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FR2313060A1 - Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) - Google Patents

Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Info

Publication number
FR2313060A1
FR2313060A1 FR7436963A FR7436963A FR2313060A1 FR 2313060 A1 FR2313060 A1 FR 2313060A1 FR 7436963 A FR7436963 A FR 7436963A FR 7436963 A FR7436963 A FR 7436963A FR 2313060 A1 FR2313060 A1 FR 2313060A1
Authority
FR
France
Prior art keywords
pyrrolidinone
substd
opt
alkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7436963A
Other languages
French (fr)
Other versions
FR2313060B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7436963A priority Critical patent/FR2313060A1/en
Priority to AR261091A priority patent/AR208414A1/en
Priority to OA55663A priority patent/OA05162A/en
Priority to NLAANVRAGE7512732,A priority patent/NL177405C/en
Priority to CA238,909A priority patent/CA1057755A/en
Priority to HU75RO868A priority patent/HU173108B/en
Priority to AU86331/75A priority patent/AU503200B2/en
Priority to ZA00756954A priority patent/ZA756954B/en
Priority to DD189261A priority patent/DD122684A5/xx
Priority to JP75132198A priority patent/JPS5422996B2/ja
Priority to IE2414/75A priority patent/IE41928B1/en
Priority to PH17740A priority patent/PH16806A/en
Priority to IL48423A priority patent/IL48423A/en
Priority to CH1437875A priority patent/CH609057A5/xx
Priority to GB4610375A priority patent/GB1468497A/en
Priority to CY1045A priority patent/CY1045A/en
Priority to LU73738A priority patent/LU73738A1/xx
Priority to SE7512477A priority patent/SE407063B/en
Priority to DK499275AA priority patent/DK141098B/en
Priority to ES442389A priority patent/ES442389A1/en
Priority to NO753713A priority patent/NO143576C/en
Priority to ES442390A priority patent/ES442390A1/en
Priority to SU752186208A priority patent/SU673173A3/en
Priority to BE161652A priority patent/BE835325A/en
Priority to FI753127A priority patent/FI60707C/en
Priority to DE2550111A priority patent/DE2550111C2/en
Priority to PL18457875A priority patent/PL100434B1/en
Priority to PL1975199797A priority patent/PL101248B1/en
Priority to AT848675A priority patent/AT343123B/en
Priority to CS757510A priority patent/CS231957B2/en
Priority to YU2815/75A priority patent/YU39583B/en
Priority to AR263835A priority patent/AR208800A1/en
Priority to SU762385529A priority patent/SU604496A3/en
Publication of FR2313060A1 publication Critical patent/FR2313060A1/en
Priority to US05/790,801 priority patent/US4220646A/en
Priority to AT401977A priority patent/AT343666B/en
Priority to CS775983A priority patent/CS231958B2/en
Application granted granted Critical
Publication of FR2313060B1 publication Critical patent/FR2313060B1/fr
Priority to JP12525778A priority patent/JPS5498790A/en
Priority to HK193/80A priority patent/HK19380A/en
Priority to YU1921/82A priority patent/YU40087B/en
Priority to YU1922/82A priority patent/YU39892B/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pyrrolidinone derivs. of formula (I) (where R1 and R2 are linked so as to form with the pyrroline nucleus an isoindoline, 6,7-dihydro-5H-pyrrolo 3,4-b pyrazine, 2,3,6,7-tetrahydro-5H-oxathiino 1,4 2,3-c -pyrrole or 2,3,6,7-tetrahydro-5H-dithiino 1,4 2,3-c -pyrrole nucleus; Het is 2-pyridyl, 2-quinolyl or 1,8-naphthyridin-2-yl opt. substd. by 1-3 substituents from halogenM 1-4C alkyl, 1-4C alkoxy and CN; Z is O or S; and R is H, 1-4C alkyl (opt. substd. by 1-3 halogen atoms), 2-4C alkenyl, 2-4C alkynyl, 3-6C cycloalkyl, 1-4c alkoxy, phenyl (opt. substd. by 1-3 substituents from halogen, 1-4C alkoxy, 1-4C alkyl, NO2 and CF3), phenyl-(1-4C alkyl)(opt. substd. in the phenyl residue as indicated for phenyl), or to 5- or 6- membered heterocyclyl with 1 or 2 hetero atoms selected from N, O and S; and when R1 and R2 are linked so as to form an isoindoline residue this opt. substd. by 1-4 substituents from halogen, 1-4C alkyl, 1-4C alkoxy, NO2 and CF3), e.g. 3- (4-acryloyl-1-piperazinyl)carbonyloxy -2-(7-chloro-1,8-naphthy- ridin-2-yl)-1-isoindolinone, are new cpds. (I) are tranquillisers, anticonvulsants, hypnogenic agents or hypnotics active at doses of 0.1-100 mg/kg p.o. in the mouse. Toxicity is low (mouse LD50 generally >300 mg/kg p.o.).
FR7436963A 1974-11-07 1974-11-07 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576) Granted FR2313060A1 (en)

Priority Applications (40)

Application Number Priority Date Filing Date Title
FR7436963A FR2313060A1 (en) 1974-11-07 1974-11-07 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)
AR261091A AR208414A1 (en) 1974-11-07 1975-01-01 PROCEDURE TO OBTAIN NEW DERIVATIVES OF ((ACIL-4PIPERAZINIL-1) CARBONYLOXI-5 PYRROLINONE-2)
OA55663A OA05162A (en) 1974-11-07 1975-10-23 New heterocyclic compounds and their preparation.
NLAANVRAGE7512732,A NL177405C (en) 1974-11-07 1975-10-30 METHOD FOR PREPARING PHARMACEUTICAL PREPARATIONS AND METHOD FOR PREPARING MEDICINAL COMPOUNDS, SUITABLE FOR USE IN THESE PREPARATIONS.
CA238,909A CA1057755A (en) 1974-11-07 1975-11-03 Heterocyclic compounds, their preparation and compositions thereof_
AU86331/75A AU503200B2 (en) 1974-11-07 1975-11-05 Esters of 1-acyl-piperazine-4-carboxylic acids
ZA00756954A ZA756954B (en) 1974-11-07 1975-11-05 Heterocyclic compounds
DD189261A DD122684A5 (en) 1974-11-07 1975-11-05
JP75132198A JPS5422996B2 (en) 1974-11-07 1975-11-05
IE2414/75A IE41928B1 (en) 1974-11-07 1975-11-05 Esters of 1-acylpiperazine-4-carboxylic acids
PH17740A PH16806A (en) 1974-11-07 1975-11-05 Isoindoline,pyrrolo(3,4-b)pyrazine,1,4 oxathiino(2,3-c)pyrole and 1,4-dithiino(2,3-c)pyrrole compounds
IL48423A IL48423A (en) 1974-11-07 1975-11-05 (4-acylpiperazin-1-yl)carbonyloxyisoindolinones,5h-pyrrolo(3,4-b)pyrazines, 5h-1,4-oxathiano(2,3-c) pyrroles, their preparation and pharmaceutical compositions containing thesame
HU75RO868A HU173108B (en) 1974-11-07 1975-11-05 SPOSOB POLUCHENIJA NOVYKH PROIZVODNYKH ISOINDOLINIL, PIRROLOPIRAZINIL, OXATININOPIRROLYL DITININOPIRROLYL-OSI-CARBONIL-PIPERAZIN
ES442390A ES442390A1 (en) 1974-11-07 1975-11-06 Procedure for preparing acilpiperazinoisoindolinonas. (Machine-translation by Google Translate, not legally binding)
CY1045A CY1045A (en) 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carbocylic acids
LU73738A LU73738A1 (en) 1974-11-07 1975-11-06
SE7512477A SE407063B (en) 1974-11-07 1975-11-06 ANALOGICAL PROCEDURE FOR PREPARATION OF PIPERAZINYL-CARBONYLOXI DERIVATIVES OF PYRROLE DERIVATIVES
DK499275AA DK141098B (en) 1974-11-07 1975-11-06 Analogous process for the preparation of naphthyridine derivatives.
ES442389A ES442389A1 (en) 1974-11-07 1975-11-06 Procedure for preparing acilpiperazinoinoindolinones. (Machine-translation by Google Translate, not legally binding)
NO753713A NO143576C (en) 1974-11-07 1975-11-06 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE HETEROCYCLIC COMPOUNDS
CH1437875A CH609057A5 (en) 1974-11-07 1975-11-06
SU752186208A SU673173A3 (en) 1974-11-07 1975-11-06 Method of producing heterocyclic compounds
BE161652A BE835325A (en) 1974-11-07 1975-11-06 NEW HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
GB4610375A GB1468497A (en) 1974-11-07 1975-11-06 Esters of 1-acylpiperazine-4-carboxylic acids
FI753127A FI60707C (en) 1974-11-07 1975-11-07 PROCEDURE FOR FRAMSTATION OF AV 2- (1,8-NAPHTHYRIDIN-2-YL) -3- (1-PIPERAZINYL) CARBONYLOXIPYRROLER ANVAENDBARA SAOSOM LAEKEMEDEL
DE2550111A DE2550111C2 (en) 1974-11-07 1975-11-07 7-chloro-1,8-naphthyridine derivatives, processes for their preparation and compositions containing them
PL18457875A PL100434B1 (en) 1974-11-07 1975-11-07 METHOD OF MAKING NEW PYROLINE DERIVATIVES
PL1975199797A PL101248B1 (en) 1974-11-07 1975-11-07 METHOD OF MAKING NEW PYROLINE DERIVATIVES
AT848675A AT343123B (en) 1974-11-07 1975-11-07 PROCESS FOR THE PRODUCTION OF NEW PIPERAZINE DERIVATIVES
CS757510A CS231957B2 (en) 1974-11-07 1975-11-07 Manufacturing process of heterocyclic compounds
YU2815/75A YU39583B (en) 1974-11-07 1975-11-07 Process for obtaining new heterocyclic compounds
AR263835A AR208800A1 (en) 1974-11-07 1976-07-02 PROCEDURE TO OBTAIN NEW DERIVATIVES OF (ACIL-4 PIPERAZINIL-1-CARBONYLOXI) -5 PYRROLINONE-2
SU762385529A SU604496A3 (en) 1974-11-07 1976-08-02 Method of obtaining heterogeneous ring compounds
US05/790,801 US4220646A (en) 1974-11-07 1977-04-25 Heterocyclic compounds
AT401977A AT343666B (en) 1974-11-07 1977-06-07 PROCESS FOR THE PRODUCTION OF NEW PIPERAZINE DERIVATIVES
CS775983A CS231958B2 (en) 1974-11-07 1977-09-14 Manufacturing process of new heteroclic compoundes
JP12525778A JPS5498790A (en) 1974-11-07 1978-10-13 Manufacture of novel heterocyclic compound
HK193/80A HK19380A (en) 1974-11-07 1980-04-10 Esters of 1-acylpiperazine-4-carboxylic acids
YU1921/82A YU40087B (en) 1974-11-07 1982-08-26 Process for obtaining new heterocyclic compounds
YU1922/82A YU39892B (en) 1974-11-07 1982-08-26 Process for obtaining new heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7436963A FR2313060A1 (en) 1974-11-07 1974-11-07 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Publications (2)

Publication Number Publication Date
FR2313060A1 true FR2313060A1 (en) 1976-12-31
FR2313060B1 FR2313060B1 (en) 1978-08-18

Family

ID=9144748

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7436963A Granted FR2313060A1 (en) 1974-11-07 1974-11-07 Pyrrolidinone deriirrivs as tranquillizers - 1-Heterocyclyl-5(1-piperazinyl-carbonyloxy)-2(5H)-pyrrolidinone derivs prepd. from 5-aryloxycarbonyloxy cpds. and piperazine (OE060576)

Country Status (2)

Country Link
FR (1) FR2313060A1 (en)
ZA (1) ZA756954B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522970A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for the preparation of optical isomers of a 2-aminonaphthyridine derivative
EP0522969A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. 2-Aminonaphthyridine, its preparation and use
EP0522972A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for preparation of a dextrorotatory isomer of an isoindolinone derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101081A1 (en) * 1970-08-19 1972-03-31 Rhone Poulenc Sa

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2101081A1 (en) * 1970-08-19 1972-03-31 Rhone Poulenc Sa

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522970A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for the preparation of optical isomers of a 2-aminonaphthyridine derivative
EP0522969A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. 2-Aminonaphthyridine, its preparation and use
EP0522972A1 (en) * 1991-07-12 1993-01-13 Aventis Pharma S.A. Process for preparation of a dextrorotatory isomer of an isoindolinone derivative
FR2678932A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF OPTICAL ISOMERS OF AN AMINO-2-NAPHTHYRIDINE DERIVATIVE
FR2678931A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa NEW AMINO-2 NAPHTHYRIDINE DERIVATIVE, ITS PREPARATION AND ITS USE.
FR2678934A1 (en) * 1991-07-12 1993-01-15 Rhone Poulenc Rorer Sa PROCESS FOR THE PREPARATION OF THE DEXTROGYE ISOMER OF AN ISOINDOLINONE DERIVATIVE
WO1993001190A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Novel 2-amino naphthyridine derivative, its preparation and use
WO1993001187A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Process for the preparation of a dextrogyral isomer of an isoindolinone derivative
WO1993001189A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer S.A. Method for preparating optical isomers of a 2-amino naphthyridine derivative

Also Published As

Publication number Publication date
ZA756954B (en) 1976-10-27
FR2313060B1 (en) 1978-08-18

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