[go: up one dir, main page]

FR2533438A2 - Use of growth factors and biological extracts containing the latter in cosmetology - Google Patents

Use of growth factors and biological extracts containing the latter in cosmetology Download PDF

Info

Publication number
FR2533438A2
FR2533438A2 FR8215559A FR8215559A FR2533438A2 FR 2533438 A2 FR2533438 A2 FR 2533438A2 FR 8215559 A FR8215559 A FR 8215559A FR 8215559 A FR8215559 A FR 8215559A FR 2533438 A2 FR2533438 A2 FR 2533438A2
Authority
FR
France
Prior art keywords
sep
animal
extracts
cosmetology
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8215559A
Other languages
French (fr)
Other versions
FR2533438B2 (en
Inventor
Daniel Greff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sederma SA
Original Assignee
Sederma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7931731A external-priority patent/FR2472385A1/en
Application filed by Sederma SA filed Critical Sederma SA
Priority to FR8215559A priority Critical patent/FR2533438B2/en
Publication of FR2533438A2 publication Critical patent/FR2533438A2/en
Application granted granted Critical
Publication of FR2533438B2 publication Critical patent/FR2533438B2/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates more generally to the use in cosmetology of growth factors as have been defined in cell biology for about twenty years, as well as to the use of biological extracts prepared so as to concentrate these growth factors and at doses adjusted so as to obtain an optimum effect on the growth in culture of human or animal cell lines of cutaneous origin.

Description

Le brevet principal cité, concerne de "Nouveaux extraits biologiques utilisables en Cosinétologie et les procédés d'obtention de ces extraits". Ces extraits contiennent des facteurs de croissance, constituants peptidiques- de bas poids moléculaires (500 a 50 000 daltons), thermorésistants jusqu'd 800 C et stables dans une gamme de pH comprise entre 2 et 9. Ils sont obtenus par dégradation thermique, digestion enzymatique et tamisage moléculaire des substances de départ. Les caractéristiques de ces extraits : activité démontrable in vitro, sur des cultures de cellules, innocuité et stabilité sont particulibrement avantageuses pour l'utilisation dans des produits cosmétiques.On a revendiqué dans le brevet principal (revendication 9) l'utilisation de produits possédant une acti vité au moins partielle de "facteurs de croissance
Le présent certificat d'addition concerne plus gEnérale- ment, l'utilisation en Cosmétologie des "facteurs de crois- sance" (growth factor, des auteurs anglo-saxons) tels qu'ils sont définis en biochimie et biologie cellulaire, depuis une vingtaine d'années et dont on trouve des revues de synthèse dans les articles suivants, par exemple
E.ROZENGURT "Biochemical basis of the early events stilated by serum and mitogenic factors in cultures of quiescent ceps, Cold Spring Harbor Conferences on Cell
Proliferation, vol. 6A & 6B, Cold Spring Harbor Laboratory, N.Y., 1978, pp. 773-788
M. PRUNIERS "Recent Advances in Epidermal Cell Cultures
Arch. Dermatol. Res., 1979, 164 : 2, 243-248. The main patent cited relates to "New biological extracts for use in Cosineology and the processes for obtaining these extracts". These extracts contain growth factors, peptidic constituents of low molecular weight (500 to 50,000 daltons), heat-resistant up to 800 C and stable in a pH range of between 2 and 9. They are obtained by thermal degradation, digestion enzymatic and molecular sieving of the starting substances. The characteristics of these extracts: demonstrable activity in vitro, on cell cultures, safety and stability are particularly advantageous for use in cosmetics.The main patent (claim 9) claims the use of products having a at least partial activity of "growth factors
This certificate of addition is more generally concerned with the use in cosmetology of growth factors, as defined in biochemistry and cell biology, since about twenty years. years and of which we find summary reviews in the following articles, for example
E.ROZENGURT "Biochemical basis of the early events by serum and mitogenic factors in cultures of quiescent ceps, Cold Spring Harbor Conferences on Cell
Proliferation, vol. 6A & 6B, Cold Spring Harbor Laboratory, NY, 1978, pp. 773-788
M. PRUNIERS Recent Advances in Epidermal Cell Cultures
Arch. Dermatol. Res., 1979, 164: 2, 243-248.

On rappelle que les facteurs de croissance en biochimie et en biologie cellulaire, sont des substances qui sont capables de stimuler la prolifération des cellules (cBest- d-dire, qui présentent une action mitoydne)O De façon plus pratique, ce sont des substances qui peuvent remplacer au moins en partie le sérum de veau, ou encore, présentent une synergie avec celui-ci, pour la survie et la croissance de lignées de cellules mises en culture dans un milieu nutritif minimum, par exemple le milieu MEM selon
HANKS. Les facteurs de croissance peuvent éventuellement présenter des spécificités pour certaines classes de cellules.It is recalled that the growth factors in biochemistry and cell biology are substances that are capable of stimulating the proliferation of cells (ie, which have a mitoyl action). In a more practical way, they are substances which may at least partly replace the calf serum, or else have a synergy therewith, for the survival and growth of cell lines cultured in a minimum nutrient medium, for example the MEM medium according to
HANKS. The growth factors may optionally have specificities for certain classes of cells.

Les inventeurs ont étudiés en vue d'une utilisation cosmétique des facteurs de croissance, ceux d'entre eux qui présentent une activité mitogène sur des lignées de cellules de peau en culture : cellules épidermiques, fibroblastes et chondrocytes. Le tableau en annexe présente des exemples de facteurs de croissance définis dont l'uti- sisation cosmétique a été étudiée, sans que cette liste ne soit limitative.The inventors have studied for a cosmetic use of growth factors, those of them which exhibit mitogenic activity on cell lines of skin in culture: epidermal cells, fibroblasts and chondrocytes. The table in the appendix presents examples of defined growth factors for which the cosmetic use has been studied, without this list being exhaustive.

Les inventeurs ont mis en évidence un parallélisme satisfaisant entre les propriétés in vitro de ces facteurs de croissance et les propriétés chimiques des préparations cosmétiques renfermant ceuxmci. Ils ont découvert que ces substances incorporées a des préparations cosmétiques finies, a faibles doses (0,001 % à 0,1 % de substances actives sèches par rapport a la préparation finie) présentent des activités cosmétologiques remarquables.The inventors have demonstrated a satisfactory parallelism between the in vitro properties of these growth factors and the chemical properties of the cosmetic preparations containing these. They discovered that these substances incorporated in finished cosmetic preparations, at low doses (0.001% to 0.1% of active ingredients dry in relation to the finished preparation) exhibit remarkable cosmetological activities.

On a également examiné à cet égard, des extraits biologiques contenant des facteurs de croissance non encore parfaitement identifiés. Ces extraits présentent des propri6- tés mitogènestrès similaires sur des lignées de cellules en culture d'origine cutanée. Ces extraits proviennent entre autres de 1- sérums animaux ou humains 2- peau embryonnaire d'origine animale 3- lait ou lactosérum humain ou bovin
Ces trois sources-6tant dOjà concernées par le brevet principal.Biological extracts containing growth factors not yet fully identified have also been examined. These extracts show very similar mitogenic properties on cultured cell lines of cutaneous origin. These extracts come inter alia from 1 animal or human serum 2 - embryonic skin of animal origin 3- milk or human or bovine whey
These three sources are already covered by the main patent.

4- des milieux de culture conditionnés (c'est-à-dire, où l'on a fait préalablement croitre des cultures de cellules spécialement des cultures de fibroblastes de peau humaine. La croissance de la première culture libérant dans le milieu des facteurs de croissance, actifs vis-avis des cultures subséquentes.Conditioned culture media (i.e., where cell cultures have been grown beforehand, especially human skin fibroblast cultures.) The growth of the first culture releasing in the medium of growth, assets in view of subsequent crops.

5- des extraits protéolytiques d'organes tels que :
- cartilages animaux
- peau animale, porcine ou bovine
- rate de bovins
- foie de bovins
- duodénum de porc
- embryons de bovins entiers sans que cette liste ne soit limitative.5- proteolytic extracts of organs such as:
- animal cartilage
- animal skin, swine or beef
- spleen of cattle
- liver of cattle
- pig duodenum
whole bovine embryos without this list being exhaustive.

Ces extraits sont obtenus de la même manière décrite dans le brevet principal, å savoir : hydrolyses enzymatiques spécifiques, traitements thermiques et tamisage moléculaire, dans le but d'en recueillir les facteurs de croissance qui ont généralement de faibles poids moléculaires (500 à 50 000 daltons) et d'en-éliminer des composants de hauts poids moléculaires 'qui sont parfois responsables de phénomènes d'inhibition de la croissance cellulaire.These extracts are obtained in the same manner as described in the main patent, namely: specific enzymatic hydrolyses, heat treatments and molecular sieving, in order to collect growth factors which generally have low molecular weights (500 to 50 000 dalton) and to remove high molecular weight components which are sometimes responsible for cellular growth inhibition phenomena.

A titre de variante, l'hydrolyse des organes précédents peut également être obtenue par fermentation bactérienne.Alternatively, the hydrolysis of the above organs can also be obtained by bacterial fermentation.

I1 a été mis à.incuber un broyat d'organes, en particulier du tissu cutané animal, avec des cultures de souches bactériennes choisies de façon à ce que l'extrait obtenu, présente des propriétés de facteur de croissance actives sur des lignées de cellules d'origine épidermique ou dermique, humaines ou animales. Incubation of organ stock, especially animal skin tissue, was incubated with cultures of selected bacterial strains so that the resulting extract exhibited active growth factor properties on cell lines. of epidermal or dermal origin, human or animal.

Après hydrplyse, les extraits protéolysés subissent un ou plusieurs traitements thermiques, puis si nécessaire, un tamisage moléculaire, de manière à récupérer des fragments de bas poids moléculaire (de 500 à 50 000 daltons, comme précédemment).After hydrplyse, the proteolyzed extracts undergo one or more heat treatments, then if necessary, molecular sieving, so as to recover low molecular weight fragments (from 500 to 50,000 daltons, as above).

Les extraits biologiques étant déjà connus et pour certains, utilisés en Cosmétologie. La présente invention consiste donc en leur utilisation en tant que facteur de croissance et pour ce faire - premièrement, à ajuster le mode de préparation pour favoriser la formation et la libération de ces facteurs de croissance selon les descriptions précédentes
- deuxièmement, à ajuster les doses d'utilisation à des valeurs optimales situées entre 0,01 % et 1 % d'extrait sec d'organes par rapport au produit cosmétique terminé.

Figure img00050001
The biological extracts are already known and for some, used in cosmetology. The present invention is therefore their use as a growth factor and to do this - first, to adjust the mode of preparation to promote the formation and release of these growth factors according to the previous descriptions
second, to adjust the use doses to optimum values of between 0.01% and 1% of dry organ extract relative to the finished cosmetic product.
Figure img00050001

<tb><Tb>

Facteur <SEP> de <SEP> Croissance <SEP> Origine <SEP> Structure <SEP> Poids <SEP> molécu- <SEP>
<tb> <SEP> courante <SEP> chimique <SEP> laire <SEP> approx.
<tb>Factor <SEP> of <SEP> Growth <SEP> Origin <SEP> Structure <SEP> Weight <SEP> molecular- <SEP>
<tb><SEP> current <SEP> chemical <SEP> same <SEP> approx.
<Tb>

Nom <SEP> (anglais) <SEP> Abréviation
<tb> Facteur <SEP> de <SEP> croissance <SEP> Glande
<tb> épidermique <SEP> (epider- <SEP> EGF <SEP> submaxil- <SEP> Polypepti- <SEP> 6 <SEP> 000
<tb> mal <SEP> growth <SEP> factor) <SEP> laire <SEP> de <SEP> de <SEP> acide
<tb> <SEP> souris
<tb> Facteur <SEP> de <SEP> croissance <SEP> cerveau
<tb> fibroblastique <SEP> (fibre <SEP> FGF <SEP> de <SEP> bo- <SEP> Polypepti- <SEP> 13 <SEP> 000
<tb> blast <SEP> growth <SEP> factor) <SEP> vins <SEP> de <SEP> basique
<tb> Facteur <SEP> de <SEP> croissance <SEP> Plaquet
<tb> plaquettaire <SEP> (platelet <SEP> PGF <SEP> tes <SEP> du <SEP> Polypepti- <SEP> 13 <SEP> 000
<tb> growth <SEP> factor) <SEP> sang <SEP> de <SEP> basique
<tb> <SEP> SM-A <SEP> Milieux
<tb> Somatomédines <SEP> A,C,MSA <SEP> SM-C <SEP> de <SEP> cul- <SEP> <SEP> Polvpept <SEP>
<tb> (MSA <SEP> = <SEP> multiplication <SEP> MSA <SEP> ture <SEP> Polypepti- <SEP> 10 <SEP> 000 <SEP> à
<tb> stimulating <SEP> activity) <SEP> d'hsspatc- <SEP> s <SEP> 20 <SEP> 000
<tb> <SEP> cytes,sé- <SEP>
<tb> <SEP> rum <SEP> san
<tb> <SEP> guin
<tb> Name <SEP> (English) <SEP> Abbreviation
<tb><SEP>Factor><SEP> Growth <SEP> Gland
<tb> epidermal <SEP> (epider- <SEP> EGF <SEP> submaxil- <SEP> Polypepti- <SEP> 6 <SEP> 000
<tb> bad <SEP> growth <SEP> factor) <SEP> laire <SEP> of <SEP> of <SEP> acid
<tb><SEP> mice
<tb><SEP>Factor> of <SEP> Growth <SEP> Brain
<tb> fibroblastic <SEP>(SEP> FGF <SEP> Fiber of <SEP> bo- <SEP> Polypepti- <SEP> 13 <SEP> 000
<tb> blast <SEP> growth <SEP> factor <SEP> wines <SEP> from <SEP> basic
<tb><SEP>Factor> of <SEP> Growth <SEP> Plaque
<tb> Platelet <SEP> (Platelet <SEP> PGF <SEP>SEP>SEP> Polypepti- <SEP> 13 <SEP> 000
<tb> growth <SEP> factor) <SEP> blood <SEP> of <SEP> basic
<tb><SEP> SM-A <SEP> Backgrounds
<tb> Somatomedins <SEP> A, C, MSA <SEP> SM-C <SEP> of <SEP> cul- <SEP><SEP> Polvpept <SEP>
<tb> (MSA <SEP> = <SEP> multiplication <SEP> MSA <SEP> ture <SEP> Polypepti- <SEP> 10 <SEP> 000 <SEP> to
<tb> stimulating <SEP> activity) <SEP> of hsspatc- <SEP> s <SEP> 20 <SEP> 000
<tb><SEP> cytes, se <SEP>
<tb><SEP> rum <SEP> san
<tb><SEP> guin
<Tb>

Claims (7)

de croissance, présentant une action mitogène sur des lignées de cellules en culture, d'origine cutanée, humaine ou animale. of growth, having a mitogenic action on cell lines in culture, cutaneous origin, human or animal. pal, caracterisés en ce que ces extraits sont des facteurs pal, characterized in that these extracts are factors giques naturelles selon la revendication 1 du brevet princi natural compounds according to claim 1 of the main patent REVENDICATIONS 1- Utilisation en Cosmétologie, d'extraits de substances biolo CLAIMS 1- Use in Cosmetology, extracts of biologic substances 2- Utilisation en Cosmétologie de facteurs de croissance selon2- Use in cosmetology of growth factors according to la revendication 1 ci-dessus, choisis dans la liste suivante: claim 1 above, selected from the following list: facteur de croissance épidermique EGF, facteur de croissance epidermal growth factor EGF, growth factor fibrobiastique FGF, facteur de croissance plaquettaire PGF, somatomédines A ou C ou MSA. fibroblastic FGF, platelet growth factor PGF, somatomedin A or C or MSA. 3- Utilisation en Cosmétologie d'extraits d'organes selon l'une3- Use in Cosmetology of Organ Extracts According to One des revendications 1 à 4 du brevet principal, caractérisés en claims 1 to 4 of the main patent, characterized in ce qu'ils contiennent des facteurs de croissance présentant what they contain presenting growth factors une action mitogène sur des lignées de cellules en culture d'origine cutanée, animale ou humaine. a mitogenic action on cell lines in cultures of cutaneous, animal or human origin. 4- Utilisation en Cosmétologie, cte.xtraits d'organes selon la4- Use in Cosmetology, cte.Extraits of organs according to the revendication 3 ci-dessus, proventTnt d'une ou plusieurs des claim 3 above, from one or more of sources suivantes - sérums animaux ou humains - peau embryonnaire d'origine animale - lait ou lactosérum humain ou boin - milieux de cultures "conditionne" - extraits protéolytiques de cartillage animaux, peau animale following sources - animal or human sera - embryonic skin of animal origin - human milk or whey or boin - "conditioned" culture media - proteolytic extracts from animal cartilage, animal skin porcine ou bovine, rate le @@@@us,foie de bovins, duodénum porcine or bovine, spleen @@@@@ us, cattle liver, duodenum de porc, elshryons de besoins sans que cette liste pork, needs elshryons without this list ne soit limitative. is not limiting. 5- Procédé de préparation d estralts d'organes selon les rewoen- 5- Method for preparing organ projections according to the rewoen- dications 3 et 4 ci-desst caractérisé en ce que l'étape 3 and 4 above, characterized in that the step d'hydrolyse est effectués par fermentation bactérienne.  hydrolysis is carried out by bacterial fermentation. 6-Préparation cosmétique caractérisée en ce qu'elle contient de6-Cosmetic preparation characterized in that it contains 0,001 % à 0,1 t de facteurs de croissance selon les revendi 0.001% to 0.1 t of growth factors according to the claims cations 1 et 2, en poids sec de facteur de croissance par cations 1 and 2, in dry weight of growth factor per rapport à la préparation cosmétique terminée. compared to the finished cosmetic preparation. 7-Préparation cosmétique caractérisée en ce qu'elle contient de7-Cosmetic preparation characterized in that it contains 0,01 % à 1 t d'extraits d'organes selon les revendications 3  0.01% to 1 t of organ extracts according to claims 3 et 4, en poids d'extraits secs d'organes par rapport à la and 4, by weight of dry organ extracts relative to the préparation cosmétique terminée.  cosmetic preparation completed.
FR8215559A 1979-12-27 1982-09-15 USE IN COSMETOLOGY OF GROWTH FACTORS AND BIOLOGICAL EXTRACTS CONTAINING THE SAME Expired FR2533438B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8215559A FR2533438B2 (en) 1979-12-27 1982-09-15 USE IN COSMETOLOGY OF GROWTH FACTORS AND BIOLOGICAL EXTRACTS CONTAINING THE SAME

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7931731A FR2472385A1 (en) 1979-12-27 1979-12-27 Extracts of natural biological substances used in cosmetology - prepd. by thermo-degradation and molecular filtration
FR8215559A FR2533438B2 (en) 1979-12-27 1982-09-15 USE IN COSMETOLOGY OF GROWTH FACTORS AND BIOLOGICAL EXTRACTS CONTAINING THE SAME

Publications (2)

Publication Number Publication Date
FR2533438A2 true FR2533438A2 (en) 1984-03-30
FR2533438B2 FR2533438B2 (en) 1986-03-07

Family

ID=26221514

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8215559A Expired FR2533438B2 (en) 1979-12-27 1982-09-15 USE IN COSMETOLOGY OF GROWTH FACTORS AND BIOLOGICAL EXTRACTS CONTAINING THE SAME

Country Status (1)

Country Link
FR (1) FR2533438B2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60258105A (en) * 1984-06-06 1985-12-20 Nonogawa Shoji:Kk Cosmetic
JPS615006A (en) * 1984-06-19 1986-01-10 Sanki Shoji Kk Agent for skin
FR2574289A1 (en) * 1984-12-06 1986-06-13 Roussel Uclaf NOVEL COSMETIC COMPOSITIONS FOR SCALP, COMPRISING A COMBINATION OF ACIDIC MUCOPOLYSACCHARIDES AND PEPTIDES, ASSOCIATED WITH PLACENT EXTRACT
JPS6219511A (en) * 1985-07-19 1987-01-28 Kanebo Ltd Cosmetic for preventing aging of skin
FR2590169A1 (en) * 1985-11-20 1987-05-22 Secta Labo Cosmetologie Y Roch Cosmetic composition containing biostimulins
FR2594690A1 (en) * 1986-02-21 1987-08-28 Thorel Jean Noel Compositions for regenerating and stimulating the dermis
EP0335554A3 (en) * 1988-03-23 1990-02-14 Unilever Plc Cosmetic composition
EP0383363A3 (en) * 1984-11-29 1990-10-03 Regents Of The University Of Minnesota Use of wound healing agents
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US5436230A (en) * 1991-01-14 1995-07-25 L'oreal Use of a growth factor in a slimming composition
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE19537297A1 (en) * 1995-07-07 1997-01-09 Paerson & Co Gmbh & Co Cosmetic, esp. skin or hair care prods. opt. stabilised with heparin and/or chondroitin sulphate - comprise growth factor prepd. directly from milk and colostrum from cows or mares, opt. in soya and/or protein phospholipid liposome form
ES2139525A1 (en) * 1997-11-17 2000-02-01 Sanchez Pedro Cuevas Use of whey-derived products as cytoprotectors and cicatrizants.
US6303112B1 (en) 1998-06-22 2001-10-16 Cytomedix Inc Enriched platelet wound healant
WO2001057082A3 (en) * 2000-02-03 2002-02-21 Regeneration Tech Inc Extraction of growth factors from tissue
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US7745106B2 (en) 1997-06-24 2010-06-29 Cascade Medical Enterprises, Llc Methods and devices for separating liquid components

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1580913A (en) * 1968-04-19 1969-09-12
FR2276316A1 (en) * 1974-06-28 1976-01-23 Carraz Maurice Peptone extd. from human placental residues - by treatment with aq. papaine under neutral conditions
FR2353282A1 (en) * 1976-06-02 1977-12-30 Invap Etablissement APPLICATION OF ELASTIN AND ITS DERIVATIVES IN COSMETICS
FR2380293A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR THE PREPARATION OF HYDROSOLUBLE HYDROLYSIS PRODUCTS FROM KERATINIC RAW MATERIALS, PRODUCTS OBTAINED AND THEIR USE FOR HAIR OR SKIN CARE
FR2380295A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR TREATING FALLS OF SKIN
FR2380294A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR THE PREPARATION OF HYDROSOLUBLE HYDROSOLUBLES OF ELASTIN FROM WASTE SKIN OR TENDONS, AND THEIR USE AS AN ACTIVE COSMETIC SUBSTANCE
FR2446634A1 (en) * 1979-01-16 1980-08-14 Nestle Sa Soc Ass Tech Prod LACTALBUMIN HYDROLYSAT COMPOSITION FOR SKIN TREATMENT AND CARE
FR2461002A1 (en) * 1979-07-13 1981-01-30 Inst Nat Sante Rech Med METHOD FOR STIMULATING THE GROWTH OF HUMAN EPIDERMIC CELLS AND PRODUCTS USING THE SAME
FR2472385A1 (en) * 1979-12-27 1981-07-03 Sederma Sa Extracts of natural biological substances used in cosmetology - prepd. by thermo-degradation and molecular filtration

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1580913A (en) * 1968-04-19 1969-09-12
FR2276316A1 (en) * 1974-06-28 1976-01-23 Carraz Maurice Peptone extd. from human placental residues - by treatment with aq. papaine under neutral conditions
FR2353282A1 (en) * 1976-06-02 1977-12-30 Invap Etablissement APPLICATION OF ELASTIN AND ITS DERIVATIVES IN COSMETICS
FR2380293A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR THE PREPARATION OF HYDROSOLUBLE HYDROLYSIS PRODUCTS FROM KERATINIC RAW MATERIALS, PRODUCTS OBTAINED AND THEIR USE FOR HAIR OR SKIN CARE
FR2380295A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR TREATING FALLS OF SKIN
FR2380294A1 (en) * 1977-02-11 1978-09-08 Freudenberg Carl PROCESS FOR THE PREPARATION OF HYDROSOLUBLE HYDROSOLUBLES OF ELASTIN FROM WASTE SKIN OR TENDONS, AND THEIR USE AS AN ACTIVE COSMETIC SUBSTANCE
FR2446634A1 (en) * 1979-01-16 1980-08-14 Nestle Sa Soc Ass Tech Prod LACTALBUMIN HYDROLYSAT COMPOSITION FOR SKIN TREATMENT AND CARE
FR2461002A1 (en) * 1979-07-13 1981-01-30 Inst Nat Sante Rech Med METHOD FOR STIMULATING THE GROWTH OF HUMAN EPIDERMIC CELLS AND PRODUCTS USING THE SAME
FR2472385A1 (en) * 1979-12-27 1981-07-03 Sederma Sa Extracts of natural biological substances used in cosmetology - prepd. by thermo-degradation and molecular filtration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol.89, no.20, novembre 1978, page 347, résumé no.168954a, COLUMBUS OHIO (US) & ES - A - 454 431 (PATRONATO DE INVESTIGACION CIENTIFICA Y TECNICA "JUAN DE LA CIERVA")(16 mars 1978) *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60258105A (en) * 1984-06-06 1985-12-20 Nonogawa Shoji:Kk Cosmetic
JPS615006A (en) * 1984-06-19 1986-01-10 Sanki Shoji Kk Agent for skin
EP0383363A3 (en) * 1984-11-29 1990-10-03 Regents Of The University Of Minnesota Use of wound healing agents
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
EP0202298B1 (en) * 1984-11-29 1992-07-15 Regents Of The University Of Minnesota Wound healing agents
FR2574289A1 (en) * 1984-12-06 1986-06-13 Roussel Uclaf NOVEL COSMETIC COMPOSITIONS FOR SCALP, COMPRISING A COMBINATION OF ACIDIC MUCOPOLYSACCHARIDES AND PEPTIDES, ASSOCIATED WITH PLACENT EXTRACT
JPS6219511A (en) * 1985-07-19 1987-01-28 Kanebo Ltd Cosmetic for preventing aging of skin
FR2590169A1 (en) * 1985-11-20 1987-05-22 Secta Labo Cosmetologie Y Roch Cosmetic composition containing biostimulins
FR2594690A1 (en) * 1986-02-21 1987-08-28 Thorel Jean Noel Compositions for regenerating and stimulating the dermis
EP0335554A3 (en) * 1988-03-23 1990-02-14 Unilever Plc Cosmetic composition
US5436230A (en) * 1991-01-14 1995-07-25 L'oreal Use of a growth factor in a slimming composition
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
DE19537297A1 (en) * 1995-07-07 1997-01-09 Paerson & Co Gmbh & Co Cosmetic, esp. skin or hair care prods. opt. stabilised with heparin and/or chondroitin sulphate - comprise growth factor prepd. directly from milk and colostrum from cows or mares, opt. in soya and/or protein phospholipid liposome form
ES2139525A1 (en) * 1997-11-17 2000-02-01 Sanchez Pedro Cuevas Use of whey-derived products as cytoprotectors and cicatrizants.
US6303112B1 (en) 1998-06-22 2001-10-16 Cytomedix Inc Enriched platelet wound healant
WO2001057082A3 (en) * 2000-02-03 2002-02-21 Regeneration Tech Inc Extraction of growth factors from tissue
US6649072B2 (en) 2001-11-16 2003-11-18 Robert Brandt Method for producing autologous platelet-rich plasma

Also Published As

Publication number Publication date
FR2533438B2 (en) 1986-03-07

Similar Documents

Publication Publication Date Title
FR2533438A2 (en) Use of growth factors and biological extracts containing the latter in cosmetology
EP1242045A2 (en) Use of an extract of at least one vaccinium-type plant as an anti-glycation agent
JPH08500595A (en) Use of diacylglycerol to increase the melanin content of melanocytes
EP0120722A1 (en) Process for stimulating the multiplication of cells; cosmetic and pharmaceutical composition and a complementary composition for cellular cultures applying this process
CN101172095A (en) Cosmetics material of protolysate containing royal jelly
FR2472385A1 (en) Extracts of natural biological substances used in cosmetology - prepd. by thermo-degradation and molecular filtration
CA2312526A1 (en) Use of dedifferentiated plant cells
EP1071747B1 (en) Immortalised cell lines derived from normal human skin tissues
CN111511901B (en) Medium composition for skin regeneration comprising cells isolated from eggs of birds
EP1014934B1 (en) Use of at least an extract of the genus chrysanthemum for stimulating skin and/or hair pigmentation
EP0373195B1 (en) Composition for increasing melanin content of melanocytes in-vivo and in-vitro and methods for the in-vitro use thereof
KR20130114808A (en) Cosmetics composition including collagen natural fermented broth
KR20150072327A (en) Cosmetic composition for prevention of depilation and improvement of hair growth having fermented peptone having activator of dermal papilla cell and geminal matrix cell, and formulation having the same
EP0237398B1 (en) Use of biologically active polypeptides and compositions containing them
EP0797981A1 (en) Use of a simarouba extract for the preparation of a skin cell culture medium
EP1702979A3 (en) Improved keratinocyte culture and uses thereof
EP0850044B1 (en) Process for obtaining amino acids from proteins and use of the amino-acid-containing products obtained
FR3046181A1 (en) GLUCIDIC FRACTION ISOLATED FROM A CLARIFIED LYSATE OBTAINED FROM A BIOMASS OF BACTERIUM (S) BELONGING TO THE GENUS VITREOSCILLA SP.
EP0396442B1 (en) Cosmetic composition containing coumpounds obtained from culture of cells, especially from fibroblasts or keratinocytes
CN111329830A (en) Method for obtaining micrococcus bacterial fermentation cytolysis liquid and application of micrococcus bacterial fermentation cytolysis liquid in anti-aging
FR2487197A2 (en) Extraction of glyco:proteins and muco:polysaccharide(s) - by macerating animal tissue in a slightly alkaline buffer
FR3060568A1 (en) OLIGOPEPTIDE FRACTION OBTAINED FROM A BIOMASS OF BACTERIUM (S) BELONGING TO THE GENUS VITREOSCILLA SP. AS A COSMETIC ACTIVE
RU2120274C1 (en) Cosmetic maricream
RU2710718C1 (en) Method of modifying proliferative activity of cell cultures of mammals
CN109097321A (en) A kind of primary separation method of hair follicle stem cells