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FR22C1052I2 - Anticorps anti-cd19 humanises et leur utilisation dans le traitement des tumeurs, de la transplantation et des maladies auto-immunes - Google Patents

Anticorps anti-cd19 humanises et leur utilisation dans le traitement des tumeurs, de la transplantation et des maladies auto-immunes

Info

Publication number
FR22C1052I2
FR22C1052I2 FR22C1052C FR22C1052C FR22C1052I2 FR 22C1052 I2 FR22C1052 I2 FR 22C1052I2 FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 C FR22C1052 C FR 22C1052C FR 22C1052 I2 FR22C1052 I2 FR 22C1052I2
Authority
FR
France
Prior art keywords
transplantation
tumors
antibodies
treatment
autoimmune diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1052C
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English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viela Bio Inc
Original Assignee
Viela Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viela Bio Inc filed Critical Viela Bio Inc
Publication of FR22C1052I1 publication Critical patent/FR22C1052I1/fr
Application granted granted Critical
Publication of FR22C1052I2 publication Critical patent/FR22C1052I2/fr
Active legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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FR22C1052C 2006-09-08 2022-10-17 Anticorps anti-cd19 humanises et leur utilisation dans le traitement des tumeurs, de la transplantation et des maladies auto-immunes Active FR22C1052I2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84293506P 2006-09-08 2006-09-08
US86691706P 2006-11-22 2006-11-22
US91139707P 2007-04-12 2007-04-12
US91530907P 2007-05-01 2007-05-01
US93942907P 2007-05-22 2007-05-22
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Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902338B2 (en) * 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
EP1769083B1 (fr) * 2004-07-16 2012-11-28 I.N.S.E.R.M. Institut National de la Santé et de la Recherche Médicale Phospholipase a2 secretoire comme marqueur prognostique et diagnostique de maladies cardio-vasculaires
US20110123440A1 (en) * 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
WO2007114319A1 (fr) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha Procédé de régulation de la cinétique sanguine d'un anticorps
EP1884571A1 (fr) * 2006-07-31 2008-02-06 INSERM (Institut National de la Santé et de la Recherche Médicale) utilisation de l'activité de spla2 pour le diagnose des maladies cardiovasculaires
EP2383297B8 (fr) 2006-08-14 2023-03-22 Xencor, Inc. Anticorps optimisés ciblant le CD19
CA2662340C (fr) * 2006-09-08 2016-08-02 Medimmune, Llc Anticorps anti-cd19 humanises, et leur utilisation dans le traitement de l'oncologie, de la transplantation et de la maladie auto-immune
WO2008069956A2 (fr) * 2006-12-01 2008-06-12 Cedars-Sinai Medical Center Épreuves pour prévoir et suivre le rejet médié par des anticorps de greffes allogéniques transplantées
CA2693053C (fr) 2007-05-30 2021-01-05 Xencor, Inc. Procedes et compositions permettant l'inhibition de cellules d'expression du cd32b
SI2202245T1 (sl) 2007-09-26 2016-10-28 Chugai Seiyaku Kabushiki Kaisha Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR
EP2211904B1 (fr) 2007-10-19 2016-08-17 Seattle Genetics, Inc. Agents de liaison au cd19 et utilisations de ceux-ci
CA2740028A1 (fr) 2008-01-23 2009-07-30 Herlev Hospital Ykl-40 en tant que marqueur general pour une maladie non specifique
ES2978400T3 (es) 2008-04-11 2024-09-11 Chugai Pharmaceutical Co Ltd Molécula de unión a antígeno capaz de unirse repetidamente a dos o más moléculas de antígeno
US8314213B2 (en) 2008-04-18 2012-11-20 Xencor, Inc. Human equivalent monoclonal antibodies engineered from nonhuman variable regions
ES2552937T3 (es) 2008-06-06 2015-12-03 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Factor de predicción de supervivencia para linfoma difuso de células B grandes
US8652843B2 (en) 2008-08-12 2014-02-18 Oncomed Pharmaceuticals, Inc. DDR1-binding agents and methods of use thereof
CN102317783A (zh) 2008-09-15 2012-01-11 海莱乌医院 作为胃肠癌的标记的ykl-40
JP5933975B2 (ja) * 2008-11-12 2016-06-15 メディミューン，エルエルシー 抗体製剤
US20120148576A1 (en) * 2009-03-06 2012-06-14 Medlmmune, Llc Humanized anti-cd 19 antibody formulations
EP2419449A1 (fr) * 2009-04-16 2012-02-22 Charité Universitätsmedizin Berlin Agents ciblant les lymphocytes b destinés à être utilisés dans un procédé de traitement d'une maladie
RU2595409C2 (ru) * 2009-09-03 2016-08-27 Мерк Шарп И Доум Корп., Анти-gitr-антитела
US8658154B2 (en) * 2009-12-21 2014-02-25 Regeneron Pharmaceuticals, Inc. Humanized FcγR mice
WO2011147834A1 (fr) 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
US8192429B2 (en) 2010-06-29 2012-06-05 Theravant, Inc. Abnormality eradication through resonance
EP2409712A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré
EP2409993A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré
EP2409989A1 (fr) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Procédé pour améliorer le profile de glycosylation d'un anticorps
UA111175C2 (uk) 2010-10-27 2016-04-11 Амген Рісьорч (Мюнхен) Гмбх ЗАСТОСУВАННЯ КОМПОЗИЦІЇ, ЯКА МІСТИТЬ БІСПЕЦИФІЧНЕ АНТИТІЛО CD19xCD3, ДЛЯ ЛІКУВАННЯ ДИФУЗНОЇ B-КРУПНОКЛІТИННОЇ ЛІМФОМИ
JP2013543869A (ja) * 2010-11-15 2013-12-09 メディミューン，エルエルシー Ｂ細胞リンパ腫のための併用療法
SG190727A1 (en) 2010-11-30 2013-07-31 Chugai Pharmaceutical Co Ltd Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
CN106117312A (zh) 2011-04-21 2016-11-16 西雅图基因公司 新的结合剂‑药物缀合物（adc）及其用途
EP2524929A1 (fr) * 2011-05-17 2012-11-21 Sanofi Utilisation d'anticorps immunoconjugués anti-CD19 maytansinoïdes pour le traitement de symptômes de malignités CD19+lymphocytes B
EP2550975A1 (fr) * 2011-07-29 2013-01-30 Sanofi Polythérapie pour le traitement de symptômes de malignités CD19+lymphocytes B comprenant un immunoconjugué anti-CD19 maytansinoïde et du rituximab
HUE058855T2 (hu) 2011-08-16 2022-09-28 Morphosys Ag Kombinációs terápia, CD19 elleni ellenanyag és purinanalóg alkalmazásával
HUE058350T2 (hu) 2011-08-16 2022-07-28 Morphosys Ag Kombinációs terápia, CD19 elleni ellenanyag és nitrogénmustár alkalmazásával
US9447194B2 (en) * 2012-02-13 2016-09-20 Seattle Children's Hospital Bispecific chimeric antigen receptors and encoding polynucleotides thereof
WO2013138244A2 (fr) * 2012-03-12 2013-09-19 Medimmune, Llc Traitement de la sclérose en plaques par un anticorps anti-cd19
US10011660B2 (en) * 2012-04-30 2018-07-03 Medimmune, Llc Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
WO2013177187A2 (fr) 2012-05-22 2013-11-28 Massachusetts Institute Of Technology Traitement de tumeur synergique avec du pk il-2 étendu et des agents thérapeutiques
HK1216854A1 (zh) * 2012-06-13 2016-12-09 以弗吉尼亚大学许可和投资集团名义经营的弗吉尼亚大学专利基金会 用於治療癌症的組合物和方法
HK1207090A1 (en) 2012-07-13 2016-01-22 宾夕法尼亚大学董事会 Enhancing activity of car t cells by co-introducing a bispecific antibody
US10919953B2 (en) 2012-08-24 2021-02-16 Chugai Seiyaku Kabushiki Kaisha FcgammaRIIB-specific Fc region variant
EP2889376A4 (fr) 2012-08-24 2016-11-02 Chugai Pharmaceutical Co Ltd ANTICORPS Fc SPÉCIFIQUE À FcyRII DE SOURIS
US9534044B2 (en) * 2013-02-28 2017-01-03 United Arab Emirates University Alpha-synuclein antibodies and uses thereof
CN105025925A (zh) * 2013-03-15 2015-11-04 拜尔健康护理有限责任公司 抗-催乳素受体抗体制剂
KR20210130260A (ko) 2013-04-02 2021-10-29 추가이 세이야쿠 가부시키가이샤 Ｆｃ영역 개변체
US9387151B2 (en) 2013-08-20 2016-07-12 Anutra Medical, Inc. Syringe fill system and method
KR102329024B1 (ko) 2013-12-23 2021-11-19 바이엘 파마 악티엔게젤샤프트 키네신 스핀들 단백질(ksp)과의 항체 약물 접합체 (adcs)
AU2015227251A1 (en) * 2014-03-04 2016-10-20 Medlmmune, Llc Compositions and methods for identifying B cell malignancies responsive to B cell depleting therapy
USD763433S1 (en) 2014-06-06 2016-08-09 Anutra Medical, Inc. Delivery system cassette
USD774182S1 (en) 2014-06-06 2016-12-13 Anutra Medical, Inc. Anesthetic delivery device
USD750768S1 (en) 2014-06-06 2016-03-01 Anutra Medical, Inc. Fluid administration syringe
WO2016025647A1 (fr) 2014-08-12 2016-02-18 Massachusetts Institute Of Technology Traitement tumoral synergique avec l'il-2, un anticorps thérapeutique, et un vaccin contre le cancer
TWI751102B (zh) 2014-08-28 2022-01-01 美商奇諾治療有限公司 對ｃｄ１９具專一性之抗體及嵌合抗原受體
LT3227336T (lt) 2014-12-05 2019-09-25 F. Hoffmann-La Roche Ag Anti-cd79b antikūnai ir jų naudojimo būdai
EP4600372A3 (fr) 2014-12-19 2025-11-19 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-myostatine, polypeptides contenant des régions fc variantes, et procédés d'utilisation
CN105837689B (zh) * 2015-01-13 2020-06-19 博生吉安科细胞技术有限公司 抗cd19单克隆抗体及其制备方法
TW202446796A (zh) 2015-02-05 2024-12-01 日商中外製藥股份有限公司 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途
WO2016149485A1 (fr) * 2015-03-17 2016-09-22 The Regents Of The University Of California Nouvelle chimio-immunothérapie pour cancer épithélial
CA2986175A1 (fr) 2015-05-26 2016-12-01 Morphosys Ag Combinaison d'un anticorps anti-cd19 et d'un inhibiteur de la tyrosine kinase de bruton et utilisations de ceux-ci
TWI870335B (zh) * 2015-06-12 2025-01-21 美商宏觀基因股份有限公司 變異的嵌合4d5抗體及其與抗pd-1抗體聯合用於治療癌症的應用
EP3310440A1 (fr) 2015-06-22 2018-04-25 Bayer Pharma Aktiengesellschaft Conjugués anticorps-médicament (adc) et conjugués lieur-promédicament (apdc) à groupes enzymatiquement clivables
WO2017008169A1 (fr) 2015-07-15 2017-01-19 Zymeworks Inc. Constructions bispécifiques de liaison à un antigène conjuguées à un médicament
MX392561B (es) 2015-08-21 2025-03-24 Morphosys Ag Combinación sinérgica de un anticuerpo anti-cd19 y un inhibidor de fosfoinositida 3-quinasa para usarse en el tratamiento de linfoma no hodgkin, leucemia linfocítica crónica y/o leucemia linfoblástica aguda.
MA44909A (fr) 2015-09-15 2018-07-25 Acerta Pharma Bv Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk
PH12018500386B1 (en) * 2015-09-18 2024-01-05 Chugai Pharmaceutical Co Ltd Il-8-binding antibodies and uses thereof
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
MA43019A (fr) * 2015-10-02 2018-08-08 Hoffmann La Roche Anticorps anti-humain cd19 à affinité élevée
WO2017060322A2 (fr) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Conjugué anticorps-médicament (adc) inhibiteur de ptefb
EP3362479A4 (fr) 2015-10-13 2019-05-15 Eureka Therapeutics, Inc. Agents de type anticorps spécifiques de l'antigène cd19 humain et leurs utilisations
AU2016342041B2 (en) 2015-10-23 2021-12-02 Eureka Therapeutics, Inc. Antibody/T-cell receptor chimeric constructs and uses thereof
JP7141336B2 (ja) 2015-12-25 2022-09-22 中外製薬株式会社 抗ミオスタチン抗体および使用方法
CN116059390A (zh) 2016-03-24 2023-05-05 拜耳制药股份公司 具有酶促可裂解基团的细胞毒性活性物质的前药
JP7037045B2 (ja) * 2016-03-28 2022-03-16 東レ株式会社 癌の治療及び／又は予防用医薬組成物
MX393455B (es) * 2016-05-27 2025-03-24 Abbvie Biotherapeutics Inc Anticuerpos anti-cd40 y sus usos.
HUE054860T2 (hu) 2016-05-30 2021-10-28 Morphosys Ag Eljárás betegekben CD19 elleni ellenanyagon alapuló terápia terápiás hasznosságának elõrejelzésére
PL3468997T3 (pl) 2016-06-08 2024-12-16 Xencor, Inc. Leczenie chorób związanych z lgG4 przeciwciałami anty-CD19 wiążącymi się krzyżowo z CD32b
US11001636B2 (en) 2016-06-15 2021-05-11 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates (ADCs) with KSP inhibitors and anti-CD123-antibodies
SG11201810429UA (en) 2016-06-27 2018-12-28 Morphosys Ag Anti-cd19 antibody formulations
EP3494991A4 (fr) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Composition pour la prophylaxie ou le traitement de maladies liées à il-8
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
US11636924B2 (en) * 2016-09-30 2023-04-25 Molecular Devices, Llc Computer device for detecting an optimal candidate compound and methods thereof
AU2017348624B2 (en) 2016-10-28 2024-09-26 Incyte Corporation Combination of anti CD19 antibody with a BCL-2 inhibitor and uses thereof
CN117731591A (zh) 2016-11-21 2024-03-22 艾里奥治疗公司 大试剂的透皮递送
CA3044682A1 (fr) 2016-12-02 2018-06-07 University Of Southern California Recepteurs immunitaires synthetiques et leurs procedes d'utilisation
CN106977605A (zh) * 2016-12-13 2017-07-25 无锡傲锐东源生物科技有限公司 抗cd19蛋白单克隆抗体及其用途
CN116327974A (zh) 2016-12-21 2023-06-27 拜耳制药股份公司 具有酶促可裂解基团的抗体-药物-缀合物(adc)
JP7030811B2 (ja) 2016-12-21 2022-03-07 バイエル・ファルマ・アクティエンゲゼルシャフト Ｋｓｐ阻害剤を有する特異的抗体－薬物コンジュゲート（ａｄｃ）
JP7174704B2 (ja) 2016-12-21 2022-11-17 バイエル・アクチエンゲゼルシヤフト 酵素開裂基を有する細胞毒性活性剤のプロドラッグ
SG11201906319XA (en) 2017-01-20 2019-08-27 Magenta Therapeutics Inc Compositions and methods for the depletion of cd137+ cells
KR20190142775A (ko) 2017-04-19 2019-12-27 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 조작된 항원 수용체를 발현하는 면역 세포
CN110741016A (zh) 2017-04-26 2020-01-31 优瑞科生物技术公司 嵌合抗体/t-细胞受体构筑体及其用途
SMT202300338T1 (it) 2017-05-31 2023-11-13 Morphosys Ag Paradigma di trattamento per un trattamento combinato di anticorpo anti-cd19 e venetoclax
WO2019011918A1 (fr) 2017-07-10 2019-01-17 International - Drug - Development - Biotech Traitement de malignités de lymphocytes b à l'aide d'anticorps anti-cd19 pro-apoptotiques afucosylés en combinaison avec des anticorps anti-cd20 ou des agents chimiothérapeutiques
CA3074524A1 (fr) 2017-09-21 2019-03-28 WuXi Biologics Ireland Limited Nouveaux anticorps anti-cd19
CN111542541B (zh) * 2017-12-22 2023-11-03 艾克隆株式会社 特异性识别恶性b细胞的抗体或其抗原结合片段、包含其的嵌合抗原受体及其用途
MY202687A (en) * 2017-12-23 2024-05-15 Uwell Biopharma Inc Pharmaceutical chimeric receptor composition and method thereof
WO2019165121A1 (fr) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Procédés d'activation et d'expansion de cellules tueuses naturelles et utilisations de celles-ci
TWI827585B (zh) 2018-03-15 2024-01-01 日商中外製藥股份有限公司 對茲卡病毒具有交叉反應性的抗登革病毒抗體及其使用方法
EP3902830A1 (fr) 2018-12-30 2021-11-03 F. Hoffmann-La Roche AG Anticorps anti-lapin cd19 et procédés d'utilisation
US11235032B2 (en) 2019-01-23 2022-02-01 Massachusetts Institute Of Technology Combination immunotherapy dosing regimen for immune checkpoint blockade
CN110009008B (zh) * 2019-03-18 2020-11-06 四川大学 基于提取的免疫固定电泳图特征对其进行自动分类的方法
WO2020219743A2 (fr) * 2019-04-24 2020-10-29 Viela Bio, Inc. Utilisation d'un anticorps anti-cd19 pour traiter une maladie auto-immune
MY209449A (en) 2019-05-03 2025-07-09 Morphosys Ag Anti-cd19 therapy in patients having a limited number of nk cells
US11246906B2 (en) 2019-06-11 2022-02-15 Alkermes Pharma Ireland Limited Compositions and methods for subcutaneous administration of cancer immunotherapy
US11642409B2 (en) 2019-06-26 2023-05-09 Massachusetts Insttute of Technology Immunomodulatory fusion protein-metal hydroxide complexes and methods thereof
WO2021067598A1 (fr) 2019-10-04 2021-04-08 Ultragenyx Pharmaceutical Inc. Procédés pour une utilisation thérapeutique améliorée d'aav recombinant
AU2020363639A1 (en) * 2019-10-08 2022-04-28 Memorial Sloan Kettering Cancer Center Combination therapy with glucarpidase with methotrexate/rituximab to treat CNS lymphoma
TWI865644B (zh) 2019-10-31 2024-12-11 德商莫菲西斯公司 用於治療白血病或淋巴瘤之抗cd19療法與來那度胺(lenalidomide)的組合
IL292213A (en) 2019-10-31 2022-06-01 Morphosys Ag Combination anti-tumor therapy including anti-cd19 antibody and gamma delta t cells
TWI790548B (zh) 2020-02-28 2023-01-21 美商美國禮來大藥廠 抗人類cd19抗體
JP2023526743A (ja) 2020-04-15 2023-06-23 アルカームス ファーマ アイルランド リミテッド 血管新生阻害剤と組み合わせた免疫刺激剤
KR20230025672A (ko) 2020-06-19 2023-02-22 에프. 호프만-라 로슈 아게 Cd3 및 cd19에 결합하는 항체
KR20230030636A (ko) 2020-06-22 2023-03-06 모르포시스 아게 항-CD19 항체, 및 SIRPα-CD47 선천성 면역 체크포인트를 차단하는 폴리펩티드를 포함하는 항-종양 조합 요법
AU2021357805A1 (en) 2020-10-06 2023-05-04 Xencor, Inc. Biomarkers, methods, and compositions for treating autoimmune disease including systemic lupus erythematous (sle)
AU2021391623A1 (en) 2020-12-04 2023-06-29 Incyte Corporation Anti-cd19 combination therapy
IL308296A (en) 2021-05-07 2024-01-01 Viela Bio Inc Use of anti-CD19 antibody to treat myasthenia gravis
AU2022325950A1 (en) 2021-08-11 2024-02-22 Viela Bio, Inc. Inebilizumab and methods of using the same in the treatment or prevention of igg4-related disease
WO2023073645A1 (fr) 2021-10-29 2023-05-04 Takeda Pharmaceutical Company Limited Thérapie avec un anticorps anti-cd19 et un inhibiteur enzymatique activateur de sumo
WO2024025602A1 (fr) 2022-07-27 2024-02-01 Viela Bio, Inc. Inebilizumab et ses méthodes d'utilisation pour une déplétion prolongée de lymphocytes b
JP2025528837A (ja) 2022-08-17 2025-09-02 インサイト・コーポレイション 抗ｃｄ１９抗体及びｅｚｈ２モジュレーターを含む治療
WO2024092031A1 (fr) 2022-10-25 2024-05-02 Seismic Therapeutic, Inc. Polypeptides fc d'igg variants et leurs utilisations

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
US5506126A (en) 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
GB8824869D0 (en) 1988-10-24 1988-11-30 Stevenson G T Synthetic antibody
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991013974A1 (fr) 1990-03-14 1991-09-19 The Biomembrane Institute Anticorps monoclonal et immunoconjugues de traitement et de detection de troubles des lymphocytes b
GB9022543D0 (en) 1990-10-17 1990-11-28 Wellcome Found Antibody production
JP4124480B2 (ja) 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
KR0137806B1 (ko) 1991-07-25 1998-04-30 케네쓰 제이. 울코트 사람의 질병 치료를 위한 재조합 항체
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
CA2118508A1 (fr) 1992-04-24 1993-11-11 Elizabeth S. Ward Production par recombinaison genetique de domaines semblables aux immunoglobulines dans les cellules procaryotes
US5686072A (en) 1992-06-17 1997-11-11 Board Of Regents, The University Of Texas Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
WO1994009363A1 (fr) 1992-10-14 1994-04-28 Board Of Regents, The University Of Texas System Diagnostic et therapie contre le cancer
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5417972A (en) 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
US5831142A (en) 1994-01-07 1998-11-03 Dana Farber Cancer Institute, Inc. Regulatory elements controlling tissue-specific gene expression
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
WO1996036360A1 (fr) 1995-05-17 1996-11-21 Regents Of The University Of Minnesota Immunoconjugues comprenant des fragments monocatenaires de regions variables d'anticorps anti-cd-19
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
JP3988200B2 (ja) 1997-03-14 2007-10-10 株式会社ジェイテクト 衝撃吸収式ステアリング装置
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6368596B1 (en) 1997-07-08 2002-04-09 Board Of Regents, The University Of Texas System Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
HK1041210A1 (zh) 1998-02-19 2002-07-05 埃克斯西特治疗公司 用於调节淋巴细胞活化的组合物及方法
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
EP1071752B1 (fr) * 1998-04-21 2003-07-09 Micromet AG Polypeptides specifiques a cd19 et cd3 et leurs utilisations
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
GB9809951D0 (en) 1998-05-08 1998-07-08 Univ Cambridge Tech Binding molecules
NZ539776A (en) 1999-01-15 2006-12-22 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP3031917A1 (fr) 1999-04-09 2016-06-15 Kyowa Hakko Kirin Co., Ltd. Procédé de contrôle de l'activité d'une molécule immunologiquement fonctionnelle
MXPA01011279A (es) 1999-05-07 2002-07-02 Genentech Inc Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b.
HK1046635B (en) 1999-06-09 2009-10-09 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target b-cells
US6451284B1 (en) 1999-08-11 2002-09-17 Idec Pharmaceuticals Corporation Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
AU6929100A (en) 1999-08-23 2001-03-19 Biocrystal Limited Methods and compositions for immunotherapy of b cell involvement in promotion ofa disease condition comprising multiple sclerosis
EP1229125A4 (fr) 1999-10-19 2005-06-01 Kyowa Hakko Kogyo Kk Procede de production d'un polypeptide
FR2801056B1 (fr) 1999-11-12 2003-03-28 Commissariat Energie Atomique Proteine presente a la surface des cellules souches hematopoietiques de la lignee lymphoide et des cellules nk, et ses applications
MXPA02009626A (es) 2000-03-31 2003-05-14 Idec Pharma Corp Uso combinado de anticuerpos anti-citocina o antagonistas y anti-cd20 para el tratamiento de linfoma de celulas b.
AU5345901A (en) 2000-04-13 2001-10-30 Univ Rockefeller Enhancement of antibody-mediated immune responses
US20020058029A1 (en) 2000-09-18 2002-05-16 Nabil Hanna Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CA2425862C (fr) 2000-11-07 2013-01-22 City Of Hope Cellules immunitaires specifiques a cd19 redirigees
WO2002060919A2 (fr) 2000-12-12 2002-08-08 Medimmune, Inc. Molecules a demi-vies longues, compositions et utilisations de celles-ci
DE10063048A1 (de) 2000-12-18 2002-07-11 Deutsches Krebsforsch Einzelketten-Antikörper mit verbesserter Stabilität
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
EP1383800A4 (fr) 2001-04-02 2004-09-22 Idec Pharma Corp Anticorps recombinants co-exprimes avec gntiii
US6661602B2 (en) 2001-09-10 2003-12-09 Hewlett-Packard Development Company, L.P. Methods and apparatus for transporting data cartridges between adjacent cartridge libraries
WO2003033654A2 (fr) 2001-10-15 2003-04-24 Immunomedics, Inc Proteines de liaison de ciblage direct
BR0213761A (pt) 2001-10-25 2005-04-12 Genentech Inc Composições, preparação farmacêutica, artigo industrializado, método de tratamento de mamìferos, célula hospedeira, método para a produção de uma glicoproteìna e uso da composição
ATE356149T1 (de) 2001-11-14 2007-03-15 Affimed Therapeutics Ag Bispezifische antikörper gegen cd19 und cd16 und deren verwendung
US20040002587A1 (en) 2002-02-20 2004-01-01 Watkins Jeffry D. Fc region variants
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
EP1534335B9 (fr) 2002-08-14 2016-01-13 Macrogenics, Inc. Anticorps specifiques du recepteur fcgammariib et procedes d'utilisation de ces anticorps
RU2346039C2 (ru) 2002-09-27 2009-02-10 БайоИ, Инк. Композиция (варианты), способ и набор для разделения клеток
KR100960560B1 (ko) 2002-09-27 2010-06-03 젠코어 인코포레이티드 최적화된 Ｆｃ 변이체 및 그의 제조 방법
US20040191328A1 (en) 2002-12-31 2004-09-30 Warrell Raymond P. Combination of gallium compounds with nonchemotherapeutic anticancer agents in the treatment of neoplasia
EP2368578A1 (fr) 2003-01-09 2011-09-28 Macrogenics, Inc. Identification et ingénierie d'anticorps avec régions FC de variante et procédés d'utilisation associés
JP2006522811A (ja) 2003-04-09 2006-10-05 ジェネンテック・インコーポレーテッド ＴＮＦαインヒビターに対して不十分な反応を示す患者の自己免疫疾患治療法
CA2737127C (fr) 2003-05-14 2016-07-26 Immunogen, Inc. Compositions d'anticorps conjugues a un maytansinoide
CA2522586C (fr) 2003-05-31 2017-02-21 Micromet Ag Compositions pharmaceutiques comprenant des constructions d'anticorps anti-cd3, anti-cd19 bispecifiques pour le traitement de troubles associes aux lymphocytes b
JP4733635B2 (ja) 2003-07-31 2011-07-27 イミューノメディクス、インコーポレイテッド 抗ｃｄ１９抗体
WO2005042019A1 (fr) 2003-10-22 2005-05-12 University Of Rochester Antiserum anti-thymocyte et son utilisation pour declencher l'apoptose des cellules b
WO2005052004A2 (fr) 2003-11-28 2005-06-09 Micromet Ag Compositions comprenant des polypeptides
DE602005016683D1 (de) 2004-07-10 2009-10-29 Fox Chase Cancer Ct Genetisch modifizierte, menschliche, natürliche killerzellenlinien:
CN1775808A (zh) * 2004-11-15 2006-05-24 中国医学科学院血液学研究所 用于靶向结合淋巴细胞白血病细胞的抗cd19的工程抗体及其用途
EP2548575A1 (fr) * 2005-02-15 2013-01-23 Duke University Anticorps anti-CD19 avec activité ADCC pour le traitement des maladies autoimmunes
JP2008538365A (ja) 2005-04-15 2008-10-23 イミュノジェン・インコーポレーテッド 腫瘍内の不均一または混合細胞集団を排除する方法
EP1885755A4 (fr) 2005-05-05 2009-07-29 Univ Duke Traitements des maladies auto-immunes par anticorps anti-cd19
US20060263367A1 (en) 2005-05-23 2006-11-23 Fey Georg H Bispecific antibody devoid of Fc region and method of treatment using same
JP2008546647A (ja) 2005-06-08 2008-12-25 デューク ユニバーシティ 移植のための抗−ｃｄ１９抗体治療
KR20080032097A (ko) 2005-06-20 2008-04-14 메다렉스, 인코포레이티드 씨디19 항체 및 그의 용도
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2007033110A2 (fr) 2005-09-12 2007-03-22 Alza Corporation Liposomes pour traiter le myélome multiple
US7759076B2 (en) 2005-10-14 2010-07-20 Esoterix, Inc. Quantitative ZAP-70 assay
AU2006332155B2 (en) 2005-12-30 2013-01-10 Cancer Research Technology Limited Anti-CD19 antibodies with reduced immunogenicity
US20070166306A1 (en) 2006-01-17 2007-07-19 Fey Georg H M Anti-CD19 antibody composition and method
US20070196274A1 (en) 2006-01-20 2007-08-23 Le Sun Immunoconjugates with improved efficacy for the treatment of diseases
US20070178103A1 (en) * 2006-01-30 2007-08-02 Fey Georg H CD19-specific immunotoxin and treatment method
JP2009533350A (ja) 2006-04-07 2009-09-17 キメロス， インコーポレイテッド Ｂ細胞悪性疾患を処置するための組成物および方法
CA2662340C (fr) * 2006-09-08 2016-08-02 Medimmune, Llc Anticorps anti-cd19 humanises, et leur utilisation dans le traitement de l'oncologie, de la transplantation et de la maladie auto-immune

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EP2066349A4 (fr) 2010-08-04
PT2066349E (pt) 2012-07-02
FIC20220042I1 (fi) 2022-10-19
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LUC00281I2 (fr) 2024-10-04
US20210061906A1 (en) 2021-03-04
BRPI0716611A8 (pt) 2022-08-09
US20180273621A1 (en) 2018-09-27
US20080138336A1 (en) 2008-06-12
MX2009002414A (es) 2009-05-20
KR20090059149A (ko) 2009-06-10
US9896505B2 (en) 2018-02-20
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ATE551071T1 (de) 2012-04-15
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LTPA2022520I1 (fr) 2022-10-25
KR101456728B1 (ko) 2014-10-31
AU2007294575B2 (en) 2013-06-27
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LTC2066349I2 (fr) 2024-05-27
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US8323653B2 (en) 2012-12-04
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US20160145335A1 (en) 2016-05-26
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