FR2337134A2 - NEW DERIVATIVES OF LYSERGIC ACID, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents
NEW DERIVATIVES OF LYSERGIC ACID, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTSInfo
- Publication number
- FR2337134A2 FR2337134A2 FR7700021A FR7700021A FR2337134A2 FR 2337134 A2 FR2337134 A2 FR 2337134A2 FR 7700021 A FR7700021 A FR 7700021A FR 7700021 A FR7700021 A FR 7700021A FR 2337134 A2 FR2337134 A2 FR 2337134A2
- Authority
- FR
- France
- Prior art keywords
- alpha
- methyl
- derivs
- cpds
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Lysergic acids derivs. of formula (I) and their acid addn. salts are novel cpds. (where R is 3-pyridyl, x y is -CH=C and the -CH2SR gp. has beta configuration or R is 2-pyridyl, x y is -CH=C or -CH2-CH and the -CH2SR gp. has alpha-configuration). Cpds. (I) are administered orally rectally or parenterally in daily doses of 1-100mg taken as one or several unit doses. The central dopaminergis stimulatory activity is potentialised by phosphodiesterase inhibitors such as theophylline, caffeine, 4-amino-1H-pyrazolo(3,4-b)pyridine-5-carboxylic acid derivs, 4-(3,4-dimethoxybenzyl)-2-imidazolidinone and analogous derivs and minor tranquillisers such as benzodiazepines and dibenzazepines (I) may be administered, with the phosphodiesterase inhibitor, in daily doses of 0.5-50mg; the ratio (I):phosphodiesterase inhibitor being 1:10 to 1:50. The three cpds. which may be prepd. by the methods of the parent patent comprise 6-methyl-8 beta-(3-pyridylthiometyl)DELTA 9-ergolene, 6-methyl-5 alpha-(2-pyridylthiomethyl)-ergoline and 6-methyl-8 alpha-(2-pyridylthiomethyl)-DELTA 9-ergolene.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4976 | 1976-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2337134A2 true FR2337134A2 (en) | 1977-07-29 |
Family
ID=9697490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7700021A Pending FR2337134A2 (en) | 1976-01-02 | 1977-01-03 | NEW DERIVATIVES OF LYSERGIC ACID, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5285197A (en) |
| AU (1) | AU2103877A (en) |
| BE (1) | BE850051R (en) |
| DE (1) | DE2657771A1 (en) |
| FR (1) | FR2337134A2 (en) |
| IL (1) | IL51195A0 (en) |
| NL (1) | NL7614523A (en) |
| ZA (1) | ZA767716B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2466465A1 (en) * | 1979-10-01 | 1981-04-10 | Lilly Co Eli | DERIVATIVES OF D-6-N-PROPYLERGOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
-
1976
- 1976-12-20 DE DE19762657771 patent/DE2657771A1/en active Pending
- 1976-12-29 NL NL7614523A patent/NL7614523A/en not_active Application Discontinuation
- 1976-12-30 ZA ZA00767716A patent/ZA767716B/en unknown
- 1976-12-31 IL IL51195A patent/IL51195A0/en unknown
- 1976-12-31 BE BE173805A patent/BE850051R/en active
-
1977
- 1977-01-01 JP JP20677A patent/JPS5285197A/en active Pending
- 1977-01-03 FR FR7700021A patent/FR2337134A2/en active Pending
- 1977-01-04 AU AU21038/77A patent/AU2103877A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2466465A1 (en) * | 1979-10-01 | 1981-04-10 | Lilly Co Eli | DERIVATIVES OF D-6-N-PROPYLERGOLINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2103877A (en) | 1978-07-13 |
| BE850051R (en) | 1977-06-30 |
| DE2657771A1 (en) | 1977-07-14 |
| JPS5285197A (en) | 1977-07-15 |
| ZA767716B (en) | 1978-08-30 |
| NL7614523A (en) | 1977-07-05 |
| IL51195A0 (en) | 1977-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9702219A2 (en) | 6-[4-(acylamino)benzoyl]-pyrazolo[3,4-d]thieno[3,2-b]azepine derivatives, process for their preparation and pharmaceutical compositions containing them | |
| EA199800907A1 (en) | DERIVATIVES OF CARBOLINE | |
| FI900307A0 (en) | Process for the preparation of therapeutically active 3- [3-oxo- (2,3) -dihydropyridazin-6-yl] -2-phenylpyrazolo [1,5-a] pyridine derivatives | |
| SE9402558D0 (en) | New use of azatricyclo derivatives and pharmaceutical compositions containing the same | |
| US3954734A (en) | Novel antibacterial amide compounds and process means for producing the same | |
| NL300084I1 (en) | Novel thiophenecarboxylic acid esters of amino alcohols, their quaternization products, and the preparation and use of these compounds. | |
| FI906438A0 (en) | Process for the preparation of novel therapeutically useful A-nor-steroid-3-carboxylic acid derivatives | |
| FR2523582B1 (en) | NOVEL 1H-PYRAZOLO (1,5-A) SUBSTITUTED PYRIMIDINES, USEFUL IN PARTICULAR AS ANTI-INFLAMMATORY AND ANALGESIC DRUGS, AND PROCESS FOR THEIR PREPARATION | |
| Baldwin et al. | 2-Pyridylimidazoles as inhibitors of xanthine oxidase | |
| IE811513L (en) | Benzisoselenazolones | |
| ZA885684B (en) | 1,4-dihydropyridines,process for preparation thereof and their application as medicinal products | |
| IE45439L (en) | Penicillanic acid derivatives | |
| FR2337134A2 (en) | NEW DERIVATIVES OF LYSERGIC ACID, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS | |
| IE39102L (en) | Piperazine derivatives | |
| GB1530413A (en) | 5,8-dihydro-5-oxopyrido(2,3-d)pyrimidines | |
| ES2013379A6 (en) | Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds | |
| ES8304937A1 (en) | Derivatives of substituted 2-amino-pyridine, process for their preparation, their use in medicaments and preparation thereof. | |
| IE36441B1 (en) | New pyridylpiperazines and process for their preparation | |
| ES2046528T3 (en) | HETEROTETRACICLIC DERIVATIVES OF LACTAMS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS BASED ON THE SAME. | |
| FR2703048B1 (en) | NOVEL N-BENZYLPIPERAZINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| FR2373541A1 (en) | NEW SULFAMOYL DERIVATIVES OF 8B-AMINOMETHYLERGOLINE USEFUL IN PARTICULAR AS SEROTONIN ANTAGONISTS AND THEIR PROCESS FOR PREPARATION | |
| GB1526126A (en) | Pyrazolopyridine ketones | |
| IE38141B1 (en) | New 3,4-dihydropyridones their production and their medicinal use | |
| BE844402A (en) | NEW ACID DERIVATIVES (& -AMINOW- (METHYLENEDIOXY-3,4 PHENYL) ACYLAMIDO) -7 CEPHALOSPORANIC, USEFUL IN PARTICULAR AS ANTIBACTERIALS, AND THEIR PROCESS FOR PREPARATION | |
| AU586707B2 (en) | New 2-(2-thienyl)-imidazo(4,5-c)pyridine derivatives and salts thereof, processes for their preparation and pharmaceutical products containing these |