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FR2682952B1 - Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent. - Google Patents

Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.

Info

Publication number
FR2682952B1
FR2682952B1 FR9113174A FR9113174A FR2682952B1 FR 2682952 B1 FR2682952 B1 FR 2682952B1 FR 9113174 A FR9113174 A FR 9113174A FR 9113174 A FR9113174 A FR 9113174A FR 2682952 B1 FR2682952 B1 FR 2682952B1
Authority
FR
France
Prior art keywords
radical
aryl
preparation
pharmaceutical compositions
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9113174A
Other languages
English (en)
Other versions
FR2682952A1 (fr
Inventor
Marie-Claude Fournie-Zaluski
Bernard Pierre Roques
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9113174A priority Critical patent/FR2682952B1/fr
Application filed by Rhone Poulenc Rorer SA, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Rhone Poulenc Rorer SA
Priority to DE69226443T priority patent/DE69226443T2/de
Priority to ES92921688T priority patent/ES2118833T3/es
Priority to AU27895/92A priority patent/AU666141B2/en
Priority to DK92921688T priority patent/DK0609310T3/da
Priority to EP92117955A priority patent/EP0539848A1/fr
Priority to CA002121801A priority patent/CA2121801A1/fr
Priority to PCT/EP1992/002412 priority patent/WO1993008162A1/fr
Priority to AT92921688T priority patent/ATE168995T1/de
Priority to JP50744693A priority patent/JP3250806B2/ja
Priority to EP92921688A priority patent/EP0609310B1/fr
Priority to MX9206149A priority patent/MX9206149A/es
Publication of FR2682952A1 publication Critical patent/FR2682952A1/fr
Application granted granted Critical
Publication of FR2682952B1 publication Critical patent/FR2682952B1/fr
Priority to JP2001155490A priority patent/JP2002030066A/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9113174A 1991-10-25 1991-10-25 Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent. Expired - Fee Related FR2682952B1 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
FR9113174A FR2682952B1 (fr) 1991-10-25 1991-10-25 Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.
EP92921688A EP0609310B1 (fr) 1991-10-25 1992-10-21 Acides n-(mercaptoacyl)amines, leurs procedes de preparation et d'utilisation therapeutique, et compositions pharmaceutiques les contenant
AU27895/92A AU666141B2 (en) 1991-10-25 1992-10-21 N-(mercaptoacyl)amino acids, methods of their preparation and therapeutic use, and pharmaceutical compositions containing them
DK92921688T DK0609310T3 (da) 1991-10-25 1992-10-21 N-(mercaptoacyl)aminosyrer, fremgangsmåder til fremstilling og terapeutisk anvendelse deraf og farmaceutiske sammensætninge
EP92117955A EP0539848A1 (fr) 1991-10-25 1992-10-21 N-(mercaptoacyl)amino-acides, leur préparation, leur utilisation thérapeutique et les compositions pharmaceutiques qui les contiennent
CA002121801A CA2121801A1 (fr) 1991-10-25 1992-10-21 Acides n-(mercaptoacyl)amines, methodes d'obtention et emploi therapeutique, et compositions pharmaceutiques qui en contiennent
DE69226443T DE69226443T2 (de) 1991-10-25 1992-10-21 N-(mercaptoacyl)aminosäure, ihre herstellung, ihre therapeutische verwendung und sie enthaltende pharmazeutische zusammensetzungen
AT92921688T ATE168995T1 (de) 1991-10-25 1992-10-21 N-(mercaptoacyl)aminosäure, ihre herstellung, ihre therapeutische verwendung und sie enthaltende pharmazeutische zusammensetzungen
JP50744693A JP3250806B2 (ja) 1991-10-25 1992-10-21 Ｎ−（メルカプトアシル）アミノ酸と、その製造方法と、その治療での使用と、それを含む医薬組成物
ES92921688T ES2118833T3 (es) 1991-10-25 1992-10-21 N-(mercaptoacil)aminoacidos, metodos para su preparacion y uso terapeutico, y composiciones farmaceuticas que los contienen.
PCT/EP1992/002412 WO1993008162A1 (fr) 1991-10-25 1992-10-21 Acides n-(mercaptoacyl)amines, leurs procedes de preparation et d'utilisation therapeutique, et compositions pharmaceutiques les contenant
MX9206149A MX9206149A (es) 1991-10-25 1992-10-23 N-(mercaptoacil)amino acidos, metodos para su preparcion y uso terapeutico, y composiciones farmaceuticas que los contienen
JP2001155490A JP2002030066A (ja) 1991-10-25 2001-05-24 Ｎ−（メルカプトアシル）アミノ酸と、その製造方法と、その治療での使用と、それを含む医薬組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9113174A FR2682952B1 (fr) 1991-10-25 1991-10-25 Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
FR2682952A1 FR2682952A1 (fr) 1993-04-30
FR2682952B1 true FR2682952B1 (fr) 1993-12-03

Family

ID=9418304

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9113174A Expired - Fee Related FR2682952B1 (fr) 1991-10-25 1991-10-25 Nouveaux n-(mercaptoacyl) amino-acides, leur preparation et les compositions pharmaceutiques qui les contiennent.

Country Status (11)

Country Link
EP (2) EP0539848A1 (fr)
JP (2) JP3250806B2 (fr)
AT (1) ATE168995T1 (fr)
AU (1) AU666141B2 (fr)
CA (1) CA2121801A1 (fr)
DE (1) DE69226443T2 (fr)
DK (1) DK0609310T3 (fr)
ES (1) ES2118833T3 (fr)
FR (1) FR2682952B1 (fr)
MX (1) MX9206149A (fr)
WO (1) WO1993008162A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1273455B (it) * 1995-01-27 1997-07-08 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
FR2731219B1 (fr) * 1995-03-03 1997-04-25 Bioprojet Soc Civ Procede de synthese d'acides acryliques alpha-substitues et leur application
IT1277736B1 (it) * 1995-12-28 1997-11-12 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
IT1277737B1 (it) * 1995-12-28 1997-11-12 Zambon Spa Derivati tiolici ad attivita' inibitrice delle metallopeptidasi

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
US4401677A (en) 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
EP0136883B1 (fr) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Inhibiteurs d'enképhalinase
US4740499A (en) 1986-07-28 1988-04-26 Monsanto Company Method of enhancing the bioactivity of atrial peptides
FR2617070A2 (fr) * 1987-03-23 1988-12-30 Collet Claude Appareil de prehension, type mandrin, entierement automatique, a commandes d'ouverture et de fermeture ultra-rapides
CA1337400C (fr) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibiteurs de l'endopeptidase neutre
US4879309A (en) * 1988-09-27 1989-11-07 Schering Corporation Mercapto-acylamino acids as antihypertensives

Also Published As

Publication number Publication date
WO1993008162A1 (fr) 1993-04-29
DK0609310T3 (da) 1999-04-26
JP3250806B2 (ja) 2002-01-28
ATE168995T1 (de) 1998-08-15
DE69226443T2 (de) 1999-02-04
EP0609310B1 (fr) 1998-07-29
FR2682952A1 (fr) 1993-04-30
MX9206149A (es) 1993-08-01
CA2121801A1 (fr) 1993-04-29
EP0539848A1 (fr) 1993-05-05
JP2002030066A (ja) 2002-01-29
AU666141B2 (en) 1996-02-01
ES2118833T3 (es) 1998-10-01
JPH07509441A (ja) 1995-10-19
DE69226443D1 (de) 1998-09-03
EP0609310A1 (fr) 1994-08-10
AU2789592A (en) 1993-05-21

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse