FR2348703A1 - Preparation d'hemoglobine appropriee pour l'injection intraveineuse et son procede d'obtention - Google Patents
Preparation d'hemoglobine appropriee pour l'injection intraveineuse et son procede d'obtentionInfo
- Publication number
- FR2348703A1 FR2348703A1 FR7711719A FR7711719A FR2348703A1 FR 2348703 A1 FR2348703 A1 FR 2348703A1 FR 7711719 A FR7711719 A FR 7711719A FR 7711719 A FR7711719 A FR 7711719A FR 2348703 A1 FR2348703 A1 FR 2348703A1
- Authority
- FR
- France
- Prior art keywords
- haemoglobin
- pyridoxal
- phosphate
- washed
- high oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 title abstract 2
- 229960001327 pyridoxal phosphate Drugs 0.000 title abstract 2
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 title 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 2
- 210000003743 erythrocyte Anatomy 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 206010018910 Haemolysis Diseases 0.000 abstract 1
- CEEQUQSGVRRXQI-UHFFFAOYSA-N Pyridoxal 5-phosphate monohydrate Chemical compound O.CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O CEEQUQSGVRRXQI-UHFFFAOYSA-N 0.000 abstract 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000008588 hemolysis Effects 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 abstract 1
- 229960000380 propiolactone Drugs 0.000 abstract 1
- 230000001698 pyrogenic effect Effects 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762617822 DE2617822C3 (de) | 1976-04-23 | 1976-04-23 | Verfahren zur Herstellung eines für die intravenöse Injektion geeigneten Hämoglobinpräparates mit erhöhter Sauerstoffabgabe gegenüber Erythrozyten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2348703A1 true FR2348703A1 (fr) | 1977-11-18 |
| FR2348703B1 FR2348703B1 (fr) | 1981-06-19 |
Family
ID=5976043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7711719A Granted FR2348703A1 (fr) | 1976-04-23 | 1977-04-19 | Preparation d'hemoglobine appropriee pour l'injection intraveineuse et son procede d'obtention |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2617822C3 (fr) |
| FR (1) | FR2348703A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986004240A1 (fr) * | 1985-01-17 | 1986-07-31 | Battelle - Institut E.V. | Succedane de plasma |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3144705C2 (de) * | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
| US4826811A (en) * | 1986-06-20 | 1989-05-02 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
-
1976
- 1976-04-23 DE DE19762617822 patent/DE2617822C3/de not_active Expired
-
1977
- 1977-04-19 FR FR7711719A patent/FR2348703A1/fr active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986004240A1 (fr) * | 1985-01-17 | 1986-07-31 | Battelle - Institut E.V. | Succedane de plasma |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2617822C3 (de) | 1981-01-08 |
| DE2617822B2 (de) | 1980-04-30 |
| FR2348703B1 (fr) | 1981-06-19 |
| DE2617822A1 (de) | 1977-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CD | Change of name or company name | ||
| CN | Change in juridical nature |