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FR22C1044I2 - ANTAGONISTS OF THE CGRP RECEIVER - Google Patents

ANTAGONISTS OF THE CGRP RECEIVER

Info

Publication number
FR22C1044I2
FR22C1044I2 FR22C1044C FR22C1044C FR22C1044I2 FR 22C1044 I2 FR22C1044 I2 FR 22C1044I2 FR 22C1044 C FR22C1044 C FR 22C1044C FR 22C1044 C FR22C1044 C FR 22C1044C FR 22C1044 I2 FR22C1044 I2 FR 22C1044I2
Authority
FR
France
Prior art keywords
antagonists
cgrp
receiver
cgrp receiver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR22C1044C
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43242489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR22C1044(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of FR22C1044I1 publication Critical patent/FR22C1044I1/en
Application granted granted Critical
Publication of FR22C1044I2 publication Critical patent/FR22C1044I2/en
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR22C1044C 2009-10-14 2022-08-11 ANTAGONISTS OF THE CGRP RECEIVER Active FR22C1044I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25147709P 2009-10-14 2009-10-14
PCT/US2010/052433 WO2011046997A1 (en) 2009-10-14 2010-10-13 Cgrp receptor antagonists

Publications (2)

Publication Number Publication Date
FR22C1044I1 FR22C1044I1 (en) 2022-09-30
FR22C1044I2 true FR22C1044I2 (en) 2023-11-17

Family

ID=43242489

Family Applications (1)

Application Number Title Priority Date Filing Date
FR22C1044C Active FR22C1044I2 (en) 2009-10-14 2022-08-11 ANTAGONISTS OF THE CGRP RECEIVER

Country Status (35)

Country Link
US (2) US8314117B2 (en)
EP (1) EP2488512B1 (en)
JP (3) JP5836279B2 (en)
KR (3) KR101875353B1 (en)
CN (1) CN102656159B (en)
AR (2) AR078638A1 (en)
AU (1) AU2010306954B2 (en)
BR (1) BR112012008828B1 (en)
CA (2) CA2777518C (en)
CL (1) CL2012000925A1 (en)
CO (1) CO6460732A2 (en)
CY (1) CY2022023I1 (en)
DK (1) DK2488512T3 (en)
EA (1) EA020409B1 (en)
ES (1) ES2441192T3 (en)
FR (1) FR22C1044I2 (en)
HR (1) HRP20140111T1 (en)
HU (1) HUS2200033I1 (en)
IL (1) IL219120A (en)
LT (1) LTC2488512I2 (en)
LU (1) LUC00272I2 (en)
MX (1) MX2012004182A (en)
NL (1) NL301187I2 (en)
NO (1) NO2022033I1 (en)
NZ (1) NZ599281A (en)
PE (1) PE20121137A1 (en)
PL (1) PL2488512T3 (en)
PT (1) PT2488512E (en)
RS (1) RS53149B (en)
SI (1) SI2488512T1 (en)
SM (1) SMT201400019B (en)
TN (1) TN2012000139A1 (en)
TW (1) TWI465448B (en)
WO (1) WO2011046997A1 (en)
ZA (1) ZA201203452B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8314117B2 (en) * 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists
US8669368B2 (en) * 2010-10-12 2014-03-11 Bristol-Myers Squibb Company Process for the preparation of cycloheptapyridine CGRP receptor antagonists
US8748429B2 (en) * 2011-04-12 2014-06-10 Bristol-Myers Squibb Company CGRP receptor antagonists
ES2746031T3 (en) * 2012-02-27 2020-03-04 Bristol Myers Squibb Co N- (5S, 6S, 9R) -5-amino-6- (2,3-difluorophenyl) -6,7,8,9-tetrahydro-5H-cyclohepta [B] pyridin-9-IL-4- salt (2-oxo-2,3-dihydro-1H-imidazo [4,5-B] pyridin-1-yl) piperidine-1-carboxylate
EP2846801B1 (en) * 2012-05-09 2017-04-05 Merck Sharp & Dohme Corp. Pyridine cgrp receptor antagonists
EP2815749A1 (en) 2013-06-20 2014-12-24 IP Gesellschaft für Management mbH Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern
TW201718574A (en) * 2015-08-12 2017-06-01 美國禮來大藥廠 CGRP receptor antagonists
GB201519195D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519196D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519194D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP receptor antagonists
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
SG11202009199YA (en) 2018-03-25 2020-10-29 Biohaven Pharm Holding Co Ltd Rimegepant for cgrp related disorders
CN114805206B (en) * 2021-01-27 2025-01-14 奥锐特药业(天津)有限公司 Industrial preparation method of high optical purity remegipam intermediate
EP4301362A1 (en) 2021-03-02 2024-01-10 CGRP Diagnostics GmbH Treatment and/or reduction of occurrence of migraine
US20250109188A1 (en) 2021-08-24 2025-04-03 Cgrp Diagnostics Gmbh Preventative treatment of migraine
CN115850266A (en) * 2021-09-26 2023-03-28 奥锐特药业(天津)有限公司 Novel crystal form of Remegeepam and preparation method thereof
CN116554164B (en) * 2022-01-27 2025-10-03 奥锐特药业(天津)有限公司 A preparation method of Remigipam
WO2023175632A1 (en) * 2022-03-17 2023-09-21 Msn Laboratories Private Limited, R&D Center Solid state forms of (5s,6s,9r)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5h-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate and processes for preparation thereof
CN116478211B (en) * 2022-04-19 2023-10-24 石家庄迪斯凯威医药科技有限公司 Novel CGRP receptor antagonist and application thereof
CN115060824B (en) * 2022-06-14 2024-03-12 浙江宏元药业股份有限公司 Liquid chromatography detection method for enantiomer impurities of ramiazepam intermediate
WO2024022434A1 (en) * 2022-07-29 2024-02-01 熙源安健医药(上海)有限公司 Pyridocycloheptane derivative, preparation method therefor, and use thereof
CN115677694A (en) * 2022-11-30 2023-02-03 南通常佑药业科技有限公司 Synthetic method of rimazepam
WO2024180562A1 (en) * 2023-03-02 2024-09-06 Natco Pharma Limited A process for the preparation of pure crystalline rimegepant and its salts thereof
CN116768938B (en) * 2023-05-17 2025-11-11 南京艾德凯腾生物医药有限责任公司 Preparation method of iron catalyst and Ruimei gem intermediate
CN119661518A (en) * 2023-09-21 2025-03-21 成都康弘药业集团股份有限公司 A small molecule drug for the treatment of CGRP-related disorders
CN117486798B (en) * 2023-12-21 2025-02-07 南京威凯尔生物医药科技有限公司 A crystal form of remegipam intermediate hydrochloride and preparation method thereof
WO2025193980A2 (en) * 2024-03-13 2025-09-18 CNS Biosciences, Inc. Method of treating neuropathic pain using an anti-cgrp inhibitor
CN119707808B (en) * 2024-12-23 2025-12-05 上海彩迩文生化科技有限公司 A method for preparing intermediates of CGRP receptor antagonists
CN119977885A (en) * 2025-04-15 2025-05-13 常州制药厂有限公司 (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ol L-tartrate and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن CGRP receptor antagonists
CA2558274A1 (en) 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd. Cycloalkanopyridine derivative
CA2583536A1 (en) 2004-10-13 2006-04-27 Merck & Co., Inc. Cgrp receptor antagonists
US20060084708A1 (en) 2004-10-14 2006-04-20 Bayer Materialscience Llc Rigid foams with good insulation properties and a process for the production of such foams
DE602005027230D1 (en) 2004-10-22 2011-05-12 Merck Sharp & Dohme CGRP RECEPTOR ANTAGONIST
EP2007763A2 (en) 2006-04-10 2008-12-31 Merck & Co., Inc. Process for the preparation of pyridine heterocycle cgrp antagonist intermediate
US8044043B2 (en) 2008-04-11 2011-10-25 Bristol-Myers Squibb Company CGRP receptor antagonists
US8143403B2 (en) 2008-04-11 2012-03-27 Bristol-Myers Squibb Company CGRP receptor antagonists
US8314117B2 (en) * 2009-10-14 2012-11-20 Bristol-Myers Squibb Company CGRP receptor antagonists

Also Published As

Publication number Publication date
EP2488512B1 (en) 2013-11-27
EA020409B1 (en) 2014-10-30
KR101875353B1 (en) 2018-07-05
IL219120A0 (en) 2012-06-28
HRP20140111T1 (en) 2014-03-14
LUC00272I2 (en) 2025-05-12
IL219120A (en) 2016-12-29
KR101755742B1 (en) 2017-07-07
US20110251223A1 (en) 2011-10-13
SI2488512T1 (en) 2014-02-28
AR078638A1 (en) 2011-11-23
PE20121137A1 (en) 2012-08-30
LTC2488512I2 (en) 2025-03-10
ES2441192T3 (en) 2014-02-03
CA2777518C (en) 2017-07-04
CY2022023I2 (en) 2023-01-05
CO6460732A2 (en) 2012-06-15
JP6109874B2 (en) 2017-04-05
KR20180080343A (en) 2018-07-11
WO2011046997A1 (en) 2011-04-21
PL2488512T3 (en) 2014-04-30
JP5836279B2 (en) 2015-12-24
HK1169390A1 (en) 2013-01-25
JP2015163625A (en) 2015-09-10
DK2488512T3 (en) 2014-02-24
HUS2200033I1 (en) 2022-08-28
PT2488512E (en) 2014-02-24
AR110069A2 (en) 2019-02-20
CL2012000925A1 (en) 2012-08-31
KR20170081737A (en) 2017-07-12
KR20120087940A (en) 2012-08-07
LTPA2022516I1 (en) 2022-08-25
CA2968176C (en) 2019-11-26
CN102656159A (en) 2012-09-05
TN2012000139A1 (en) 2013-09-19
RS53149B (en) 2014-06-30
AU2010306954A1 (en) 2012-05-03
TWI465448B (en) 2014-12-21
CA2968176A1 (en) 2011-04-21
TW201118096A (en) 2011-06-01
JP2013508281A (en) 2013-03-07
CY2022023I1 (en) 2023-01-05
ZA201203452B (en) 2014-10-29
NZ599281A (en) 2013-01-25
JP2017125054A (en) 2017-07-20
MX2012004182A (en) 2012-05-29
BR112012008828A2 (en) 2020-09-15
BR112012008828B1 (en) 2021-11-23
EA201270561A1 (en) 2012-12-28
EP2488512A1 (en) 2012-08-22
AU2010306954B2 (en) 2016-05-26
US8314117B2 (en) 2012-11-20
JP6258537B2 (en) 2018-01-10
NO2022033I1 (en) 2022-07-22
US20130053570A1 (en) 2013-02-28
NL301187I2 (en) 2022-08-04
CN102656159B (en) 2015-07-01
KR101990755B1 (en) 2019-06-18
SMT201400019B (en) 2014-05-07
FR22C1044I1 (en) 2022-09-30
CA2777518A1 (en) 2011-04-21

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