FR2239471A1 - Corynanthine hydrazides - as therapeutic agents - Google Patents
Corynanthine hydrazides - as therapeutic agentsInfo
- Publication number
- FR2239471A1 FR2239471A1 FR7427032A FR7427032A FR2239471A1 FR 2239471 A1 FR2239471 A1 FR 2239471A1 FR 7427032 A FR7427032 A FR 7427032A FR 7427032 A FR7427032 A FR 7427032A FR 2239471 A1 FR2239471 A1 FR 2239471A1
- Authority
- FR
- France
- Prior art keywords
- corynanthine
- hydrazides
- therapeutic agents
- alkyl
- r1cox
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BLGXFZZNTVWLAY-DKJBZYCGSA-N Corynanthine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-DKJBZYCGSA-N 0.000 title abstract 2
- DDRUVFKWNXGBTK-UHFFFAOYSA-N Corynanthine Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)OC(=O)C)=C3NC2=C1 DDRUVFKWNXGBTK-UHFFFAOYSA-N 0.000 title abstract 2
- BLGXFZZNTVWLAY-UHFFFAOYSA-N beta-Yohimbin Natural products C1=CC=C2C(CCN3CC4CCC(O)C(C4CC33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D459/00—Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Title cpds. of formula (I): (where R is NHCOOR1 or R1 is alkyl, arylalkyl, alkylaryl or aryl; R2-4 are each H, OH, alkoxy, mono- or dialkylamino or R2 + R3 are -OCH2O and R4 is H and "alkyl" contain 1-6C) are prepd. by reacting corynanthine with N2H4 and treating the hydrazide thus obtd. with R1COX or (where X is halogen).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE803210 | 1973-08-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2239471A1 true FR2239471A1 (en) | 1975-02-28 |
| FR2239471B3 FR2239471B3 (en) | 1977-06-03 |
Family
ID=3860893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7427032A Granted FR2239471A1 (en) | 1973-08-03 | 1974-08-02 | Corynanthine hydrazides - as therapeutic agents |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2239471A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700087B2 (en) | 1997-09-11 | 2010-04-20 | Cambridge Enterprise Limited | Compounds and methods to inhibit or augment an inflammatory response |
| US7989466B2 (en) | 1999-03-17 | 2011-08-02 | Cambridge Enterprise Limited | Methods to inhibit or augment an inflammatory response |
-
1974
- 1974-08-02 FR FR7427032A patent/FR2239471A1/en active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7700087B2 (en) | 1997-09-11 | 2010-04-20 | Cambridge Enterprise Limited | Compounds and methods to inhibit or augment an inflammatory response |
| US7989466B2 (en) | 1999-03-17 | 2011-08-02 | Cambridge Enterprise Limited | Methods to inhibit or augment an inflammatory response |
| US8481558B2 (en) | 1999-03-17 | 2013-07-09 | Cambridge Enterprise Limited | Compounds to inhibit or augment an inflammatory response |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2239471B3 (en) | 1977-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |