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FR2436148A1 - 3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer - Google Patents

3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer

Info

Publication number
FR2436148A1
FR2436148A1 FR7826304A FR7826304A FR2436148A1 FR 2436148 A1 FR2436148 A1 FR 2436148A1 FR 7826304 A FR7826304 A FR 7826304A FR 7826304 A FR7826304 A FR 7826304A FR 2436148 A1 FR2436148 A1 FR 2436148A1
Authority
FR
France
Prior art keywords
thione
thiazoline
cpds
pyridyl
corresp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826304A
Other languages
French (fr)
Other versions
FR2436148B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7826304A priority Critical patent/FR2436148A1/en
Priority to NL7810230A priority patent/NL7810230A/en
Priority to GR57454A priority patent/GR64044B/en
Priority to US05/952,198 priority patent/US4167571A/en
Priority to GB7840801A priority patent/GB2006210A/en
Priority to AU40786/78A priority patent/AU4078678A/en
Priority to JP12691678A priority patent/JPS5479285A/en
Priority to NZ188676A priority patent/NZ188676A/en
Priority to LU80389A priority patent/LU80389A1/en
Priority to SE7810864A priority patent/SE7810864L/en
Priority to CA313,694A priority patent/CA1098906A/en
Priority to SU782674199A priority patent/SU793398A3/en
Priority to DK464378A priority patent/DK464378A/en
Priority to IL7855757A priority patent/IL55757A0/en
Priority to PT68668A priority patent/PT68668A/en
Priority to NO783529A priority patent/NO783529L/en
Priority to ES474350A priority patent/ES474350A1/en
Priority to FI783184A priority patent/FI783184A7/en
Priority to AT0750578A priority patent/ATA750578A/en
Priority to CS786806A priority patent/CS203932B2/en
Priority to DE19782845624 priority patent/DE2845624A1/en
Priority to HU78RO996A priority patent/HU175528B/en
Priority to IT28911/78A priority patent/IT1101658B/en
Publication of FR2436148A1 publication Critical patent/FR2436148A1/en
Application granted granted Critical
Publication of FR2436148B1 publication Critical patent/FR2436148B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-Pyridyl-thiazoline-2-thione derivs of formula (I) are new In (I), (a) R1 is H, 1-2C alkyl or methoxymethyl, R2 is 1-2C alkyl in position 4,5 or 6 and R3 is methyl, or (b) R3 is H and R1 is H, 1-4C alkyl or 1-4C opt. branched alkoxy methyl and R2 is 1-4C alkyl in position 4,5 or 6 or R1 is cyclopropyl and R2 is H. (I) are anti-ulcer cpds which are active in rats at doses of 5-100 mg/kg p.o (Rossi and Shay tests) and in guinea pigs at the same dose levels (Anderson and Watt test). Oral LD50 N 100 mg/kg.
FR7826304A 1977-10-19 1978-09-13 3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer Granted FR2436148A1 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR7826304A FR2436148A1 (en) 1978-09-13 1978-09-13 3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer
NL7810230A NL7810230A (en) 1977-10-19 1978-10-11 THIAZOLIN COMPOUNDS, METHOD FOR THE PREPARATION OF SUCH COMPOUNDS, PHARMACOLOGICAL PREPARATIONS CONTAINING ONE OR MORE OF THESE THIAZOLIN COMPOUNDS, AND PROCESS FOR THE PREPARATION OF SUCH PHARMACOLOGICAL PREPARATIONS.
US05/952,198 US4167571A (en) 1977-10-19 1978-10-17 Thiazoline derivatives
GB7840801A GB2006210A (en) 1977-10-19 1978-10-17 Thiazoline derivatives
AU40786/78A AU4078678A (en) 1977-10-19 1978-10-17 Thiazoline derivatives
JP12691678A JPS5479285A (en) 1977-10-19 1978-10-17 Thiazoline derivative
NZ188676A NZ188676A (en) 1977-10-19 1978-10-17 Thiazoline derivatives and pharmaceutical compositions
GR57454A GR64044B (en) 1977-10-19 1978-10-17 Method for the preparation of new derivatives of thiazolines
IL7855757A IL55757A0 (en) 1977-10-19 1978-10-18 Novel thiazoline derivatives,process for their preparationand pharmaceutical composition containing them
CA313,694A CA1098906A (en) 1977-10-19 1978-10-18 Derivatives of thiazolin, their preparation and compositions containing them
SU782674199A SU793398A3 (en) 1977-10-19 1978-10-18 Method of preparing thiazoline derivatives
DK464378A DK464378A (en) 1977-10-19 1978-10-18 PROCEDURE FOR THE PREPARATION OF THIAZOLINE DERIVATIVES
LU80389A LU80389A1 (en) 1977-10-19 1978-10-18 NEW THIAZOLINE DERIVATIVES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
PT68668A PT68668A (en) 1977-10-19 1978-10-18 NOVEL DERIVATIVES OF THIAZOLINE PREPARATION AND COMPOSITIONS CONTAINING THEM
NO783529A NO783529L (en) 1977-10-19 1978-10-18 NEW TIAZOLIN DERIVATIVES.
SE7810864A SE7810864L (en) 1977-10-19 1978-10-18 NEW TIAZOLIN DERIVATIVES
FI783184A FI783184A7 (en) 1977-10-19 1978-10-19 NYA THIAZOLINDERIVAT, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DESAMMA INNEHAOLLANDE FOERENINGAR
AT0750578A ATA750578A (en) 1977-10-19 1978-10-19 METHOD FOR PRODUCING NEW PYRIDOTHIAZOLINES
CS786806A CS203932B2 (en) 1977-10-19 1978-10-19 Process for prepating new derivatives of thiazoline
DE19782845624 DE2845624A1 (en) 1977-10-19 1978-10-19 NEW DERIVATIVES OF THIAZOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM
ES474350A ES474350A1 (en) 1977-10-19 1978-10-19 Thiazoline derivatives
HU78RO996A HU175528B (en) 1977-10-19 1978-10-19 Process for producing new pyridyl-thiazoline derivatives
IT28911/78A IT1101658B (en) 1977-10-19 1978-10-19 THIAZOLINE DERIVATIVES THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7826304A FR2436148A1 (en) 1978-09-13 1978-09-13 3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer

Publications (2)

Publication Number Publication Date
FR2436148A1 true FR2436148A1 (en) 1980-04-11
FR2436148B1 FR2436148B1 (en) 1981-02-27

Family

ID=9212605

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826304A Granted FR2436148A1 (en) 1977-10-19 1978-09-13 3-Pyridyl-4-thiazoline-2-thione antiulcer cpds. - prepd. by dehydration of corresp. 4-hydroxy-thiazolidine thione or its tautomer

Country Status (1)

Country Link
FR (1) FR2436148A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725422A (en) * 1971-09-07 1973-04-03 Parke Davis & Co New organic sulfur compounds and methods for their production
US3726880A (en) * 1971-09-07 1973-04-10 Parke Davis & Co Organic amides and methods for their production
US3761485A (en) * 1971-09-07 1973-09-25 Parke Davis & Co 3-(5-chloro-2-pyridyl)rhodanine and 3-(5-chloro-2-pyridyl)-5-(lower alkyl)rhodanines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725422A (en) * 1971-09-07 1973-04-03 Parke Davis & Co New organic sulfur compounds and methods for their production
US3726880A (en) * 1971-09-07 1973-04-10 Parke Davis & Co Organic amides and methods for their production
US3761485A (en) * 1971-09-07 1973-09-25 Parke Davis & Co 3-(5-chloro-2-pyridyl)rhodanine and 3-(5-chloro-2-pyridyl)-5-(lower alkyl)rhodanines

Also Published As

Publication number Publication date
FR2436148B1 (en) 1981-02-27

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