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FR2152345A1 - Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity - Google Patents

Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity

Info

Publication number
FR2152345A1
FR2152345A1 FR7132088A FR7132088A FR2152345A1 FR 2152345 A1 FR2152345 A1 FR 2152345A1 FR 7132088 A FR7132088 A FR 7132088A FR 7132088 A FR7132088 A FR 7132088A FR 2152345 A1 FR2152345 A1 FR 2152345A1
Authority
FR
France
Prior art keywords
antiinflammatory
analgesic
alpha
thiazolyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7132088A
Other languages
French (fr)
Other versions
FR2152345B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7132088A priority Critical patent/FR2152345A1/en
Publication of FR2152345A1 publication Critical patent/FR2152345A1/en
Application granted granted Critical
Publication of FR2152345B1 publication Critical patent/FR2152345B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula: also their metallic and acid-addition salts and their esters with alkanols (1-4C) R1 = alkyl (1-3C); 2-thienyl opt. substd. by Cl; phenyl opt. substd. by one or two F, Cl, Br or by alkoxy (1-3C), alkylthio (1-3C); R2 = H, alkyl (1-3C), phenyl optionally substituted by F, Cl, Br, alkoxy (1-3C), alkylthio (1-3C), R3 = H, alkyl (1-3C). The cpds. have analgesic, antiinflammatory and antipyretic activity, and are prepd. by reacting the corresp. 2-chlorothiazoles with alpha-hydroxyalkanoic acids.
FR7132088A 1971-09-06 1971-09-06 Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity Granted FR2152345A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7132088A FR2152345A1 (en) 1971-09-06 1971-09-06 Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7132088A FR2152345A1 (en) 1971-09-06 1971-09-06 Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity

Publications (2)

Publication Number Publication Date
FR2152345A1 true FR2152345A1 (en) 1973-04-27
FR2152345B1 FR2152345B1 (en) 1975-06-06

Family

ID=9082542

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7132088A Granted FR2152345A1 (en) 1971-09-06 1971-09-06 Alpha-(2-thiazolyl)oxyalkanoic acids and derivatives - - with analgesic,antiinflammatory and antipyretic activity

Country Status (1)

Country Link
FR (1) FR2152345A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648498A (en) * 1991-10-30 1997-07-15 Astra Aktiebolag Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
WO1999054314A1 (en) * 1998-04-17 1999-10-28 Boehringer Ingelheim Pharma Kg Novel diphenyl-substituted 5-ring-heterocycles, method for producing them and their use as medicaments
WO2013146754A1 (en) * 2012-03-27 2013-10-03 塩野義製薬株式会社 Aromatic heterocyclic five-membered ring derivative having trpv4 inhibitory activity

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648498A (en) * 1991-10-30 1997-07-15 Astra Aktiebolag Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof
WO1999054314A1 (en) * 1998-04-17 1999-10-28 Boehringer Ingelheim Pharma Kg Novel diphenyl-substituted 5-ring-heterocycles, method for producing them and their use as medicaments
WO2013146754A1 (en) * 2012-03-27 2013-10-03 塩野義製薬株式会社 Aromatic heterocyclic five-membered ring derivative having trpv4 inhibitory activity
JPWO2013146754A1 (en) * 2012-03-27 2015-12-14 塩野義製薬株式会社 Aromatic hetero 5-membered ring derivative having TRPV4 inhibitory activity
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity

Also Published As

Publication number Publication date
FR2152345B1 (en) 1975-06-06

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