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FR2424275A1 - 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate - Google Patents

4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Info

Publication number
FR2424275A1
FR2424275A1 FR7812187A FR7812187A FR2424275A1 FR 2424275 A1 FR2424275 A1 FR 2424275A1 FR 7812187 A FR7812187 A FR 7812187A FR 7812187 A FR7812187 A FR 7812187A FR 2424275 A1 FR2424275 A1 FR 2424275A1
Authority
FR
France
Prior art keywords
pyridyl
cpds
alkyl
thiazolidine
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7812187A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7812187A priority Critical patent/FR2424275A1/en
Priority to NL7804977A priority patent/NL7804977A/en
Priority to NL7804971A priority patent/NL7804971A/en
Priority to GR56236A priority patent/GR63587B/en
Priority to IL54736A priority patent/IL54736A/en
Priority to IT23470/78A priority patent/IT1096218B/en
Priority to AU36138/78A priority patent/AU514150B2/en
Priority to US05/906,599 priority patent/US4164579A/en
Priority to PT68048A priority patent/PT68048B/en
Priority to SE7805588A priority patent/SE7805588L/en
Priority to LU79662A priority patent/LU79662A1/en
Priority to JP5816578A priority patent/JPS5416476A/en
Priority to BE187745A priority patent/BE867129A/en
Priority to GB19927/78A priority patent/GB1575274A/en
Priority to NO78781712A priority patent/NO781712L/en
Priority to ES469896A priority patent/ES469896A1/en
Priority to NZ187289A priority patent/NZ187289A/en
Priority to IE982/78A priority patent/IE46828B1/en
Priority to CA303,572A priority patent/CA1092120A/en
Priority to DE19782821566 priority patent/DE2821566A1/en
Priority to FI781567A priority patent/FI781567A7/en
Priority to PH21171A priority patent/PH14032A/en
Publication of FR2424275A1 publication Critical patent/FR2424275A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

4-Hydroxy-3-pyridyl-thiazolidine-2-thiones of formula (I) are new: In the formulae, R1 is opt. branched, 1-4C alkyl in position 4,5, or 6 and R2 is H or opt. branched 1-4C alkyl. The cpds. may be administered orally, rectally or parenterally e.g. orally to adults in daily doses of 50-1000 mg. Typical cpds. are (I) where R1 = 6-methyl. Cpds. where R2 = H or 1-4C primary or secondary alkyl have predominantly structure (A) whilst R2 = t-butyl has predominantly structure (B).
FR7812187A 1977-05-17 1978-04-25 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate Withdrawn FR2424275A1 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
FR7812187A FR2424275A1 (en) 1978-04-25 1978-04-25 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate
NL7804977A NL7804977A (en) 1977-05-17 1978-05-09 NEW 4-HYDROXYTHIAZOLIDINETHION-2 DERIVATIVES, ITS PREPARATIONS AND PREPARATIONS CONTAINING THE NEW DERIVATIVES.
NL7804971A NL7804971A (en) 1977-05-17 1978-05-09 NEW 4-HYDROXYTHIAZOLIDINETHION-2 DERIVATIVES, ITS PREPARATIONS AND PREPARATIONS CONTAINING THE NEW DERIVATIVES.
GR56236A GR63587B (en) 1977-05-17 1978-05-15 Method for preparation of new derivations of hydroxy-4-thiazolidinethione-2
IL54736A IL54736A (en) 1977-05-17 1978-05-16 3-(substituted pyridinyl)-4-hydroxythiazolidine-2-thione derivatives, a process for their preparation and pharmaceutical compositions containing them
IT23470/78A IT1096218B (en) 1977-05-17 1978-05-16 DERIVATIVES OF HYDROXY-4 THIAZOLIDINTION-2, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
AU36138/78A AU514150B2 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2 thiones
US05/906,599 US4164579A (en) 1977-05-17 1978-05-16 Hydroxythiazolidine-2-thiones
PT68048A PT68048B (en) 1977-05-17 1978-05-16 NOVEL HYDROXY-THIAZOLIDINE THIONE-2 DERIVATIVES AND THE COMPOSITIONS CONTAINING THEM
SE7805588A SE7805588L (en) 1977-05-17 1978-05-16 PROCEDURE FOR THE PREPARATION OF NEW 4-HYDROXITIAZOLIDIN-2-THION DERIVATIVES
LU79662A LU79662A1 (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINE THIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
JP5816578A JPS5416476A (en) 1977-05-17 1978-05-16 44hydroxythiazolidinee22 thione
BE187745A BE867129A (en) 1977-05-17 1978-05-16 NEW DERIVATIVES OF HYDROXY-4 THIAZOLIDINETHIONE-2, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
GB19927/78A GB1575274A (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thiones
NO78781712A NO781712L (en) 1977-05-17 1978-05-16 PROCEDURE FOR PREPARING NEW DERIVATIVES OF 4-HYDROXYTIAZOLIDIN-2-THION
ES469896A ES469896A1 (en) 1977-05-17 1978-05-16 Hydroxythiazolidine-2-thiones
NZ187289A NZ187289A (en) 1977-05-17 1978-05-16 4-hydroxy-3-(pyrid-2-yl)-thiazolidine-2-thione derivatives and pharmaceutical compositions
IE982/78A IE46828B1 (en) 1977-05-17 1978-05-16 4-hydroxythiazolidine-2-thiones
CA303,572A CA1092120A (en) 1977-05-17 1978-05-17 Pas de traduction disponible
DE19782821566 DE2821566A1 (en) 1977-05-17 1978-05-17 4-HYDROXY-THIAZOLIDINE-2-THIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS OF THESE
FI781567A FI781567A7 (en) 1977-05-17 1978-05-17 NYA 4-HYDROXI-THIAZOLIDIN-2-TIONER OCH FOERFARANDE FOER DESSAS FRAMSTAELLNING
PH21171A PH14032A (en) 1978-04-25 1978-05-22 4-hydroxythiazolidine-2-thiones and compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7812187A FR2424275A1 (en) 1978-04-25 1978-04-25 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Publications (1)

Publication Number Publication Date
FR2424275A1 true FR2424275A1 (en) 1979-11-23

Family

ID=9207550

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7812187A Withdrawn FR2424275A1 (en) 1977-05-17 1978-04-25 4-Hydroxy-3-alkyl-pyridyl-thiazolidine-2-thione derivs. - are antiulcer cpds. prepd. from alpha-halo-ketone and N-pyridyl-di:thiocarbamate

Country Status (2)

Country Link
FR (1) FR2424275A1 (en)
PH (1) PH14032A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725422A (en) * 1971-09-07 1973-04-03 Parke Davis & Co New organic sulfur compounds and methods for their production
US3761485A (en) * 1971-09-07 1973-09-25 Parke Davis & Co 3-(5-chloro-2-pyridyl)rhodanine and 3-(5-chloro-2-pyridyl)-5-(lower alkyl)rhodanines
FR2381212A1 (en) * 1977-02-22 1978-09-15 Honda Motor Co Ltd HYDRAULIC SHOCK ABSORBER FOR VEHICLES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725422A (en) * 1971-09-07 1973-04-03 Parke Davis & Co New organic sulfur compounds and methods for their production
US3761485A (en) * 1971-09-07 1973-09-25 Parke Davis & Co 3-(5-chloro-2-pyridyl)rhodanine and 3-(5-chloro-2-pyridyl)-5-(lower alkyl)rhodanines
FR2381212A1 (en) * 1977-02-22 1978-09-15 Honda Motor Co Ltd HYDRAULIC SHOCK ABSORBER FOR VEHICLES

Also Published As

Publication number Publication date
PH14032A (en) 1980-12-12

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