FR2320752A1 - NEW DERIVATIVES OF PYRIDO (2,3-B) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents
NEW DERIVATIVES OF PYRIDO (2,3-B) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTSInfo
- Publication number
- FR2320752A1 FR2320752A1 FR7624661A FR7624661A FR2320752A1 FR 2320752 A1 FR2320752 A1 FR 2320752A1 FR 7624661 A FR7624661 A FR 7624661A FR 7624661 A FR7624661 A FR 7624661A FR 2320752 A1 FR2320752 A1 FR 2320752A1
- Authority
- FR
- France
- Prior art keywords
- pyrido
- alkyl
- pyridine
- preparation
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical class N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 150000005058 1,8-naphthyridines Chemical class 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- JCZMXVGQBBATMY-UHFFFAOYSA-N nitro acetate Chemical compound CC(=O)O[N+]([O-])=O JCZMXVGQBBATMY-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- ZLUFFTHTGNGRJE-UHFFFAOYSA-N pyrido[2,3-d]oxazine-2,4-dione Chemical compound N=1C(CC(C=2C1C=NOC2)=O)=O ZLUFFTHTGNGRJE-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pyrido (2,3-b) pyridines of formula (I) and their salts are novel. In (I) R is H, 1-6C alkyl, 3-6C alkenyl or alkynyl in which the multiple bond is not in the alpha position with respect to the N atom, 3-6C cycloalkyl, 3-6C cycloalkyl-1-2C alkyl or Y, Y1 are each H, F, Cl, Br, 1-3C alkyl, 1-3C alkoxy or CF3; n = 0 or 1; R1, R2 are each H or 1-4C alkyl. With the condition that at least one of R, R1, R2 is not H). (I) have activity similar to that of disodium chromoglycate in particular inhibiting the liberation of histamine. They are used to treat allergic states e.g. allergic asthma by administration in daily doses of 20-200 mg by oral, parenteral or rectal routes. (I) are prepd. by reacting nitroacetate with strong base and pyrido (2,3-d) oxazine-2,4-dione. Pref. cpds. are R1=7-methyl, R2=H and R=methyl or allyl.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60515275A | 1975-08-15 | 1975-08-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2320752A1 true FR2320752A1 (en) | 1977-03-11 |
| FR2320752B1 FR2320752B1 (en) | 1978-11-17 |
Family
ID=24422480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7624661A Granted FR2320752A1 (en) | 1975-08-15 | 1976-08-12 | NEW DERIVATIVES OF PYRIDO (2,3-B) PYRIDINE, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5236694A (en) |
| AU (1) | AU1684576A (en) |
| BE (1) | BE845196A (en) |
| DE (1) | DE2635216A1 (en) |
| DK (1) | DK357676A (en) |
| FI (1) | FI762259A7 (en) |
| FR (1) | FR2320752A1 (en) |
| IL (1) | IL50262A0 (en) |
| NL (1) | NL7608906A (en) |
| NO (1) | NO762736L (en) |
| NZ (1) | NZ181763A (en) |
| PT (1) | PT65478B (en) |
| SE (1) | SE7608838L (en) |
| ZA (1) | ZA764882B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2913977A1 (en) * | 2007-03-21 | 2008-09-26 | Centre Nat Rech Scient | TRANSANNUAL REARRANGEMENT OF ACTIVE LACTAMS |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452800A (en) * | 1982-04-26 | 1984-06-05 | Schering Corporation | Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases |
| JP2988739B2 (en) * | 1990-04-16 | 1999-12-13 | 協和醗酵工業株式会社 | 1,8-naphthyridin-2-one derivatives |
-
1976
- 1976-08-05 DE DE19762635216 patent/DE2635216A1/en active Pending
- 1976-08-06 FI FI762259A patent/FI762259A7/fi not_active Application Discontinuation
- 1976-08-06 NO NO762736A patent/NO762736L/no unknown
- 1976-08-06 DK DK357676A patent/DK357676A/en unknown
- 1976-08-06 SE SE7608838A patent/SE7608838L/en unknown
- 1976-08-11 NL NL7608906A patent/NL7608906A/en not_active Application Discontinuation
- 1976-08-12 FR FR7624661A patent/FR2320752A1/en active Granted
- 1976-08-13 PT PT65478A patent/PT65478B/en unknown
- 1976-08-13 ZA ZA00764882A patent/ZA764882B/en unknown
- 1976-08-13 IL IL50262A patent/IL50262A0/en unknown
- 1976-08-13 JP JP51096198A patent/JPS5236694A/en active Pending
- 1976-08-13 AU AU16845/76A patent/AU1684576A/en not_active Expired
- 1976-08-13 BE BE169820A patent/BE845196A/en unknown
- 1976-08-13 NZ NZ181763A patent/NZ181763A/en unknown
Non-Patent Citations (1)
| Title |
|---|
| JOURNAL OF MEDICINAL CHEMISTRY, 18, 726-32 1975 ) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2913977A1 (en) * | 2007-03-21 | 2008-09-26 | Centre Nat Rech Scient | TRANSANNUAL REARRANGEMENT OF ACTIVE LACTAMS |
| WO2008125421A1 (en) * | 2007-03-21 | 2008-10-23 | Centre National De La Recherche Scientifique (Cnrs) | Trans-annular rearrangement of active lactames |
| US8592587B2 (en) | 2007-03-21 | 2013-11-26 | Centre National De La Recherche Scientifique (Cnrs) | Transannular rearrangement of activated lactams |
Also Published As
| Publication number | Publication date |
|---|---|
| BE845196A (en) | 1977-02-14 |
| FI762259A7 (en) | 1977-02-16 |
| NZ181763A (en) | 1978-07-10 |
| FR2320752B1 (en) | 1978-11-17 |
| NL7608906A (en) | 1977-02-17 |
| PT65478B (en) | 1978-05-10 |
| AU1684576A (en) | 1978-02-16 |
| ZA764882B (en) | 1978-03-29 |
| PT65478A (en) | 1976-09-01 |
| SE7608838L (en) | 1977-02-16 |
| DK357676A (en) | 1977-02-16 |
| NO762736L (en) | 1977-02-16 |
| IL50262A0 (en) | 1976-10-31 |
| DE2635216A1 (en) | 1977-03-03 |
| JPS5236694A (en) | 1977-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |