FR2354997A1 - Nouveaux derives 1-substitues du diphenyl-2,2 cyclopropane et leur application comme medicament - Google Patents
Nouveaux derives 1-substitues du diphenyl-2,2 cyclopropane et leur application comme medicamentInfo
- Publication number
- FR2354997A1 FR2354997A1 FR7716540A FR7716540A FR2354997A1 FR 2354997 A1 FR2354997 A1 FR 2354997A1 FR 7716540 A FR7716540 A FR 7716540A FR 7716540 A FR7716540 A FR 7716540A FR 2354997 A1 FR2354997 A1 FR 2354997A1
- Authority
- FR
- France
- Prior art keywords
- esp
- cyclopropanes
- acylamino
- diphenyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000747 cardiac effect Effects 0.000 title 1
- 239000002327 cardiovascular agent Substances 0.000 title 1
- 229940125692 cardiovascular agent Drugs 0.000 title 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 title 1
- 229940124549 vasodilator Drugs 0.000 title 1
- 239000003071 vasodilator agent Substances 0.000 title 1
- PKKBKEDDJYUWCT-UHFFFAOYSA-N 2-(diethylamino)-n-[(2,2-diphenylcyclopropyl)methyl]acetamide Chemical compound CCN(CC)CC(=O)NCC1CC1(C=1C=CC=CC=1)C1=CC=CC=C1 PKKBKEDDJYUWCT-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000005792 cardiovascular activity Effects 0.000 abstract 1
- 210000004351 coronary vessel Anatomy 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- -1 piperidino, morpholino, piperazino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Dérivés 1-substitués de l'aminométhyl-1- diphényl-2,2 cyclopropane de formule :
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2489876 | 1976-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2354997A1 true FR2354997A1 (fr) | 1978-01-13 |
Family
ID=10219013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7716540A Withdrawn FR2354997A1 (fr) | 1976-06-16 | 1977-05-31 | Nouveaux derives 1-substitues du diphenyl-2,2 cyclopropane et leur application comme medicament |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS537654A (fr) |
| BE (1) | BE855689A (fr) |
| CH (1) | CH603553A5 (fr) |
| DD (1) | DD129902A5 (fr) |
| DE (1) | DE2726993A1 (fr) |
| DK (1) | DK265277A (fr) |
| ES (1) | ES459650A1 (fr) |
| FR (1) | FR2354997A1 (fr) |
| GR (1) | GR58465B (fr) |
| NL (1) | NL7706364A (fr) |
| NO (1) | NO772106L (fr) |
| PT (1) | PT66589B (fr) |
| SE (1) | SE7706895L (fr) |
| ZA (1) | ZA773350B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999033786A1 (fr) * | 1997-12-29 | 1999-07-08 | Ortho-Mcneil Pharmaceutical Corporation | Composes anti-inflammatoires |
-
1977
- 1977-05-24 PT PT66589A patent/PT66589B/fr unknown
- 1977-05-31 FR FR7716540A patent/FR2354997A1/fr not_active Withdrawn
- 1977-06-02 GR GR53613A patent/GR58465B/el unknown
- 1977-06-03 ZA ZA00773350A patent/ZA773350B/xx unknown
- 1977-06-06 JP JP6721877A patent/JPS537654A/ja active Pending
- 1977-06-08 ES ES459650A patent/ES459650A1/es not_active Expired
- 1977-06-09 NL NL7706364A patent/NL7706364A/xx not_active Application Discontinuation
- 1977-06-13 CH CH722177A patent/CH603553A5/xx not_active IP Right Cessation
- 1977-06-14 DD DD7700199486A patent/DD129902A5/xx unknown
- 1977-06-15 DE DE19772726993 patent/DE2726993A1/de active Pending
- 1977-06-15 DK DK265277A patent/DK265277A/da unknown
- 1977-06-15 SE SE7706895A patent/SE7706895L/xx unknown
- 1977-06-15 NO NO772106A patent/NO772106L/no unknown
- 1977-06-15 BE BE2055987A patent/BE855689A/fr unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999033786A1 (fr) * | 1997-12-29 | 1999-07-08 | Ortho-Mcneil Pharmaceutical Corporation | Composes anti-inflammatoires |
| US6372779B1 (en) | 1997-12-29 | 2002-04-16 | Ortho Pharmaceutical Corporation | Anti-inflammatory compounds |
| US6509369B2 (en) | 1997-12-29 | 2003-01-21 | Ortho-Mcneil Pharmaceutical, Inc. | Anti-inflammatory compounds |
| US7141674B2 (en) | 1997-12-29 | 2006-11-28 | Johnson & Johnson Consumer Companies, Inc. | Anti-inflammatory compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| PT66589A (fr) | 1977-06-01 |
| PT66589B (fr) | 1978-10-23 |
| ES459650A1 (es) | 1978-05-01 |
| NO772106L (no) | 1977-12-19 |
| SE7706895L (sv) | 1977-12-17 |
| DK265277A (da) | 1977-12-17 |
| NL7706364A (nl) | 1977-12-20 |
| JPS537654A (en) | 1978-01-24 |
| DD129902A5 (de) | 1978-02-15 |
| CH603553A5 (fr) | 1978-08-31 |
| ZA773350B (en) | 1978-04-26 |
| GR58465B (en) | 1977-10-12 |
| BE855689A (fr) | 1977-12-15 |
| DE2726993A1 (de) | 1977-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |