FR2100698A1 - 4-amino-1-substd-1h-pyrazolo (3,4-b) pyridine -5-carboxylic acids - and esters cns depressants antiinflammatories - Google Patents
4-amino-1-substd-1h-pyrazolo (3,4-b) pyridine -5-carboxylic acids - and esters cns depressants antiinflammatoriesInfo
- Publication number
- FR2100698A1 FR2100698A1 FR7119340A FR7119340A FR2100698A1 FR 2100698 A1 FR2100698 A1 FR 2100698A1 FR 7119340 A FR7119340 A FR 7119340A FR 7119340 A FR7119340 A FR 7119340A FR 2100698 A1 FR2100698 A1 FR 2100698A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- antiinflammatories
- substd
- pyrazolo
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000003874 central nervous system depressant Substances 0.000 title abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- -1 R3 and R4 are H Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The new cpds are of formula: in which R is H or alkyl, R1 is alkyl, phenyl or phenyl alkylene, R2 is H or alkyl, R3 and R4 are H, alkyl, phenylalkylene, dialkylamino-alkylene or R5, R6-phenyl where R5 and R6 are H, alkyl, CF3 or COOH, or NR3R4 represents R7, R8-pyrrolidino, R7, R8 pyridazinyl R7, R8-piperidino, R7, R8-pyrazolyl, R7, R8-pyrimidyl R7, R8 dihydropyridazinyl or R7, R8-piperazinyl, where R7 and R8 are H, alkyl or hydeozyalkyl, (all alkyl gps being lower alkyl) together with their acid addn salts. They are prepared by reaction of the corres. 4-alkoxy, or 4-halo-cpds with HNR3R4. They have CNS depressant antiinflammatory and analgesic activity, and may be used in the treatment of asthma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4156870A | 1970-05-28 | 1970-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2100698A1 true FR2100698A1 (en) | 1972-03-24 |
| FR2100698B1 FR2100698B1 (en) | 1974-08-23 |
Family
ID=21917210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7119340A Granted FR2100698A1 (en) | 1970-05-28 | 1971-05-27 | 4-amino-1-substd-1h-pyrazolo (3,4-b) pyridine -5-carboxylic acids - and esters cns depressants antiinflammatories |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS554105B1 (en) |
| BE (1) | BE767842A (en) |
| CA (1) | CA920592A (en) |
| CH (1) | CH527208A (en) |
| DE (1) | DE2123318C2 (en) |
| ES (1) | ES390163A1 (en) |
| FR (1) | FR2100698A1 (en) |
| HU (1) | HU163173B (en) |
| IE (1) | IE35118B1 (en) |
| NL (1) | NL172657C (en) |
| SE (1) | SE367202B (en) |
| YU (1) | YU37344B (en) |
| ZA (1) | ZA711710B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2187781A1 (en) * | 1972-06-13 | 1974-01-18 | Fratmann Ag | |
| FR2189037A1 (en) * | 1972-06-16 | 1974-01-25 | Squibb & Sons Inc | |
| FR2206102A1 (en) * | 1972-11-15 | 1974-06-07 | Squibb & Sons Inc |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3804843A (en) * | 1971-12-23 | 1974-04-16 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine carbonitriles |
| US3833598A (en) * | 1972-12-29 | 1974-09-03 | Squibb & Sons Inc | Amino derivatives of pyrazolopyridine-6-carboxylic acids and esters |
| EP2690101B1 (en) | 2007-12-19 | 2015-06-24 | Genentech, Inc. | 5-Anilinoimidazopyridines and Methods of Use |
| PE20110570A1 (en) * | 2008-07-01 | 2011-08-26 | Genentech Inc | REPLACED BICYCLE HETEROCYCLES |
| CA2727252A1 (en) | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Isoindolone derivatives as mek kinase inhibitors and methods of use |
-
1971
- 1971-03-16 CA CA107869A patent/CA920592A/en not_active Expired
- 1971-03-16 ZA ZA711710A patent/ZA711710B/en unknown
- 1971-03-23 IE IE379/71A patent/IE35118B1/en unknown
- 1971-04-14 ES ES390163A patent/ES390163A1/en not_active Expired
- 1971-04-21 HU HUSU614A patent/HU163173B/hu unknown
- 1971-04-28 YU YU1066/71A patent/YU37344B/en unknown
- 1971-05-03 CH CH652971A patent/CH527208A/en not_active IP Right Cessation
- 1971-05-11 JP JP3147571A patent/JPS554105B1/ja active Pending
- 1971-05-11 DE DE2123318A patent/DE2123318C2/en not_active Expired
- 1971-05-14 NL NLAANVRAGE7106688,A patent/NL172657C/en not_active IP Right Cessation
- 1971-05-27 SE SE06895/71A patent/SE367202B/xx unknown
- 1971-05-27 FR FR7119340A patent/FR2100698A1/en active Granted
- 1971-05-28 BE BE767842A patent/BE767842A/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2187781A1 (en) * | 1972-06-13 | 1974-01-18 | Fratmann Ag | |
| FR2189037A1 (en) * | 1972-06-16 | 1974-01-25 | Squibb & Sons Inc | |
| FR2206102A1 (en) * | 1972-11-15 | 1974-06-07 | Squibb & Sons Inc |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2123318C2 (en) | 1984-05-03 |
| ES390163A1 (en) | 1973-07-01 |
| SE367202B (en) | 1974-05-20 |
| CA920592A (en) | 1973-02-06 |
| CH527208A (en) | 1972-08-31 |
| FR2100698B1 (en) | 1974-08-23 |
| NL172657B (en) | 1983-05-02 |
| HU163173B (en) | 1973-06-28 |
| IE35118L (en) | 1971-11-28 |
| NL7106688A (en) | 1971-11-30 |
| DE2123318A1 (en) | 1971-12-09 |
| JPS554105B1 (en) | 1980-01-29 |
| NL172657C (en) | 1983-10-03 |
| BE767842A (en) | 1971-11-29 |
| YU106671A (en) | 1983-04-27 |
| ZA711710B (en) | 1971-12-29 |
| IE35118B1 (en) | 1975-11-12 |
| YU37344B (en) | 1984-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |