FR2356423A1 - Stone-removing (N)-acyl-(2)-pyridyl-thiazolidine-(4)-carboxylic acids - prepd. by (N)-acylating the (N)-unsubstd. cpds. - Google Patents
Stone-removing (N)-acyl-(2)-pyridyl-thiazolidine-(4)-carboxylic acids - prepd. by (N)-acylating the (N)-unsubstd. cpds.Info
- Publication number
- FR2356423A1 FR2356423A1 FR7620068A FR7620068A FR2356423A1 FR 2356423 A1 FR2356423 A1 FR 2356423A1 FR 7620068 A FR7620068 A FR 7620068A FR 7620068 A FR7620068 A FR 7620068A FR 2356423 A1 FR2356423 A1 FR 2356423A1
- Authority
- FR
- France
- Prior art keywords
- unsubstd
- prepd
- cpds
- thiazolidine
- acylating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 abstract 1
- DZLNHFMRPBPULJ-VKHMYHEASA-N L-thioproline Chemical compound OC(=O)[C@@H]1CSCN1 DZLNHFMRPBPULJ-VKHMYHEASA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 201000001883 cholelithiasis Diseases 0.000 abstract 1
- 229960003067 cystine Drugs 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 208000001130 gallstones Diseases 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
New thiazolidine carboxylic acid derivs. are of formula (I) (where R1 is 2-17C alkanoyl; and R2 is carboxy or one of its functional derivs. i.e. an ester or amide gp. or an inorganic (esp. alkali(ne earth)) or organic (esp. amine) salt of the carboxy gp). (I), their optical isomers and acceptable acid addn. salts are useful for treating kidney, liver and gallstones, in that they are capable of bringing about dissolution of oxalate, phosphate, uric acid, cystine, etc. accretions. In addn., they are also useful for treating metabolic disorders; this is because they introduce biological sulphur into the organism, where it has a plastic, energetic and protective effect. (I) can also be used in veterinary medicine, e.g. to increase the wt. of piglets, foals, etc. and to reduce their mortality during the first 56 days of life.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7620068A FR2356423A1 (en) | 1976-07-01 | 1976-07-01 | Stone-removing (N)-acyl-(2)-pyridyl-thiazolidine-(4)-carboxylic acids - prepd. by (N)-acylating the (N)-unsubstd. cpds. |
| DE19772729414 DE2729414A1 (en) | 1976-07-01 | 1977-06-29 | THIAZOLIDINE CARBONIC ACID DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7620068A FR2356423A1 (en) | 1976-07-01 | 1976-07-01 | Stone-removing (N)-acyl-(2)-pyridyl-thiazolidine-(4)-carboxylic acids - prepd. by (N)-acylating the (N)-unsubstd. cpds. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2356423A1 true FR2356423A1 (en) | 1978-01-27 |
| FR2356423B1 FR2356423B1 (en) | 1978-12-15 |
Family
ID=9175106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7620068A Granted FR2356423A1 (en) | 1976-07-01 | 1976-07-01 | Stone-removing (N)-acyl-(2)-pyridyl-thiazolidine-(4)-carboxylic acids - prepd. by (N)-acylating the (N)-unsubstd. cpds. |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2729414A1 (en) |
| FR (1) | FR2356423A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421889A1 (en) * | 1978-04-08 | 1979-11-02 | Santen Pharmaceutical Co Ltd | NEW DERIVATIVES OF THIAZOLIDINECARBOXYLIC-4 ACID USEFUL AS ANTIHYPERTENSIVE MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION |
| FR2439197A1 (en) * | 1978-10-16 | 1980-05-16 | Lilly Co Eli | 1-THIA-3-AZA-4-ONES, SUBSTITUTED, THEIR PREPARATION AND THEIR USE IN AGRICULTURE |
| EP0062612A1 (en) * | 1981-04-02 | 1982-10-13 | Ciba-Geigy Ag | Thiazoline derivatives |
| EP0279681A3 (en) * | 1987-02-20 | 1989-11-15 | Yamanouchi Pharmaceutical Co. Ltd. | Saturated heterocyclic carboxamide derivatives |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4482712A (en) * | 1978-10-16 | 1984-11-13 | Eli Lilly And Company | Substituted 1-thia-3-aza-4-ones |
| US4436739A (en) | 1978-10-16 | 1984-03-13 | Eli Lilly And Company | Substituted 1-thia-3-aza-4-ones |
| DE3170401D1 (en) | 1980-07-28 | 1985-06-13 | Ciba Geigy Ag | Triazoline derivatives and processes for their preparation |
| HU200177B (en) * | 1985-06-18 | 1990-04-28 | Biogal Gyogyszergyar | Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds |
| CN102917685B (en) | 2010-05-28 | 2015-11-25 | 味之素株式会社 | Cysteine derivative |
-
1976
- 1976-07-01 FR FR7620068A patent/FR2356423A1/en active Granted
-
1977
- 1977-06-29 DE DE19772729414 patent/DE2729414A1/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421889A1 (en) * | 1978-04-08 | 1979-11-02 | Santen Pharmaceutical Co Ltd | NEW DERIVATIVES OF THIAZOLIDINECARBOXYLIC-4 ACID USEFUL AS ANTIHYPERTENSIVE MEDICINAL PRODUCTS AND METHODS FOR THEIR PREPARATION |
| FR2439197A1 (en) * | 1978-10-16 | 1980-05-16 | Lilly Co Eli | 1-THIA-3-AZA-4-ONES, SUBSTITUTED, THEIR PREPARATION AND THEIR USE IN AGRICULTURE |
| EP0062612A1 (en) * | 1981-04-02 | 1982-10-13 | Ciba-Geigy Ag | Thiazoline derivatives |
| EP0279681A3 (en) * | 1987-02-20 | 1989-11-15 | Yamanouchi Pharmaceutical Co. Ltd. | Saturated heterocyclic carboxamide derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2729414A1 (en) | 1978-01-05 |
| FR2356423B1 (en) | 1978-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |