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FR2387988A1 - CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION - Google Patents

CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2387988A1
FR2387988A1 FR7811514A FR7811514A FR2387988A1 FR 2387988 A1 FR2387988 A1 FR 2387988A1 FR 7811514 A FR7811514 A FR 7811514A FR 7811514 A FR7811514 A FR 7811514A FR 2387988 A1 FR2387988 A1 FR 2387988A1
Authority
FR
France
Prior art keywords
preparation
therapeutic application
cefuroxime
esters
cefuroxime esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811514A
Other languages
French (fr)
Other versions
FR2387988B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Glaxo Wellcome SA
Glaxo Laboratories Ltd
Original Assignee
Laboratoires Glaxo SA
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Glaxo SA, Glaxo Laboratories Ltd filed Critical Laboratoires Glaxo SA
Publication of FR2387988A1 publication Critical patent/FR2387988A1/en
Application granted granted Critical
Publication of FR2387988B1 publication Critical patent/FR2387988B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/06—Preparation of esters of carbonic or haloformic acids from organic carbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés de la céfuroxime. Les composés répondent à la formule suivante :The invention relates to derivatives of cefuroxime. The compounds correspond to the following formula:

FR7811514A 1977-04-19 1978-04-19 CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Granted FR2387988A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB16202/77A GB1598568A (en) 1977-04-19 1977-04-19 Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid

Publications (2)

Publication Number Publication Date
FR2387988A1 true FR2387988A1 (en) 1978-11-17
FR2387988B1 FR2387988B1 (en) 1982-06-11

Family

ID=10073017

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811514A Granted FR2387988A1 (en) 1977-04-19 1978-04-19 CEFUROXIME ESTERS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Country Status (20)

Country Link
JP (1) JPS53132592A (en)
KR (1) KR840000081B1 (en)
AT (1) AT363183B (en)
AU (1) AU521098B2 (en)
BE (1) BE866093A (en)
CA (1) CA1093068A (en)
CH (1) CH639096A5 (en)
DE (1) DE2816873A1 (en)
DK (1) DK147513C (en)
ES (1) ES468895A1 (en)
FR (1) FR2387988A1 (en)
GB (1) GB1598568A (en)
IE (1) IE46726B1 (en)
IL (1) IL54531A (en)
IT (1) IT1104842B (en)
NL (1) NL7804097A (en)
NZ (1) NZ186998A (en)
SE (1) SE433748B (en)
YU (1) YU90978A (en)
ZA (1) ZA782211B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061162A3 (en) * 1981-03-23 1983-06-08 Kyoto Yakuhin Kogyo Kabushiki Kaisha Cephalosporin derivatives, pharmaceutical compositions containing the same and production thereof
FR2532933A1 (en) * 1982-06-29 1984-03-16 Astra Laekemedel Ab Improvements made to the preparation of antibiotics
US4592874A (en) * 1980-05-14 1986-06-03 Societe Nationale Des Poudres Et Explosifs Process for the synthesis of alpha-chlorinated chloroformates
US4820857A (en) * 1982-09-20 1989-04-11 Astra Lakemedel Aktiebolag α-bromodiethylcarbonate
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454879B (en) * 1982-06-29 1988-06-06 Astra Laekemedel Ab ALFA-BROMODYTHYL CARBONATE AND ITS USE AS INTERMEDIATE IN PENICILLIN G PREPARATION
GB2123821B (en) * 1982-06-29 1987-04-23 Astra Laekemedel Ab At-halogeno diethyl carbonates and their use in the preparation of antibiotics
IT1190897B (en) * 1982-06-29 1988-02-24 Opos Biochimica Srl PROCEDURE FOR THE PREPARATION OF THE 1-ETHOXYCARBONYLOXYETHYL ACID ACID 6- (D (-) - ALPHA AMINOALPHA-PHENYLACETAMIDE) -PENICILLANIC
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
IL67623A (en) * 1983-01-05 1984-09-30 Teva Pharma 1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
GB8320521D0 (en) * 1983-07-29 1983-09-01 Glaxo Group Ltd Chemical process
FR2551058B1 (en) * 1983-08-26 1986-09-26 Poudres & Explosifs Ste Nale PROCESS FOR THE PREPARATION OF A-CHLORINATED CHLOROFORMIATES
GB8400024D0 (en) * 1984-01-03 1984-02-08 Glaxo Group Ltd Cephalosporin antibiotics
US4612143A (en) * 1984-09-17 1986-09-16 Societe Nationale Des Poudres Et Explosifs Process for the preparation of fluoroformates
KR100342944B1 (en) * 1999-11-08 2002-07-02 민경윤 Method for preparing highly pure cefpodoxime proxetil
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2241318A2 (en) * 1973-08-21 1975-03-21 Glaxo Lab Ltd
FR2340950A1 (en) * 1976-02-16 1977-09-09 Glaxo Lab Ltd CEFUROXIME ESTERS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2340951A1 (en) * 1976-02-16 1977-09-09 Glaxo Lab Ltd CEFUROXIME DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2241318A2 (en) * 1973-08-21 1975-03-21 Glaxo Lab Ltd
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
FR2340950A1 (en) * 1976-02-16 1977-09-09 Glaxo Lab Ltd CEFUROXIME ESTERS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR2340951A1 (en) * 1976-02-16 1977-09-09 Glaxo Lab Ltd CEFUROXIME DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4592874A (en) * 1980-05-14 1986-06-03 Societe Nationale Des Poudres Et Explosifs Process for the synthesis of alpha-chlorinated chloroformates
US4592872A (en) * 1980-05-14 1986-06-03 Societe Nationale Des Poudres Et Explosifs Process for the synthesis of α-chlorinated chloroformates
EP0061162A3 (en) * 1981-03-23 1983-06-08 Kyoto Yakuhin Kogyo Kabushiki Kaisha Cephalosporin derivatives, pharmaceutical compositions containing the same and production thereof
FR2532933A1 (en) * 1982-06-29 1984-03-16 Astra Laekemedel Ab Improvements made to the preparation of antibiotics
US4820857A (en) * 1982-09-20 1989-04-11 Astra Lakemedel Aktiebolag α-bromodiethylcarbonate
US5202454A (en) * 1986-07-11 1993-04-13 Societe Nationale Des Poudres Et Explosifs Process for the manufacture of 1-bromoalkyl hydrocarbyl carbonates

Also Published As

Publication number Publication date
NZ186998A (en) 1981-05-01
AU521098B2 (en) 1982-03-18
IE780760L (en) 1978-10-19
KR840000081B1 (en) 1984-02-08
ZA782211B (en) 1979-04-25
CA1093068A (en) 1981-01-06
JPS53132592A (en) 1978-11-18
GB1598568A (en) 1981-09-23
FR2387988B1 (en) 1982-06-11
ES468895A1 (en) 1978-12-01
DK147513C (en) 1985-03-18
NL7804097A (en) 1978-10-23
DK168778A (en) 1978-10-20
DK147513B (en) 1984-09-10
IL54531A (en) 1981-07-31
KR830000246A (en) 1983-03-30
YU90978A (en) 1983-01-21
IL54531A0 (en) 1978-07-31
DE2816873A1 (en) 1978-11-02
SE433748B (en) 1984-06-12
ATA274878A (en) 1980-12-15
AT363183B (en) 1981-07-10
IT1104842B (en) 1985-10-28
AU3518778A (en) 1979-10-25
IE46726B1 (en) 1983-09-07
CH639096A5 (en) 1983-10-31
IT7848941A0 (en) 1978-04-18
SE7804400L (en) 1978-10-20
BE866093A (en) 1978-10-18

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