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FR2253522B1 - - Google Patents

Info

Publication number
FR2253522B1
FR2253522B1 FR7440041A FR7440041A FR2253522B1 FR 2253522 B1 FR2253522 B1 FR 2253522B1 FR 7440041 A FR7440041 A FR 7440041A FR 7440041 A FR7440041 A FR 7440041A FR 2253522 B1 FR2253522 B1 FR 2253522B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7440041A
Other versions
FR2253522A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2253522A1 publication Critical patent/FR2253522A1/fr
Application granted granted Critical
Publication of FR2253522B1 publication Critical patent/FR2253522B1/fr
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FR7440041A 1973-12-10 1974-12-06 Expired FR2253522B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2361390A DE2361390A1 (de) 1973-12-10 1973-12-10 Isochinolinderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
FR2253522A1 FR2253522A1 (fr) 1975-07-04
FR2253522B1 true FR2253522B1 (fr) 1978-06-30

Family

ID=5900348

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7440041A Expired FR2253522B1 (fr) 1973-12-10 1974-12-06

Country Status (18)

Country Link
US (1) US3985881A (fr)
JP (1) JPS5088077A (fr)
AT (1) AT351026B (fr)
BE (1) BE823027A (fr)
CA (1) CA1053675A (fr)
CH (1) CH605776A5 (fr)
CS (1) CS188933B2 (fr)
DD (1) DD115666A5 (fr)
DE (1) DE2361390A1 (fr)
DK (1) DK137007C (fr)
ES (1) ES432716A1 (fr)
FR (1) FR2253522B1 (fr)
GB (1) GB1447611A (fr)
HU (1) HU171483B (fr)
IL (1) IL46160A0 (fr)
NL (1) NL7416050A (fr)
SE (1) SE7415247L (fr)
ZA (1) ZA747820B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504250A1 (de) * 1975-02-01 1976-08-05 Merck Patent Gmbh Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) * 1978-10-18 1980-11-04 Miles Laboratories, Inc. Isoquinoline propionamides exhibiting analgesic properties
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
DE3713743A1 (de) * 1987-04-24 1988-11-17 Boehringer Ingelheim Kg Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE68910999T2 (de) * 1988-02-19 1994-03-24 Smithkline Beecham Farma 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten.
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
GB0225884D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US9604930B2 (en) * 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
AU2016316436B2 (en) * 2015-09-01 2021-04-29 Merck Patent Gmbh Method for the production of praziquantel and precursors thereof
CA3001857A1 (fr) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Composes, compositions et methodes d'utilisation contre des granules de stress
IL273428B2 (en) 2017-09-22 2023-09-01 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
BR112020008851A2 (pt) 2017-11-06 2020-10-20 Jubilant Prodel LLC composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas
JP7368369B2 (ja) 2017-11-24 2023-10-24 ジュビラント・エピスクライブ・エルエルシー Prmt5阻害剤としてのヘテロ環式化合物
JP7279063B6 (ja) 2018-03-13 2024-02-15 ジュビラント プローデル エルエルシー Pd1/pd-l1相互作用/活性化の阻害剤としての二環式化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612503A (en) * 1949-04-19 1952-09-30 Smith Kline French Lab Basic ether-substituted isoquinolines
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3483206A (en) * 1967-12-15 1969-12-09 Ciba Geigy Corp N-isoquinolylalkanoyl-n-arylamines
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils

Also Published As

Publication number Publication date
DK137007C (da) 1978-06-05
GB1447611A (en) 1976-08-25
CS188933B2 (en) 1979-03-30
CH605776A5 (fr) 1978-10-13
JPS5088077A (fr) 1975-07-15
DK639674A (fr) 1975-08-11
HU171483B (hu) 1978-01-28
NL7416050A (nl) 1975-06-12
US3985881A (en) 1976-10-12
BE823027A (fr) 1975-06-06
DK137007B (da) 1978-01-02
FR2253522A1 (fr) 1975-07-04
ZA747820B (en) 1975-12-31
IL46160A0 (en) 1975-02-10
AU7625774A (en) 1976-06-10
PL93405B1 (fr) 1977-05-30
AT351026B (de) 1979-07-10
DE2361390A1 (de) 1975-06-19
CA1053675A (fr) 1979-05-01
ATA981974A (de) 1978-12-15
SE7415247L (fr) 1975-06-11
DD115666A5 (fr) 1975-10-12
ES432716A1 (es) 1977-03-01

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Legal Events

Date Code Title Description
ST Notification of lapse