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FR2456098A2 - Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. - Google Patents

Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.

Info

Publication number
FR2456098A2
FR2456098A2 FR7911707A FR7911707A FR2456098A2 FR 2456098 A2 FR2456098 A2 FR 2456098A2 FR 7911707 A FR7911707 A FR 7911707A FR 7911707 A FR7911707 A FR 7911707A FR 2456098 A2 FR2456098 A2 FR 2456098A2
Authority
FR
France
Prior art keywords
isoquinoline
antipyretic
derivs
rboxamide
thiazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7911707A
Other languages
French (fr)
Other versions
FR2456098B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7739028A external-priority patent/FR2412545A1/en
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7911707A priority Critical patent/FR2456098A2/en
Priority to GB8014441A priority patent/GB2048880A/en
Priority to NL8002540A priority patent/NL8002540A/en
Priority to JP5988280A priority patent/JPS55151591A/en
Priority to US06/147,248 priority patent/US4287197A/en
Priority to BE0/200532A priority patent/BE883191A/en
Priority to IT21956/80A priority patent/IT1130588B/en
Priority to DE19803017895 priority patent/DE3017895A1/en
Publication of FR2456098A2 publication Critical patent/FR2456098A2/en
Publication of FR2456098B2 publication Critical patent/FR2456098B2/fr
Application granted granted Critical
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Isoquilins derivs. of formula (I) (in the (R)- or (S)- form or mixts. and their acid addn. salts are new: In (I), R' is -(CH2)n-OR2 in which R2 is 1-8C alkyl and n is 1 or 2. (I) have analgesic, anti-inflammatory and antipyretic activie. The (S)-isomers also have antiviral activity (esp. against rhinoviruses). Acute toxicity is low.
FR7911707A 1977-12-23 1979-05-09 Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds. Granted FR2456098A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
FR7911707A FR2456098A2 (en) 1977-12-23 1979-05-09 Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.
GB8014441A GB2048880A (en) 1979-05-09 1980-05-01 Isoquinoline derivatives
NL8002540A NL8002540A (en) 1979-05-09 1980-05-01 NEW ISOCHINOLINE DERIVATIVES, METHODS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW DERIVATIVES.
US06/147,248 US4287197A (en) 1979-05-09 1980-05-06 Antiviral isoquinoline derivatives
JP5988280A JPS55151591A (en) 1979-05-09 1980-05-06 Isoquinoline derivative and its manufacture
BE0/200532A BE883191A (en) 1979-05-09 1980-05-08 NOVEL ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IT21956/80A IT1130588B (en) 1979-05-09 1980-05-09 ISOKINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
DE19803017895 DE3017895A1 (en) 1979-05-09 1980-05-09 NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR7739028A FR2412545A1 (en) 1977-12-23 1977-12-23 Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties
FR7911707A FR2456098A2 (en) 1977-12-23 1979-05-09 Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.

Publications (2)

Publication Number Publication Date
FR2456098A2 true FR2456098A2 (en) 1980-12-05
FR2456098B2 FR2456098B2 (en) 1982-05-21

Family

ID=26220364

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7911707A Granted FR2456098A2 (en) 1977-12-23 1979-05-09 Antiinflammatory and antipyretic thiazolo-(3,4-b)-isoquinoline derivs. - prepd. e.g. by cyclisation of 3-hydroxymethyl-N-iso-quinolyl-tetra-hydro-isoquinoline-2-thio:ca- rboxamide cpds.

Country Status (1)

Country Link
FR (1) FR2456098A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802453A1 (en) * 1977-01-20 1978-07-27 Rhone Poulenc Ind NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM
FR2378030A1 (en) * 1977-01-20 1978-08-18 Rhone Poulenc Ind Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties
FR2412545A1 (en) * 1977-12-23 1979-07-20 Rhone Poulenc Ind Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2802453A1 (en) * 1977-01-20 1978-07-27 Rhone Poulenc Ind NEW DERIVATIVES OF ISOCHINOLINE, THEIR PRODUCTION AND THE COMPOSITIONS THAT CONTAIN THEM
FR2378030A1 (en) * 1977-01-20 1978-08-18 Rhone Poulenc Ind Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties
FR2412545A1 (en) * 1977-12-23 1979-07-20 Rhone Poulenc Ind Isoquinolino-imino-tetra:hydro-thiazolo-isoquinoline(s) - having antiinflammatory, analgesic and anti-thermic properties

Also Published As

Publication number Publication date
FR2456098B2 (en) 1982-05-21

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