FR2196794A1 - 1-(pyridyl)-3-substd-thiourea derivs - hypoxia inhibitors - Google Patents
1-(pyridyl)-3-substd-thiourea derivs - hypoxia inhibitorsInfo
- Publication number
- FR2196794A1 FR2196794A1 FR7230248A FR7230248A FR2196794A1 FR 2196794 A1 FR2196794 A1 FR 2196794A1 FR 7230248 A FR7230248 A FR 7230248A FR 7230248 A FR7230248 A FR 7230248A FR 2196794 A1 FR2196794 A1 FR 2196794A1
- Authority
- FR
- France
- Prior art keywords
- substd
- pyridyl
- opt
- hypoxia
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010021143 Hypoxia Diseases 0.000 title 1
- 230000007954 hypoxia Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 101100037762 Caenorhabditis elegans rnh-2 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- -1 piperazino Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel title cpds of formula- R-NH-C-NH-R1 (where one of R and R1=pyridyl the other is pyridyl, lower alkyl (substd by lower alkoxy, hydroxy, lower alkoxycarbonyl, carbonyl, aralkylthio, N3-pyridylthioureido-alkyl-dithio or lower alkylamino), amino (opt. substd by lower alkyl, aryl, aralkyl or acyl). morpholino opt. aralkyl substd piperazino or lower alkylidene-amino (the alkylidene radical being opt. substd by pyridyl) and their acid addn salts are prepd by reaction of RNH2 with R1NCS and R1NGCSSA (where A=lower alkyl).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7230248A FR2196794A1 (en) | 1972-08-24 | 1972-08-24 | 1-(pyridyl)-3-substd-thiourea derivs - hypoxia inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7230248A FR2196794A1 (en) | 1972-08-24 | 1972-08-24 | 1-(pyridyl)-3-substd-thiourea derivs - hypoxia inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2196794A1 true FR2196794A1 (en) | 1974-03-22 |
| FR2196794B1 FR2196794B1 (en) | 1975-08-08 |
Family
ID=9103526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7230248A Granted FR2196794A1 (en) | 1972-08-24 | 1972-08-24 | 1-(pyridyl)-3-substd-thiourea derivs - hypoxia inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2196794A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1218247B (en) * | 1960-06-09 | 1966-06-02 | Riedel & Co | Acid galvanic copper bath |
| GB1211041A (en) * | 1967-01-24 | 1970-11-04 | Egyt Gyogyszervegyeszeti Gyar | Thiocarbamide derivatives |
-
1972
- 1972-08-24 FR FR7230248A patent/FR2196794A1/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1218247B (en) * | 1960-06-09 | 1966-06-02 | Riedel & Co | Acid galvanic copper bath |
| GB1211041A (en) * | 1967-01-24 | 1970-11-04 | Egyt Gyogyszervegyeszeti Gyar | Thiocarbamide derivatives |
Non-Patent Citations (1)
| Title |
|---|
| CHEMICAL ABSTRACTS VOL.75, 20217C 1971 CITE : JA 71 12 447 DAINIPPON PHARMACEUTICAL CO. ) * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2196794B1 (en) | 1975-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |