FR2452490A1 - 2-Hydroxy-3-aminopropoxy thieno-pyridine derivs. - useful as antiinflammatories, beta blockers and antiarrhythmics for human and veterinary medicine - Google Patents
2-Hydroxy-3-aminopropoxy thieno-pyridine derivs. - useful as antiinflammatories, beta blockers and antiarrhythmics for human and veterinary medicineInfo
- Publication number
- FR2452490A1 FR2452490A1 FR7908048A FR7908048A FR2452490A1 FR 2452490 A1 FR2452490 A1 FR 2452490A1 FR 7908048 A FR7908048 A FR 7908048A FR 7908048 A FR7908048 A FR 7908048A FR 2452490 A1 FR2452490 A1 FR 2452490A1
- Authority
- FR
- France
- Prior art keywords
- antiinflammatories
- antiarrhythmics
- hydroxy
- human
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- FMJZTTOQXZISEK-UHFFFAOYSA-N OC(COC1=CC2=C(C=CC=N2)S1)CN Chemical compound OC(COC1=CC2=C(C=CC=N2)S1)CN FMJZTTOQXZISEK-UHFFFAOYSA-N 0.000 title 1
- 239000002876 beta blocker Substances 0.000 title 1
- 229940097320 beta blocking agent Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 abstract 1
- 229940125670 thienopyridine Drugs 0.000 abstract 1
- 239000002175 thienopyridine Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Thienopyridine derivs. of formulae (I) and (II) and their acid addition salts are new: In the formulae, R1 and R2 are each H, 1-6C alkyl, 3-7C cycloalkyl (opt. substd. by a 1-4C alkyl), 5-9C alkenyl or alkynyl, aralkyl or benzylhydryl opt. ring-substd. by 1 or more halo, hydroxy or lower alkyl or alkoxy, or NR1R2 is a satd. 5-7 membered heterocycle opt. contg. an additional O, S or N atom, the N atom opt. being substd. by lower alkyl. (I) and (II) are useful in human or veterinary medicine as antiinflammatories, beta-adrenergic receptor blockers and antiarrhythmics e.g. for treating rheumatism, angina pectoris or hypertension.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7908048A FR2452490A1 (en) | 1979-03-30 | 1979-03-30 | 2-Hydroxy-3-aminopropoxy thieno-pyridine derivs. - useful as antiinflammatories, beta blockers and antiarrhythmics for human and veterinary medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7908048A FR2452490A1 (en) | 1979-03-30 | 1979-03-30 | 2-Hydroxy-3-aminopropoxy thieno-pyridine derivs. - useful as antiinflammatories, beta blockers and antiarrhythmics for human and veterinary medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2452490A1 true FR2452490A1 (en) | 1980-10-24 |
| FR2452490B1 FR2452490B1 (en) | 1982-07-09 |
Family
ID=9223762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7908048A Granted FR2452490A1 (en) | 1979-03-30 | 1979-03-30 | 2-Hydroxy-3-aminopropoxy thieno-pyridine derivs. - useful as antiinflammatories, beta blockers and antiarrhythmics for human and veterinary medicine |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2452490A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999062908A3 (en) * | 1998-06-04 | 2000-03-30 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2282886A1 (en) * | 1974-08-27 | 1976-03-26 | Sandoz Sa | NEW DERIVATIVES OF AMINOPROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| FR2340320A1 (en) * | 1976-02-09 | 1977-09-02 | Sandoz Sa | NEW DERIVATIVES OF THIENO (3,2-C) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
-
1979
- 1979-03-30 FR FR7908048A patent/FR2452490A1/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2282886A1 (en) * | 1974-08-27 | 1976-03-26 | Sandoz Sa | NEW DERIVATIVES OF AMINOPROPANE-2-OL, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| FR2340320A1 (en) * | 1976-02-09 | 1977-09-02 | Sandoz Sa | NEW DERIVATIVES OF THIENO (3,2-C) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999062908A3 (en) * | 1998-06-04 | 2000-03-30 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6579882B2 (en) | 1998-06-04 | 2003-06-17 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2452490B1 (en) | 1982-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |