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FR2385714A1 - NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT - Google Patents

NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT

Info

Publication number
FR2385714A1
FR2385714A1 FR7730339A FR7730339A FR2385714A1 FR 2385714 A1 FR2385714 A1 FR 2385714A1 FR 7730339 A FR7730339 A FR 7730339A FR 7730339 A FR7730339 A FR 7730339A FR 2385714 A1 FR2385714 A1 FR 2385714A1
Authority
FR
France
Prior art keywords
application
preparation process
medicinal product
new antibiotic
antibiotic named
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7730339A
Other languages
French (fr)
Other versions
FR2385714B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP52037166A external-priority patent/JPS6034556B2/en
Priority claimed from US05/811,448 external-priority patent/US4162940A/en
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2385714A1 publication Critical patent/FR2385714A1/en
Application granted granted Critical
Publication of FR2385714B1 publication Critical patent/FR2385714B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The antibiotic C-15003 is a valuable fungicidal agent, antiprotozoal agent and cytostatic. It corresponds to the formula: in which R represents the radical -COCH(CH3)2, -COCH2CH2CH3 or -COCH2CH(CH3)2. The preparation is effected by cultivating a microorganism of the genus Nocardia. The radical R can be eliminated by reductive hydrolysis, thus giving rise to Maytansinol.
FR7730339A 1977-03-31 1977-10-07 NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT Granted FR2385714A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP52037166A JPS6034556B2 (en) 1977-03-31 1977-03-31 Antibiotic C-15003
US81144977A 1977-06-29 1977-06-29
US05/811,448 US4162940A (en) 1977-03-31 1977-06-29 Method for producing Antibiotic C-15003 by culturing nocardia

Publications (2)

Publication Number Publication Date
FR2385714A1 true FR2385714A1 (en) 1978-10-27
FR2385714B1 FR2385714B1 (en) 1982-05-14

Family

ID=27289347

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7730339A Granted FR2385714A1 (en) 1977-03-31 1977-10-07 NEW ANTIBIOTIC NAMED C-15003, ITS PREPARATION PROCESS AND ITS APPLICATION AS A MEDICINAL PRODUCT

Country Status (2)

Country Link
CH (1) CH637137A5 (en)
FR (1) FR2385714A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2409307A1 (en) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF ANTIBIOTIC C-15003 P-3 BY CULTURE OF A MICRO-ORGANISM
FR2409306A1 (en) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF THE ANTIBIOTIC C-15003 P-4 BY CULTURE OF A MICRO-ORGANISM OF THE GENUS NOCARDIA
EP0011302A1 (en) * 1978-11-20 1980-05-28 Takeda Chemical Industries, Ltd. Maytansinoids, their production and use
EP0019934A1 (en) * 1979-06-05 1980-12-10 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PND and process for their preparation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/75 *
EXBK/77 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2409307A1 (en) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF ANTIBIOTIC C-15003 P-3 BY CULTURE OF A MICRO-ORGANISM
FR2409306A1 (en) * 1977-11-18 1979-06-15 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF THE ANTIBIOTIC C-15003 P-4 BY CULTURE OF A MICRO-ORGANISM OF THE GENUS NOCARDIA
EP0011302A1 (en) * 1978-11-20 1980-05-28 Takeda Chemical Industries, Ltd. Maytansinoids, their production and use
EP0019934A1 (en) * 1979-06-05 1980-12-10 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PND and process for their preparation

Also Published As

Publication number Publication date
CH637137A5 (en) 1983-07-15
FR2385714B1 (en) 1982-05-14

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Legal Events

Date Code Title Description
ST Notification of lapse