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FR2439196A1 - NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS - Google Patents

NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS

Info

Publication number
FR2439196A1
FR2439196A1 FR7829496A FR7829496A FR2439196A1 FR 2439196 A1 FR2439196 A1 FR 2439196A1 FR 7829496 A FR7829496 A FR 7829496A FR 7829496 A FR7829496 A FR 7829496A FR 2439196 A1 FR2439196 A1 FR 2439196A1
Authority
FR
France
Prior art keywords
lower alkyl
opt
hypertenstant
thrombotic
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR7829496A
Other languages
French (fr)
Inventor
Toru Nakao
Shinro Setoguchi
Osamu Yaoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Yoshitomi Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd
Priority to FR7829496A priority Critical patent/FR2439196A1/en
Publication of FR2439196A1 publication Critical patent/FR2439196A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Pyridazinone derivs. of formula (I) and their acid addition salts are new. In (I) A is CH2, CH2CH2 or CH=CH, the last two opt. bustd. by lower alkyl. B is oxo or 2H atoms. R1 is H, lower alkyl, lakanoyl, alkylsulphonyl or benzoyl (opt. substd. by 1 same or different halo or lower alkyl or alkoxy). R2 is H, alkyl (opt. substd. by carbamoyl, naphthyloxy or oxo), lower hydroxyalkyl or R6R7N (CH2)n. R6 and R7 are each H or lower alkyl, or together complete a heterocycle n=2 or 3. R4 is H, lower alkyl, hydroxymethyl or alkanoyloxymethyl. R5 is H or lower alkyl. R3 is H, or R3 plus either R4 or R5 make up a bond). (I) have platelet-aggregation inhibiting activity and are useful e.g. in cases of transitory ischaemic incidients, shock, myocardial infarct, thrombosis ek, and for patients with prosthetic cardiac values or arterial-venous shunts.
FR7829496A 1978-10-17 1978-10-17 NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS Pending FR2439196A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7829496A FR2439196A1 (en) 1978-10-17 1978-10-17 NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7829496A FR2439196A1 (en) 1978-10-17 1978-10-17 NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS

Publications (1)

Publication Number Publication Date
FR2439196A1 true FR2439196A1 (en) 1980-05-16

Family

ID=9213816

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7829496A Pending FR2439196A1 (en) 1978-10-17 1978-10-17 NOVEL PYRIDAZINONE DERIVATIVES FOR USE IN THERAPEUTICS AS ANTI-THROMBOTIC AND ANTI-HYPERTENSTANT AGENTS

Country Status (1)

Country Link
FR (1) FR2439196A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148623A3 (en) * 1983-12-22 1986-06-04 Pfizer Limited Quinolone inotropic agents
WO1999050263A1 (en) * 1998-03-31 1999-10-07 Warner-Lambert Company Quinolones as serine protease inhibitors

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0148623A3 (en) * 1983-12-22 1986-06-04 Pfizer Limited Quinolone inotropic agents
WO1999050263A1 (en) * 1998-03-31 1999-10-07 Warner-Lambert Company Quinolones as serine protease inhibitors
US6855726B1 (en) 1998-03-31 2005-02-15 Warner-Lambert Company Llc Quinolones as serine protease inhibitors

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