FR2418222A2 - Procede de preparation de derives benzylideniques - Google Patents
Procede de preparation de derives benzylideniquesInfo
- Publication number
- FR2418222A2 FR2418222A2 FR7805578A FR7805578A FR2418222A2 FR 2418222 A2 FR2418222 A2 FR 2418222A2 FR 7805578 A FR7805578 A FR 7805578A FR 7805578 A FR7805578 A FR 7805578A FR 2418222 A2 FR2418222 A2 FR 2418222A2
- Authority
- FR
- France
- Prior art keywords
- phenyl
- hydroxy
- amino
- alpha
- anticonvulsants
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Alpha-phenyl 2-hydroxy-benzylidene Chemical group 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 229940125681 anticonvulsant agent Drugs 0.000 title abstract 2
- 239000001961 anticonvulsive agent Substances 0.000 title abstract 2
- 206010015037 epilepsy Diseases 0.000 title abstract 2
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 241000699670 Mus sp. Species 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- IYGYMKDQCDOMRE-QRWMCTBCSA-N Bicculine Chemical compound O([C@H]1C2C3=CC=4OCOC=4C=C3CCN2C)C(=O)C2=C1C=CC1=C2OCO1 IYGYMKDQCDOMRE-QRWMCTBCSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 abstract 1
- 238000011047 acute toxicity test Methods 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000008366 benzophenones Chemical class 0.000 abstract 1
- AACMFFIUYXGCOC-UHFFFAOYSA-N bicuculline Natural products CN1CCc2cc3OCOc3cc2C1C4OCc5c6OCOc6ccc45 AACMFFIUYXGCOC-UHFFFAOYSA-N 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- IYGYMKDQCDOMRE-UHFFFAOYSA-N d-Bicucullin Natural products CN1CCC2=CC=3OCOC=3C=C2C1C1OC(=O)C2=C1C=CC1=C2OCO1 IYGYMKDQCDOMRE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004970 halomethyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Préparation de dérivés benzylidéniques par réaction entre une benzophénone
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7805578A FR2418222A2 (fr) | 1975-08-01 | 1978-02-27 | Procede de preparation de derives benzylideniques |
| SE7901706A SE7901706L (sv) | 1978-02-27 | 1979-02-26 | Bensylidenderivat |
| NO790646A NO790646L (no) | 1978-02-27 | 1979-02-26 | Fremgangsmaate for fremstilling av benzylidenderivater |
| ZA79906A ZA79906B (en) | 1978-02-27 | 1979-02-26 | Benzylidine derivates |
| PT69288A PT69288A (fr) | 1978-02-27 | 1979-02-26 | Procede de preparation de derives benzylideniques |
| DK82079A DK82079A (da) | 1978-02-27 | 1979-02-26 | Fremgangsmaade til fremstilling af benzylidenderivater |
| JP2247179A JPS54125644A (en) | 1978-02-27 | 1979-02-26 | Benzylidene derivative and its manufacture |
| NL7901474A NL7901474A (nl) | 1978-02-27 | 1979-02-26 | Werkwijze ter bereiding van een geneesmiddel dat actief is ten aanzien van het centrale zenuwstelsel, het aldus bereide geneesmiddel en werkwijze ter bereiding van de actieve benzylideen derivaat. |
| IL56737A IL56737A (en) | 1976-07-12 | 1979-02-26 | Diphenylmethyleneaminoalkanoic acid derivatives,their preparation and pharmaceutical compositions containing them |
| IT20543/79A IT1113010B (it) | 1978-02-27 | 1979-02-26 | Derivati benzilidenici |
| ES478070A ES478070A1 (es) | 1978-02-27 | 1979-02-26 | Un procedimiento de preparacion de derivados bencilidenicos. |
| NZ189769A NZ189769A (en) | 1978-02-27 | 1979-02-26 | Benzylidene derivatives and pharmaceutical compositions |
| AU44602/79A AU520618B2 (en) | 1978-02-27 | 1979-02-26 | Benzylidene derivatives |
| CH188579A CH637112A5 (fr) | 1978-02-27 | 1979-02-26 | Derives benzylideniques. |
| DE19792907379 DE2907379A1 (de) | 1978-02-27 | 1979-02-26 | Benzylidenderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| FI790656A FI790656A7 (fi) | 1978-02-27 | 1979-02-27 | Benzylidenderivat |
| CA000322406A CA1119613A (fr) | 1978-02-27 | 1979-02-27 | Methode de preparation de derives de la benzylidene |
| GB7906963A GB2021559B (en) | 1978-02-27 | 1979-02-27 | Benzylidene derivatives |
| LU80974A LU80974A1 (fr) | 1978-02-27 | 1979-02-27 | Derives benzylideniques |
| BE0/193728A BE874488A (fr) | 1978-02-27 | 1979-02-27 | Derives benzylideniques |
| AT0149179A AT365564B (de) | 1978-02-27 | 1979-02-27 | Verfahren zur herstellung von neuen alpha-phenylbenzylidenaminoalkansaeurederivaten |
| GR58490A GR66971B (fr) | 1978-02-27 | 1979-02-27 | |
| IE556/79A IE47930B1 (en) | 1978-02-27 | 1979-08-08 | Benzylidene derivatives |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7524065A FR2319338A1 (fr) | 1975-08-01 | 1975-08-01 | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
| FR7621922A FR2358887A2 (fr) | 1976-07-19 | 1976-07-19 | Derives a-phenyl-benzylideniques des acides amines |
| FR7805578A FR2418222A2 (fr) | 1975-08-01 | 1978-02-27 | Procede de preparation de derives benzylideniques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2418222A2 true FR2418222A2 (fr) | 1979-09-21 |
| FR2418222B2 FR2418222B2 (fr) | 1982-09-17 |
Family
ID=27250502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7805578A Granted FR2418222A2 (fr) | 1975-08-01 | 1978-02-27 | Procede de preparation de derives benzylideniques |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2418222A2 (fr) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2282870A1 (fr) * | 1974-05-01 | 1976-03-26 | Lawson Alexander | Produit pharmaceutique et procede pour sa fabrication |
| FR2358887A2 (fr) * | 1976-07-19 | 1978-02-17 | Synthelabo | Derives a-phenyl-benzylideniques des acides amines |
-
1978
- 1978-02-27 FR FR7805578A patent/FR2418222A2/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2282870A1 (fr) * | 1974-05-01 | 1976-03-26 | Lawson Alexander | Produit pharmaceutique et procede pour sa fabrication |
| FR2358887A2 (fr) * | 1976-07-19 | 1978-02-17 | Synthelabo | Derives a-phenyl-benzylideniques des acides amines |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2418222B2 (fr) | 1982-09-17 |
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