a brake mechanism, not shown, controlled by the control and command unit 1, so as to ensure, when it is deactivated, the rotation blocking of the driving pulley and therefore the blocking in vertical translation of the handling device 20. The terminal motor assembly 72 is displaceable in translation in a horizontal direction by the second motor assembly 73. This second motor assembly is constituted by a motorized cart. This carriage receives in fixing the hollow beam 75 and is mounted in guidance, by rollers, on two horizontal rails 80 parallel to the plane P '. Adjoining one of the rails is provided a rack 81 with which cooperates in meshing with a toothed pinion 82 coupled to the output shaft of a controlled electric motor 84 carried by the carriage and supplied with electrical energy via an electric power circuit controlled by the control and command unit 1. This electric motor 84, the toothed pinion and the rack constitute the motorization of the carriage 73. The servo electric motor 84 is associated with a piloted brake mechanism by the control and command unit 1, so as to ensure, when it is deactivated, the blocking in rotation of the toothed pinion 82 therefore the blocking in horizontal translation of the motor assembly 73. Thus it is understood that by piloting the circuits of the servo motors 78 and 84, the control and command unit 1 moves the handling device 20 along a vertical axis and along a horizontal axis and its precise positioning either opposite the downstream end of the delivery zone 17, or opposite one of the compartments of the transport carriage.

 The manipulator device 20 comprises a frame constituted by a yoke 85 substantially of cross section in the shape of an inverted U, formed by two wings joined at the top by a core, said yoke comprising a lower opening facing downwards and two opposite lateral openings, formed at each of its two ends. The yoke, by one of its wings, is fixed to the motor end element 72. The yoke is intended to receive from the zone 17, the container 10 and is provided on the one hand with holding and guiding means. of the container 10 and on the other hand with a means of introduction 87 of the latter into the corresponding rack of the carriage. The container is introduced into the rack by passing said container 10 through one of the lateral openings of the yoke under the effect of a pushing movement applied to said container.

 The holding and guiding means, carried by the yoke, are intended to be engaged under two opposite segments of the rim 101 of the container and are preferably formed in the wings of the yoke. Each holding and guiding means is constituted by a hooking flange 86, horizontal, formed in the corresponding wing, said flange 86 being turned towards the inside of the yoke.

 The means 87 for inserting the container 10 into one of the compartments of the transport carriage comprises at least one pusher mechanism 93 positioned at one of the lateral openings of the yoke, acting on the container 10, by displacement in direction of the other opening of the yoke 85, a pushing force, horizontal, in order to move said container 10 through this lateral opening, and introduce it into the rack opposite which the manipulator device 20 has been previously positioned. The pusher mechanism 93 is carried by an elevating mechanism 88 controlled by the control and command unit 1, fixed to a slide 98 mounted on a rail 99 for guiding in translation fixed against the underside of the clevis web 85 and extending from one of the side openings to the other. The slide 98 with the lifting mechanism and the pusher mechanism 93 are sometimes placed at the level of one of the lateral openings and sometimes at the level of the other and are moved from one of the openings to the other by a drive member 100 piloted by the control and command unit 1 and acting in push or pull on the slide 98 to move it on its rail 99. The lifting mechanism 88 aims, for the introduction of the container 10 into the manipulator device 20 , to position the pusher mechanism above the trajectory of said container. The pusher mechanism is then brought opposite the container so as to be able to act in pushing on the container when the drive member 100 is activated. The lifting mechanism 88 consists of a single or double-acting pneumatic cylinder fixed by its body to the slide 98 and carrying by its rod, the pusher mechanism 93. This pneumatic cylinder is connected to a solenoid valve connected to a source of compressed air and controlled by the control and command unit 1. The motor unit 100 is also constituted by a jack controlled by the control and command unit.

Preferably, the push mechanism consists of a pneumatic cylinder brought into contact by its rod, with the container 10. This pneumatic cylinder is connected to a solenoid valve controlled by the control and command unit 1. At the end of the cylinder stroke 100, the jack 93 is activated so that its rod is deployed, which makes it possible to complete the introduction of the container into the rack of the carriage.

Advantageously, two pusher mechanisms 93 are provided, arranged in opposition to one another and facing respectively towards one of the lateral openings and towards the other.

The essential advantage of this arrangement is that it allows, by moving the slide on one side and the other and sometimes activating one of the push mechanisms 93 sometimes the other, the loading of transport trolleys arranged according to two rows as mentioned above.

 The installation as described makes it possible to automate the production of batches of drugs from medical prescriptions. To this installation can be added a machine for deconditioning 104 of medicament in the form of tablets or capsules in their original packaging, as well as a machine for packaging 150 of these medicaments in packaging 13 in the form of a strip.

 The original packaging of the drugs is in the form of a thermoformed 105, quadrangular plate in which are practiced in rows and columns, 105A cells each containing a unit dose dose, the 105A cells being closed by a sheet of obturation 105B perforable under the effect of mechanical pressure. Around the area occupied by the cells, the packaging includes a continuous marginal area formed by four contiguous 105C margin segments.

 The drug deconditioning machine 104 comprises on the one hand on a table 104A, at least one punching device 106 comprising a punch 107 movable vertically, moved in translation by a motor member 108 carried by a support structure integral with the table and a fixed counter-punch 109, arranged in alignment with the movable punch 107 below the latter. The counter-punch 109 is traversed right through along its longitudinal axis by a hole of sufficiently large diameter to allow, after punching, the passage of the tablets. This hole is aligned with a through hole made in the table, this second hole allowing the flow by gravity of the tablets or capsules towards a receptacle 110 arranged below. On the other hand the machine 104 comprises at least one means 111 for gripping a wafer by two of its contiguous margin segments, said wafer being held by the gripping means 111 horizontally, its closure sheet facing the bottom. The gripping means 111 is movable in a horizontal plane along two axes perpendicular to each other by two motor elements 112, 113 to bring each of the cells of the wafer between the punch 107 and the counter-punch 109, so that each of the cells of the wafer is perforated and the capsule or the tablet which it contains is driven towards the piercing of the counter-punch 109 under the effect of the perforation movement.

 The vertical punch 107, of cylindrical shape, is removably attached to its actuating motor member 108 so that it can be replaced if necessary by a punch of different diameter. The diameter of the punch is less than the diameter of the hole passing through the counter-punch so that it can penetrate said hole over a distance of a few millimeters during its downward travel. This arrangement is conducive to ensuring the complete opening of the cells 105A of the package 105.

 The motor member 108 for actuating the punch consists of a double-acting pneumatic cylinder. This cylinder is fixed by any known means to the support structure. The rod of this jack receives the free end of the removable punch 107. The pneumatic jack is connected to a two-way three-way solenoid valve controlled by a control and command means specific to the machine, typically this means which may consist of a programmable controller, not shown.

 The counter-punch 109 is removably attached to the table 104 so that it can be replaced if necessary by a counter-punch of different dimensional characteristics. The counter-punch forms at the upper end, around the upper mouth of the through hole, a collar against which the packaging 105 is brought to bear by its sealing sheet. The cell to be opened is arranged by the gripping means in a centered manner with respect to the through bore, the diameter of the latter being greater than the diameter or the length of the cell, in order to avoid crushing of the tablet or the capsule. against the upper flange of the counter-punch 109.

 The two motor elements 112, 113 associated with the gripping means 111 are arranged in an open kinematic chain and are controlled by the programmable automaton of the machine. The gripping means 111 is fixed to the terminal motor element 112 and comprises at the end of a horizontal plate 114 secured to the terminal element 112, two gripping jaws 115 each actuated in clamping by a motor member 116 towards the face top of plate 114.

These jaws are intended to cooperate in tightening with two contiguous margin segments and allow the packaging to be applied firmly, by these two margin segments, against the upper face of the plate in order to maintain the packaging. The upper face of the plate 114 is situated substantially at the same height level as the upper mouth of the bore passing through the counter-punch.

 Each jaw 115 is in the form of a circular buffer and the drive member 116 associated with the jaw is constituted for example by a single-acting pneumatic cylinder supplied with compressed air by a two-port type solenoid valve piloted by the 'programmable robot. The jaw is fixed at the end of the rod of this pneumatic cylinder.

Each cylinder will be fixed by its body to a support integral with the upper face of the plate.

 The terminal motor element 112, in its preferred embodiment, comprises, in the same horizontal plane on a frame, two parallel cylindrical slides 117, for guiding in translation a movable carriage 119 to which the plate is fixed on the one hand support 114 and on the other hand, the horizontal upper strand of an endless belt 120 tensioned between a driven pulley 121 and a driving pulley 122 coupled to the output shaft of a servo motor 123 mounted for fixing on the chassis of the terminal motor element 112 and controlled by the programmable controller.

The carriage 119 is provided with two through guide bores engaged on the slides 117.

 The frame of the motor end element 112 is fixed to the first motor element 113. This motor element comprises a frame supporting in the same horizontal plane, perpendicular to the slides 117, two slides 124, cylindrical, parallel, for guiding in translation, with which cooperates in guiding, by two guide bores 125 a movable carriage 126 to which is fixed on the one hand, the frame of the first motor element 112 and on the other hand, the horizontal upper strand of an endless belt 127 mounted in tension between a driven pulley 128 and a driving pulley 129 coupled to the output shaft of a servo motor 130 controlled by the programmable controller and mounted in fixing on the chassis of the motor element 113. Thus, by activation of the two motor members enslaved, the gripping means is moved along two axes perpendicular to one another and positions each of the cells of the packaging in turn between the punch and the counterpunch with a view to deconditioning.

 The deconditioning machine as described further comprises on the table 104A, a vertical magazine 134 in which the packages 105 are stacked horizontally on top of each other in a stack, their closure sheets being turned downwards. This magazine 134 has an upper loading opening for the packaging 105 and a lower packaging distribution opening 105 opposite which, in the magazine, the lower packaging of the stack is arranged. In the axis of the store, the table 104A has a circular opening 140 passing through.

Furthermore, a second gripping means 135 is provided, mounted under the magazine, in the axis of the latter and in the axis of the through opening, on a structure integral with the underside of the table 104A. This gripping means is actuated along a vertical axis by a drive member 136 between a lower erasing position under the path of the first means and preferably under the table, in the axis of the through opening, and an upper position of gripping according to which it grasps the last packaging of the stack, said last packaging being extracted from the store by movement of the gripping member 135 from its upper position to an intermediate position in which it maintains said packaging 105 in the horizontal plane of evolution of the first gripping means 111. Thus the packaging is placed in a position according to which it can be grasped by the first means 111. The gripping means 111 is then moved towards the packaging, and is engaged by the upper face of the plate 114 and jaws 115 on either side of two margin segments of the packaging. Then the jacks 116 are activated so that the jaws are brought into pressure against the packaging and the second gripping member deactivated so that the packaging 105 is released from the grip of said second member 135.

 The second gripping means 135 develops vertically and is constituted by a suction cup mounted at the end of a vertical air suction pipe 137 connected to a solenoid valve itself connected to a vacuum source, this solenoid valve being controlled by the programmable machine controller. The suction pipe 137 is carried by the drive member 136. This drive member is preferably constituted by a double-acting pneumatic cylinder, comprising two rods, axially aligned, arranged in opposition to each other. The suction line 137 is formed in the upper rod of the jack. At the end of the suction pipe 137 is fixed a presence sensor 139. The lower rod of the jack cooperates with a retractable stop formed by the rod of a second jack 136A disposed under the previous one axially aligned with the latter. These two cylinders are fixed by their body to the supporting structure.

Each cylinder is connected to a source of compressed air via a two-port type one-way solenoid valve, controlled by the machine's programmable controller.

 In the lower position of the suction cup, the upper rod of the jack 136 and the rod of the jack 136A are retracted in their body by supplying compressed air to the front chambers thereof. In the upper position at least the upper rod of the jack 136 is deployed by supplying compressed air to the rear chamber. In the intermediate position of the suction cup, the rod of the cylinder 136A is deployed by supplying compressed air to the rear chamber of said cylinder and the front chamber of the front cylinder of the cylinder 136 is supplied with compressed air so that the lower rod of said cylinder its end comes to bear against the end of the rod of the jack 136A.

 As said previously, the installation according to the invention can be equipped with a machine 150 for packaging drugs in packaging in the form of a strip 13.

 This packaging machine 150 comprises on a frame 151, along a guide path 152 of the thermoformed strip 13A, carried by the frame, from upstream to downstream, a station 153 for automatic filling with drugs or pharmaceutical products, cells 131 of the strip 13A, a station 154 for installing the sealing sheet 132 on the strip 13A and for sealing the latter, a station 155 for winding around the hub of a reel 156, for the package 13 formed, or cut to length of said strip, said machine 150 further comprising a mechanism 157 for advancing the strip 13A step by step along these various positions, the advance step corresponding to the spacing of the cells 131. This machine also comprises a control and command means such as for example a programmable automaton, not shown for reasons of clarity.

 The guide path 152 of the packaging machine is constituted by two horizontal guides 152A, parallel, spaced from one another and resting respectively on two guide supports 152B longitudinal, fixed to the frame of the machine. On the guides 152A bear the longitudinal edges 133 of the thermoformed strip 13A, the row of cells 131 coming in the gap between the two horizontal guides. The spacing between the guides 152A of the guide path 152 is adjustable so as to be able to adapt this guide path to rows of cells of different widths. In the preferred embodiment, each longitudinal guide 152A is mounted on its guide support so that it can be moved laterally and comprises several removable positioning pins 158 intended to be engaged in blind holes 159 formed in the guide support 152B, these blind holes embodying one of the possible spacing adjustment positions. The blind holes are organized in longitudinal rows spaced laterally from each other, each of these rows embodying one of the possible spacing adjustment positions.

 The mechanism 157 for advancing the strip 13A step by step is arranged in the frame 151 and under the guide path of the thermoformed strip 13A. This mechanism comprises a horizontal chassis 160 mounted on horizontal guide rails 161 movably in horizontal translation from upstream to downstream and downstream upstream, considering the direction of progression of the strip 13A on the guide path 152, chassis 160 being actuated in translation in one direction and then in the other by a drive member 162 and supporting at least one pusher device 163 comprising a pusher 164 actuated by a drive member 165 between an erasing position according to which it is released from the thermoformed strip 13A and a pushing position according to which it is engaged in the interval between two consecutive cells 131 of the strip 13A, said pusher 164 being held by its motor member 165 in the pushing position during movement of the chassis 160 from its position upstream to its downstream position, in order to communicate to said strip 13A the movement of the chassis and to move it in translation on the guide path 152 of the value of the movement of the chassis 160, said pusher 164 being held by its motor member 165 in the erasing position during the movement of the chassis 160 from its downstream position to its upstream position.

 The chassis 160 is in the form of a horizontal frame formed by the assembly of two longitudinal members with two end crosspieces and with several intermediate crosspieces. The end crosspieces and the intermediate crosspieces each carry a pusher device 163. To each side member of the frame 160 are fixed two slides 166 each provided with a through guide bore, horizontal for sliding engagement on one of the slides guide 161.

Each cylindrical slide is fixed at its ends to two support legs integral with the frame 151.

 At the upstream end cross member of the chassis 160 is secured the motor member 162, this member being also secured to the frame 151 of the machine. This motor member consists of at least one double-acting pneumatic cylinder connected to a two-way three-way solenoid valve connected to a source of compressed air, said solenoid valve being controlled by the programmable controller of the packaging machine. By its rod, this jack is secured to the upstream end cross member of the chassis 160 and by its body to the frame of the machine.

 The drive member 162 for actuating the chassis 160 in translation cooperates with a system of stops to limit the advance movement of said chassis to the value of the spacing step of the cells 131 of the strip 13A. According to the preferred embodiment, this stop system is constituted by a rotary barrel cooperating with indexing means in angular position and carrying rods of different lengths embodying the different spacing steps of the cells.

By rotation of the barrel about its axis, one of the rods is brought into the path of a movable stop secured to the rod of the jack. This arrangement limits the stroke of the cylinder rod.

 The pusher 164 of each pusher device 163 is constituted by a vertical pallet mounted in attachment to the motor member 165 which is advantageously constituted by a single or double-acting pneumatic cylinder associated with a solenoid valve connected to a source of compressed air and controlled by the programmable controller of the packaging machine. Pallet 164 is fixed at the end of the cylinder rod.

The station for filling the cells 131 with medication in the form of a tablet or capsule of the packaging machine comprises on a horizontal base 167 mounted above the guide path 152 of the thermoformed strip.
a rotary vacuum distributor 168 known per se,
a reserve 169 of tablets or capsules from which the rotary dispenser 168 draws the tablets or capsules one after the other,
- a bottomless distribution drawer 170, movable in translation, with upper loading opening, receiving from the rotary distributor 168, by means of an inclined chute 171 whose downstream end is located above the loading opening , the tablets or capsules one after the other, said movable drawer 170 being first placed on a horizontal fixed wall 172,
- An image analysis device 173 suitable for photographing the tablet or capsule placed in the drawer 170, on the fixed wall 172, and for recognizing the deteriorated drug or the absence of drug, said device image analysis being controlled by the programmable controller of the packaging machine,
- a drive member 174 for actuating the drawer 170 in translation, controlled by the image analysis device so as to move the drawer 170, from a central position above the fixed wall, or, if the capsule or tablet is not damaged, towards a first position lateral to this wall and in the axis of the upper mouth of a conduit 177 for gravity flow of each tablet or capsule to the corresponding cell 131 of the strip 13A either, if the tablet is damaged or if several tablets are present, towards a second position lateral to the fixed wall and opposite to the previous one. In this latter position, the drawer is placed above a container for receiving damaged tablets or capsules.

 The programmable controller only activates the step-by-step advance mechanism if a tablet or capsule has been dispensed to cell 131 of band 13A. This arrangement avoids any lack of drug in the 131 cells of the 13A band. Furthermore, the image analysis device makes it possible to detect duplicates which avoids the distribution of several unit dosage doses to the same cell. It should be noted that the risk of distribution of duplicates is reduced due to the uniformity of the dimensions of the tablets or capsules of the same medicine which allows the effective treatment of this defect, at the level of the vacuum distributor by any suitable means. and known to those skilled in the art.

 The slide 170 is mounted in guidance along an axis perpendicular to the direction of advance of the strip 13A in a rail element 175 to which is fixed, by a plate, the downstream end of the inclined chute 171. The drive member 174 is fixed on the one hand to the movable drawer and on the other hand to a projecting tab fixed at the end of the rail-forming element. This drive member is constituted by two single or double acting pneumatic cylinders, axially aligned, arranged in opposition to one another and fixed to one another by their body. The rod of one of these jacks is fixed to the movable drawer while the rod of the other is fixed to the projecting tab. Each cylinder is connected to a solenoid valve connected to a source of compressed air and controlled by the programmable controller of the packaging machine. In the central position of the drawer, the rod of one of the cylinders is retracted into the body while the rod of the other is deployed. In this way by supplying compressed air, sometimes one, sometimes the other, it is possible to move the drawer either to one of the two lateral positions or to the other.

The rail-forming element 175 is fixedly mounted on a support piece 176 which is itself fixed to the base 167. This support piece 196 carries the fixed horizontal wall 172. Adjoining the wall 172, the support piece is provided with a vertical through hole positioned opposite a vertical through hole made in the base 167. In these two holes is engaged the duct 177 for gravity flow of each tablet or capsule to the corresponding cell of the strip 13A. This conduit comprises an upper flange for fixing to the support part. Furthermore, this conduit 177, in the lower part is freely engaged in a sliding tube 178, coming under the effect of its own weight to be disposed by its lower mouth as close as possible to the strip 13A while coming to bear by this mouth on two sheets 179 covering, at this level, guides 152A. These cover sheets are spaced from their guide 152A by a value slightly greater than the thickness of the flanges 133 of the strip 13A.

 Advantageously, the fixed wall 172 is transparent and closes at the top, a solenoid valve cav connected to a source of compressed air, said solenoid valve being controlled by the programmable controller of the packaging machine. Each heating element is mounted at the end of the rod of the corresponding jack. The heating element 184 is long enough to seal strips of any width.

 The supporting structure of each drive member 183 is mounted on the corresponding guide 152A and is constituted by a vertical member. The supporting structure of the element 184 is in the form of a gantry. This structure spans the guide path and is fixed to the machine frame. During the heat sealing operation, under the effect of the pressure of the heating elements 183 arranged in line with the guides 152A, the edges of the strip 13A are applied firmly against the said guides 152A, the latter constituting the pressure plate. With the transverse sealing heating element 184 is associated a vertical pressure plate 187 of rectangular shape, arranged under the guide path and actuated in vertical translation by a drive member 188 between a low position according to which it is released from the trajectory of the cells of the strip 13A and a high position according to which it is arranged between two contiguous cells in contact with the thermoformed strip 13A, by its upper horizontal edge. Advantageously, the pressure plate is guided in two vertical guide rails. The drive member 188 consists of a single-acting pneumatic cylinder associated with a two-port type solenoid valve connected to a pressure source and controlled by the programmable controller of the packaging machine. The vertical pressure plate 187 is fixed at the end of the cylinder rod, the latter being fixed by its body to the frame of the machine.

 The packaging machine is equipped downstream of the station for laying and sealing the closure sheet, with a station 189 for perforating the intervals between the cells so as to subsequently facilitate separation by the cutting members 44, 45 of the handling head 4 of the packaging portions 13. The station 189 comprises under the guide path a punch 190 and above the guide path, a die 191 extended upwards by a chute 192 for discharging waste. The punch 190 is actuated in vertical translation by a motor member 193 between a lower erasing position under the guide path and a higher position, of perforation according to which it penetrates into the die 191 after having perforated the interval between the two band cells. This punch 190 comprises several perforating elements 194 spaced apart from each other and adapted to penetrate into perforation orifices 195 formed in the die 191, these perforation orifices being in communication with the upper chute 192. The drive member 193 is constituted by a double-acting pneumatic cylinder, associated with a two-way three-way solenoid valve connected to a source of compressed air and controlled by the programmable controller of the packaging machine.

 Upstream of the heat-sealing station, the packaging machine is equipped with means, not shown, for printing on the closure sheet, identification markings of the medicament contained in each cell of the packaging. This means, known per se, and comprising a printing head arranged opposite the path of the closure sheet, is controlled by the programmable controller of the packaging machine.

 The station 155 for winding around the hub of a receiving coil 156, of the package 13 formed, comprises a known carrying structure carrying above the guide path a drive pin mounted on bearings, intended to cooperate in coupling with the hollow hub of the coil. The drive axis is coupled by any known means to the output shaft of a pneumatic motor 193 controlled by the programmable controller of the packaging machine.

 The winding station can be replaced by a cutting station to the length of the package 13, constituted for example by a guillotine shears.

 The installation may be equipped with a thermoforming machine 194 of the strip 13A of the packaging 13. For example, this machine 194 comprises a frame 195 on which is installed a horizontal upper plate 196 provided with a central opening 197 , quadrangular, in the axis of which, under the plate 196 is installed a forming die 198, movable in vertical translation between a lower erasing position and an upper forming position, and on the plate 196, a punch 207 movable in vertical translation between an upper erasing position and a lower forming position according to which it comes by passing through the opening 197 of the plate 196, into the die 198 to push back the strip to be formed, which is previously heated and made suitable for thermoforming by contact with a heating plate 199. The strip to be thermoformed is in the form of a flat ribbon conditioned in the form of a roll 200 formed around the hollow hub of a reel reel mounted by said hub on a horizontal axis secured by one of its ends, with a lug fixed to the frame 195. The roller 200 is installed upstream of the die punch system. Downstream of this system is installed a step-by-step advance mechanism 201 formed by two clamp members 202 mounted on a movable assembly 203 actuated in translation from upstream to downstream and downstream upstream by a motor member 204, the clamp members 202 being activated in clamping on the edges 133 of the strip 13A during the upstream-downstream stroke of the moving assembly 203 and disabled during the return stroke of this crew.

The activation of the motor member 204 in the upstream-downstream direction is carried out only if the punch and the die are both in the erasing position.

 The forming die 198 and the heating plate 199 are both carried by the same mobile assembly 205 which ensures their mobility in vertical translation, this mobile assembly being provided with a driving member 206.

 The punch 207 is carried by a motor means constituted for example by two double-acting pneumatic cylinders.

It should be noted that the punch and the die are easily interchangeable.

 Finally, the thermoforming machine 194 can be coupled to the packaging machine 150 so that the strip 13A is introduced directly into the packaging machine. Similarly or may provide to couple the deconditioning machine 104 to the packaging machine so that the drugs fall directly into the drawer 170, the drilling of the counter punch 109 being disposed above the median position of the drawer 170. We can also provide for placing the hole in the counter-punch above the reserve of the vacuum distributor so as to directly supply the latter.

 It goes without saying that without departing from the scope defined by the claims, the present invention can receive all arrangements and variants of the field of technical equivalents.

Claims (1)

CLAIMS.  11 Installation for the automatic dispensing of drugs or more generally of pharmaceutical products in separate batches, individualized, from information relating to medical prescriptions, comprising a vertical magazine (11) comprising a vertical rear face, formed by juxtaposition of horizontal compartments (12) each containing a package (13) having cells (131) aligned, spaced apart from each other by a constant pitch and each containing one or more unit dose (s) of the same drug or pharmaceutical product , each locker (12) being intended to contain a particular type of medicine or pharmaceutical product distinct from that contained by each of the other lockers, said installation comprising a handling head (4) with controlled movements, movable by at least one motor assembly in look of the vertical rear face of the magazine (11) to be selectively positioned facing the lockers (12) afi n that the gripping member (7) which it possesses is disposed in the axis of the packaging (13) of medication from the corresponding rack (12) to grip the end of this packaging in the form of a strip and by movement step back, extract from this rack (12) the packaging portion corresponding to the desired number of doses of medication and place this packaging portion behind a geometric plane (C) or cutting plane, parallel to the rear face vertical of the magazine (11), according to which a cutting member (8) which the handling head (4) then carries out a cut to separate said portion of packaging from the rest of the packaging, said installation also comprising a unit (9) for storing semi-rigid containers (10) nesting in each other according to at least one vertical stack, in each of which an individualized batch of drugs corresponding to a medical prescription is intended to be formed, said medical prescription e being entered on the keyboard (2) of a computer terminal (3) and delivered to a command and control unit (1) which in particular controls the movements of the handling head (4), the movements of the organ gripping (7) and the movements of the cutting member (8) and activates the cutting member (8) for the separation of the packaging portion when the length of the packaging portion extracted from the rack and disposed behind the geometric plane (C) is compatible with the drug dosage required by the prescription, characterized in that the handling head (4), under the gripping member (7), is provided with a support (33) on which rests a container (10) previously extracted from the container stack, in which are deposited, by the gripping member (7), the packaging portions separated from the rest of the packaging (13) by the cutting member (8), said packaging portions corresponding to the drug or pharmaceutical doses ques of the same prescription.  2 / Installation according to claim 1 characterized in that each container (10) substantially of parallelepiped shape is made of a synthetic material capable of absorbing shocks and is provided with a continuous annular rim (101) formed by four segments of opposite rims two to two respectively running on the four sides of the opening of said container.  3 / Installation according to claim 1, or claim 2 characterized in that the handling head (4) is movable parallel to the rear vertical face of the store both horizontally and vertically, by two motor assemblies, (5), (6) controlled by the command and control unit (1) and arranged according to a so-called open kinematic chain, the handling head (4) being fixed to the terminal motor element of said chain by means of a support plate (21).  4 / Installation according to any one of claims 1, 2, 3 characterized in that the lockers (12) of the store (11) are arranged in juxtaposed horizontal lines and juxtaposed vertical columns.  5 / Installation according to any one of the preceding claims, characterized in that the support (33) of the container (10) is mobilized horizontally by a motor member (51) controlled by the command and control unit (1), between a first position or erasing position in the handling head (4), and a second position or position overflowing with respect to said head (4).  6 / Installation according to any one of the preceding claims, characterized in that the support (33) intended to receive each container consists of a U-shaped bracket, horizontal, comprising two lateral branches joined to each other by a core, the container resting by its peripheral rim on the branches of the stirrup as well as on the core.  7 / Installation according to any one of the preceding claims, characterized in that the back region of each package (13) of drug or pharmaceutical product, in line with each cell (131), includes an identification marking of the pharmaceutical product or drug in the cell.  8 / installation according to claim 7 characterized in that the handling head (4) is equipped with a reading means (43) of the identification marking, this reading means (43), provided with a sensitive element of reading opposite which the back of the packaging (13) is arranged, being electrically connected to the control and command unit (1) for verification by this unit, before separation by sectioning of the packaging portion, the concordance between the prescribed drugs and those of the seized packaging.  9 / Installation according to any one of the preceding claims, characterized by a detection means (49), (50) disposed on either side of the packaging path in the handling head (4) and according to the plane geometric (C) of sectioning of the package (13) by the cutting members (8), said detection means being able to detect the intervals between the cells (131) of the package (13) and being electrically connected to the command and control unit (1), the activation of the cutting member (8) being controlled by the command and control unit (1) only if in particular, the packaging portion in back of the section plane corresponds to the required drug dose and if the signal emitted by the detection means is representative of the detection of an interval between two cells.  10 / Installation according to any one of the preceding claims, characterized in that the handling head (4) is mounted on its plate (21) movably in translation by a drive member (21A) along an axis perpendicular to the geometric plane (P).  11 / Installation according to any one of the preceding claims, characterized in that the unit (9) for storing containers (10) semi-rigid is attached to the magazine (11) for packaging (13) of medicaments and comprises:  - a circular plate (52) supporting at least one vertical magazine (53) in which a container stack (10) is formed, said plate (52) being provided at a distance from its center in the axis of the magazine with a light through (54) in which is engaged the lower container of the container stack, said stack of containers being supported on the plate (52) by pressing the risk peripheral edge (101) of the lower container on the marginal zone of the upper mouth through light (54),  a means for gripping (55) the containers in the container stack disposed under the tray in line with the container stack (10), controlled by the control and command unit (1), said means (52) being activated and deactivated by the control and command unit (1), and being movable along a vertical axis between a lower position and a higher position, by a motor member (55) controlled by the control and command unit ( 1), said motor member (56) being first activated from the bottom upwards to bring the gripping means (55) to the level of the lower container (10) after which the gripping means (55) is activated to grip the lower container (10) of the container stack, after which the drive member (56) is activated in the top-down direction to extract the container (10) from said stack and position it at the end of travel descending on the support (33) of container (10) which comprises the handling head (4), said support (33) being in the overflow position with respect to said head and being brought back into the erasing position in said head (4), with the container which it carries after deactivation of the gripping member ( 55).  12 / Installation according to any one of the preceding claims, characterized by a station (14) for printing identification labels (15) and affixing the latter to the containers, (l0) controlled by the unit command and control (1), to which is brought, by the handling head (4) after formation of a batch of drugs the corresponding container, to affix the printed label (15) on one of the blanks of the latter, said identification label (15) comprising, in plain text and in code form, various information such as, for example, the patient's first and last name, date of birth, geographic location in the care center, date of completion of the batch, the serial number of the latter, the practitioner's name and the date of the prescription.  13 / installation according to claim 12, characterized in that the handling head (4) is provided with a pressure plate engaged in the container to come opposite the side intended to receive the identification label and to avoid deformation of said sidewall when the label (15) is affixed by the printing and affixing station.  14 / Installation according to any one of the preceding claims, characterized by means (16) for evacuating the containers (10) with batches formed towards a delivery zone (17), controlled by the command and control unit ( 1), and by a manipulator device (20) controlled by the control and command unit (1) intended to receive from the delivery area (17), each container (10) and store it in the locker of a transport and distribution cart.  15 / Installation according to claim 14, characterized in that the discharge means (16) consists of an endless belt conveyor formed by two endless bands spaced from one another and arranged in tension between the same driven roller and the same driving roller coupled to a drive member controlled by the command and control unit (1), the upstream end of said conveyor belt being located adjacent to the container storage unit (9) (10).  16 / Installation according to claim 14 or claim 15, characterized by a transfer means (60) controlled by the command and control unit (1), said transfer means coming to grip the container (10) carried by the support (33) that comprises the handling head (4) and place it on the upstream end of the discharge means (16).  17 / Installation according to claims 12, 15 and 16 taken together, characterized by:  a means for reading (18) the label of the container (10) carried by the transfer means (60), said reading means (18) being electrically connected to the control and command unit (1) and operating, before delivery of the container (10) to the discharge means (16), a reading of the coded entries carried on the label (15), the result of this reading being compared, by the control and order (1), to the data relating to the batch of medicaments or pharmaceutical products which has just been formed in the container (10),  - a means (19) for extracting the containers (10), controlled by the control and command unit (1), and activated by this unit to extract from the evacuation means (16), before it reaches the delivery zone (17), the container whose batch must be completed manually, said extraction means being transverse to the discharge means (16) and being intended to convey the container to a manual processing zone,  - a means (19A) for extracting the containers (10), controlled by the control and command unit (1), said extraction means (19A) being activated by the control and command unit (1 ) to extract from the evacuation means (16), the container (10), the coded inscriptions of which its label (15) is either illegible, or absent, or relating to another batch than that which has just been formed in the recipient.  18 / Installation according to any one of claims 14, 15, 17, characterized by a movable stop (68) disposed immediately upstream of the delivery zone (17), is maintained according to the stop position of the containers as long as a container (10) is present on the reception area (17).  19 / Installation according to claims 18 and 21, taken together, characterized in that at the upstream end of the delivery zone (17) of the containers (10) is provided a means of reading (70) of the label ( 15) of the container (10), said reading means (70) being electrically connected to the control and command unit (1) and operating a reading of the coded inscriptions carried on the label (15), the result of this reading serving as a basis for the control and command unit (1) for the choice of the rack of the storage and transport trolley intended to receive from the manipulator device 20, the corresponding container, the reading means (70) of the the label (15) of the container (10) being turned towards the downstream end of the delivery zone (17), and that, before placing the container (10) on the upstream end of the discharge means (16), the transfer device (60) makes the container (10) undergo a quarter turn along a vertical axis fa çon that the label (15) it carries is oriented towards the upstream end of said means (16).  20 / Installation according to claim 14, characterized in that the delivery zone (17) is equipped with a container turning station.  21 / Installation according to any one of claims 14 to 20 characterized in that the manipulator device (20) is movable in a vertical plane both horizontally and vertically, by two motor assemblies (72), (73), controlled by the command and control unit (1) and arranged in a so-called open kinematic chain, the manipulator device (20) being fixed to the terminal drive element of said kinematic chain.  22 / Installation according to claim 21 characterized in that the manipulator device (20) comprises a yoke (85) substantially of cross section in the shape of an inverted U formed by two wings joined in the upper part by a core, said yoke comprising a lower opening facing downwards and two opposite lateral openings, formed at each of the two ends of the yoke, said yoke being intended to receive from the zone 17 a container (10) and being provided on the one hand with means (86), for holding and for guiding the container (10) and on the other hand a means of introduction (87) of the latter into the corresponding compartment, this introduction taking place by passage of said container (10) through one of the lateral openings of the yoke (85) under the effect of a pushing movement, the yoke (85) by one of its wings being fixed to the motor end element (72).  23 / Installation according to claim 22 characterized in that the holding and guiding means (86), carried by the yoke (85) are intended to be engaged under two opposite segments of the rim (101) of the container (10), and that each holding and guiding means (86) is constituted by a horizontal catching rim, formed on the corresponding wing, said rim (86) being turned towards the inside of the yoke (85).  24 / Installation according to any one of claims 22 or 23, characterized in that:  - The means of introduction (87) of the container (10) in one of the compartments of the transport carriage comprises at least one pusher mechanism (93) controlled by the control and command unit (1), positioned at level of one of the lateral openings of the yoke exerting on the container (10), by displacement in the direction of the other lateral opening of the yoke (85) a pushing force, horizontal, in order to move said container (10) through this opening, and introduce it into the rack opposite which the manipulator device (20) has been previously positioned,  - The pusher mechanism (93) is carried by a lifting mechanism (88) piloted by the control and command unit (1), fixed to a slide (98) mounted on a rail (99) for guiding in translation fixed against the underside of the yoke core (85) and extending from one of the lateral openings to the other, said slide (98) with the lifting mechanism and the pusher mechanism (93) being arranged earlier at the level of one of the lateral openings, sometimes at the level of the other and moved from one of the openings to the other by a motor member (100) piloted by the control and command unit (1) and acting in pushing or pulling on the slide (98) to move it on its rail (99), the lifting mechanism (88), for the introduction of the container (10) into the manipulator device 20, positioning the pushing mechanism (93 ) above the trajectory of said container.  25 / Installation according to claim 24, characterized by two pusher mechanisms (93) arranged in opposition relative to each other and respectively turned towards one of the side openings and towards the other.  26 / Installation according to any one of the preceding claims, characterized in that it is equipped with a machine (104) for deconditioning medicaments in the form of tablets or capsules and packaged in a packaging in the form of a plate. thermoformed (105), quadrangular, in which are practiced in rows and columns, cells (105A) each containing a unit dosage dose, the cells (105A) being closed by a sealing sheet (105B) perforable under the effect of mechanical pressure, a continuous marginal zone formed by four margin segments (105C), contiguous being formed around the zone occupied by the cells (105A).  27 / Installation according to claim 26, characterized in that the drug deconditioning machine (104) comprises:  - At least one punching device (106) comprising a punch (107) movable vertically, moved in translation by a motor member (108) and a fixed counter-punch (109), arranged in alignment with the punch (107) at below the latter, said counter-punch (109) being traversed right through along its longitudinal axis by a hole of sufficiently large diameter to allow after punching, the passage and the flow by gravity of the tablets or capsules towards a receptacle (110) disposed under said counter-punch (109),  - At least one means (111) for gripping a plate (105) by two contiguous margin segments (105C), said plate (105) being held by the horizontal gripping means, its sealing sheet ( 105B) turned downwards, the gripping means (111) being movable in a horizontal plane along two axes perpendicular to each other, to bring each of the cells (105A) of the plate (105) between the punch ( 107) and the counter-punch (109), so that each of the cells (105A) of the wafer (105) is perforated and the capsule or the tablet which it contains is expelled towards the piercing of the counter-punch (109) under the effect of the perforation movement.  28 / Installation according to claim 27, characterized in that the deconditioning machine (104) further comprises:  - A vertical magazine (134) in which the packages (105) are stacked horizontally on top of each other in a stack, their closure sheets (105B) facing downwards, said magazine (134) having an opening upper loading of the packaging and a lower opening for distributing the packaging opposite which, in the store, the lower packaging of the stack is arranged,  - A second gripping means (135), positioned under the magazine (134) opposite the lower opening of the latter, said gripping means (135) being actuated along a vertical axis by a motor member (136) between a lower erasing position under the trajectory of the first gripping means (111), an upper gripping position in which it comes to grip the last packaging of the stack, said last packaging being removed from the magazine by movement of the gripping member (135) from its upper position to an intermediate position for positioning the packaging in the plane of evolution of the first means (111) so that said packaging can be gripped by the first gripping means (111).  29 / Installation according to any one of the preceding claims, characterized in that it is equipped with a machine (150) for packaging drugs or pharmaceutical products in a package (13) consisting on the one hand:  - a thermoformed strip (13A) comprising, at constant pitch along a row, cells (131) intended to receive unit doses of drugs or pharmaceutical products, and on either side of the row of cells, two flanges ( 133) longitudinal, marginal,  - And on the other hand a sealing sheet (132) of the cells (131) fixed to the said strip (13A).  30 / Installation according to claim 43, characterized in that the packaging machine (150) comprises along a guide path (152) of the thermoformed strip (13A), from upstream to downstream, a filling station for cells (131) in medicine or pharmaceutical product, a station (154) for placing the sealing sheet (132) on the strip (13A) and for sealing the latter, a station (155) for winding around the hub of a reel, (156) of the packaging formed, or of cutting to length, said packaging machine further comprising a mechanism (157) for advancing the strip (13A) step by step along these various stations , the advancement step corresponding to the cell spacing step (131).  31 / Installation according to claim 30, characterized in that the mechanism (157) for step-by-step advancing of the strip (13A) is disposed under the guide path (152) of the thermoformed strip and comprises:  - A horizontal frame (160) mounted on guide rails (161) movably in horizontal translation from upstream to downstream and downstream upstream, considering the direction of progression of the strip (13A) on the guide path , said chassis being actuated in translation in one direction then in the other by a motor member (162), cooperating. with a system of stops for limiting the advance movement of said chassis to the value of the spacing step of the cells of the strip (13A),  - at least one pusher device (163) carried by the movable frame (160), the pusher device (163) comprising a pusher (164) actuated by a motor member (165) between an erasing position according to which it is released from the thermoformed strip (13A) and a pushing position according to which it is engaged in the interval between two consecutive cells (131), said pusher (164) being held by its motor member (165) in the pushing position during the movement of the chassis (160) from its upstream position to its downstream position, in order to communicate to said strip (13A) the movement of the chassis (160) and to move it in translation on the guide path (152) by the value of the displacement of the chassis ( 160), said pusher (164) being held by its drive member (165) in the erasing position during movement of the chassis (160) from its downstream position to its upstream position.  32 / Installation according to any one of claims 30 or 31, characterized in that the guide path (152) consists of two horizontal guides (152A), parallel, spaced from one another on which the longitudinal edges (133) of the thermoformed strip (13A) (13A), the cell row (131) coming between the two horizontal guides (152A), the spacing between the guides (152A) of the guide path (152) of the packaging machine (150) being adjustable so as to adapt the guide path to rows of cells of different widths.  33 / Installation according to any one of claims 44 to 48 characterized in that in that the station (153) for filling the cells (131) with drugs in the form of tablets or capsules of the packaging machine comprises on a base horizontal (167) mounted above the guide path (152) of the thermoformed strip (13A):  - a rotary vacuum distributor (168),  - a reserve (169) of tablets or capsules from which the rotary distributor (168) draws the tablets or capsules one after the other,  - A drawer (170) movable in translation, bottomless, receiving from the rotary distributor (168), via an inclined chute (171), the tablets or capsules one after the other, said movable drawer (170) being first placed on a fixed wall (172), horizontal,  - an image analysis device (173) capable of photographing the medication placed in the drawer (170), on the fixed wall (172), and of recognizing the deteriorated medication, or the absence of medication,  - a motor member (174) for actuating the drawer (170) in translation controlled by the image analysis device (173) so as to move the drawer (170), from a central position above the fixed wall (172), either if the capsule or the tablet is not damaged, towards a first position lateral to the wall (172) and in the axis of the upper mouth of a conduit (177) of flow by gravity of each tablet or capsule to the corresponding cell (131) of the strip (13A) or, if the capsule or the tablet is damaged, to a second lateral position, opposite to the previous one, according to which it is arranged above a container for receiving damaged tablets.  34 / Installation according to claim 33, characterized in that the horizontal base (167) of the filling station (153) of the packaging machine (150) is mounted movably on horizontal rails extending above the path of guide (152) perpendicular to the latter.  35 / Installation according to any one of claims 33 or 35, characterized in that the station (154) for installing and sealing the sealing sheet (132) on the thermoformed strip (13A) comprises two heating elements (183 ) facing longitudinal sealing intended to seal the sealing sheet (132) on the two longitudinal edges (133) of the thermo-formed strip (13A) and a transverse sealing heating element (184) intended to seal the sealing sheet sealing on the intervals between the cells (131) of the strip (13A), each heating element (183), (184) of the installation and sealing station of the packaging machine being actuated in translation by a motor member (185 ), (186), between a high position or waiting position and a low position or heat-sealing position according to which it is applied firmly to the closure sheet (132) in order to seal the latter to the thermoformed strip (13A) .  36 / Installation according to any one of claims 30 to 35 characterized in that the packaging machine is equipped downstream of the station (154) for laying and sealing the sealing sheet of a station (189) for perforation intervals between the cells (131) so as to subsequently facilitate separation by the cutting members (44), (45) from the head