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FR2435469A1 - MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES WITH HYPOTENSIVE ACTION - Google Patents

MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES WITH HYPOTENSIVE ACTION

Info

Publication number
FR2435469A1
FR2435469A1 FR7919590A FR7919590A FR2435469A1 FR 2435469 A1 FR2435469 A1 FR 2435469A1 FR 7919590 A FR7919590 A FR 7919590A FR 7919590 A FR7919590 A FR 7919590A FR 2435469 A1 FR2435469 A1 FR 2435469A1
Authority
FR
France
Prior art keywords
substituted prolines
hypotensive action
mercaptoacyl derivatives
derivatives
mercaptoacyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7919590A
Other languages
French (fr)
Other versions
FR2435469B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2435469A1 publication Critical patent/FR2435469A1/en
Application granted granted Critical
Publication of FR2435469B1 publication Critical patent/FR2435469B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Nouveaux dérivés mercapto acylés de prolines substituées. Ils ont pour formule générale :New acylated mercapto derivatives of substituted prolines. Their general formula:

FR7919590A 1978-08-11 1979-07-30 MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES WITH HYPOTENSIVE ACTION Granted FR2435469A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93288378A 1978-08-11 1978-08-11
KR1019790002731A KR830002450B1 (en) 1978-08-11 1979-08-10 Method for preparing mercaptoacyl derivative of substituted proline

Publications (2)

Publication Number Publication Date
FR2435469A1 true FR2435469A1 (en) 1980-04-04
FR2435469B1 FR2435469B1 (en) 1983-02-11

Family

ID=26626596

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7919590A Granted FR2435469A1 (en) 1978-08-11 1979-07-30 MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES WITH HYPOTENSIVE ACTION

Country Status (30)

Country Link
JP (2) JPS5527199A (en)
KR (1) KR830002450B1 (en)
AR (1) AR229081A1 (en)
AT (1) AT379589B (en)
AU (1) AU530690B2 (en)
BE (1) BE878191A (en)
CA (1) CA1144930A (en)
CH (1) CH642064A5 (en)
CS (1) CS228118B2 (en)
DD (1) DD145749A5 (en)
DE (1) DE2932021C2 (en)
DK (1) DK154553C (en)
ES (1) ES483311A1 (en)
FI (1) FI69834C (en)
FR (1) FR2435469A1 (en)
GB (1) GB2028327B (en)
GR (1) GR72420B (en)
IE (1) IE48802B1 (en)
IN (1) IN152712B (en)
IT (1) IT1117782B (en)
LU (2) LU81593A1 (en)
NL (2) NL193374C (en)
NZ (1) NZ191036A (en)
PH (1) PH15030A (en)
PT (1) PT70049A (en)
RO (1) RO78870B (en)
SE (1) SE447477B (en)
SU (1) SU1066460A3 (en)
YU (1) YU41876B (en)
ZA (1) ZA793633B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
FR2444669A1 (en) * 1978-12-22 1980-07-18 Squibb & Sons Inc MERCAP ACETALS AND THIOACETALS
FR2462428A1 (en) * 1979-07-30 1981-02-13 Squibb & Sons Inc DITHIOACYLDIHYDROPYRAZOLE CARBOXYLIC ACID DERIVATIVES, DITHIOACYLPROLINE DERIVATIVES, AND RELATED COMPOUNDS WITH ANTIHYPERTENSIVE ACTION
FR2467845A1 (en) * 1979-10-22 1981-04-30 Squibb & Sons Inc NOVEL MERCAPTO-ACYL DERIVATIVES OF 4,4-DISUBSTITUTED PROLINES AND 4-SUBSTITUTED DEHYDROPROLINS, SUITABLE IN PARTICULAR AS HYDROPOTENANT DRUGS, THERAPEUTIC COMPOSITIONS AND PHARMACEUTICAL FORMATES CONTAINING THEM, AND INTERMEDIATE MATERIALS FOR THEIR USEFUL

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347371A (en) * 1978-12-30 1982-08-31 Santen Pharmaceutical Co., Ltd. Disulfide compounds
US4234489A (en) * 1979-06-25 1980-11-18 E. R. Squibb & Sons, Inc. Pyroglutamic acid derivatives and analogs
US4692458A (en) * 1980-03-05 1987-09-08 University Of Miami Anti-hypertensive agents
AU542211B2 (en) * 1980-03-07 1985-02-14 Gruppo Lepetit S.P.A. Mercaptocycloalkyl carbonyl prolines
GB2070586A (en) * 1980-03-21 1981-09-09 Squibb & Sons Inc Derivatives of Proline or Pipecolic Acid
US4284624A (en) 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
US4578474A (en) * 1980-06-23 1986-03-25 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4390695A (en) * 1980-06-23 1983-06-28 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines
US4332726A (en) * 1980-08-25 1982-06-01 E. R. Squibb & Sons, Inc. Purification of mercaptoacyl amino acids
US4307110A (en) * 1980-09-12 1981-12-22 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of 3-substituted proline derivatives
US4311705A (en) * 1980-10-06 1982-01-19 E. R. Squibb & Sons, Inc. Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines
US4312809A (en) 1980-10-31 1982-01-26 E. R. Squibb & Sons, Inc. Lactam derivatives of mercaptoacylamino acids
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4374131A (en) 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4416831A (en) 1981-04-27 1983-11-22 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds
US4381297A (en) 1981-05-04 1983-04-26 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4416833A (en) 1981-05-04 1983-11-22 E. R. Squibb & Sons, Inc. Substituted carbonyl phosphinyl-alkanoyl compounds
US4497953A (en) * 1981-06-01 1985-02-05 E. R. Squibb & Sons, Inc. Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids
US4377701A (en) * 1981-09-21 1983-03-22 E. R. Squibb & Sons, Inc. 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4703043A (en) * 1982-06-23 1987-10-27 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive
US4616005A (en) * 1982-06-23 1986-10-07 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4452790A (en) * 1982-06-23 1984-06-05 E. R. Squibb & Sons, Inc. Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives
US4567166A (en) * 1982-07-14 1986-01-28 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
AU632596B2 (en) * 1989-08-21 1993-01-07 E.R. Squibb & Sons, Inc. Phosphonate substituted amino or imino acids useful as antihypertensives
JPH05344844A (en) * 1992-06-12 1993-12-27 Suzumo Kiko Kk Method for producing roasted rice ball cracker
EP0640594A1 (en) 1993-08-23 1995-03-01 Fujirebio Inc. Hydantoin derivative as metalloprotease inhibitor
US5435286A (en) * 1994-05-02 1995-07-25 Cummins Engine Company, Inc. Ball link assembly for vehicle engine drive trains
GB0225379D0 (en) * 2002-10-31 2002-12-11 Pfizer Ltd Therapeutic proline derivatives
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
WO2006038119A1 (en) * 2004-10-08 2006-04-13 Warner-Lambert Company Llc Stereoselective synthesis of n-protected alkoxy prolines
GB0715626D0 (en) * 2007-08-10 2007-09-19 Generics Uk Ltd Crystalline form of zofenopril calcium
WO2009106894A1 (en) * 2008-02-27 2009-09-03 Generics [Uk] Limited Novel crystalline forms
US8853421B2 (en) 2008-02-27 2014-10-07 Generics [Uk] Limited Crystalline forms of zofenopril calcium
SI23949A (en) 2011-12-19 2013-06-28 Silverstone Pharma The new crystalline salts of zofenopril, the procedure for obtaining them and their use in therapy

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (en) * 1976-02-09 1977-09-02 Roussel Uclaf Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole
FR2372803A1 (en) * 1976-12-03 1978-06-30 Squibb & Sons Inc ACYL DERIVATIVES SUBSTITUTED FOR AMINO ACIDS, WITH ANTI-HYPERTENSIVE ACTIVITY
FR2377374A1 (en) * 1977-01-17 1978-08-11 Squibb & Sons Inc ACYL DERIVATIVES OF AMINO ACIDS AND THEIR USE AS MEDICINAL PRODUCTS
FR2383171A1 (en) * 1977-03-11 1978-10-06 Squibb & Sons Inc THIOPROPANOYLAMINOACID DERIVATIVES USEFUL AS HYPOTENSORS
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids
FR2417499A1 (en) * 1978-02-21 1979-09-14 Squibb & Sons Inc MERCAPTOACYLAMINO-HALOGEN ACIDS AND THEIR THERAPEUTIC USE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340092A2 (en) * 1976-02-09 1977-09-02 Roussel Uclaf Analgesic (N)-thiazolyl-quinoline carboxamides - prepd. from the corresp. quinoline carboxylic acid and (2)-amino-thiazole
FR2372803A1 (en) * 1976-12-03 1978-06-30 Squibb & Sons Inc ACYL DERIVATIVES SUBSTITUTED FOR AMINO ACIDS, WITH ANTI-HYPERTENSIVE ACTIVITY
FR2377374A1 (en) * 1977-01-17 1978-08-11 Squibb & Sons Inc ACYL DERIVATIVES OF AMINO ACIDS AND THEIR USE AS MEDICINAL PRODUCTS
FR2383171A1 (en) * 1977-03-11 1978-10-06 Squibb & Sons Inc THIOPROPANOYLAMINOACID DERIVATIVES USEFUL AS HYPOTENSORS
FR2417499A1 (en) * 1978-02-21 1979-09-14 Squibb & Sons Inc MERCAPTOACYLAMINO-HALOGEN ACIDS AND THEIR THERAPEUTIC USE
US4154934A (en) * 1978-08-11 1979-05-15 E. R. Squibb & Sons, Inc. Mercaptoacylamino derivatives of heterocyclic carboxylic acids

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
FR2444669A1 (en) * 1978-12-22 1980-07-18 Squibb & Sons Inc MERCAP ACETALS AND THIOACETALS
FR2462428A1 (en) * 1979-07-30 1981-02-13 Squibb & Sons Inc DITHIOACYLDIHYDROPYRAZOLE CARBOXYLIC ACID DERIVATIVES, DITHIOACYLPROLINE DERIVATIVES, AND RELATED COMPOUNDS WITH ANTIHYPERTENSIVE ACTION
FR2467845A1 (en) * 1979-10-22 1981-04-30 Squibb & Sons Inc NOVEL MERCAPTO-ACYL DERIVATIVES OF 4,4-DISUBSTITUTED PROLINES AND 4-SUBSTITUTED DEHYDROPROLINS, SUITABLE IN PARTICULAR AS HYDROPOTENANT DRUGS, THERAPEUTIC COMPOSITIONS AND PHARMACEUTICAL FORMATES CONTAINING THEM, AND INTERMEDIATE MATERIALS FOR THEIR USEFUL

Also Published As

Publication number Publication date
SE7906722L (en) 1980-02-12
AU530690B2 (en) 1983-07-28
IE791544L (en) 1980-02-11
ES483311A1 (en) 1980-04-16
CA1144930A (en) 1983-04-19
FI69834C (en) 1986-05-26
NL990024I1 (en) 1999-11-01
GB2028327A (en) 1980-03-05
KR830001269A (en) 1983-04-29
RO78870B (en) 1985-01-30
JPS5527199A (en) 1980-02-27
DK154553C (en) 1989-04-17
FI69834B (en) 1985-12-31
NL990024I2 (en) 1999-11-01
CS228118B2 (en) 1984-05-14
ZA793633B (en) 1980-07-30
CH642064A5 (en) 1984-03-30
KR830002450B1 (en) 1983-10-26
IT7949954A0 (en) 1979-08-03
SU1066460A3 (en) 1984-01-07
NZ191036A (en) 1984-05-31
DE2932021A1 (en) 1980-02-21
IE48802B1 (en) 1985-05-15
BE878191A (en) 1980-02-11
YU41876B (en) 1988-02-29
SE447477B (en) 1986-11-17
PT70049A (en) 1979-09-01
FR2435469B1 (en) 1983-02-11
AR229081A1 (en) 1983-06-15
DD145749A5 (en) 1981-01-07
RO78870A (en) 1982-07-06
DK335879A (en) 1980-02-12
GB2028327B (en) 1982-11-24
AU4919079A (en) 1980-02-14
AT379589B (en) 1986-01-27
LU90403I2 (en) 2000-07-07
ATA541679A (en) 1985-06-15
NL7906120A (en) 1980-02-13
LU81593A1 (en) 1979-12-07
IT1117782B (en) 1986-02-24
IN152712B (en) 1984-03-17
JPH0134987B2 (en) 1989-07-21
JPH01287069A (en) 1989-11-17
YU192379A (en) 1983-02-28
NL193374B (en) 1999-04-01
FI792498A7 (en) 1980-02-12
DK154553B (en) 1988-11-28
PH15030A (en) 1982-05-13
DE2932021C2 (en) 1994-05-19
NL193374C (en) 1999-08-03
GR72420B (en) 1983-11-03

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Free format text: PRODUCT NAME: ZOFENOPRIL CALCIUM; NAT. REGISTRATION NO/DATE: NL 24 268 19990329; FIRST REGISTRATION: GB - PL 16 239/0 002 19980730

Spc suppl protection certif: 99C0025

Filing date: 19990707

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