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FR2365571A1 - 7-ACYLAMINO-3- (SULFOMETHYLTHIADIAZOLYL- OR TRIAZOLYL-THIOMETHYL) -3-CEPHEME-4-CARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION - Google Patents

7-ACYLAMINO-3- (SULFOMETHYLTHIADIAZOLYL- OR TRIAZOLYL-THIOMETHYL) -3-CEPHEME-4-CARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION

Info

Publication number
FR2365571A1
FR2365571A1 FR7727983A FR7727983A FR2365571A1 FR 2365571 A1 FR2365571 A1 FR 2365571A1 FR 7727983 A FR7727983 A FR 7727983A FR 7727983 A FR7727983 A FR 7727983A FR 2365571 A1 FR2365571 A1 FR 2365571A1
Authority
FR
France
Prior art keywords
acylamino
sulfomethylthiadiazolyl
carboxylic acids
cepheme
thiomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7727983A
Other languages
French (fr)
Other versions
FR2365571B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/726,378 external-priority patent/US4079134A/en
Priority claimed from US05/726,377 external-priority patent/US4083975A/en
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of FR2365571A1 publication Critical patent/FR2365571A1/en
Application granted granted Critical
Publication of FR2365571B1 publication Critical patent/FR2365571B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/1251,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention a pour objet des acides 7-acylamino-3-(sulfométhylthiadiazolyl- ou triazolylthiométhyl)-3-céphème-4-carboxyliques ainsi que leurs esters, sels et produits de solvatation non toxiques pharmaceutiquement acceptables, le groupe acylamino étant un groupe acylamino pharmaceutiquement acceptable présent en position 7 de céphalosporines connues, ayant une activité antibactérienne, sous réserve que le groupe acylamino ne contienne pas un noyau thiazole. Ces nouveaux composés ont une importante activité antibactérienne.The invention relates to 7-acylamino-3- (sulfomethylthiadiazolyl- or triazolylthiomethyl) -3-cephem-4-carboxylic acids as well as their non-toxic pharmaceutically acceptable esters, salts and solvates, the acylamino group being an acylamino group. Pharmaceutically acceptable present in position 7 of known cephalosporins, having antibacterial activity, provided that the acylamino group does not contain a thiazole ring. These new compounds have significant antibacterial activity.

FR7727983A 1976-09-24 1977-09-16 7-ACYLAMINO-3- (SULFOMETHYLTHIADIAZOLYL- OR TRIAZOLYL-THIOMETHYL) -3-CEPHEME-4-CARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION Granted FR2365571A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/726,378 US4079134A (en) 1976-09-24 1976-09-24 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acids
US05/726,377 US4083975A (en) 1976-09-24 1976-09-24 7-Acylamino-3-(3-sulfomethyl-1,2,4-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Publications (2)

Publication Number Publication Date
FR2365571A1 true FR2365571A1 (en) 1978-04-21
FR2365571B1 FR2365571B1 (en) 1983-02-25

Family

ID=27111308

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7727983A Granted FR2365571A1 (en) 1976-09-24 1977-09-16 7-ACYLAMINO-3- (SULFOMETHYLTHIADIAZOLYL- OR TRIAZOLYL-THIOMETHYL) -3-CEPHEME-4-CARBOXYLIC ACIDS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FR7828261A Pending FR2392014A1 (en) 1976-09-24 1978-10-03 SULFOMETHYL THIADIAZOLE- OR TRIAZOLE-THIOLS

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7828261A Pending FR2392014A1 (en) 1976-09-24 1978-10-03 SULFOMETHYL THIADIAZOLE- OR TRIAZOLE-THIOLS

Country Status (9)

Country Link
JP (1) JPS5340796A (en)
CH (1) CH633557A5 (en)
DE (1) DE2742726A1 (en)
DK (1) DK417777A (en)
FR (2) FR2365571A1 (en)
GB (1) GB1591990A (en)
IE (1) IE45686B1 (en)
LU (1) LU78164A1 (en)
NL (1) NL7710439A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6140291A (en) * 1984-07-31 1986-02-26 Shionogi & Co Ltd Hydroxyalkylthiocephalosporin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1201621A (en) * 1967-05-18 1970-08-12 Agfa Gevaert Nv Process for stabilizing developed photographic images

Also Published As

Publication number Publication date
FR2392014A1 (en) 1978-12-22
IE45686B1 (en) 1982-10-20
LU78164A1 (en) 1978-01-24
JPS6156237B2 (en) 1986-12-01
NL7710439A (en) 1978-03-29
GB1591990A (en) 1981-07-01
JPS5340796A (en) 1978-04-13
CH633557A5 (en) 1982-12-15
DE2742726A1 (en) 1978-03-30
FR2365571B1 (en) 1983-02-25
IE45686L (en) 1978-03-24
DK417777A (en) 1978-03-25

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Legal Events

Date Code Title Description
ST Notification of lapse