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FR2358415A1 - Derives peptidiques, leur preparation et leur application en tant que medicaments - Google Patents

Derives peptidiques, leur preparation et leur application en tant que medicaments

Info

Publication number
FR2358415A1
FR2358415A1 FR7721281A FR7721281A FR2358415A1 FR 2358415 A1 FR2358415 A1 FR 2358415A1 FR 7721281 A FR7721281 A FR 7721281A FR 7721281 A FR7721281 A FR 7721281A FR 2358415 A1 FR2358415 A1 FR 2358415A1
Authority
FR
France
Prior art keywords
preparation
application
medicinal products
peptidic derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7721281A
Other languages
English (en)
Other versions
FR2358415B1 (fr
Inventor
Frank Ratcliffe Atherton
Michael John Hall
Cedric Herbert Hassall
Robert Wilson Lambert
Peter Stuart Ringrose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2358415A1 publication Critical patent/FR2358415A1/fr
Application granted granted Critical
Publication of FR2358415B1 publication Critical patent/FR2358415B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouveaux composés chimiques utiles comme médicaments, un procédé pour leur préparation, ainsi que leur utilisation. Les nouveaux composés sont des dérivés peptidiques de formule générale :
FR7721281A 1976-07-13 1977-07-11 Derives peptidiques, leur preparation et leur application en tant que medicaments Granted FR2358415A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29102/76A GB1585076A (en) 1976-07-13 1976-07-13 Peptides of phosphonic and phosphinic acids

Publications (2)

Publication Number Publication Date
FR2358415A1 true FR2358415A1 (fr) 1978-02-10
FR2358415B1 FR2358415B1 (fr) 1979-06-01

Family

ID=10286190

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7721281A Granted FR2358415A1 (fr) 1976-07-13 1977-07-11 Derives peptidiques, leur preparation et leur application en tant que medicaments

Country Status (17)

Country Link
US (1) US4128542A (fr)
JP (1) JPS539761A (fr)
AT (1) AT354655B (fr)
AU (1) AU513547B2 (fr)
BE (1) BE856725A (fr)
CA (1) CA1106361A (fr)
DE (1) DE2730549A1 (fr)
DK (1) DK317277A (fr)
FR (1) FR2358415A1 (fr)
GB (1) GB1585076A (fr)
IL (1) IL52470A (fr)
IT (1) IT1080784B (fr)
LU (1) LU77746A1 (fr)
NL (1) NL7707823A (fr)
NZ (1) NZ184593A (fr)
SE (1) SE7708121L (fr)
ZA (1) ZA774074B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195018A (en) * 1977-07-01 1980-03-25 Nippon Kayaku Kabushiki Kaisha 3-[(S)-1'-Phenylethylamino]propylaminobleomycin, non-toxic salt thereof, and method for producing same
DE2901843A1 (de) * 1979-01-18 1980-07-31 Hoechst Ag Verfahren zur herstellung von carbonsaeureamiden und peptiden
EP0026867A1 (fr) * 1979-09-28 1981-04-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Acides peptidylphosphoniques, leur préparation et leur utilisation et préparations pharmaceutiques les contenant
EP0103867B1 (fr) * 1982-09-17 1986-12-17 Kyowa Hakko Kogyo Co., Ltd. Dérivé de peptide contenant du phosphore
US4970297A (en) * 1987-03-13 1990-11-13 Syntex (U.S.A.) Inc. Transglutaminase inhibitors
HUT52785A (en) * 1988-03-03 1990-08-28 Squibb & Sons Inc Process for producing 1,2-hydroxy-phosphonates and derivatives
FI910084A0 (fi) * 1988-07-08 1991-01-07 Smithkline Beckman Corp Retrovirala proteaser bindande peptider.
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
WO1990009172A1 (fr) * 1989-02-16 1990-08-23 Pfizer Inc. Inhibiteurs de renine contenant du phosphore
GB0022556D0 (en) * 2000-09-14 2000-11-01 Oxoid Ltd Improvements in or relating to selective agents for biological cultures
EP2684865A1 (fr) * 2012-07-13 2014-01-15 Heidelberg Pharma GmbH Procédés de synthèse de bloc de construction dýamatoxine et amatoxine
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
WO2020049616A1 (fr) 2018-09-03 2020-03-12 コンドーエフアルピー工業株式会社 Siphon d'évacuation d'eau

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2298335A1 (fr) * 1975-01-27 1976-08-20 Hoffmann La Roche Nouveaux derives de peptides d'acides phosphonique et phosphinique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922262A (en) * 1971-04-28 1975-11-25 Nippon Kayaku Kk N-Substituted derivatives of bleomycins
US3826794A (en) * 1971-09-13 1974-07-30 Abbott Lab Protected decapeptide derivatives of gonadotropin releasing hormone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2298335A1 (fr) * 1975-01-27 1976-08-20 Hoffmann La Roche Nouveaux derives de peptides d'acides phosphonique et phosphinique

Also Published As

Publication number Publication date
FR2358415B1 (fr) 1979-06-01
AT354655B (de) 1979-01-25
BE856725A (fr) 1978-01-12
US4128542A (en) 1978-12-05
DE2730549A1 (de) 1978-01-19
DK317277A (da) 1978-01-14
ZA774074B (en) 1978-05-30
JPS539761A (en) 1978-01-28
IL52470A (en) 1980-06-30
GB1585076A (en) 1981-02-25
ATA500877A (de) 1979-06-15
CA1106361A (fr) 1981-08-04
SE7708121L (sv) 1978-01-14
LU77746A1 (fr) 1978-09-14
AU513547B2 (en) 1980-12-11
NL7707823A (nl) 1978-01-17
IT1080784B (it) 1985-05-16
AU2684877A (en) 1979-01-11
NZ184593A (en) 1980-04-28

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Legal Events

Date Code Title Description
ST Notification of lapse