FR2336132A1 - Antiinflammatory thieno-indolizines - also with blood platelet aggregation inhibitory activity - Google Patents
Antiinflammatory thieno-indolizines - also with blood platelet aggregation inhibitory activityInfo
- Publication number
- FR2336132A1 FR2336132A1 FR7539442A FR7539442A FR2336132A1 FR 2336132 A1 FR2336132 A1 FR 2336132A1 FR 7539442 A FR7539442 A FR 7539442A FR 7539442 A FR7539442 A FR 7539442A FR 2336132 A1 FR2336132 A1 FR 2336132A1
- Authority
- FR
- France
- Prior art keywords
- thieno
- indolizines
- antiinflammatory
- inhibitory activity
- platelet aggregation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 210000001772 blood platelet Anatomy 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XQJAHBHCLXUGEP-UHFFFAOYSA-N 2-bromo-1-(4-methoxyphenyl)ethanone Chemical compound COC1=CC=C(C(=O)CBr)C=C1 XQJAHBHCLXUGEP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Thieno-indolizines of formulae (I) and II) together with their acid-addn. salts are new. In the formulae, Z is -CH2CH2- or -CH:CH-; R1 is H or one or more halo, OH, alkyl or alkoxy gps.; R2 is H or alkyl). Alkyls and alkoxy have 1-6C. Cpds. have antiinflammatory and inhibitory activity on blood platelet aggregation. A typical cpd., 5-(4-methoxyphenyl)-thieno 2,3-g -indolizine, was prepd. by reaction of 4-methyl-thieno 3,2-c -pyridine with alpha-bromo-4-methoxyacetophenone in acetone, then the salt was heated under reflux with NaHCO3 in ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7539442A FR2336132A1 (en) | 1975-12-23 | 1975-12-23 | Antiinflammatory thieno-indolizines - also with blood platelet aggregation inhibitory activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7539442A FR2336132A1 (en) | 1975-12-23 | 1975-12-23 | Antiinflammatory thieno-indolizines - also with blood platelet aggregation inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2336132A1 true FR2336132A1 (en) | 1977-07-22 |
| FR2336132B1 FR2336132B1 (en) | 1981-12-18 |
Family
ID=9164062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7539442A Granted FR2336132A1 (en) | 1975-12-23 | 1975-12-23 | Antiinflammatory thieno-indolizines - also with blood platelet aggregation inhibitory activity |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2336132A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999062908A3 (en) * | 1998-06-04 | 2000-03-30 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
-
1975
- 1975-12-23 FR FR7539442A patent/FR2336132A1/en active Granted
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999062908A3 (en) * | 1998-06-04 | 2000-03-30 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6579882B2 (en) | 1998-06-04 | 2003-06-17 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| WO2000075145A1 (en) * | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2336132B1 (en) | 1981-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |