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FR2188608A5 - Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids - Google Patents

Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids

Info

Publication number
FR2188608A5
FR2188608A5 FR7221319A FR7221319A FR2188608A5 FR 2188608 A5 FR2188608 A5 FR 2188608A5 FR 7221319 A FR7221319 A FR 7221319A FR 7221319 A FR7221319 A FR 7221319A FR 2188608 A5 FR2188608 A5 FR 2188608A5
Authority
FR
France
Prior art keywords
apa
penicillins
prepn
acylating
free acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7221319A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7221319A priority Critical patent/FR2188608A5/en
Application granted granted Critical
Publication of FR2188608A5 publication Critical patent/FR2188608A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Penicillins of formula: R.CH.CO- 6-APA (where R is opt. substd) benzyl and 6-APA is 6-aminopenicillanic acid are prepd by acylation of 6-APA in presence of a catalytic enzyme, using the acid R-CH(NH2)CO2H, instead of the acid halides or anhydrides of known processes, high yields are obtd.
FR7221319A 1972-06-14 1972-06-14 Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids Expired FR2188608A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7221319A FR2188608A5 (en) 1972-06-14 1972-06-14 Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7221319A FR2188608A5 (en) 1972-06-14 1972-06-14 Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids

Publications (1)

Publication Number Publication Date
FR2188608A5 true FR2188608A5 (en) 1974-01-18

Family

ID=9100165

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7221319A Expired FR2188608A5 (en) 1972-06-14 1972-06-14 Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids

Country Status (1)

Country Link
FR (1) FR2188608A5 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009136A1 (en) * 1989-12-12 1991-06-27 Consejo Superior Investigaciones Cientificas Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin
NL1006266C2 (en) * 1997-06-10 1998-12-14 Chemferm Vof Method for the preparation of ampicillin.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009136A1 (en) * 1989-12-12 1991-06-27 Consejo Superior Investigaciones Cientificas Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin g acylase
US5268271A (en) * 1989-12-12 1993-12-07 Cosejo Superior De Invetigaciones Certificas Method for the synthesis of semi-synthetic antibiotics in thermodynamically controlled water-cosolvent organic miscible apolar systems by using penicillin G acylase
WO1996030376A1 (en) * 1995-03-31 1996-10-03 Chemferm V.O.F. Process for the recovery of ampicillin
BE1009264A3 (en) * 1995-03-31 1997-01-07 Dsm Nv Process for the extraction of ampicillin.
CN1103777C (en) * 1995-03-31 2003-03-26 Dsm有限公司 Recovery of ampicillin
NL1006266C2 (en) * 1997-06-10 1998-12-14 Chemferm Vof Method for the preparation of ampicillin.
WO1998056946A1 (en) * 1997-06-10 1998-12-17 Dsm N.V. Process for the preparation of ampicillin
US7029885B2 (en) 1997-06-10 2006-04-18 Dsm Ip Assests B.V. Process for the preparation of ampicillin

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Legal Events

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ST Notification of lapse