FR2267777A1 - 1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictors - Google Patents
1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictorsInfo
- Publication number
- FR2267777A1 FR2267777A1 FR7413521A FR7413521A FR2267777A1 FR 2267777 A1 FR2267777 A1 FR 2267777A1 FR 7413521 A FR7413521 A FR 7413521A FR 7413521 A FR7413521 A FR 7413521A FR 2267777 A1 FR2267777 A1 FR 2267777A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- methyl
- chromanes
- constrictors
- broncho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002269 analeptic agent Substances 0.000 title 1
- 230000003555 analeptic effect Effects 0.000 title 1
- 229940035676 analgesics Drugs 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 230000003361 anti-bronchoconstrictory effect Effects 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 239000003699 antiulcer agent Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- NZVZVGPYTICZBZ-UHFFFAOYSA-N 1-benzylpiperidine Chemical compound C=1C=CC=CC=1CN1CCCCC1 NZVZVGPYTICZBZ-UHFFFAOYSA-N 0.000 abstract 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical group CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
- QXLWTFHKUXETCB-UHFFFAOYSA-N 2,3,4,7-tetrahydropyrano[2,3-e]indole Chemical class C1CCOC2=C1C=CC1=C2C=CN1 QXLWTFHKUXETCB-UHFFFAOYSA-N 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Pyrrolochromanes of formula (I): (where R1 = H, 1-4C alkyl, phenyl, or methoxycarbonyl; R2 and R3 = H, 1-4C alkyl, or together with the C atoms to which they are attached from a cyclopentane, cyclohexane, N-benzyl piperidine, or N-methyl piperidine ring; and R4= OH, amino opt. subst. by 1 or 2, 1-4C alkyl gps, or pyrrolidino) are new (I) may be given orally as tablets etc. at dosages of 50-400 mg (1-6 daily), as drops containing 0.5-5% (I) (20-60 drops, 1-3 times daily), parenterally as injectable ampoules containing 10-250 mg (I) (1-3 daily), or rectally as suppositories containing 25-250 mg (I) (1-3 daily).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7413521A FR2267777A1 (en) | 1974-04-18 | 1974-04-18 | 1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7413521A FR2267777A1 (en) | 1974-04-18 | 1974-04-18 | 1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2267777A1 true FR2267777A1 (en) | 1975-11-14 |
| FR2267777B1 FR2267777B1 (en) | 1977-11-10 |
Family
ID=9137789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7413521A Granted FR2267777A1 (en) | 1974-04-18 | 1974-04-18 | 1-Phenyl-2-methyl-3-ethoxy carbonyl pyrrolo chromanes - useful as anti-ulcer agents, analgesics, anti-inflammatories, respiratory analeptics and anti-broncho constrictors |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2267777A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485539A1 (en) * | 1980-06-26 | 1981-12-31 | Sori Soc Rech Ind | NEW PYRANNO-INDOLE DERIVATIVE, PROCESS FOR PREPARING THE SAME AND THERAPEUTIC APPLICATION THEREOF |
-
1974
- 1974-04-18 FR FR7413521A patent/FR2267777A1/en active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485539A1 (en) * | 1980-06-26 | 1981-12-31 | Sori Soc Rech Ind | NEW PYRANNO-INDOLE DERIVATIVE, PROCESS FOR PREPARING THE SAME AND THERAPEUTIC APPLICATION THEREOF |
| EP0043752A1 (en) * | 1980-06-26 | 1982-01-13 | SOCIETE DE RECHERCHES INDUSTRIELLES S.O.R.I. Société anonyme dite: | Pyranoindole derivative and process for its preparation |
| US4680411A (en) * | 1980-06-26 | 1987-07-14 | Societe De Recherches Industrielles | Pyrano[2,3-g]indoles useful as anti-ulcerous, anti-inflammatory and antalgic agent |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2267777B1 (en) | 1977-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |