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FR2291745A1 - Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications - Google Patents

Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications

Info

Publication number
FR2291745A1
FR2291745A1 FR7438080A FR7438080A FR2291745A1 FR 2291745 A1 FR2291745 A1 FR 2291745A1 FR 7438080 A FR7438080 A FR 7438080A FR 7438080 A FR7438080 A FR 7438080A FR 2291745 A1 FR2291745 A1 FR 2291745A1
Authority
FR
France
Prior art keywords
alpha
cpds
inflammatory
unsubstd
chromone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7438080A
Other languages
English (en)
Other versions
FR2291745B1 (fr
Inventor
Eugene Boschetti
Philippe Briet
Jean-Jacques Berthelon
Jean-Claude Depin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS filed Critical LIPHA SAS
Priority to FR7438080A priority Critical patent/FR2291745A1/fr
Priority to DE19752549745 priority patent/DE2549745A1/de
Priority to CH1460375A priority patent/CH612193A5/xx
Priority to IL48465A priority patent/IL48465A/xx
Priority to US05/631,401 priority patent/US4097582A/en
Priority to ZA00757151A priority patent/ZA757151B/xx
Priority to CA239,665A priority patent/CA1067074A/fr
Priority to ES442616A priority patent/ES442616A1/es
Priority to IE2518/75A priority patent/IE43539B1/en
Priority to AU86707/75A priority patent/AU491931B2/en
Priority to SE7512994A priority patent/SE420606B/xx
Priority to BE161999A priority patent/BE835724A/fr
Priority to GB47707/75A priority patent/GB1512537A/en
Priority to MX002840U priority patent/MX3009E/es
Priority to DK519975A priority patent/DK519975A/da
Priority to NO753886A priority patent/NO146636C/no
Priority to HU75LI283A priority patent/HU175952B/hu
Priority to DD7500199188A priority patent/DD130935A5/xx
Priority to NL7513597A priority patent/NL7513597A/xx
Priority to JP50138775A priority patent/JPS6039676B2/ja
Priority to AT884275A priority patent/AT345829B/de
Priority to DD7500189584A priority patent/DD128866A5/xx
Publication of FR2291745A1 publication Critical patent/FR2291745A1/fr
Priority to US05/823,144 priority patent/US4122200A/en
Application granted granted Critical
Publication of FR2291745B1 publication Critical patent/FR2291745B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7438080A 1974-10-10 1974-11-20 Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications Granted FR2291745A1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR7438080A FR2291745A1 (fr) 1974-11-20 1974-11-20 Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications
DE19752549745 DE2549745A1 (de) 1974-11-20 1975-11-06 Durch einen chromonylrest substituierte propionsaeuren sowie deren derivate und verwendungen
CH1460375A CH612193A5 (fr) 1974-11-20 1975-11-11
IL48465A IL48465A (en) 1974-11-20 1975-11-11 2-(2'-(substituted phenyl-,thienyl-or furyl)chromon-6'-yl)propionic acids and their salts,their preparation and pharmaceutical compositions containing them
US05/631,401 US4097582A (en) 1974-10-10 1975-11-12 6',2-(2'-Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof
ZA00757151A ZA757151B (en) 1974-11-20 1975-11-13 New 6',2-(2'-acrylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof
CA239,665A CA1067074A (fr) 1974-11-20 1975-11-14 Acides 6',2-(2'-arylchromonyl) propioniques
ES442616A ES442616A1 (es) 1974-11-20 1975-11-14 Procedimiento de preparacion de acidos propionicos sustitui-dos por una radical cromonilo y sus esteres.
AU86707/75A AU491931B2 (en) 1974-11-20 1975-11-18 Chromone derivatives
IE2518/75A IE43539B1 (en) 1974-11-20 1975-11-18 2-(2'-aryl-6-chromonyl) propionic acids, and an analgesic and anti-inflammatory derivatives thereof
MX002840U MX3009E (es) 1974-11-20 1975-11-19 Procedimiento para la obtencion de acidos propionicos substituidos por un radical cromonilo y sus esteres
GB47707/75A GB1512537A (en) 1974-11-20 1975-11-19 2-(2'-aryl-6'-chromonyl) propionic acids and analgesic and anti-inflammatory derivatives thereof
SE7512994A SE420606B (sv) 1974-11-20 1975-11-19 Forfarande for framstellning av med kromonylgrupp substituerade propionsyror
DK519975A DK519975A (da) 1974-11-20 1975-11-19 Fremgangsmade til fremstilling af 6', 2-(2'-arylkromonyl)-propionsyrer
NO753886A NO146636C (no) 1974-11-20 1975-11-19 Analogifremgangsmaate for fremstilling av nye propionsyrederivater.
HU75LI283A HU175952B (en) 1974-11-20 1975-11-19 Process for preparing propionic acids substituted with chromonyl group and derivatives thereof
BE161999A BE835724A (fr) 1974-11-20 1975-11-19 Nouveaux acides propioniques substitues par un radical chromonyle, leurs derives et leurs applications
NL7513597A NL7513597A (nl) 1974-11-20 1975-11-20 Werkwijze voor de bereiding van met een chromonyl- groep gesubstitueerde propionzuur.
DD7500199188A DD130935A5 (de) 1974-11-20 1975-11-20 Verfahren zur herstellung von propionsaeureestern
JP50138775A JPS6039676B2 (ja) 1974-11-20 1975-11-20 クロモニル置換プロピオン酸及びそれらのエステルの製造法
AT884275A AT345829B (de) 1974-11-20 1975-11-20 Verfahren zur herstellung von neuen chromonylpropionsaeurederivaten und deren salzen
DD7500189584A DD128866A5 (de) 1974-11-20 1975-11-20 Verfahren zur herstellung von durch einen chromonylrest substituierten propionsaeuren
US05/823,144 US4122200A (en) 1974-11-20 1977-08-09 6',2-(2'Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7438080A FR2291745A1 (fr) 1974-11-20 1974-11-20 Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications

Publications (2)

Publication Number Publication Date
FR2291745A1 true FR2291745A1 (fr) 1976-06-18
FR2291745B1 FR2291745B1 (fr) 1978-07-28

Family

ID=9145063

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7438080A Granted FR2291745A1 (fr) 1974-10-10 1974-11-20 Nouveaux acides inferieurs substitues par un radical chromonyl, leurs derives et leurs applications

Country Status (6)

Country Link
BE (1) BE835724A (fr)
DD (1) DD130935A5 (fr)
FR (1) FR2291745A1 (fr)
HU (1) HU175952B (fr)
SE (1) SE420606B (fr)
ZA (1) ZA757151B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440933A1 (fr) * 1978-11-13 1980-06-06 Givaudan & Cie Sa Derive du dibenzoylmethane utilisable comme agent de protection contre la lumiere
FR2513992A1 (fr) * 1981-05-20 1983-04-08 Oreal Nouveaux derives hydroxyles du dibenzoylmethane et leur procede de preparation
EP0080419A3 (en) * 1981-11-25 1983-10-12 Lipha, Lyonnaise Industrielle Pharmaceutique 8-haloalkyl-4h-(1)-benzopyran-4-ones and preparation processes
FR2526658A2 (fr) * 1981-05-20 1983-11-18 Oreal Compositions cosmetiques contenant des derives hydroxyles du dibenzoylmethane et leur utilisation pour la protection de l'epiderme humain contre les rayons ultraviolets, nouveaux derives hydroxyles du dibenzoylmethane utilises et leur procede de preparation
US4814162A (en) * 1981-05-20 1989-03-21 L'oreal Cosmetic compositions containing hydroxyl derivatives of dibenzoylmethane and their use in protecting the skin against ultraviolet rays and derivatives for use therein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440933A1 (fr) * 1978-11-13 1980-06-06 Givaudan & Cie Sa Derive du dibenzoylmethane utilisable comme agent de protection contre la lumiere
FR2513992A1 (fr) * 1981-05-20 1983-04-08 Oreal Nouveaux derives hydroxyles du dibenzoylmethane et leur procede de preparation
FR2526658A2 (fr) * 1981-05-20 1983-11-18 Oreal Compositions cosmetiques contenant des derives hydroxyles du dibenzoylmethane et leur utilisation pour la protection de l'epiderme humain contre les rayons ultraviolets, nouveaux derives hydroxyles du dibenzoylmethane utilises et leur procede de preparation
US4814162A (en) * 1981-05-20 1989-03-21 L'oreal Cosmetic compositions containing hydroxyl derivatives of dibenzoylmethane and their use in protecting the skin against ultraviolet rays and derivatives for use therein
EP0080419A3 (en) * 1981-11-25 1983-10-12 Lipha, Lyonnaise Industrielle Pharmaceutique 8-haloalkyl-4h-(1)-benzopyran-4-ones and preparation processes

Also Published As

Publication number Publication date
FR2291745B1 (fr) 1978-07-28
SE420606B (sv) 1981-10-19
DD130935A5 (de) 1978-05-17
SE7512994L (sv) 1976-05-21
ZA757151B (en) 1976-10-27
HU175952B (en) 1980-11-28
BE835724A (fr) 1976-05-19

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