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FR2360574A1 - Benzo-indolyl guanidine(s) - having salidiuretic and antihypertensive properties, prepd. from benzo-indolyl amine(s) - Google Patents

Benzo-indolyl guanidine(s) - having salidiuretic and antihypertensive properties, prepd. from benzo-indolyl amine(s)

Info

Publication number
FR2360574A1
FR2360574A1 FR7723729A FR7723729A FR2360574A1 FR 2360574 A1 FR2360574 A1 FR 2360574A1 FR 7723729 A FR7723729 A FR 7723729A FR 7723729 A FR7723729 A FR 7723729A FR 2360574 A1 FR2360574 A1 FR 2360574A1
Authority
FR
France
Prior art keywords
benzo
indolyl
guanidine
salidiuretic
prepd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7723729A
Other languages
French (fr)
Inventor
Heinrich Wilkens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2360574A1 publication Critical patent/FR2360574A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouveaux dérivés de la benzoØc,dõindolyl-1-guanidine et leur préparation. Les composés de l'invention répondent à la formule :The invention relates to novel benzoc, dõindolyl-1-guanidine derivatives and their preparation. The compounds of the invention correspond to the formula:

FR7723729A 1976-08-03 1977-08-02 Benzo-indolyl guanidine(s) - having salidiuretic and antihypertensive properties, prepd. from benzo-indolyl amine(s) Withdrawn FR2360574A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH988276 1976-08-03
CH988176 1976-08-03

Publications (1)

Publication Number Publication Date
FR2360574A1 true FR2360574A1 (en) 1978-03-03

Family

ID=25705456

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7723729A Withdrawn FR2360574A1 (en) 1976-08-03 1977-08-02 Benzo-indolyl guanidine(s) - having salidiuretic and antihypertensive properties, prepd. from benzo-indolyl amine(s)

Country Status (9)

Country Link
JP (1) JPS5318561A (en)
AU (1) AU2758777A (en)
DE (1) DE2733440A1 (en)
DK (1) DK335477A (en)
FI (1) FI772270A7 (en)
FR (1) FR2360574A1 (en)
IL (1) IL52629A0 (en)
NL (1) NL7708420A (en)
PT (1) PT66873B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728663A (en) * 1986-01-13 1988-03-01 American Cyanamid Company N-[(1H-imidazol-1-yl)alkyl]benz[cd]-indol-2-amines and use in inhibiting thromboxane synthetase enzyme
US7041702B1 (en) 1997-10-21 2006-05-09 Scion Pharmaceuticals, Inc. Pharmaceutically active compounds and methods of use
KR20010031065A (en) * 1997-10-21 2001-04-16 케임브리지 뉴로사이언스, 인코포레이티드 Pharmaceutically active compounds and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518935A (en) * 1969-12-23 1972-02-15 Sandoz Ag Guanidine derivs - from (5-alkoxybenzindolyl)-2-methylisothiourea salt and substd amines - circulating stabilisation, vasoconstriction,
CH518934A (en) * 1969-12-23 1972-02-15 Sandoz Ag Guanidine derivs - from acetoxybenzindolymethylisothiourea salt and liquid ammonia stabilising circulation,vasoconstriction antihyper
CH518932A (en) * 1969-12-23 1972-02-15 Sandoz Ag 1-acetylguanidino-hexahydro benzindoles prodn - as antihypertensives and circulatory stabilisers from guanidino-derivs by acylation
CH521967A (en) * 1969-12-23 1972-04-30 Sandoz Ag Subst benzindolylaminoguanidines - with circulatory activity
CH521966A (en) * 1969-12-23 1972-04-30 Sandoz Ag Subst benzindolylaminoguanidines - with circulatory activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH518935A (en) * 1969-12-23 1972-02-15 Sandoz Ag Guanidine derivs - from (5-alkoxybenzindolyl)-2-methylisothiourea salt and substd amines - circulating stabilisation, vasoconstriction,
CH518934A (en) * 1969-12-23 1972-02-15 Sandoz Ag Guanidine derivs - from acetoxybenzindolymethylisothiourea salt and liquid ammonia stabilising circulation,vasoconstriction antihyper
CH518932A (en) * 1969-12-23 1972-02-15 Sandoz Ag 1-acetylguanidino-hexahydro benzindoles prodn - as antihypertensives and circulatory stabilisers from guanidino-derivs by acylation
CH521967A (en) * 1969-12-23 1972-04-30 Sandoz Ag Subst benzindolylaminoguanidines - with circulatory activity
CH521966A (en) * 1969-12-23 1972-04-30 Sandoz Ag Subst benzindolylaminoguanidines - with circulatory activity

Also Published As

Publication number Publication date
DK335477A (en) 1978-02-04
JPS5318561A (en) 1978-02-20
AU2758777A (en) 1979-02-08
PT66873A (en) 1977-09-01
FI772270A7 (en) 1978-02-04
IL52629A0 (en) 1977-10-31
NL7708420A (en) 1978-02-07
PT66873B (en) 1979-03-13
DE2733440A1 (en) 1978-02-09

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Legal Events

Date Code Title Description
RE Withdrawal of published application