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FR2396757A2 - Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology - Google Patents

Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology

Info

Publication number
FR2396757A2
FR2396757A2 FR7721088A FR7721088A FR2396757A2 FR 2396757 A2 FR2396757 A2 FR 2396757A2 FR 7721088 A FR7721088 A FR 7721088A FR 7721088 A FR7721088 A FR 7721088A FR 2396757 A2 FR2396757 A2 FR 2396757A2
Authority
FR
France
Prior art keywords
substd
alkyl
alkoxy
amino
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721088A
Other languages
French (fr)
Other versions
FR2396757B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ILE DE FRANCE ETUDES SCIENTIFIQU
Original Assignee
ILE DE FRANCE ETUDES SCIENTIFIQU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ILE DE FRANCE ETUDES SCIENTIFIQU filed Critical ILE DE FRANCE ETUDES SCIENTIFIQU
Priority to FR7721088A priority Critical patent/FR2396757A2/en
Publication of FR2396757A2 publication Critical patent/FR2396757A2/en
Application granted granted Critical
Publication of FR2396757B2 publication Critical patent/FR2396757B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

bis(oxy) benzamides of formula (I), their quat. ammonium salts, oxides, and their dextrorotatory and laevorotatory isomers, are new. In (I) A=1-3C alkylene, opt. substd. by 1-4C alkyl, 2-4C alkenyl or hydroxyalkyl, R=H, 1-4C alkyl or a group-B-N-R1 R2 B=a single bond, 1-3C alkylene opt. substd. by 1-4C alkyl or 2-4C alkenyl, R1=H, 1-4C alkyl, 2-4C alkenyl or alkynyl, alkyl substd. by OH, SH, acyl, thioacyl alkoxy, alkylthio, amino or may be attached to B to form a satd or unsatd. N-heterocycle, R2=H, 1-4C alkyl, 2-4C alkenyl or alkynyl, alkyl substd by OH, SH, acyl, thioacyl, alkoxy, alkyl thio, amino, or a satd. or unsatd. opt. substd. heterocycle phenyl, adamantyl, cycloalkyl, bicyclolakyl, cycloalkenyl, attached directly or through an alkylene chain, or R1 & R2 together form a heterocycle which contain further heteroatoms, and may be substd by 1-4C alkyl, 2-4C alkenyl or alkynyl, phenyl, benzyl, cycloalkyl, cycloalkenyl, cycloalkanealkyl, adamantyl, bicycloalkyl or alkyl substd by OH, SH acyl, thioacyl, alkoxy or alklthio. R'=H, 1-4C alkyl, 2-4C alkenyl or alkynyl, adamantyl, pyrimidinyl, pyrazinyl, diazepinyl, quinuclidinyl, azabicycloalkyl, diazabicyloalkyl, bicycloalkyl, phenyl opt. substd. or R' & B may together form a N heterocycle, which may be substd, or R' & R1 a di-N heterocycle which may be substd. X=H, halogen, OH, 1-4C alkoxy or alkyl, amino, mono or di-alkyl substd, amino, acyl, aralkyl, furanyl, pyranyl, or alkoxycarbonyl. Y=H, halogen, OH, 1-4C alkoxy, NO2, amino, alkyl substd. amono, acyl, aralkyl, furanyl, pyranyl, alkoxy-carbonyl, 1-4C alkylsulphonyl, adamantyl sulphoncycloalkyl sulphonyl or sulphonyl substd by a mono - or di-substd amino gp. Z=H, halogen, OH, 1-4C alkoxy, NO2 amino opt. mono-or di- substd. by 1-4C alkyl, acyl, aralkyl, furanyl, pyranyl, or alkoxycarbonyl, or X & Y or Y & Z may be bonded together by one or ore heteroatoms, which may be substd. to form a ring. Daily dose is 50-900 (50-300)mg.
FR7721088A 1977-07-08 1977-07-08 Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology Granted FR2396757A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7721088A FR2396757A2 (en) 1977-07-08 1977-07-08 Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7721088A FR2396757A2 (en) 1977-07-08 1977-07-08 Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology

Publications (2)

Publication Number Publication Date
FR2396757A2 true FR2396757A2 (en) 1979-02-02
FR2396757B2 FR2396757B2 (en) 1980-07-25

Family

ID=9193153

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721088A Granted FR2396757A2 (en) 1977-07-08 1977-07-08 Psycho-functional alkylene bis:oxy benzamide cpds. - useful in gastroenterology, cardiology, urology, rheumatology and gynaecology

Country Status (1)

Country Link
FR (1) FR2396757A2 (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438044A2 (en) * 1978-04-10 1980-04-30 Delalande Sa Alkylene di:oxy benzene derivs. - intermediates for cinnamoyl piperazine(s) having anti-angina activity and also effect on circulation (SW 12.11.79)
FR2447918A1 (en) * 1979-02-05 1980-08-29 Delalande Sa 1-Cinnamoyl-4-phenyl-hydroxy-propyl-piperazine derivs. - used to treat angina, cardiovascular troubles and improve cerebral and peripheral circulation
EP0123386A1 (en) * 1983-02-28 1984-10-31 Sumitomo Chemical Company, Limited Fungicidal N-(condensed phenyl) carbamates
EP0147044A3 (en) * 1983-12-22 1985-11-21 Adria Laboratories Inc. Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them
EP0171636A1 (en) * 1984-08-14 1986-02-19 RAVIZZA S.p.A. Pharmacologically active piperazino derivatives and the process for their preparation
FR2586018A1 (en) * 1985-08-12 1987-02-13 Ile De France NOVEL BENZODIOXEPANNE, METHOD OF SYNTHESIS AND THERAPEUTIC APPLICATIONS
WO1988001866A1 (en) * 1986-09-09 1988-03-24 Adria Laboratories, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
US5185335A (en) * 1990-03-06 1993-02-09 Janssen Pharmaceutica N.V. N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives
WO1993005038A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
GR920100469A (en) * 1992-10-19 1994-06-30 Smithkline Beecham Plc Pharmaceutical substances.
AP373A (en) * 1991-09-14 1994-12-07 Smithkline Beecham Plc Compounds having 5TH4 receptor antagonist activity.
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
WO1994029298A1 (en) * 1993-06-16 1994-12-22 Smithkline Beecham Plc 8-amino-7-chloro-1,4-benzodioxan-5-carboxylic acid, -1-butyl-4-piperidinyl ester as a 5-ht4-receptor antagonist
ES2065238A1 (en) * 1992-11-20 1995-02-01 Smithkline Beecham Plc Condensed benzene derivatives with 5-HT4 receptor antagonistic activity, procedure for the preparation thereof, compositions which contain them, and applications
EP0943613A4 (en) * 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk HETEROCYCLIC COMPOUNDS CONTAINING OXYGEN
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
WO2006014134A1 (en) * 2004-08-02 2006-02-09 Astrazeneca Ab Novel piperidine derivative for the treatment of depression

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2438044A2 (en) * 1978-04-10 1980-04-30 Delalande Sa Alkylene di:oxy benzene derivs. - intermediates for cinnamoyl piperazine(s) having anti-angina activity and also effect on circulation (SW 12.11.79)
FR2447918A1 (en) * 1979-02-05 1980-08-29 Delalande Sa 1-Cinnamoyl-4-phenyl-hydroxy-propyl-piperazine derivs. - used to treat angina, cardiovascular troubles and improve cerebral and peripheral circulation
EP0123386A1 (en) * 1983-02-28 1984-10-31 Sumitomo Chemical Company, Limited Fungicidal N-(condensed phenyl) carbamates
US5175173A (en) * 1983-12-22 1992-12-29 Sun Jung Hui Carboxamides useful as antiemetic or antipsychotic agents
EP0147044A3 (en) * 1983-12-22 1985-11-21 Adria Laboratories Inc. Benzofurancarboxamides, process for their preparation and pharmaceutical preparations containing them
EP0171636A1 (en) * 1984-08-14 1986-02-19 RAVIZZA S.p.A. Pharmacologically active piperazino derivatives and the process for their preparation
EP0216658A1 (en) * 1985-08-12 1987-04-01 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Benzodioxepane, process for its preparation and its therapeutical use
FR2586018A1 (en) * 1985-08-12 1987-02-13 Ile De France NOVEL BENZODIOXEPANNE, METHOD OF SYNTHESIS AND THERAPEUTIC APPLICATIONS
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
WO1988001866A1 (en) * 1986-09-09 1988-03-24 Adria Laboratories, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US4772459A (en) * 1986-09-09 1988-09-20 Erbamont, Inc. Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5576448A (en) * 1989-03-22 1996-11-19 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5185335A (en) * 1990-03-06 1993-02-09 Janssen Pharmaceutica N.V. N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2h-benzopyran) carboxamide derivatives
US5262418A (en) * 1990-03-06 1993-11-16 Tanssen Pharmaceutica N.V. N-(4-piperidinyl) (dihydroxybenzofuran or dihydro-2H-benzopyran)carboxamide derivatives
WO1993005038A1 (en) * 1991-09-12 1993-03-18 Smithkline Beecham Plc 5-ht4 receptor antagonists
AU668102B2 (en) * 1991-09-12 1996-04-26 Smithkline Beecham Plc 5-HT4 receptor antagonists
US5580885A (en) * 1991-09-12 1996-12-03 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
AP373A (en) * 1991-09-14 1994-12-07 Smithkline Beecham Plc Compounds having 5TH4 receptor antagonist activity.
GR920100469A (en) * 1992-10-19 1994-06-30 Smithkline Beecham Plc Pharmaceutical substances.
ES2065238A1 (en) * 1992-11-20 1995-02-01 Smithkline Beecham Plc Condensed benzene derivatives with 5-HT4 receptor antagonistic activity, procedure for the preparation thereof, compositions which contain them, and applications
WO1994029298A1 (en) * 1993-06-16 1994-12-22 Smithkline Beecham Plc 8-amino-7-chloro-1,4-benzodioxan-5-carboxylic acid, -1-butyl-4-piperidinyl ester as a 5-ht4-receptor antagonist
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
US6716987B1 (en) 1995-05-19 2004-04-06 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxazole compounds
EP0943613A4 (en) * 1996-11-19 2002-07-10 Kyowa Hakko Kogyo Kk HETEROCYCLIC COMPOUNDS CONTAINING OXYGEN
WO2006014134A1 (en) * 2004-08-02 2006-02-09 Astrazeneca Ab Novel piperidine derivative for the treatment of depression

Also Published As

Publication number Publication date
FR2396757B2 (en) 1980-07-25

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