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FR2115060A1 - Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin - Google Patents

Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin

Info

Publication number
FR2115060A1
FR2115060A1 FR7042536A FR7042536A FR2115060A1 FR 2115060 A1 FR2115060 A1 FR 2115060A1 FR 7042536 A FR7042536 A FR 7042536A FR 7042536 A FR7042536 A FR 7042536A FR 2115060 A1 FR2115060 A1 FR 2115060A1
Authority
FR
France
Prior art keywords
aspirin
derivs
arginine
lysine
freeze
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7042536A
Other languages
French (fr)
Other versions
FR2115060B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabio
Original Assignee
Metabio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabio filed Critical Metabio
Priority to FR7042536A priority Critical patent/FR2115060A1/en
Publication of FR2115060A1 publication Critical patent/FR2115060A1/en
Application granted granted Critical
Publication of FR2115060B1 publication Critical patent/FR2115060B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/90—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl and carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. are soluble derivs. of aspirin which are more easily prepd. than by earlier crystallisation processes. Prepd. by gradual addn. of aspirin to a stirred soln. of lysine or arginine, e.g. in water, filtering and freeze-drying, e.g. in vials.
FR7042536A 1970-11-26 1970-11-26 Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin Granted FR2115060A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7042536A FR2115060A1 (en) 1970-11-26 1970-11-26 Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7042536A FR2115060A1 (en) 1970-11-26 1970-11-26 Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin

Publications (2)

Publication Number Publication Date
FR2115060A1 true FR2115060A1 (en) 1972-07-07
FR2115060B1 FR2115060B1 (en) 1974-08-30

Family

ID=9064778

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7042536A Granted FR2115060A1 (en) 1970-11-26 1970-11-26 Freeze-dried acetylsalicylates of lysine and arginine - easily prepd derivs of aspirin

Country Status (1)

Country Link
FR (1) FR2115060A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2210389A1 (en) * 1972-12-15 1974-07-12 Synthelabo Diacetoxy benzoic acid salts with amino acids - inhibitors of thrombocyte aggregation, free from undesirable side effects
EP0324402A1 (en) * 1988-01-13 1989-07-19 EURORESEARCH S.r.L. Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process
EP0425362A3 (en) * 1989-10-24 1991-11-21 Roussel-Uclaf Furosemide salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them
GB2240041B (en) * 1989-12-22 1993-09-01 Scras Agents for blocking endothelin derived relaxing factor
FR2714292A1 (en) * 1993-12-23 1995-06-30 Synthelabo Medicaments contg. lysine acetyl-salicylate and vitamin E
EP0736301A1 (en) * 1995-04-07 1996-10-09 Synthelabo Pharmaceutical composition containing lysine acetylsalicylate and vitamin E
WO2002005782A3 (en) * 2000-07-18 2003-10-02 Bayer Ag Stable salts of o-acetylsalicyclic with basic amino acids
AU2004218728B2 (en) * 2000-07-18 2006-11-09 Bayer Healthcare Ag Stable salts of O-acetylsalicyclic acid with basic amino acids
FR2950625A1 (en) * 2009-09-30 2011-04-01 Holis Technologies Making O-acetylsalicylic acid salt of basic amino acid comprises collecting aqueous solution of basic amino acid, O-acetylsalicylic acid solution in organic solvent, reacting to obtain desired salt, adding acetone to medium and isolating
WO2011039432A1 (en) * 2009-09-30 2011-04-07 Holis Technologies Method for preparing a salt of o-acetylsalicylic acid and a basic amino acid, and resulting composition
CN114795988A (en) * 2022-03-07 2022-07-29 山东滨州智源生物科技有限公司 Water-soluble salicylic acid and preparation method and application thereof

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2210389A1 (en) * 1972-12-15 1974-07-12 Synthelabo Diacetoxy benzoic acid salts with amino acids - inhibitors of thrombocyte aggregation, free from undesirable side effects
EP0324402A1 (en) * 1988-01-13 1989-07-19 EURORESEARCH S.r.L. Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process
EP0425362A3 (en) * 1989-10-24 1991-11-21 Roussel-Uclaf Furosemide salts, process for their preparation, their use as medicines and pharmaceutical compositions containing them
GB2240041B (en) * 1989-12-22 1993-09-01 Scras Agents for blocking endothelin derived relaxing factor
FR2714292A1 (en) * 1993-12-23 1995-06-30 Synthelabo Medicaments contg. lysine acetyl-salicylate and vitamin E
EP0736301A1 (en) * 1995-04-07 1996-10-09 Synthelabo Pharmaceutical composition containing lysine acetylsalicylate and vitamin E
WO2002005782A3 (en) * 2000-07-18 2003-10-02 Bayer Ag Stable salts of o-acetylsalicyclic with basic amino acids
AU2001278471B2 (en) * 2000-07-18 2004-07-22 Bayer Schering Pharma Aktiengesellschaft Stable salts of o-acetylsalicyclic with basic amino acids
AU2004218728B2 (en) * 2000-07-18 2006-11-09 Bayer Healthcare Ag Stable salts of O-acetylsalicyclic acid with basic amino acids
AU2004218728B8 (en) * 2000-07-18 2006-12-07 Bayer Healthcare Ag Stable salts of O-acetylsalicyclic acid with basic amino acids
US7449198B2 (en) 2000-07-18 2008-11-11 Bayer Healthcare Ag Stable salts of O-acetylsalicylic acid with basic amino acids
CZ300337B6 (en) * 2000-07-18 2009-04-22 Bayer Healthcare Ag Stable salts of o-acetylsalicylic acid with basic amino acids
FR2950625A1 (en) * 2009-09-30 2011-04-01 Holis Technologies Making O-acetylsalicylic acid salt of basic amino acid comprises collecting aqueous solution of basic amino acid, O-acetylsalicylic acid solution in organic solvent, reacting to obtain desired salt, adding acetone to medium and isolating
WO2011039432A1 (en) * 2009-09-30 2011-04-07 Holis Technologies Method for preparing a salt of o-acetylsalicylic acid and a basic amino acid, and resulting composition
FR2965261A1 (en) * 2009-09-30 2012-03-30 Holis Technologies PROCESS FOR THE PREPARATION OF AN O-ACETYLSALICYLIC ACID SALT OF A BASIC AMINO ACID AND COMPOSITION OBTAINED THEREBY
CN114795988A (en) * 2022-03-07 2022-07-29 山东滨州智源生物科技有限公司 Water-soluble salicylic acid and preparation method and application thereof

Also Published As

Publication number Publication date
FR2115060B1 (en) 1974-08-30

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Legal Events

Date Code Title Description
TP Transmission of property