FR2369248A1 - Thymosine utile comme medicament et son procede de preparation - Google Patents
Thymosine utile comme medicament et son procede de preparationInfo
- Publication number
- FR2369248A1 FR2369248A1 FR7732259A FR7732259A FR2369248A1 FR 2369248 A1 FR2369248 A1 FR 2369248A1 FR 7732259 A FR7732259 A FR 7732259A FR 7732259 A FR7732259 A FR 7732259A FR 2369248 A1 FR2369248 A1 FR 2369248A1
- Authority
- FR
- France
- Prior art keywords
- glu
- thymosin
- useful
- lys
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010046075 Thymosin Proteins 0.000 title abstract 2
- 102000007501 Thymosin Human genes 0.000 title abstract 2
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- SITLTJHOQZFJGG-UHFFFAOYSA-N N-L-alpha-glutamyl-L-valine Natural products CC(C)C(C(O)=O)NC(=O)C(N)CCC(O)=O SITLTJHOQZFJGG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003047 N-acetyl group Chemical group 0.000 abstract 1
- 108010078233 Thymalfasin Proteins 0.000 abstract 1
- 102400000800 Thymosin alpha-1 Human genes 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 108010056243 alanylalanine Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical group CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 abstract 1
- 229960004231 thymalfasin Drugs 0.000 abstract 1
- 108010027845 thymosin alpha(1) (24-28) Proteins 0.000 abstract 1
- 210000001541 thymus gland Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un polypeptide acide présent dans la fraction de thymosine 5. Il s'agit de la thymosine alpha 1 caractérisé par la séquence (N-Acétyl) - Ser - Asp - Ala - Ala - Val - Asp - Thr - Ser - Ser - Glu -Ile - Thr - Thr - Lys - Asp - Leu - Lys - Glu - Lys -Lys - Glu - Val - Val - Glu - Glu - Ala - Glu - Asn - OH et de ses sels utilisables en pharmacie, exempts d'autres polypeptides du thymus. Ces composés sont utiles comme médicaments.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73663876A | 1976-10-28 | 1976-10-28 | |
| US05/766,638 US4079127A (en) | 1976-10-28 | 1977-02-08 | Thymosin alpha 1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2369248A1 true FR2369248A1 (fr) | 1978-05-26 |
| FR2369248B1 FR2369248B1 (fr) | 1981-01-02 |
Family
ID=27113070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7732259A Granted FR2369248A1 (fr) | 1976-10-28 | 1977-10-26 | Thymosine utile comme medicament et son procede de preparation |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5411220A (fr) |
| AR (1) | AR214903A1 (fr) |
| AT (1) | AT362493B (fr) |
| AU (1) | AU514996B2 (fr) |
| CA (1) | CA1101842A (fr) |
| CH (1) | CH633258A5 (fr) |
| DE (1) | DE2748213A1 (fr) |
| DK (1) | DK149094C (fr) |
| ES (1) | ES463588A1 (fr) |
| FI (1) | FI56317C (fr) |
| FR (1) | FR2369248A1 (fr) |
| GB (1) | GB1590457A (fr) |
| IL (1) | IL53218A (fr) |
| IT (1) | IT1195254B (fr) |
| LU (1) | LU78395A1 (fr) |
| MC (1) | MC1167A1 (fr) |
| NL (1) | NL188699C (fr) |
| NO (1) | NO143346C (fr) |
| NZ (1) | NZ185519A (fr) |
| PT (1) | PT67204B (fr) |
| SE (1) | SE442479B (fr) |
| YU (1) | YU40314B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2919592A1 (de) * | 1979-05-15 | 1981-01-15 | Max Planck Gesellschaft | Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon |
| US4339427A (en) * | 1980-04-14 | 1982-07-13 | Hoffmann-La Roche Inc. | Radioimmunoassay of thymosinα |
| FR2492663B1 (fr) * | 1980-10-24 | 1985-11-08 | Vtoroi Mo G | Produit medicamenteux regulateur du t-systeme de l'immunite et son procede de preparation |
| DE3137231A1 (de) * | 1981-09-18 | 1983-04-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Bis-thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-verbindungen |
| JPH01250018A (ja) * | 1988-03-30 | 1989-10-05 | Noble Sangyo Kk | 電子計測器用変位検知器 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1605258A (en) * | 1966-08-24 | 1973-11-30 | Hormone like preparations from thymus - gland |
-
1977
- 1977-10-05 CH CH1216177A patent/CH633258A5/de not_active IP Right Cessation
- 1977-10-14 AU AU29699/77A patent/AU514996B2/en not_active Expired
- 1977-10-25 IL IL53218A patent/IL53218A/xx unknown
- 1977-10-26 CA CA289,510A patent/CA1101842A/fr not_active Expired
- 1977-10-26 FR FR7732259A patent/FR2369248A1/fr active Granted
- 1977-10-26 NZ NZ185519A patent/NZ185519A/xx unknown
- 1977-10-26 IT IT29020/77A patent/IT1195254B/it active
- 1977-10-26 SE SE7712071A patent/SE442479B/xx not_active IP Right Cessation
- 1977-10-26 JP JP12766677A patent/JPS5411220A/ja active Granted
- 1977-10-26 MC MC771268A patent/MC1167A1/fr unknown
- 1977-10-27 NL NLAANVRAGE7711814,A patent/NL188699C/xx not_active IP Right Cessation
- 1977-10-27 DE DE19772748213 patent/DE2748213A1/de active Granted
- 1977-10-27 DK DK478277A patent/DK149094C/da not_active IP Right Cessation
- 1977-10-27 AT AT765877A patent/AT362493B/de not_active IP Right Cessation
- 1977-10-27 LU LU7778395A patent/LU78395A1/xx unknown
- 1977-10-27 ES ES463588A patent/ES463588A1/es not_active Expired
- 1977-10-27 PT PT67204A patent/PT67204B/pt unknown
- 1977-10-27 NO NO773681A patent/NO143346C/no unknown
- 1977-10-27 AR AR269752A patent/AR214903A1/es active
- 1977-10-27 YU YU2578/77A patent/YU40314B/xx unknown
- 1977-10-28 GB GB45001/77A patent/GB1590457A/en not_active Expired
- 1977-10-28 FI FI773221A patent/FI56317C/fi not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1605258A (en) * | 1966-08-24 | 1973-11-30 | Hormone like preparations from thymus - gland |
Non-Patent Citations (2)
| Title |
|---|
| CA1975 * |
| CA1977 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property |