FR2620024A1 - Cosmetic composition containing an anti-free-radical agent, and corresponding agent - Google Patents
Cosmetic composition containing an anti-free-radical agent, and corresponding agent Download PDFInfo
- Publication number
- FR2620024A1 FR2620024A1 FR8712516A FR8712516A FR2620024A1 FR 2620024 A1 FR2620024 A1 FR 2620024A1 FR 8712516 A FR8712516 A FR 8712516A FR 8712516 A FR8712516 A FR 8712516A FR 2620024 A1 FR2620024 A1 FR 2620024A1
- Authority
- FR
- France
- Prior art keywords
- cosmetic composition
- composition according
- hydroxyxanthine
- acid
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 10
- 239000002537 cosmetic Substances 0.000 title claims description 15
- 239000000203 mixture Substances 0.000 title claims description 15
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims abstract description 24
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 20
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims abstract description 16
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims abstract description 15
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 claims abstract description 14
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims abstract description 14
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims abstract description 13
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 claims abstract description 12
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940116269 uric acid Drugs 0.000 claims abstract description 11
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229960001948 caffeine Drugs 0.000 claims abstract description 10
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 10
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930024421 Adenine Natural products 0.000 claims abstract description 8
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960000643 adenine Drugs 0.000 claims abstract description 8
- 229960000278 theophylline Drugs 0.000 claims abstract description 8
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims abstract description 7
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims abstract description 7
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229940029575 guanosine Drugs 0.000 claims abstract description 7
- 229960005010 orotic acid Drugs 0.000 claims abstract description 7
- 229940075420 xanthine Drugs 0.000 claims abstract description 7
- 229920002477 rna polymer Polymers 0.000 claims abstract description 6
- 229960004559 theobromine Drugs 0.000 claims abstract description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000004472 Lysine Substances 0.000 claims abstract description 5
- OKOYRJGOOZACDF-UHFFFAOYSA-N OC(C1=NC(NC(N(C2=O)O)=O)=C2N1)=O Chemical compound OC(C1=NC(NC(N(C2=O)O)=O)=C2N1)=O OKOYRJGOOZACDF-UHFFFAOYSA-N 0.000 claims abstract description 5
- 230000032683 aging Effects 0.000 claims abstract description 5
- -1 hydroxyxanthinate lysine Chemical compound 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 102000039446 nucleic acids Human genes 0.000 claims description 7
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 150000002632 lipids Chemical class 0.000 claims description 6
- 125000005639 glycero group Chemical group 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 101710095468 Cyclase Proteins 0.000 claims 1
- 241000446313 Lamella Species 0.000 claims 1
- 206010041303 Solar dermatitis Diseases 0.000 claims 1
- 229960003646 lysine Drugs 0.000 claims 1
- 229940035893 uracil Drugs 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- 239000002304 perfume Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 239000002480 mineral oil Substances 0.000 description 4
- 235000010446 mineral oil Nutrition 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229940075529 glyceryl stearate Drugs 0.000 description 3
- 238000005502 peroxidation Methods 0.000 description 3
- 150000002978 peroxides Chemical class 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 102000030621 adenylate cyclase Human genes 0.000 description 2
- 108060000200 adenylate cyclase Proteins 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 229940072107 ascorbate Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 208000017983 photosensitivity disease Diseases 0.000 description 2
- 231100000434 photosensitization Toxicity 0.000 description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 2
- 229940113124 polysorbate 60 Drugs 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 229950011392 sorbitan stearate Drugs 0.000 description 2
- ABTZKZVAJTXGNN-UHFFFAOYSA-N stearyl heptanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCC ABTZKZVAJTXGNN-UHFFFAOYSA-N 0.000 description 2
- 229940098758 stearyl heptanoate Drugs 0.000 description 2
- 150000007971 urates Chemical class 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 241001135917 Vitellaria paradoxa Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000002225 anti-radical effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229940049638 carbomer homopolymer type c Drugs 0.000 description 1
- 229940082484 carbomer-934 Drugs 0.000 description 1
- 229940043234 carbomer-940 Drugs 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000001455 metallic ions Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940057910 shea butter Drugs 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
Description
Composition cosmétique comportant UL axent arti- radicaux libres. et agent correspondant
L'invention concerne une composition cosmétique comportant un agent anti-radicaux libres, et l'agent correspondant.Cosmetic composition comprising UL axis free radicals. and corresponding agent
The invention relates to a cosmetic composition comprising an anti-free radical agent, and the corresponding agent.
Le problème du vieillissement de la peau est particulièrement lié à l'action des radicaux libres tels que : hydroxyles, alcoxy, péroxy. Ces radicaux libres sont générés essentiellement par les espèces activées de l'oxygene (oxygène singulet, ion superoxyde. peroxydes), qui ont un effet oxydant puissant. The problem of skin aging is particularly linked to the action of free radicals such as: hydroxyls, alkoxy, peroxy. These free radicals are mainly generated by activated oxygen species (singlet oxygen, superoxide ion. Peroxides), which have a strong oxidizing effect.
Les facteurs de l'initiation radicalaire sont par brdre d'importance
. les mécanismes photochimiques
. les mecanismes de photosensibilisation
. les mécanismes de réactions chimiques
. les mécanismes de reactions enzymatiques.The factors of radical initiation are therefore of importance
. photochemical mechanisms
. photosensitization mechanisms
. chemical reaction mechanisms
. the mechanisms of enzymatic reactions.
Ce sont bien évidemment les mécanismes photochimiques qui son une constante pour tous les sujets et tous les ages, variant d'intensité selon les fréquences d'exposition au soleil. It is obviously the photochemical mechanisms which are a constant for all subjects and all ages, varying in intensity according to the frequency of exposure to the sun.
La photosensibilisation aboutit aux mêmes effets générateurs. Le rayonnement solaire influence une molécule chimique généralement externe et sensible a la lumière, et des mécanismes en cascade, sensiblement identiques à ceux évoqués ci-dessus vont également générer les divers radicaux libres. Photosensitization leads to the same generative effects. Solar radiation influences a generally external and light-sensitive chemical molecule, and cascading mechanisms, substantially identical to those mentioned above, will also generate the various free radicals.
Une fois liberés, les radicaux libres vont avoir divers effets biochimiques qui vont tous participer au vieillissement de la peau. Parmi ces effets, on peut retenir
- les effets de dépolymérisation de macromolécules biologiques telles que
ADN, collagene, acide hyaluroniq,e. Once released, free radicals will have various biochemical effects that will all contribute to the aging of the skin. Among these effects, we can retain
- the effects of depolymerization of biological macromolecules such as
DNA, collagen, hyaluroniq acid, e.
Dépolymérisées, ces molécules perdent l'essentiel de leurs propriétés biologiques et physiques. Depolymerized, these molecules lose most of their biological and physical properties.
- les effets de péroxydation des lipides membranaires. Ces lipides, qui constituent l'architecture de la membrane cellulaire perdent, sou l'effet des péroxydations, leurs propriété de fluidité ou méme de stabilité;
- les effets d'activation enzymatique qui vont participer directement ou indirectement aux phénomènes d'inflammation et d'oedème que l'on observe fréquemment suite aux expositions solaires trop intenses.- the effects of peroxidation of membrane lipids. These lipids, which constitute the architecture of the cell membrane lose, under the effect of peroxidation, their property of fluidity or even of stability;
- the effects of enzymatic activation which will participate directly or indirectly in the phenomena of inflammation and edema which are frequently observed following excessively intense sun exposure.
Pour bloquer ou diminuer les effets des phenomènes d'oxydation, la cosmétologie utilise des anti-oxydants comme la vitamine C et le glutathion, ou des anti-radicalaires comme la vitamine E et les carotenoïdes. To block or reduce the effects of oxidation phenomena, cosmetology uses antioxidants like vitamin C and glutathione, or anti-free radicals like vitamin E and carotenoids.
La présente invention a pour objet une composition cosmétique caractérisée en ce qu'elle comporte un agent anti-radicaux libres constitué par un dérivé de base nucléique. The present invention relates to a cosmetic composition characterized in that it comprises an anti-free radical agent consisting of a derivative of nucleic base.
Selon d'autres caractéristiques de l'invention:
-le dérivé de base nucléique est pris dans le groupe adénine, guanosi ne, - xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthinate de lysine, caféine, théobromine et théophylline;
-le dérivé de base nucléique est présent en solution;
-le dérivé de base nucléique est présent a l'intérieur de phases lipidiques lamellaires dispersées, c'est-à-dire de liposomes.According to other characteristics of the invention:
-the nucleic base derivative is taken from the adenine, guanosine group, - xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyl hydroxyxanthine, lysine hydroxyxanthinate, caffeine, theobromine and theophylline;
the nucleic base derivative is present in solution;
the nucleic acid derivative is present inside dispersed lamellar lipid phases, that is to say liposomes.
L'invention a également pour objet l'application d'une composition cosmétique ci-dessus definie à la protection contre le vieillissement de la peau, à la protection contre les inflammations ou érythèmes solaires, à la protection de l'ADN, ou à l'activation de i' adényl cyclase. The subject of the invention is also the application of a cosmetic composition defined above for protection against aging of the skin, for protection against inflammations or erythemas of sun, for the protection of DNA, or for l 'activation of adenyl cyclase.
L'invention a encore pour objet un agent antiradicaux libres, constitué par un dérivé de base nucléique pris dans le groupe : adenine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, glycéro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthînate de lys ne, caféine, théobromine et théophylline. The subject of the invention is also a free anti-radical agent, consisting of a nucleic acid derivative taken from the group: adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, glycero hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthine of lily ne, caffeine, theobromine and theophylline.
Comme exemple pratique de dérivé de base nucléique, on peut retenir l'acide urique et ses dérivés, notamment les urates. L'acide urique n'est autre que la 8-hyaroxyxanthine. As a practical example of a nucleic acid derivative, uric acid and its derivatives, in particular urates, can be used. Uric acid is none other than 8-hyaroxyxanthine.
L'acide urique et les urates ont des effets anti-oxydants qui se manifestent de la manière suivante:
- l'urate est un coilecteur de l'oxygene singulet,
- il est sensible aux radicaux libres hydroxyles issus de l'irradiation,
- il est oxydable par l'hémoglobine et les peroxydes,
- il assure la protection des membranes de globules rouges contre les péroxydations (t-butylhydroperoxyde),
- il assure la protection des globule- rouges contre la lyse par les péroxydes.Uric acid and urates have antioxidant effects that manifest themselves in the following way:
- the urate is a singlet oxygen collector,
- it is sensitive to hydroxyl free radicals from irradiation,
- it can be oxidized by hemoglobin and peroxides,
- it protects the membranes of red blood cells against peroxidation (t-butylhydroperoxide),
- it ensures the protection of red blood cells against lysis by peroxides.
Outre l'effet anti-oxydant évoqué ci-dessus par piégeage des radicaux oxygènes activés et radicaux libres, l'acide urique présente une autre propriété anti-oxydante sans doute liée à sa capacité de former des complexes avec l'ion métallique Fer. Le compiexe urate-Fe inhibe l'oxydation de l'ascorbate catalysée par l'ion Fe ; de façon surprenante, et en opposition avec ce qui est connu des autres pièges à radicaux libres, l'inhibition par l'urate de l'ascorbate ainsi que la peroxydase lipidique n'impliquent pas une oxydation parallèle de l'urate. L'urate peut être un puissant agent anti-oxydant physiologique. In addition to the antioxidant effect mentioned above by trapping activated oxygen radicals and free radicals, uric acid has another antioxidant property probably linked to its ability to form complexes with the metal ion Iron. The urate-Fe compound inhibits the oxidation of ascorbate catalyzed by the Fe ion; surprisingly, and in contrast to what is known from other free radical traps, the urate inhibition of ascorbate as well as lipid peroxidase do not imply a parallel oxidation of the urate. Urate can be a powerful physiological antioxidant.
Les derives de bases nucléiques, notamment adenine, guanosine, xanthine, hypoxanthine, acide urique, uracyl, acide orotique, acide ribonucléique, caféine, théobromîne et théophylline présentent un effet anti-oxydant vis-à-vis de l'oxydation a l'air de l'acide linoléique. Ces dérivés sont donc utilisablea pour éviter l'oxydation des lipides. Leur effet anti.- oxydant est sensible à pH neutre, acide ou legrement basique. The derivatives of nucleic bases, in particular adenine, guanosine, xanthine, hypoxanthine, uric acid, uracyl, orotic acid, ribonucleic acid, caffeine, theobromine and theophylline have an antioxidant effect with respect to air oxidation linoleic acid. These derivatives are therefore usable to avoid the oxidation of lipids. Their antioxidant effect is sensitive to neutral, acidic or slightly basic pH.
Par ailleurs, les dérivés de bases nucleiques, en même temps que leur pouvoir de piéger les radicaux libres, présentent une capacité de chélation des ions metalliques. In addition, the derivatives of nucleic bases, at the same time as their capacity to trap the free radicals, present a capacity of chelation of the metallic ions.
Il faut retenir également que la caféine est dotee de propriétés de protection contre les effets de dénaturation de l'ADN par les radiations ultraviolettes, et qu'elle joue un rôle d'activateur de l'adenylcyclase. It should also be remembered that caffeine has protective properties against the effects of DNA denaturation by ultraviolet radiation, and that it plays a role in activating adenylcyclase.
L'invention concerne également l'application en cosmétologie des derivés de bases nucléiques, par exemple adénine, guanosine, xanthine, hypoxanth~ne. The invention also relates to the application in cosmetology of derivatives of nucleic bases, for example adenine, guanosine, xanthine, hypoxanth ~ ne.
acide urique, uracyl, acide orotique, acce ribonucléique, glycèro hydroxyxanthine, ribosyl hydroxyxanthine, hydroxyxanthinate de lysine, cafeine, thesbromine et theophylline.uric acid, uracyl, orotic acid, ribonucleic acce, glycero hydroxyxanthine, ribosyl hydroxyxanthine, lysine hydroxyxanthinate, caffeine, thesbromine and theophylline.
Tous ces derives peuvent être employes e solution aqueuse, dans des émulsions ou dans des phases lamellaires lipidiques dispersées du type liposomes. All these derivatives can be used in aqueous solution, in emulsions or in dispersed lipidic lamellar phases of the liposome type.
Les compositions cosmétiques correspondantes trouvent leur application chaque fois que des radicaux libres sont produits en quantité importante. C'est le cas, en particulier, dans les tissus inflammes, pour les tissus soumis à une dose excessive de rayons ultraviolets. Elles peuvent également etre utilisées à titre préventif, dans le cadre plus général de la lutte contre le vieillissement de la peau. The corresponding cosmetic compositions find their application whenever free radicals are produced in large quantities. This is the case, in particular, in inflamed tissues, for tissues subjected to an excessive dose of ultraviolet rays. They can also be used as a preventive measure, in the more general context of the fight against aging of the skin.
Des exemples de composition cosmétique selon l'invention sont mentionnés ci-dessous
Exemple 1 : Lait après soleil
glycéryl stéarate (se) ...........Examples of cosmetic composition according to the invention are mentioned below
Example 1: After sun milk
glyceryl stearate (se) ...........
cire d'abeilles ................... beeswax ...................
huile minerale .................... mineral oil ....................
huile minérale + alcool de lanoline
beurre de karite .................... 3,00
carbomer-934 ........................... 0,50
triéthanolamine ........................ 0,35
propylène glycol ....................... 3,00
hydroxyxanthînate de lysine .......mineral oil + lanolin alcohol
shea butter .................... 3.00
carbomer-934 ........................... 0.50
triethanolamine ........................ 0.35
propylene glycol ....................... 3.00
lysine hydroxyxanthînate .......
acide protique ......................... 0,50
eau déminéralisée ...................... qsp100
conservateurs .......................... qs
parfum ................................. qs 2 : Créme amincissante
polysorbate 60 ......................... 3,000
stéarate de sorbitan ................... 3,00
glyceryl stéarate (se) ................. 3,50
alcool oléique ......................... 1,50
octyldodecanol ......................... 10,00
huile minérale ......................... 16,00
caféine ................................ 0,50
theophylline ........................... 0,50
eau déminéralisée ...................... qsp100
conservateur ........................... qs
parfum qs
Exemple 3 : Gel anti-radicaux libres.protic acid ......................... 0.50
demineralized water ...................... qsp100
preservatives .......................... qs
perfume ................................. qs 2: Slimming cream
polysorbate 60 ......................... 3,000
sorbitan stearate ................... 3.00
glyceryl stearate (se) ................. 3.50
oleic alcohol ......................... 1.50
octyldodecanol ......................... 10.00
mineral oil ......................... 16.00
caffeine ................................ 0.50
theophylline ........................... 0.50
demineralized water ...................... qsp100
curator ........................... qs
perfume qs
Example 3: Anti-free radical gel.
carboxyméthyl cellulose ................ 1,20
glycérine .............................. 0,50
propylène glycol ....................... 1.50
8-hydroxyxanthine ...................... 1,00
caféine ................................ 0,50
eau deminéralisée ...................... qsp100
conservateurs .......................... qs
parfum q
Exemple 4 : Emulsion pour la protection de l'ADA.carboxymethyl cellulose ................ 1.20
glycerin .............................. 0.50
propylene glycol ....................... 1.50
8-hydroxyxanthine ...................... 1.00
caffeine ................................ 0.50
demineralized water ...................... qsp100
preservatives .......................... qs
perfume q
Example 4: Emulsion for the protection of ADA.
polysorbate 60 ....................... polysorbate 60 .......................
stéarate de sorbitan ................. sorbitan stearate .................
alcool de lanoline acétyle ......... acetylated lanolin alcohol .........
alcool pléique ....................... pleic alcohol .......................
cétéaryl-octanoate î,e
stéaryl-heptanoate .................... 2.00
buile minérale ........................ 10,00
sorbitol .............................. 3,00
silicate d'aluminium & de magnésium
hypoxanthine ..........................cetaryl-octanoate î, e
stearyl-heptanoate .................... 2.00
mineral buil ........................ 10.00
sorbitol .............................. 3.00
aluminum & magnesium silicate
hypoxanthine ..........................
guanosine ............................. guanosine .............................
eau déminéralisée .................... qspl
conservateurs ......................... qs
parfum ................................ qs Exemple 5 : Creme anti-vieillissement. demineralized water .................... qspl
preservatives ......................... qs
perfume ................................ qs Example 5: Anti-aging cream.
PEG-30 glycéryl stéarate .............. PEG-30 glyceryl stearate ..............
huile végétale ........................ vegetable oil ........................
huile minèrale ........................ mineral oil ........................
huile de silicone ................... 1,50
stérols de soja ........................silicone oil ................... 1.50
soy sterols ........................
stéaryl-heptanoate .................... 2,00
cétéaryl-octanoate .................... 1,00
isopropyl-myristate ................... 2,00
carbomer-940 .......................... 0,30
triéthanolamine ....................... 0,20
propylène glycol ...................... 3,00
8-hydroxyxanthine ..................... 1,00
uracyle ............................... 0,50
adenine ............................... 0,50
eau déminéralisée .................... qspl
conservateurs ......................... qs
parfum ................................ qs stearyl heptanoate .................... 2.00
cetearyl octanoate .................... 1.00
isopropyl-myristate ................... 2.00
carbomer-940 .......................... 0.30
triethanolamine ....................... 0.20
propylene glycol ...................... 3.00
8-hydroxyxanthine ..................... 1.00
uracyle ............................... 0.50
adenine ............................... 0.50
demineralized water .................... qspl
preservatives ......................... qs
perfume ................................ qs
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8712516A FR2620024B1 (en) | 1987-09-09 | 1987-09-09 | COSMETIC COMPOSITION COMPRISING A FREE ANTIRADICAL AGENT, AND CORRESPONDING AGENT |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8712516A FR2620024B1 (en) | 1987-09-09 | 1987-09-09 | COSMETIC COMPOSITION COMPRISING A FREE ANTIRADICAL AGENT, AND CORRESPONDING AGENT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2620024A1 true FR2620024A1 (en) | 1989-03-10 |
| FR2620024B1 FR2620024B1 (en) | 1991-03-15 |
Family
ID=9354752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8712516A Expired - Fee Related FR2620024B1 (en) | 1987-09-09 | 1987-09-09 | COSMETIC COMPOSITION COMPRISING A FREE ANTIRADICAL AGENT, AND CORRESPONDING AGENT |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2620024B1 (en) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990000894A1 (en) * | 1988-07-19 | 1990-02-08 | Laboratoires Serobiologiques | Cyto-photo-protector agent based on nucleic acids and/or their derivatives |
| EP0504040A1 (en) * | 1991-03-13 | 1992-09-16 | L'oreal | Use of lactoferrin to protect hair keratin from atmospheric aggressions, particularly light, and process for protecting the hair using this compound |
| DE4323615A1 (en) * | 1993-07-12 | 1995-01-19 | Schreiner Edelgard | Compositions to prevent premature ageing of the skin |
| US5540914A (en) * | 1989-12-15 | 1996-07-30 | The Board Of Regents Of The University Of Oklahoma | Pigmentation enhancer and method |
| WO2000054743A1 (en) * | 1999-03-12 | 2000-09-21 | Biotec Asa | Cosmetic and/or pharmaceutical preparations |
| US6316012B1 (en) | 1992-09-01 | 2001-11-13 | L'oreal | Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent |
| US6383514B1 (en) | 1996-11-28 | 2002-05-07 | Henkel Kommanditgesellschaft Auf Aktien | Use of mixtures of active substances for the production of hypocholesterolemic agents |
| US6623746B1 (en) | 1998-07-16 | 2003-09-23 | Cognis Deutschland Gmbh & Co. Kg | PIT emulsions, methods of softening paper using the same, and paper substrates treated therewith |
| WO2003084485A1 (en) | 2002-04-09 | 2003-10-16 | Otsuka Pharmaceutical Co., Ltd. | Composition for cell proliferation |
| EP1396261A1 (en) * | 2002-09-06 | 2004-03-10 | Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG | Skincare composition containing caffeine |
| EP1562423A4 (en) * | 2002-10-31 | 2007-03-14 | Eric F Bernstein | Compositions and methods for prevention of photoaging |
| WO2007101493A1 (en) * | 2006-03-07 | 2007-09-13 | Henkel Ag & Co. Kgaa | Cosmetic agents comprising purine and/or purine deratives ii |
| EP2465581A1 (en) * | 2010-12-15 | 2012-06-20 | Han-Min Chen | Composition for promoting hair growth |
| FR2975595A1 (en) * | 2011-05-24 | 2012-11-30 | Oreal | Cosmetic use of guanosine and/or its derivative to prevent an alteration of, and/or maintain the homeostasis of the skin |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2164938A1 (en) * | 1971-12-23 | 1973-08-03 | Waldhof Aschaffenburg Papier | |
| FR2221122A1 (en) * | 1971-10-12 | 1974-10-11 | Bayer Ag | Encapsulation of chemical substances - in liposomes for medicinal use |
| US3892844A (en) * | 1968-12-16 | 1975-07-01 | Hoffmann La Roche | Method of protecting the skin from ultraviolet radiation |
| FR2574661A1 (en) * | 1984-12-19 | 1986-06-20 | Roussel Uclaf | New skin care compositions containing Oenothera oil and spleen tissue extracts |
| FR2590169A1 (en) * | 1985-11-20 | 1987-05-22 | Secta Labo Cosmetologie Y Roch | Cosmetic composition containing biostimulins |
-
1987
- 1987-09-09 FR FR8712516A patent/FR2620024B1/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3892844A (en) * | 1968-12-16 | 1975-07-01 | Hoffmann La Roche | Method of protecting the skin from ultraviolet radiation |
| FR2221122A1 (en) * | 1971-10-12 | 1974-10-11 | Bayer Ag | Encapsulation of chemical substances - in liposomes for medicinal use |
| FR2164938A1 (en) * | 1971-12-23 | 1973-08-03 | Waldhof Aschaffenburg Papier | |
| FR2574661A1 (en) * | 1984-12-19 | 1986-06-20 | Roussel Uclaf | New skin care compositions containing Oenothera oil and spleen tissue extracts |
| FR2590169A1 (en) * | 1985-11-20 | 1987-05-22 | Secta Labo Cosmetologie Y Roch | Cosmetic composition containing biostimulins |
Non-Patent Citations (3)
| Title |
|---|
| CHEMICAL ABSTRACTS, vol. 96, 1982, page 368, no. 74511w, Columbus, Ohio, US; & CS-A-189 906 (TIKALOVA, JANA et al.) 15-07-1981 * |
| CHEMICAL ABSTRACTS, vol. 99, 1983, page 304, no. 18847k, Columbus, Ohio, US; Y.MIYACHI et al.: "Sunburn cell formation is prevented by scavenging oxygen intermediates" & CLIN. EXP. DERMATOL. 1983, 8(3), 305-10 * |
| RIECHSTOFFE, AROMEN, KOSMETICA, vol. 30, no. 12, décembre 1980, pages 345-348, St. Peter-Ording, DE; Dr. NIEDERM]LLER: "Ein neuer Wirkstoff und seine Testergebnisse" * |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2233557A (en) * | 1988-07-19 | 1991-01-16 | Serobiologiques Lab Sa | Cyto-photo-protector agent based on nucleic acids and/or their derivatives |
| GB2233557B (en) * | 1988-07-19 | 1993-03-31 | Serobiologiques Lab Sa | An agent for cytoprotection based on nucleic acids and/or derivatives thereof |
| WO1990000894A1 (en) * | 1988-07-19 | 1990-02-08 | Laboratoires Serobiologiques | Cyto-photo-protector agent based on nucleic acids and/or their derivatives |
| US5628987A (en) * | 1989-12-15 | 1997-05-13 | The Board Of Regents Of The University Of Oklahoma | Pigmentation enhancer and method |
| US5540914A (en) * | 1989-12-15 | 1996-07-30 | The Board Of Regents Of The University Of Oklahoma | Pigmentation enhancer and method |
| US5589161A (en) * | 1989-12-15 | 1996-12-31 | The Board Of Regents Of The University Oklahoma | Pigmentation enhancer and method |
| US5591423A (en) * | 1989-12-15 | 1997-01-07 | The Board Of Regents Of The University Of Oklahoma | Pigmentation enhancer and method |
| EP0504040A1 (en) * | 1991-03-13 | 1992-09-16 | L'oreal | Use of lactoferrin to protect hair keratin from atmospheric aggressions, particularly light, and process for protecting the hair using this compound |
| FR2673839A1 (en) * | 1991-03-13 | 1992-09-18 | Oreal | USE OF LACTOFERRIN FOR THE PROTECTION OF HAIR KERATIN AGAINST ATMOSPHERIC AGGRESSIONS, IN PARTICULAR LIGHT, AND HAIR PROTECTION METHOD USING THE SAME. |
| US6316012B1 (en) | 1992-09-01 | 2001-11-13 | L'oreal | Cosmetic or pharmaceutical composition comprising, in combination, a peroxidase and an anti-singlet oxygen agent |
| DE4323615A1 (en) * | 1993-07-12 | 1995-01-19 | Schreiner Edelgard | Compositions to prevent premature ageing of the skin |
| US6383514B1 (en) | 1996-11-28 | 2002-05-07 | Henkel Kommanditgesellschaft Auf Aktien | Use of mixtures of active substances for the production of hypocholesterolemic agents |
| US6623746B1 (en) | 1998-07-16 | 2003-09-23 | Cognis Deutschland Gmbh & Co. Kg | PIT emulsions, methods of softening paper using the same, and paper substrates treated therewith |
| DE19911053A1 (en) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Cosmetic and / or pharmaceutical preparations |
| WO2000054743A1 (en) * | 1999-03-12 | 2000-09-21 | Biotec Asa | Cosmetic and/or pharmaceutical preparations |
| US6706696B1 (en) | 1999-03-12 | 2004-03-16 | Biotec Asa | Cosmetic and/or pharmaceutical preparations |
| DE19911053B4 (en) * | 1999-03-12 | 2004-10-28 | Biotec Asa | Cosmetic and / or pharmaceutical preparations |
| EP1498101A4 (en) * | 2002-04-09 | 2007-09-12 | Otsuka Pharma Co Ltd | Composition for cell proliferation |
| WO2003084485A1 (en) | 2002-04-09 | 2003-10-16 | Otsuka Pharmaceutical Co., Ltd. | Composition for cell proliferation |
| EP1396261A1 (en) * | 2002-09-06 | 2004-03-10 | Alcina Cosmetic, Dr. Kurt Wolff GmbH & Co.KG | Skincare composition containing caffeine |
| EP1562423A4 (en) * | 2002-10-31 | 2007-03-14 | Eric F Bernstein | Compositions and methods for prevention of photoaging |
| WO2007101493A1 (en) * | 2006-03-07 | 2007-09-13 | Henkel Ag & Co. Kgaa | Cosmetic agents comprising purine and/or purine deratives ii |
| EP2465581A1 (en) * | 2010-12-15 | 2012-06-20 | Han-Min Chen | Composition for promoting hair growth |
| FR2975595A1 (en) * | 2011-05-24 | 2012-11-30 | Oreal | Cosmetic use of guanosine and/or its derivative to prevent an alteration of, and/or maintain the homeostasis of the skin |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2620024B1 (en) | 1991-03-15 |
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