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FR2648045B1 - Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus - Google Patents

Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus

Info

Publication number
FR2648045B1
FR2648045B1 FR8907782A FR8907782A FR2648045B1 FR 2648045 B1 FR2648045 B1 FR 2648045B1 FR 8907782 A FR8907782 A FR 8907782A FR 8907782 A FR8907782 A FR 8907782A FR 2648045 B1 FR2648045 B1 FR 2648045B1
Authority
FR
France
Prior art keywords
retroviruses
inhibiting replication
oligonucleotide compounds
compounds inhibiting
alpha anomeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8907782A
Other languages
English (en)
Other versions
FR2648045A1 (fr
Inventor
Jean Louis Imbach
Bernard Rayner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR8907782A priority Critical patent/FR2648045B1/fr
Priority to EP90909462A priority patent/EP0477248A1/fr
Priority to JP2508923A priority patent/JPH04506074A/ja
Priority to PCT/FR1990/000412 priority patent/WO1990015813A1/fr
Publication of FR2648045A1 publication Critical patent/FR2648045A1/fr
Application granted granted Critical
Publication of FR2648045B1 publication Critical patent/FR2648045B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/337—Chemical structure of the base in alpha-anomeric form

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FR8907782A 1989-06-13 1989-06-13 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus Expired - Lifetime FR2648045B1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR8907782A FR2648045B1 (fr) 1989-06-13 1989-06-13 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
EP90909462A EP0477248A1 (fr) 1989-06-13 1990-06-12 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus
JP2508923A JPH04506074A (ja) 1989-06-13 1990-06-12 レトロウイルス複製を阻害するαアノマーオリゴヌクレオチド化合物
PCT/FR1990/000412 WO1990015813A1 (fr) 1989-06-13 1990-06-12 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8907782A FR2648045B1 (fr) 1989-06-13 1989-06-13 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus

Publications (2)

Publication Number Publication Date
FR2648045A1 FR2648045A1 (fr) 1990-12-14
FR2648045B1 true FR2648045B1 (fr) 1991-09-27

Family

ID=9382646

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8907782A Expired - Lifetime FR2648045B1 (fr) 1989-06-13 1989-06-13 Composes oligonucleotidiques anomeres alpha inhibant la replication des retrovirus

Country Status (4)

Country Link
EP (1) EP0477248A1 (fr)
JP (1) JPH04506074A (fr)
FR (1) FR2648045B1 (fr)
WO (1) WO1990015813A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166195A (en) * 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
IL107150A0 (en) * 1992-09-29 1993-12-28 Isis Pharmaceuticals Inc Oligonucleotides having a conserved g4 core sequence
FR2717081B1 (fr) * 1994-03-14 1996-06-21 Centre Nat Rech Scient Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro.
US6776986B1 (en) 1996-06-06 2004-08-17 Novartis Ag Inhibition of HIV-1 replication by antisense RNA expression
FR2906532B1 (fr) * 2006-09-28 2008-12-12 Biomerieux Sa Nouvel oligonucleotide marque
FR2933410B1 (fr) 2008-07-04 2010-08-20 Biomerieux Sa Nouvelle sonde de detection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988004301A1 (fr) * 1986-12-02 1988-06-16 Centre National De La Recherche Scientifique (Cnrs OLIGONUCLEOTIDES alpha
SE8701605D0 (sv) * 1987-04-16 1987-04-16 Astra Ab Novel medicinal compounds
FR2621816B1 (fr) * 1987-10-14 1990-12-28 Centre Nat Rech Scient Application antivirale des ologonucleotides

Also Published As

Publication number Publication date
EP0477248A1 (fr) 1992-04-01
WO1990015813A1 (fr) 1990-12-27
FR2648045A1 (fr) 1990-12-14
JPH04506074A (ja) 1992-10-22

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Legal Events

Date Code Title Description
ST Notification of lapse