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FR2336673A1 - NEW SAMPLE INTRODUCTION HEAD FOR HIGH PRESSURE LIQUID PHASE CHROMATOGRAPHY COLUMNS - Google Patents

NEW SAMPLE INTRODUCTION HEAD FOR HIGH PRESSURE LIQUID PHASE CHROMATOGRAPHY COLUMNS

Info

Publication number
FR2336673A1
FR2336673A1 FR7638695A FR7638695A FR2336673A1 FR 2336673 A1 FR2336673 A1 FR 2336673A1 FR 7638695 A FR7638695 A FR 7638695A FR 7638695 A FR7638695 A FR 7638695A FR 2336673 A1 FR2336673 A1 FR 2336673A1
Authority
FR
France
Prior art keywords
needle
feed inlet
high pressure
chromatography columns
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7638695A
Other languages
French (fr)
Inventor
Rene Amstutz
Fritz Erni
Gerhard Hirt
Walter Oetliker
Adolf Otmar Wehrli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2336673A1 publication Critical patent/FR2336673A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/328—Control of physical parameters of the fluid carrier of pressure or speed valves, e.g. check valves of pumps

Landscapes

  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Feed appts. for high pressure liq. chromatography columns comprises a housing, with feed inlet, into which the injection needle can be introduced. A non-return valve normally keeps the feed inlet closed and thus isolated from the high-pressure liq. in the column. To introduce a specimen, the injection needle is inserted into the feed inlet and forces back the non-return valve either by direct pressure of the needle tip upon the tapered point of the valve, or if the needle is short, by the higher pressure of the injected specimen. Previously where a polymer partition was used, and was pierced by the needle, after a certain number of uses this polymer started to absorb small quantities of specimens and thus contaminated further specimens. With the new arrangement, this difficulty does not arise. A satisfactory seal is provided by a succession of sealing plugs, each having a smaller internal dia. than the previous one, thus facilitating introduction of the needle tip.
FR7638695A 1975-12-22 1976-12-22 NEW SAMPLE INTRODUCTION HEAD FOR HIGH PRESSURE LIQUID PHASE CHROMATOGRAPHY COLUMNS Withdrawn FR2336673A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB5231875 1975-12-22
GB1451976 1976-04-09
GB1451676 1976-04-09
GB1451876 1976-04-09

Publications (1)

Publication Number Publication Date
FR2336673A1 true FR2336673A1 (en) 1977-07-22

Family

ID=27448248

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7638695A Withdrawn FR2336673A1 (en) 1975-12-22 1976-12-22 NEW SAMPLE INTRODUCTION HEAD FOR HIGH PRESSURE LIQUID PHASE CHROMATOGRAPHY COLUMNS

Country Status (4)

Country Link
JP (1) JPS5280198A (en)
DE (1) DE2656737A1 (en)
FR (1) FR2336673A1 (en)
IT (1) IT1066792B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058378A1 (en) * 2002-12-24 2004-07-15 Bezhan Chankvetadze Device for separating substance mixtures by means of liquid chromatography

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53163191U (en) * 1977-05-27 1978-12-20
US4737292A (en) * 1986-06-05 1988-04-12 Separations Technology, Inc. HPLC column and a column packing method
US9816971B2 (en) 2014-09-08 2017-11-14 Waters Technologies Corporation Controllable injector sample dilution for a liquid chromatography system
WO2020121365A1 (en) * 2018-12-10 2020-06-18 株式会社島津製作所 Autosampler for chromatograph

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1435538A (en) * 1964-06-01 1966-04-15 Ceskoslovenska Akademie Ved Method and device for introducing dosed samples into a pressurized circuit, in particular for column chromatography
US3431783A (en) * 1967-03-13 1969-03-11 Thomas H Radgens Chromatograph tape septum injection port
US3566698A (en) * 1969-10-23 1971-03-02 Hamilton Co Septumless inlet for chromatographs
DE1698224A1 (en) * 1968-03-08 1971-11-18 Halasz Istvan Dr Sample application device for analytical purposes, especially for chromatography
US3631724A (en) * 1969-01-20 1972-01-04 Siemens Ag Process of liquid chromatography for dosed introduction of small amounts of liquid into a flow of carrier liquid
US3643511A (en) * 1969-04-24 1972-02-22 Bayer Ag Sample-inlet valve for gas chromatographs
DE2100089A1 (en) * 1971-01-02 1972-07-20 Siemens Ag Gas chromatograph injection system - for automatic dispensing from a syringe into the evaporation chamber
US3848469A (en) * 1972-10-11 1974-11-19 L Chizhov Sample introduction system for gas chromatograph
US3884802A (en) * 1973-10-05 1975-05-20 Packard Becker Bv Liquid chromatography injection system
US3985166A (en) * 1975-06-02 1976-10-12 Klee Richard E High-pressure sample injection for liquid chromatography

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1435538A (en) * 1964-06-01 1966-04-15 Ceskoslovenska Akademie Ved Method and device for introducing dosed samples into a pressurized circuit, in particular for column chromatography
US3431783A (en) * 1967-03-13 1969-03-11 Thomas H Radgens Chromatograph tape septum injection port
DE1698224A1 (en) * 1968-03-08 1971-11-18 Halasz Istvan Dr Sample application device for analytical purposes, especially for chromatography
US3631724A (en) * 1969-01-20 1972-01-04 Siemens Ag Process of liquid chromatography for dosed introduction of small amounts of liquid into a flow of carrier liquid
US3643511A (en) * 1969-04-24 1972-02-22 Bayer Ag Sample-inlet valve for gas chromatographs
US3566698A (en) * 1969-10-23 1971-03-02 Hamilton Co Septumless inlet for chromatographs
DE2100089A1 (en) * 1971-01-02 1972-07-20 Siemens Ag Gas chromatograph injection system - for automatic dispensing from a syringe into the evaporation chamber
US3848469A (en) * 1972-10-11 1974-11-19 L Chizhov Sample introduction system for gas chromatograph
US3884802A (en) * 1973-10-05 1975-05-20 Packard Becker Bv Liquid chromatography injection system
US3985166A (en) * 1975-06-02 1976-10-12 Klee Richard E High-pressure sample injection for liquid chromatography

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058378A1 (en) * 2002-12-24 2004-07-15 Bezhan Chankvetadze Device for separating substance mixtures by means of liquid chromatography

Also Published As

Publication number Publication date
JPS5280198A (en) 1977-07-05
DE2656737A1 (en) 1977-07-14
IT1066792B (en) 1985-03-12

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Legal Events

Date Code Title Description
ST Notification of lapse