FR2148362A1 - 2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity - Google Patents
2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activityInfo
- Publication number
- FR2148362A1 FR2148362A1 FR7129317A FR7129317A FR2148362A1 FR 2148362 A1 FR2148362 A1 FR 2148362A1 FR 7129317 A FR7129317 A FR 7129317A FR 7129317 A FR7129317 A FR 7129317A FR 2148362 A1 FR2148362 A1 FR 2148362A1
- Authority
- FR
- France
- Prior art keywords
- halogen
- lower alkyl
- opt
- alkoxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000202 analgesic effect Effects 0.000 title 1
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 229960003965 antiepileptics Drugs 0.000 title 1
- 230000001882 diuretic effect Effects 0.000 title 1
- 239000003158 myorelaxant agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 7
- 150000002367 halogens Chemical class 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 5
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 4
- -1 benzenesulphonyl Chemical group 0.000 abstract 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 2
- 125000004617 chromonyl group Chemical group O1C(=CC(C2=CC=CC=C12)=O)* 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000005504 styryl group Chemical group 0.000 abstract 2
- BMTSZVZQNMNPCT-UHFFFAOYSA-N 2-aminopyridin-3-ol Chemical compound NC1=NC=CC=C1O BMTSZVZQNMNPCT-UHFFFAOYSA-N 0.000 abstract 1
- 230000006181 N-acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Abstract
Title cpds. of formula (I): (where R is H, benzenesulphonyl, p-halo- or p-(lower alkyl)benzenesulphonyl, or a gp. -COR1 in which: R1 is lower alkyl; cycloalkyl; a gp. of formula (a) in which R2-6 are H, halogen, lower alkyl, alkoxy, CF3 or NO2; mono- or diaryl-alkyl opt. substd. by halogen; styryl opt. substd. by halogen, lower alkyl, alkoxy or NO2; styrylvinyl; 2-thienylvinyl; 2-furylvinyl; furyl; 2-nitrofuryl; thienyl; pyridyl; chromonyl; a gp. of formula (b) in which R7-11 are H, halogen, lower alkyl, alkoxy, allyl, naphthyl, or cinnamyl opt. substd. by halogen; or a gp. -NHR1 in which R1 is lower alkyl or a gp. of formula (c) in which R12-16 are H, halogen, lower alkyl, alkoxy, NO2, allyl, p-alkylbenzenesulphonyl, phenoxyalkyl, cycloalkyl, naphthyl, chromonyl, pyridyl, or styryl, opt. substd. by halogen, alkoxy or NO2) are prepd. by reacting 2-amino-3-hydroxypyridine with Br-Cn and opt. subjecting the resulting (I; R=H) to an appropriate N-acylation reaction.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7129317A FR2148362A1 (en) | 1971-08-11 | 1971-08-11 | 2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity |
| LU65879D LU65879A1 (en) | 1971-08-11 | 1972-08-09 | |
| ES405676A ES405676A1 (en) | 1971-08-11 | 1972-08-09 | Procedure for preparing compounds amino - 2 - oxazolo - (4,5 b) -piridine and its derivatives. (Machine-translation by Google Translate, not legally binding) |
| DE19722239311 DE2239311A1 (en) | 1971-08-11 | 1972-08-10 | 2-AMINO- (4.5 B) -OXAZOLE PYRIDINE AND DERIVATIVES |
| BE787438A BE787438A (en) | 1971-08-11 | 1972-08-11 | AMINO-2 OXAZOLO- (4,5 B) -PYRIDINE AND ITS DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7129317A FR2148362A1 (en) | 1971-08-11 | 1971-08-11 | 2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2148362A1 true FR2148362A1 (en) | 1973-03-23 |
| FR2148362B1 FR2148362B1 (en) | 1974-09-06 |
Family
ID=9081722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7129317A Granted FR2148362A1 (en) | 1971-08-11 | 1971-08-11 | 2-amino-(4,5-b)-oxazolopyridine cpds - with analgesic,anti-inflammato anticonvulsant,muscle relaxant and diuretic activity |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE787438A (en) |
| DE (1) | DE2239311A1 (en) |
| ES (1) | ES405676A1 (en) |
| FR (1) | FR2148362A1 (en) |
| LU (1) | LU65879A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011326A (en) * | 1975-07-29 | 1977-03-08 | Merck & Co., Inc. | 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents |
| DE3030996A1 (en) * | 1980-08-16 | 1982-04-01 | Basf Ag, 6700 Ludwigshafen | NEW ARYLOXYALKYLISOCYANATES AND METHOD FOR USE THEREOF |
| EP1020451B1 (en) * | 1997-03-25 | 2005-06-15 | Kowa Co., Ltd. | Anilide compounds and drugs containing the same |
| EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| CA2998647A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
| RU2725886C1 (en) | 2017-03-30 | 2020-07-07 | ЭксДабл-Ю ЛЭБОРЕТРИЗ ИНК. | Bicyclic heteroaryl derivatives and production and use thereof |
-
1971
- 1971-08-11 FR FR7129317A patent/FR2148362A1/en active Granted
-
1972
- 1972-08-09 ES ES405676A patent/ES405676A1/en not_active Expired
- 1972-08-09 LU LU65879D patent/LU65879A1/xx unknown
- 1972-08-10 DE DE19722239311 patent/DE2239311A1/en active Pending
- 1972-08-11 BE BE787438A patent/BE787438A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2148362B1 (en) | 1974-09-06 |
| DE2239311A1 (en) | 1973-02-22 |
| BE787438A (en) | 1972-12-01 |
| LU65879A1 (en) | 1973-01-15 |
| ES405676A1 (en) | 1975-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |