FR2673536A1 - Depigmenting preparation - Google Patents
Depigmenting preparation Download PDFInfo
- Publication number
- FR2673536A1 FR2673536A1 FR9103009A FR9103009A FR2673536A1 FR 2673536 A1 FR2673536 A1 FR 2673536A1 FR 9103009 A FR9103009 A FR 9103009A FR 9103009 A FR9103009 A FR 9103009A FR 2673536 A1 FR2673536 A1 FR 2673536A1
- Authority
- FR
- France
- Prior art keywords
- depigmenting
- weight
- preparation according
- hydroquinone
- depigmenting preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 39
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- -1 pH correctors Substances 0.000 claims abstract description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 7
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 239000003086 colorant Substances 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 239000003755 preservative agent Substances 0.000 claims abstract description 4
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 14
- CNHDIAIOKMXOLK-UHFFFAOYSA-N toluquinol Chemical compound CC1=CC(O)=CC=C1O CNHDIAIOKMXOLK-UHFFFAOYSA-N 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000000473 propyl gallate Substances 0.000 claims description 7
- 235000010388 propyl gallate Nutrition 0.000 claims description 7
- 229940075579 propyl gallate Drugs 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 6
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 5
- NWVVVBRKAWDGAB-UHFFFAOYSA-N hydroquinone methyl ether Natural products COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- XRCRJFOGPCJKPF-UHFFFAOYSA-N 2-butylbenzene-1,4-diol Chemical compound CCCCC1=CC(O)=CC=C1O XRCRJFOGPCJKPF-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 235000019388 lanolin Nutrition 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
- 229960002216 methylparaben Drugs 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 235000010265 sodium sulphite Nutrition 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- 229920000896 Ethulose Polymers 0.000 claims description 2
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims description 2
- 239000004166 Lanolin Substances 0.000 claims description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 2
- 229960003957 dexamethasone Drugs 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 229940039717 lanolin Drugs 0.000 claims description 2
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229930002330 retinoic acid Natural products 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 229960001727 tretinoin Drugs 0.000 claims description 2
- DHCKHFFQROKZFP-UHFFFAOYSA-L N(CCO)(CCO)CCO.S(=O)([O-])[O-].[Na+].[Na+] Chemical compound N(CCO)(CCO)CCO.S(=O)([O-])[O-].[Na+].[Na+] DHCKHFFQROKZFP-UHFFFAOYSA-L 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 239000003605 opacifier Substances 0.000 abstract description 2
- 238000012216 screening Methods 0.000 abstract 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 244000060011 Cocos nucifera Species 0.000 description 3
- 235000013162 Cocos nucifera Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 208000000069 hyperpigmentation Diseases 0.000 description 2
- 230000003810 hyperpigmentation Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 229960004418 trolamine Drugs 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- ZNRLMGFXSPUZNR-UHFFFAOYSA-N 2,2,4-trimethyl-1h-quinoline Chemical compound C1=CC=C2C(C)=CC(C)(C)NC2=C1 ZNRLMGFXSPUZNR-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- HEOVGVNITGAUKL-UHFFFAOYSA-N 3-Methyl-1-phenyl-1-butanone Chemical compound CC(C)CC(=O)C1=CC=CC=C1 HEOVGVNITGAUKL-UHFFFAOYSA-N 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 240000004246 Agave americana Species 0.000 description 1
- 235000012871 Arctostaphylos uva ursi Nutrition 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 240000002529 Muntingia calabura Species 0.000 description 1
- 235000003886 Muntingia calabura Nutrition 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 244000003892 Vaccinium erythrocarpum Species 0.000 description 1
- 240000001717 Vaccinium macrocarpon Species 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229920003064 carboxyethyl cellulose Polymers 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000008278 cosmetic cream Substances 0.000 description 1
- 235000021019 cranberries Nutrition 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 150000002194 fatty esters Chemical class 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- UHUSDOQQWJGJQS-UHFFFAOYSA-N glycerol 1,2-dioctadecanoate Chemical class CCCCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCCCCCCCC UHUSDOQQWJGJQS-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000008250 pharmaceutical cream Substances 0.000 description 1
- 239000008336 pharmaceutical lotion Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940001482 sodium sulfite Drugs 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940029614 triethanolamine stearate Drugs 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0089—Pearlescent compositions; Opacifying agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
Description
Préparation dépigmentante
La présente invention concerne le domaine du traitement de l'hyperpigmentation cutanée, notamment des chloasmas et des taches se développant chez les personnes âgées ou à la suite d'applications de parfums, et a pour objet une préparation dépigmentante destinée à être appliquée sur la peau à l'aide d'un flacon à bille.Depigmenting preparation
The present invention relates to the field of the treatment of cutaneous hyperpigmentation, in particular chloasmas and spots developing in the elderly or following the application of perfumes, and relates to a depigmenting preparation intended to be applied to the skin. using a ball bottle.
I1 existe actuellement différents types de produits dépigmentants, notamment sous forme de crèmes cosmétiques ou de crèmes et de lotions pharmaceutiques. Néanmoins, les premières présentent une efficacité très faible et les secondes peuvent entraîner des risques de réactions secondaires, notamment au niveau des surfaces de peau avoisinant les taches hyperpigmentées. There are currently different types of depigmenting products, in particular in the form of cosmetic creams or pharmaceutical creams and lotions. However, the former have very low efficacy and the latter can lead to the risk of side reactions, particularly in the areas of skin around hyperpigmented spots.
Afin d'essayer de pallier les inconvénients précités, on a également tenté de conditionner les préparations dépigmentantes sous forme de sticks solides, autorisant une application localisée desdites préparations. In order to try to overcome the aforementioned drawbacks, an attempt has also been made to condition the depigmenting preparations in the form of solid sticks, allowing localized application of said preparations.
Néanmoins, ces sticks ne permettent que de réaliser difficilement une enduction uniforme et contrôlée sur les endroits à traiter. However, these sticks only make it difficult to achieve a uniform and controlled coating on the places to be treated.
Le problème posé à la présente invention consiste, par conséquent, à réaliser une préparation dépigmentante, dont la composition permet un traitement efficace des taches d'hyperpigmentation et présentant une viscosité telle qu'elle puisse être appliquée de manière localisée et uniforme au moyen d'un flacon à bille. The problem posed in the present invention therefore consists in producing a depigmenting preparation, the composition of which allows effective treatment of hyperpigmentation spots and having a viscosity such that it can be applied in a localized and uniform manner by means of a ball bottle.
A cet effet, l'invention a pour objet une prépa- ration dépigmentante destinée à être appliquée sur la peau, notamment à base de principes actifs dépigmentants tels que l'hydroquinone ou des composés dérivés de l'hydroquinone, caractérisée en ce qu'elle comporte également, d'une part, au moins un excipient compatible avec les principes actifs utilisés et contribuant à la viscosité de la préparation dépigmentante et, d'autre part, au moins un composant additionnel, tel que des solvants complémentaires, des correcteurs de pH, des agents conservateurs et antioxydants, des filtres ultraviolets et/ou des agents nacrants, opacifiants ou colorants, ladite préparation dépigmentante étant destinée à être appliquée au moyen d'un flacon à bille. To this end, the subject of the invention is a depigmenting preparation intended to be applied to the skin, in particular based on depigmenting active principles such as hydroquinone or compounds derived from hydroquinone, characterized in that it also comprises, on the one hand, at least one excipient compatible with the active principles used and contributing to the viscosity of the depigmenting preparation and, on the other hand, at least one additional component, such as additional solvents, pH correctors , preservatives and antioxidants, ultraviolet filters and / or pearlescent, opacifying or coloring agents, said depigmenting preparation being intended to be applied by means of a ball bottle.
Selon une caractéristique de l'invention, la préparation dépigmentante est avantageusement composée de 0,1 O/o à 15 /O en poids de principes actifs dépigmentants, de 40 % à 99,7 % en poids d'un ou de plusieurs excipients et de 0,2 % à 45 % en poids d'un ou de plusieurs composants additionnels. According to a characteristic of the invention, the depigmenting preparation is advantageously composed of 0.1 O / o to 15 / O by weight of depigmenting active principles, from 40% to 99.7% by weight of one or more excipients and from 0.2% to 45% by weight of one or more additional components.
Conformément à une autre caractéristique de l'invention, le ou les solvants complémentaires, éven- tuellement intégrés dans la préparation dépigmentante, se présentent avantageusement sous la forme de corps gras ou huileux, du type saturé ou insaturé, assurant une pénétration contrôlée et une action rémanente du ou des principes actifs au niveau de la peau. According to another characteristic of the invention, the additional solvent (s), optionally incorporated into the depigmenting preparation, advantageously take the form of fatty or oily bodies, of the saturated or unsaturated type, ensuring controlled penetration and action residual of the active ingredient (s) in the skin.
Pour les préparations à usage cosmétique, les principes actifs sont préférentiellement limités à un mélange d'hydroquinone et de certains extraits de plantes telles que des extraits d'agaves, d'airelles, d'arbousiers ou de busseroles, la teneur en hydroquinone étant limitée à 2 % en poids. For preparations for cosmetic use, the active ingredients are preferably limited to a mixture of hydroquinone and certain plant extracts such as extracts of agaves, cranberries, strawberry trees or bearberry, the hydroquinone content being limited. at 2% by weight.
Par contre, les préparations dépigmentantes à usage pharmaceutique peuvent comporter des formules plus actives telles que, par exemple, la composition très active correspondant à la formule de Kligmann (mélange d'hydroquinone, d'acide rétinoique et de corticoide), connue en elle-même. Ces préparations pharmaceutiques pourront également, selon une variante de réalisation de l'invention, comprendre des composés actifs dérivés de l'hydroquinone, tels que la monométhylhydroquinone, la butylhydroquinone ou encore des esters gras de l'hydroqui none, en combinaison ou non avec un complément tel que l'acide ascorbique, l'acide nicotinique ou l'acide kojique. On the other hand, depigmenting preparations for pharmaceutical use can include more active formulas such as, for example, the very active composition corresponding to Kligmann's formula (mixture of hydroquinone, retinoic acid and corticosteroid), known in itself. even. These pharmaceutical preparations may also, according to an alternative embodiment of the invention, include active compounds derived from hydroquinone, such as monomethylhydroquinone, butylhydroquinone or fatty esters of hydroquin none, in combination or not with a supplement such as ascorbic acid, nicotinic acid or kojic acid.
Le ou les excipients utilisés, se présentant sous forme d'émulsions, de gels ou de solutions, choisis en fonction du ou des principes actifs mis en oeuvre, doivent assurer la formation d'un film de préparation dépigmentante sur la bille du flacon lors de la rotation de cette dernière, permettant ainsi une application régulière et contrôlée de ladite préparation, tout en empêchant un écoulement de cette dernière au-delà des zones traitées.A titre d'exemples, le ou les excipients peuvent être choisis dans le groupe formé par les glycérides stéariques ou palmitiques, les glycérides de coco éthoxylés, le stéarate de triéthanolamine, l'amidopolyglycoléther de coprah, les polymères carboxy vinyliques, notamment celui connu sous la désignation Carbopol 934 et fabriqué par la société
GOODRICH BF, la carboxyéthylcellulose, l'alcool éthylique ou propylique, l'acétate d'éthyle, l'acétone, le diéthyléther, les esters dibasiques, le propylèneglycol, la glycérine ou encore le polyéthylèneglycol, notamment sous la forme d'un mélange de polyéthylèneglycols, dont l'un présente un poids molaire moléculaire de 4 000 et l'autre un poids molaire moléculaire de 400.The excipient (s) used, in the form of emulsions, gels or solutions, chosen according to the active ingredient (s) used, must ensure the formation of a film of depigmenting preparation on the ball of the bottle during the rotation of the latter, thus allowing a regular and controlled application of said preparation, while preventing a flow of the latter beyond the treated areas. By way of examples, the excipient (s) can be chosen from the group formed by stearic or palmitic glycerides, ethoxylated coconut glycerides, triethanolamine stearate, coconut amidopolyglycolether, vinyl carboxy polymers, in particular that known under the designation Carbopol 934 and manufactured by the company
GOODRICH BF, carboxyethylcellulose, ethyl or propyl alcohol, ethyl acetate, acetone, diethyl ether, dibasic esters, propylene glycol, glycerin or even polyethylene glycol, in particular in the form of a mixture of polyethylene glycols, one of which has a molecular molecular weight of 4,000 and the other of which has a molecular molecular weight of 400.
La préparation dépigmentante conforme à l'invention contient aussi un ou plusieurs solvants complémentaires, dont le mélange et les proportions dépendent des principes actifs utilisés, et de la rémanence et de la pé- nétration souhaitées. Parmi les substances pouvant être utilisées figurent, notamment, les lanolines éthoxylées, le monoéthanolamide d'acide stéarique, le diéthalolamide d'acide linoléique, oléique, laurique ou de coprah, l'huile de jojoba, l'huile de ricin, les huiles de silicones, plus particulièrement celles présentant un poids molaire moléculaire compris entre 500 et 5 000, ou encore le myristate d'isopropyle. The depigmenting preparation according to the invention also contains one or more additional solvents, the mixture and the proportions of which depend on the active principles used, and on the desired persistence and penetration. Among the substances which can be used are, in particular, ethoxylated lanolines, monoethanolamide of stearic acid, diethalolamide of linoleic, oleic, lauric or coconut acid, jojoba oil, castor oil, silicones, more particularly those having a molecular molar weight of between 500 and 5,000, or else isopropyl myristate.
Les correcteurs de pH pouvant être mis en oeuvre sont, par exemples, le borate de sodium, l'acide citrique, et l'acide lactique, alors que les conservateurs éventuellement intégrés dans la préparation dépigmentante conforme à l'invention, peuvent être le méthylparaben, le parachlorométacrésol, l'acide édétique, le gallate de propyle, le sulfite de sodium et le métabisulfite de sodium. The pH correctors that can be used are, for example, sodium borate, citric acid, and lactic acid, while the preservatives optionally incorporated into the depigmenting preparation according to the invention, can be methylparaben , parachlorometacresol, edetic acid, propyl gallate, sodium sulfite and sodium metabisulfite.
Par ailleurs, la préparation dépigmentante contient, le cas échéant, également des filtres ultraviolets, tels que l'isopropylbenzoylméthane, ou le méthylbenzilidène camphre, permettant de limiter la formation ultérieure de ménaline. Furthermore, the depigmenting preparation contains, where appropriate, also ultraviolet filters, such as isopropylbenzoylmethane, or methylbenzilidene camphor, making it possible to limit the subsequent formation of menaline.
En outre, des agents nacrants, opacifiants ou colorants inclus accessoirement dans la préparation dépigmentante conforme à l'invention, permettront d'assurer le contrôle de l'application et de réaliser un maquillage éclaircissant des taches hyperpigmentées à éliminer. Ces agents pourront être choisis dans le groupe représenté par les distéarates de glycérol et l'oxyde de titane. In addition, pearlescent agents, opacifiers or colorants included incidentally in the depigmenting preparation in accordance with the invention, will make it possible to control the application and to make up a lightening makeup for the hyperpigmented spots to be eliminated. These agents can be chosen from the group represented by glycerol distearates and titanium oxide.
Les matériaux constituant le corps du flacon et la bille applicatrice devront, bien entendu, être compatibles avec les compositions des préparations dépigmentantes à conditionner. The materials constituting the body of the bottle and the applicator ball must, of course, be compatible with the compositions of the depigmenting preparations to be packaged.
L'invention sera à présent décrite de manière plus précise, mais non limitative, par l'intermédiaire d'exemples précis de compositions pouvant agir en tant que préparation dépigmentante. The invention will now be described in a more precise, but non-limiting manner, by means of precise examples of compositions which can act as depigmenting preparation.
Exemple 1 : Acide rétinolque 0,1
Dexaméthasone 0,1
Hydroquinone 5,0
Ethylhydroxyéthylcellulose 1,7
Polyester d'acides gras 10,0
Gallate de Propyle 0,3
Alcool à 90" 40,0
Eau q.s.p. 100,0
Exemple 2 : Hydroquinone 2,0
Propylèneglycol 2,0
Polymère carboxy vinylique 0,4
Sulfite de sodium 0,1
Bisulfite de sodium 072
Triéthanolamine q.s.p. pH = 6,8
Eau q.s.p. 100,0
Exemple 3 : Méthylhydroquinone 8,0
Acide stéarique 2,0
Stéarate de glycérine 2,0
Lanoline éthoxylée 1,6
Glycérine 6,0
Triéthanolamine 0,2
Huile de silicone 1,0
Méthylparaben 0,2
Eau q.s.p. 100,0
Exemple 4 : Monométhylhydroquinone 12,0
Gallate de propyle 0,2
Acide citrique 0,2
Polyéthylèneglycol 87,6
Exemple 5 :Méthylhydroquinone 10,0
Butylhydroquinone 2,0
Propylèneglycol 5,0
Gallate de propyle 0,2
Ethylhydroxycellulose 1,8
Alcool à 90" 38,5
Eau q.s.p. 100,0
Grâce à l'invention, il est par conséquent possible de réaliser des préparations dépigmentantes se pré sentant sous des formes pouvant être appliquées de manière très localisée au moyen, notamment, d'un flacon à bille.Example 1: Retinolic acid 0.1
Dexamethasone 0.1
Hydroquinone 5.0
Ethylhydroxyethylcellulose 1.7
10.0 fatty acid polyester
Propyl gallate 0.3
90 "alcohol 40.0
Water qs 100.0
Example 2: Hydroquinone 2.0
Propylene glycol 2.0
Vinyl carboxy polymer 0.4
Sodium sulfite 0.1
Sodium bisulfite 072
Triethanolamine qs pH = 6.8
Water qs 100.0
Example 3: Methylhydroquinone 8.0
Stearic acid 2.0
Glycerin stearate 2.0
Ethoxylated lanolin 1.6
Glycerin 6.0
0.2 triethanolamine
Silicone oil 1.0
Methylparaben 0.2
Water qs 100.0
Example 4: Monomethylhydroquinone 12.0
Propyl gallate 0.2
Citric acid 0.2
Polyethylene glycol 87.6
Example 5: Methylhydroquinone 10.0
Butylhydroquinone 2.0
Propylene glycol 5.0
Propyl gallate 0.2
Ethylhydroxycellulose 1.8
90 "alcohol 38.5
Water qs 100.0
Thanks to the invention, it is therefore possible to produce depigmenting preparations in forms which can be applied in a very localized manner by means, in particular, of a ball bottle.
En outre, l'application de ces préparations entraine un traitement efficace des taches cutanées hyperpigmentées, du fait, notamment, du ou des principes actifs utilisés et de l'action prolongée et localisée desdites préparations après application.In addition, the application of these preparations results in an effective treatment of hyperpigmented skin spots, due in particular to the active ingredient (s) used and to the prolonged and localized action of said preparations after application.
Bien entendu, la présente invention ne se limite nullement aux indications et aux applications décrites. Of course, the present invention is in no way limited to the indications and the applications described.
D'autres indications et applications sont possibles, ainsi que des modifications aux indications et aux applications décrites, sans sortir pour autant du domaine de protection de l'invention. Other indications and applications are possible, as well as modifications to the indications and applications described, without departing from the scope of protection of the invention.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9103009A FR2673536A1 (en) | 1991-03-08 | 1991-03-08 | Depigmenting preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9103009A FR2673536A1 (en) | 1991-03-08 | 1991-03-08 | Depigmenting preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2673536A1 true FR2673536A1 (en) | 1992-09-11 |
| FR2673536B1 FR2673536B1 (en) | 1995-01-20 |
Family
ID=9410667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR9103009A Granted FR2673536A1 (en) | 1991-03-08 | 1991-03-08 | Depigmenting preparation |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2673536A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2783714A1 (en) * | 1998-09-29 | 2000-03-31 | Led Evolution Dermatolog | COMPOSITION BASED ON HYDROQUINONE AND METABISULPHITE FOR TOPICAL USE FOR DEPIGMENTATION OF THE SKIN |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1932232A1 (en) * | 1968-12-02 | 1970-06-11 | Elder Paul B Co | Skin preparation for suppression of pigmen - tation |
| US3856934A (en) * | 1970-06-24 | 1974-12-24 | A Kligman | Skin depigmentation |
| FR2383663A1 (en) * | 1977-03-18 | 1978-10-13 | Nemet Pierre | Prepn. of skin cream having de:pigmenting action - contains hydroquinone, retinoic acid and corticoid |
| US4136166A (en) * | 1977-04-18 | 1979-01-23 | Helena Rubinstein, Inc. | Skin lightening composition |
| EP0060092A2 (en) * | 1981-03-05 | 1982-09-15 | Sunstar Kabushiki Kaisha | Topical skin depigmenting composition |
| WO1985003434A1 (en) * | 1984-02-06 | 1985-08-15 | Neutrogena Corporation | Vehicle for delivering active pharmaceutical ingredientsto the h uman skin |
| JPS61207317A (en) * | 1985-03-13 | 1986-09-13 | Shiseido Co Ltd | External agent for skin |
-
1991
- 1991-03-08 FR FR9103009A patent/FR2673536A1/en active Granted
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1932232A1 (en) * | 1968-12-02 | 1970-06-11 | Elder Paul B Co | Skin preparation for suppression of pigmen - tation |
| US3856934A (en) * | 1970-06-24 | 1974-12-24 | A Kligman | Skin depigmentation |
| FR2383663A1 (en) * | 1977-03-18 | 1978-10-13 | Nemet Pierre | Prepn. of skin cream having de:pigmenting action - contains hydroquinone, retinoic acid and corticoid |
| US4136166A (en) * | 1977-04-18 | 1979-01-23 | Helena Rubinstein, Inc. | Skin lightening composition |
| EP0060092A2 (en) * | 1981-03-05 | 1982-09-15 | Sunstar Kabushiki Kaisha | Topical skin depigmenting composition |
| WO1985003434A1 (en) * | 1984-02-06 | 1985-08-15 | Neutrogena Corporation | Vehicle for delivering active pharmaceutical ingredientsto the h uman skin |
| JPS61207317A (en) * | 1985-03-13 | 1986-09-13 | Shiseido Co Ltd | External agent for skin |
Non-Patent Citations (1)
| Title |
|---|
| PATENT ABSTRACTS OF JAPAN vol. 11, no. 43 (C-402)(2490) 7 février 1987, & JP-A-61 207317 (SHISEIDO CO. LTD.) 13 septembre 1986, * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2783714A1 (en) * | 1998-09-29 | 2000-03-31 | Led Evolution Dermatolog | COMPOSITION BASED ON HYDROQUINONE AND METABISULPHITE FOR TOPICAL USE FOR DEPIGMENTATION OF THE SKIN |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2673536B1 (en) | 1995-01-20 |
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