FR2439783A1 - Procede d'extraction de la serpentine et de l'alstonine - Google Patents
Procede d'extraction de la serpentine et de l'alstonineInfo
- Publication number
- FR2439783A1 FR2439783A1 FR7830663A FR7830663A FR2439783A1 FR 2439783 A1 FR2439783 A1 FR 2439783A1 FR 7830663 A FR7830663 A FR 7830663A FR 7830663 A FR7830663 A FR 7830663A FR 2439783 A1 FR2439783 A1 FR 2439783A1
- Authority
- FR
- France
- Prior art keywords
- alstonine
- serpentine
- extracting
- extraction
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 title abstract 6
- QVBOOBQEGOUUGN-RCBQFDQVSA-N alstonine Chemical compound C1=C[CH]C2=NC3=C(C[C@@H]4C(C(=O)OC)=CO[C@@H](C)[C@@H]4C4)[N+]4=CC=C3C2=C1 QVBOOBQEGOUUGN-RCBQFDQVSA-N 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000000284 extract Substances 0.000 title abstract 2
- 238000000605 extraction Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 title 3
- 244000061121 Rauvolfia serpentina Species 0.000 title 1
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 241000208332 Rauvolfia Species 0.000 abstract 1
- 239000000287 crude extract Substances 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000003808 methanol extraction Methods 0.000 abstract 1
- 231100000167 toxic agent Toxicity 0.000 abstract 1
- 239000003440 toxic substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDE D'EXTRACTION DE LA SERPENTINE ET DE L'ALSTONINE A L'ETAT PUR A PARTIR DE RAUWOLFIA, QUI CONSISTE A EXTRAIRE PAR LE CHLOROFORME LES EXTRAITS METHANOLIQUES EVAPORES A SEC ET REPRIS PAR L'EAU, ET A RECUPERER LA SERPENTINE DE LA PHASE AQUEUSE ET L'ALSTONINE DE L'UNE ET L'AUTRE DES PHASES PAR EXTRACTION PAR LA METHYLETHYLCETONE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7830663A FR2439783A1 (fr) | 1978-03-13 | 1978-10-27 | Procede d'extraction de la serpentine et de l'alstonine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7807155A FR2419725A1 (fr) | 1978-03-13 | 1978-03-13 | Serpentine, alstonine et sempervirine, medicaments inhibant specifiquement les cellules cancereuses et tumorales |
| FR7830663A FR2439783A1 (fr) | 1978-03-13 | 1978-10-27 | Procede d'extraction de la serpentine et de l'alstonine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2439783A1 true FR2439783A1 (fr) | 1980-05-23 |
| FR2439783B1 FR2439783B1 (fr) | 1981-07-17 |
Family
ID=26220481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7830663A Granted FR2439783A1 (fr) | 1978-03-13 | 1978-10-27 | Procede d'extraction de la serpentine et de l'alstonine |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2439783A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994002829A1 (fr) * | 1992-07-28 | 1994-02-03 | Abraxas Bio Labs Sa | Methode de cytodiagnostic utilisant l'alstonine comme marqueur selectif et kit de diagnostic contenant ce marqueur |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1397537A (fr) * | 1964-03-05 | 1965-04-30 | Ciba Geigy | Procédé pour l'obtention d'alcaloïdes de rauwolfia |
| FR1441520A (fr) * | 1961-09-01 | 1966-06-10 | Isolement de la serpentine à partir des racines de diverses espèces de rauwolfia |
-
1978
- 1978-10-27 FR FR7830663A patent/FR2439783A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1441520A (fr) * | 1961-09-01 | 1966-06-10 | Isolement de la serpentine à partir des racines de diverses espèces de rauwolfia | |
| FR1397537A (fr) * | 1964-03-05 | 1965-04-30 | Ciba Geigy | Procédé pour l'obtention d'alcaloïdes de rauwolfia |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994002829A1 (fr) * | 1992-07-28 | 1994-02-03 | Abraxas Bio Labs Sa | Methode de cytodiagnostic utilisant l'alstonine comme marqueur selectif et kit de diagnostic contenant ce marqueur |
| FR2694193A1 (fr) * | 1992-07-28 | 1994-02-04 | Abraxas Bio Labs Sa | Méthode de cytodiagnostic utilisant l'alstonine comme marqueur sélectif et kit de diagnostic contenant ce marqueur. |
| US5567593A (en) * | 1992-07-28 | 1996-10-22 | Beljanski; Mirko | Cytodiagnostic method using alstonine as a selective marker, and diagnostic kit containing marker |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2439783B1 (fr) | 1981-07-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| TP | Transmission of property | ||
| TP | Transmission of property | ||
| SN | Distraint notified (in the national patent register) | ||
| JU | Final juridical decision affecting the ownership or exploitation of an industrial property right | ||
| ML | Cancellation of distraint | ||
| TP | Transmission of property |