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FR2147953A1 - 2-hydroxy-phenylethyl guanidines and their alkyl ethers - useful as hypotensives and antihypertensives - Google Patents

2-hydroxy-phenylethyl guanidines and their alkyl ethers - useful as hypotensives and antihypertensives

Info

Publication number
FR2147953A1
FR2147953A1 FR7223195A FR7223195A FR2147953A1 FR 2147953 A1 FR2147953 A1 FR 2147953A1 FR 7223195 A FR7223195 A FR 7223195A FR 7223195 A FR7223195 A FR 7223195A FR 2147953 A1 FR2147953 A1 FR 2147953A1
Authority
FR
France
Prior art keywords
hypotensives
antihypertensives
guanidines
phenylethyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7223195A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2147953A1 publication Critical patent/FR2147953A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Anti-hypertensive title cpds. of formula (I):- (n = 0-4) and salts of (I), are prepd. by (a) condensing a phenyl-ethylamine with H2NC triple bond N or H2NC(=NH)Y, where Y is a labile gp. e.g. l.S-alkyl; (b) ammonolysis of the cyanoamide, iso-thiourea etc. derivs. of (I); (c) by reducing the corres. urethane with LiAlH4, or (d) by condensing guanidine with a reactive ester of the phenylethanol.
FR7223195A 1971-06-29 1972-06-27 2-hydroxy-phenylethyl guanidines and their alkyl ethers - useful as hypotensives and antihypertensives Withdrawn FR2147953A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15810571A 1971-06-29 1971-06-29

Publications (1)

Publication Number Publication Date
FR2147953A1 true FR2147953A1 (en) 1973-03-11

Family

ID=22566703

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7223195A Withdrawn FR2147953A1 (en) 1971-06-29 1972-06-27 2-hydroxy-phenylethyl guanidines and their alkyl ethers - useful as hypotensives and antihypertensives

Country Status (8)

Country Link
JP (1) JPS4856638A (en)
AU (1) AU4392272A (en)
BE (1) BE785522A (en)
DE (1) DE2229931A1 (en)
FR (1) FR2147953A1 (en)
IL (1) IL39673A0 (en)
NL (1) NL7208961A (en)
ZA (1) ZA724018B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000181A1 (en) * 1986-06-26 1988-01-14 Harbor Branch Oceanographic Institution, Inc. Antiviral guanidine derivative compositions and their methods of use

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3312516A1 (en) * 1983-04-07 1984-10-11 Brigitte Dr. 7400 Tübingen Pfeiffer CORE-SUBSTITUTED PHENYLALKYLENGUANIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THE SAME
JP2717916B2 (en) * 1993-05-11 1998-02-25 日本化成株式会社 Method for removing carbon adhering to riser in coke oven
US8846955B2 (en) 2009-08-24 2014-09-30 National Institute Of Information And Communications Technology Second-order nonlinear optical compound and nonlinear optical element comprising the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000181A1 (en) * 1986-06-26 1988-01-14 Harbor Branch Oceanographic Institution, Inc. Antiviral guanidine derivative compositions and their methods of use

Also Published As

Publication number Publication date
BE785522A (en) 1972-12-28
ZA724018B (en) 1973-07-25
DE2229931A1 (en) 1973-01-18
NL7208961A (en) 1973-01-03
JPS4856638A (en) 1973-08-09
IL39673A0 (en) 1972-08-30
AU4392272A (en) 1974-01-03

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Legal Events

Date Code Title Description
ST Notification of lapse