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FR2412537A1 - Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique - Google Patents

Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique

Info

Publication number
FR2412537A1
FR2412537A1 FR7738728A FR7738728A FR2412537A1 FR 2412537 A1 FR2412537 A1 FR 2412537A1 FR 7738728 A FR7738728 A FR 7738728A FR 7738728 A FR7738728 A FR 7738728A FR 2412537 A1 FR2412537 A1 FR 2412537A1
Authority
FR
France
Prior art keywords
radical
thiobutyramides
alcoxy
obtaining
substitute
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738728A
Other languages
English (en)
Other versions
FR2412537B1 (fr
Inventor
Charles Malen
Pierre Roger
Michel Laubie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to FR7738728A priority Critical patent/FR2412537A1/fr
Priority to DE19782854877 priority patent/DE2854877A1/de
Priority to ZA00787196A priority patent/ZA787196B/xx
Priority to GR57961A priority patent/GR66839B/el
Priority to PT68966A priority patent/PT68966A/fr
Priority to BE192487A priority patent/BE872972A/fr
Priority to IL56279A priority patent/IL56279A0/xx
Priority to NZ189280A priority patent/NZ189280A/xx
Priority to AR274935A priority patent/AR222815A1/es
Priority to IT52406/78A priority patent/IT1158184B/it
Priority to SE7813180A priority patent/SE7813180L/xx
Priority to DK573878A priority patent/DK573878A/da
Priority to ES476314A priority patent/ES476314A1/es
Priority to FI783968A priority patent/FI783968A7/fi
Priority to AU42847/78A priority patent/AU4284778A/en
Priority to GB7849881A priority patent/GB2014132B/en
Priority to DD78210134A priority patent/DD142545A5/de
Priority to NL7812533A priority patent/NL7812533A/xx
Priority to SU782704624A priority patent/SU860696A1/ru
Priority to OA56695A priority patent/OA06139A/fr
Publication of FR2412537A1 publication Critical patent/FR2412537A1/fr
Application granted granted Critical
Publication of FR2412537B1 publication Critical patent/FR2412537B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA PRESENTE INVENTION SE RAPPORTE A DES O-THIOBUTYRAMIDES N-SUBSTITUES DE FORMULE GENERALE I: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE DE L'HYDROGENE, UN RADICAL ALCOYLE INFERIEUR, ALCENYLE INFERIEUR, ACYLE DERIVE D'UN ACIDE ALCOYL-CARBOXYLIQUE OU ARYLCARBOXYLIQUE AYANT JUSQU'A 10ATOMES DE CARBONE; R EST UN HYDROXYLE, UN RADICAL ALCOXY INFERIEUR, UN RADICAL DIHYDROXY ALCOXY INFERIEUR, UN RADICAL AMINO, UN RADICAL AMINO MONOSUBSTITUE, UN RADICAL AMINO DISUBSTITUE, UN RADICAL DIALCOYLAMINO ALCOXY INFERIEUR. A ET B ENSEMBLE REPRESENTENT UN RADICAL ALCOYLENE DE LA FORME (CH)-CH, UN RADICAL THIALCOYLENE-Z-CH, UN RADICAL ALCENYLENE DE LA FORME (CH)-CHCH- OU UN RADICAL ALCOYLENE SUBSTITUE DE LA FORME -C-(CH)2
FR7738728A 1977-12-22 1977-12-22 Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique Granted FR2412537A1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (fr) 1977-12-22 1977-12-22 Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique
DE19782854877 DE2854877A1 (de) 1977-12-22 1978-12-19 N-substituierte omega-thiobutyramide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DK573878A DK573878A (da) 1977-12-22 1978-12-21 Fremgangsmaade til fremstilling af thiobutyramider
PT68966A PT68966A (fr) 1977-12-22 1978-12-21 Procede de preparation de nouveaux thiobutyramides
BE192487A BE872972A (fr) 1977-12-22 1978-12-21 Nouveaux thiobutyramides substitues et leurs procedes d'obtention
IL56279A IL56279A0 (en) 1977-12-22 1978-12-21 Novel thiobutyramides, their production and pharmaceuticalcompositions containing them
NZ189280A NZ189280A (en) 1977-12-22 1978-12-21 N-substituted-w-thiobutyramides and pharmaceutical compositions
AR274935A AR222815A1 (es) 1977-12-22 1978-12-21 Procedimiento para la preparacion de acidos(alfa-trifluorometil-mercapto-propionil)-pirrolidinil-o tiazolidinil-carboxilicos
IT52406/78A IT1158184B (it) 1977-12-22 1978-12-21 Procedimento per ottenere tiobutirrammidi
SE7813180A SE7813180L (sv) 1977-12-22 1978-12-21 Nya substituerade tiobutyramider och sett att framstella desamma
ZA00787196A ZA787196B (en) 1977-12-22 1978-12-21 Novel thiobutyramides and processes for their production
GR57961A GR66839B (fr) 1977-12-22 1978-12-21
ES476314A ES476314A1 (es) 1977-12-22 1978-12-22 Procedimiento de obtencion de nuevas tiobutiramidas sustituidas.
FI783968A FI783968A7 (fi) 1977-12-22 1978-12-22 Foerfarande foer framstaellning av nya tiobutyramider
AU42847/78A AU4284778A (en) 1977-12-22 1978-12-22 Novel thiobutyramides
GB7849881A GB2014132B (en) 1977-12-22 1978-12-22 Thio propionamides processes for their preparation and pharmaceutical compositions containing them
DD78210134A DD142545A5 (de) 1977-12-22 1978-12-22 Verfahren zur herstellung neuer omega thiobutyramide
NL7812533A NL7812533A (en) 1977-12-22 1978-12-22 (N)-3-Mercapto-2-methyl-propionyl thiazolidinyl-4-carboxylic acids - useful as carboxy-peptidase inhibitors used to treat hypertension
SU782704624A SU860696A1 (ru) 1977-12-22 1978-12-22 Способ получени N-замещенных тиобутирамидов или их солей
OA56695A OA06139A (fr) 1977-12-22 1978-12-22 Nouveaux thiobutyramides substitués et leurs procédés d'obtention.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7738728A FR2412537A1 (fr) 1977-12-22 1977-12-22 Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique

Publications (2)

Publication Number Publication Date
FR2412537A1 true FR2412537A1 (fr) 1979-07-20
FR2412537B1 FR2412537B1 (fr) 1981-10-16

Family

ID=9199179

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738728A Granted FR2412537A1 (fr) 1977-12-22 1977-12-22 Nouveaux thiobutyramides substitues, leurs procedes d'obtention et leur application pharmaceutique

Country Status (14)

Country Link
AR (1) AR222815A1 (fr)
BE (1) BE872972A (fr)
DD (1) DD142545A5 (fr)
DE (1) DE2854877A1 (fr)
ES (1) ES476314A1 (fr)
FR (1) FR2412537A1 (fr)
GB (1) GB2014132B (fr)
GR (1) GR66839B (fr)
IT (1) IT1158184B (fr)
OA (1) OA06139A (fr)
PT (1) PT68966A (fr)
SE (1) SE7813180L (fr)
SU (1) SU860696A1 (fr)
ZA (1) ZA787196B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432019A1 (fr) * 1978-07-27 1980-02-22 Squibb & Sons Inc Thiopropanoylamino-acides et leur utilisation therapeutique
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
EP0021883A3 (fr) * 1979-05-30 1981-03-25 Merrell Toraude Et Compagnie Dérivés d'aminoacides N-acylés et compositions pharmaceutiques les contenant, intermédiaires et produits de départ
FR2467198A1 (fr) * 1979-05-18 1981-04-17 Squibb & Sons Inc Derives de mercaptoacyl amino-acides, substitues sur l'atome de soufre par un groupement a-amino ou a-imino a atome d'azote protege
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4284561A (en) 1979-12-03 1981-08-18 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
US4308392A (en) 1979-12-03 1981-12-29 E. R. Squibb & Sons, Inc. Hydroxamic acid derivatives of mercaptoacyl amino acids
JPS56139455A (en) * 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid
US4482725A (en) * 1980-04-03 1984-11-13 E. R. Squibb & Sons, Inc. S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
US4438031A (en) 1982-02-24 1984-03-20 American Home Products Corporation N-(Alkylsulfonyl)-L-proline amide and N-(alkylsulfonyl)-2-carboxylic acid amide-indoline derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340933A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Carboxyalkylacylamino-acides derives de la proline, de l'acide pipecolique et de l'acide azetidine-2-carboxylique
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2340933A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Carboxyalkylacylamino-acides derives de la proline, de l'acide pipecolique et de l'acide azetidine-2-carboxylique
FR2340932A1 (fr) * 1976-02-13 1977-09-09 Squibb & Sons Inc Derives de proline et composes apparentes, utiles pour reduire la tension sanguine

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2432019A1 (fr) * 1978-07-27 1980-02-22 Squibb & Sons Inc Thiopropanoylamino-acides et leur utilisation therapeutique
FR2440365A1 (fr) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd Nouveaux derives d'acides mercapto-azolidine-carboxyliques utiles comme hypertenseurs
FR2467198A1 (fr) * 1979-05-18 1981-04-17 Squibb & Sons Inc Derives de mercaptoacyl amino-acides, substitues sur l'atome de soufre par un groupement a-amino ou a-imino a atome d'azote protege
FR2468589A1 (fr) * 1979-05-18 1981-05-08 Squibb & Sons Inc Derives aminoacyles de mercaptoacyl amino-acides, a action antihypertensive
EP0021883A3 (fr) * 1979-05-30 1981-03-25 Merrell Toraude Et Compagnie Dérivés d'aminoacides N-acylés et compositions pharmaceutiques les contenant, intermédiaires et produits de départ
EP0031104A1 (fr) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Composés de thiazolidine, procédés pour leur préparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ES476314A1 (es) 1979-04-16
PT68966A (fr) 1979-01-01
BE872972A (fr) 1979-06-21
DE2854877A1 (de) 1979-06-28
GB2014132A (en) 1979-08-22
GR66839B (fr) 1981-05-04
ZA787196B (en) 1979-11-28
DD142545A5 (de) 1980-07-02
IT7852406A0 (it) 1978-12-21
FR2412537B1 (fr) 1981-10-16
IT1158184B (it) 1987-02-18
GB2014132B (en) 1982-08-11
AR222815A1 (es) 1981-06-30
OA06139A (fr) 1981-06-30
SU860696A1 (ru) 1981-08-30
SE7813180L (sv) 1979-06-23

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