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FR2639638B1 - PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS - Google Patents

PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS

Info

Publication number
FR2639638B1
FR2639638B1 FR8815414A FR8815414A FR2639638B1 FR 2639638 B1 FR2639638 B1 FR 2639638B1 FR 8815414 A FR8815414 A FR 8815414A FR 8815414 A FR8815414 A FR 8815414A FR 2639638 B1 FR2639638 B1 FR 2639638B1
Authority
FR
France
Prior art keywords
radiopharmaceuticals
synthesis
preparation
transition metal
metal complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8815414A
Other languages
French (fr)
Other versions
FR2639638A1 (en
Inventor
Roberto Pasqualini
Andre Bardy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oris Industrie SA
Original Assignee
Oris Industrie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR8815414A priority Critical patent/FR2639638B1/en
Application filed by Oris Industrie SA filed Critical Oris Industrie SA
Priority to EP89903166A priority patent/EP0403524B1/en
Priority to CA000593139A priority patent/CA1340899C/en
Priority to JP1502987A priority patent/JPH07110869B2/en
Priority to PCT/FR1989/000094 priority patent/WO1989008657A2/en
Priority to US07/571,570 priority patent/US5300278A/en
Priority to DE8989903166T priority patent/DE68904905T2/en
Priority to AT89903166T priority patent/ATE85619T1/en
Priority to AU33518/89A priority patent/AU619538B2/en
Publication of FR2639638A1 publication Critical patent/FR2639638A1/en
Priority to SU904831069A priority patent/RU2026300C1/en
Application granted granted Critical
Publication of FR2639638B1 publication Critical patent/FR2639638B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR8815414A 1988-03-09 1988-11-25 PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS Expired - Lifetime FR2639638B1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR8815414A FR2639638B1 (en) 1988-11-25 1988-11-25 PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS
AU33518/89A AU619538B2 (en) 1988-03-09 1989-03-08 Preparation of nitruro compounds usable as radio-pharmaceutical products
JP1502987A JPH07110869B2 (en) 1988-03-09 1989-03-08 Method for producing nitride complex of 99mTc, 186Re or 188Re that can be used as a radiopharmaceutical
PCT/FR1989/000094 WO1989008657A2 (en) 1988-03-09 1989-03-08 Preparation of nitruro compounds usable as radio-pharmaceutical products
US07/571,570 US5300278A (en) 1988-03-09 1989-03-08 Process for the preparation of 99m Tc, 186 Re or 188 Re nitride complexes usable as radiopharmaceutical products
DE8989903166T DE68904905T2 (en) 1988-03-09 1989-03-08 PRODUCTION OF NITRURO COMPOUNDS TO BE USED AS RADIOPHARMACEUTICAL PRODUCTS.
EP89903166A EP0403524B1 (en) 1988-03-09 1989-03-08 Preparation of nitruro compounds usable as radio-pharmaceutical products
CA000593139A CA1340899C (en) 1988-03-09 1989-03-08 Procede de preparation de complexes nitruro 99m tc, 186 re ou 188 re utilisables comme produits radiopharmaceutiques
AT89903166T ATE85619T1 (en) 1988-03-09 1989-03-08 PREPARATION OF NITRURIUM COMPOUNDS USABLE AS RADIOPHARMACEUTICAL PRODUCTS.
SU904831069A RU2026300C1 (en) 1988-03-09 1990-09-07 Method of preparing of transient metal complexes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8815414A FR2639638B1 (en) 1988-11-25 1988-11-25 PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS

Publications (2)

Publication Number Publication Date
FR2639638A1 FR2639638A1 (en) 1990-06-01
FR2639638B1 true FR2639638B1 (en) 1991-07-26

Family

ID=9372250

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8815414A Expired - Lifetime FR2639638B1 (en) 1988-03-09 1988-11-25 PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES FOR USE AS RADIOPHARMACEUTICALS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICALS

Country Status (1)

Country Link
FR (1) FR2639638B1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4851515A (en) * 1983-12-29 1989-07-25 The Commonwealth Of Australia Preparation of 99m Tc radiopharmaceuticals

Also Published As

Publication number Publication date
FR2639638A1 (en) 1990-06-01

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