[go: up one dir, main page]

FR2351125A1 - PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION - Google Patents

PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Info

Publication number
FR2351125A1
FR2351125A1 FR7714551A FR7714551A FR2351125A1 FR 2351125 A1 FR2351125 A1 FR 2351125A1 FR 7714551 A FR7714551 A FR 7714551A FR 7714551 A FR7714551 A FR 7714551A FR 2351125 A1 FR2351125 A1 FR 2351125A1
Authority
FR
France
Prior art keywords
alanyl
acid
formula
configuration
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7714551A
Other languages
French (fr)
Inventor
Frank Ratcliffe Atherton
Michael John Hall
Cedric Herbert Hassall
Robert Wilson Lambert
Peter Stuart Ringrose
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2351125A1 publication Critical patent/FR2351125A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Peptide derivs. of formula (I) and their pharmaceutically acceptable salts are new. In the formula, n is 1,2 or 3; and R1-3 are each residues of alpha-amino acids normally occurring in protein; provided that R1 is not = H and R4 is OH or CH3; the configuration at C-atoms (a) and (b) being L (when R2 and R3 are other than H), and the configuration at C-atom (c) being S. (I) have antibacterial activity against organisms such as Streptococcus faecalis and Haemophilus influenzae. Specific cpds. (I) include (1S)-1-(L-alanyl-L-alanylamino)-ethylphosphonic acid. In an example, this was prepd. by converting (1S)-1-/N-benzyloxycarbonyl-L-alanyl-L-alanyl)amino/ethylphosphon- ic acid monobenzylamide salt (obtained in 5 stages from (1R,S)-1-(benzyloxycarbonylamino)ethylphosphonic acid) into the free acid and hydrogenating in the presence of Pd/C.
FR7714551A 1976-05-14 1977-05-12 PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION Withdrawn FR2351125A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2001376 1976-05-14

Publications (1)

Publication Number Publication Date
FR2351125A1 true FR2351125A1 (en) 1977-12-09

Family

ID=10138906

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7714551A Withdrawn FR2351125A1 (en) 1976-05-14 1977-05-12 PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION

Country Status (3)

Country Link
JP (1) JPS52139022A (en)
DE (1) DE2721761A1 (en)
FR (1) FR2351125A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010067A3 (en) * 1978-10-05 1980-04-30 Ciba-Geigy Ag Agent and process for influencing plant growth

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331591A (en) 1978-10-05 1982-05-25 Ciba-Geigy Corporation Chemical process for the production of α-aminophosphonic acids and peptide derivatives
DE3368418D1 (en) * 1982-09-17 1987-01-29 Kyowa Hakko Kogyo Kk Phosphorus-containing peptide derivative

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2298335A1 (en) * 1975-01-27 1976-08-20 Hoffmann La Roche NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2298335A1 (en) * 1975-01-27 1976-08-20 Hoffmann La Roche NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/72 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010067A3 (en) * 1978-10-05 1980-04-30 Ciba-Geigy Ag Agent and process for influencing plant growth
US4431438A (en) * 1978-10-05 1984-02-14 Ciba-Geigy Corporation Aminoethane-methylphosphinic acid derivatives for influencing plant growth

Also Published As

Publication number Publication date
DE2721761A1 (en) 1977-12-01
JPS52139022A (en) 1977-11-19

Similar Documents

Publication Publication Date Title
DE69532760T2 (en) AGENTS FOR THE ADMINISTRATION OF ANTIGENS
OA06421A (en) Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
CH553800A (en) PROCESS FOR PREPARING AMINO DERIVATIVES OF PYRAZOLO (3,4-B) PYRIDINE-5-CARBOXYLIC ACIDS.
PT65853A (en) PROCESS FOR THE PREPARATION OF AMINO ALCOHOL DERIVATIVES
SE454699B (en) PEPTIDES AND MEDICINAL PRODUCTS CONTAINING THEM
FR2351125A1 (en) PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION
ES476264A1 (en) A PROCEDURE FOR THE PREPARATION OF PEPTIDIC DERIVATIVES
GB1429976A (en) Production of an optically active enantiomorph of an amino acid
ATE11217T1 (en) ANTIBIOTIC SUBSTANCES, PROCESSES FOR THEIR PREPARATION AND THEIR COMPOSITIONS; STRAIN OF STAPHYLOCOCCUS EPIDERMIDIS WHICH PRODUCES THIS ANTIBIOTIC SUBSTANCE AND ITS COMPOSITIONS.
BE828546A (en) NEW AMINO ACID DERIVATIVES AND THEIR PREPARATION PROCESS
US3035041A (en) Method of preparing amides
SE8006119L (en) TRIPEPTID DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF
ES506192A0 (en) PROCEDURE FOR THE PREPARATION OF NEW HEXAPEPTIDES
IL43056A (en) Peptides having acth activity containing alpha-aminooxy carboxylic acids on both terminal groups and a process for the preparation thereof
US3433779A (en) Long-chain aliphatic esters of lysine and other basic amino acids and peptides thereof
ATA258276A (en) PROCESS FOR THE PREPARATION OF AMINO ACIDS FROM THEIR N-CARBAMYL DERIVATIVES
JPS5615256A (en) Novel tetrapeptide derivative
ES417951A1 (en) A PROCEDURE FOR THE PREPARATION OF NEW ACTH ACTIVITIES PEPTIDES.
RU94027564A (en) Amino acid derivatives, mixture of their isomers and separate isomers and their salts, method of their synthesis and pharmaceutical composition
DE3278075D1 (en) NEW N-NITROSO-N- (BETA CHLORO-ETHYL) CARBAMOYL PEPTIDES
ES418929A1 (en) Procedure for the preparation of polipeptides. (Machine-translation by Google Translate, not legally binding)
IE36346L (en) 3-heterocyclylthiomethyl cephalosporins
ES8505932A1 (en) Process for preparing optically active phenylalanine.
AU518792B2 (en) Amino acid derivatives of 2,3 dioxopiperazine
GB1407744A (en) Peptide compounds and methods for their production

Legal Events

Date Code Title Description
ST Notification of lapse