FR20C1033I2 - Anticorps anti-cd79b, immuno-conjugues et procedes d'utilisation - Google Patents
Anticorps anti-cd79b, immuno-conjugues et procedes d'utilisationInfo
- Publication number
- FR20C1033I2 FR20C1033I2 FR20C1033C FR20C1033C FR20C1033I2 FR 20C1033 I2 FR20C1033 I2 FR 20C1033I2 FR 20C1033 C FR20C1033 C FR 20C1033C FR 20C1033 C FR20C1033 C FR 20C1033C FR 20C1033 I2 FR20C1033 I2 FR 20C1033I2
- Authority
- FR
- France
- Prior art keywords
- immunoconjugates
- methods
- cd79b antibodies
- cd79b
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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| US3279008P | 2008-02-29 | 2008-02-29 | |
| US5470908P | 2008-05-20 | 2008-05-20 | |
| EP08781859A EP2176296B1 (fr) | 2007-07-16 | 2008-07-15 | Anticorps anti-cd79b, immunoconjugués, et procédés d'utilisation |
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Families Citing this family (136)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2749110B2 (ja) | 1989-03-24 | 1998-05-13 | 住友スリーエム株式会社 | 電力ケーブルの耐火接続部 |
| US20110045005A1 (en) | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| DK1994155T4 (da) | 2006-02-13 | 2022-07-25 | Daiichi Sankyo Co Ltd | Polynukleotid- og polypeptidsekvenser involveret i fremgangsmåden med knogleremodellering |
| PL2032166T3 (pl) | 2006-06-13 | 2013-09-30 | Oncomed Pharm Inc | Kompozycje i sposoby diagnozowania i leczenia nowotworów |
| CA2676008A1 (fr) | 2007-01-24 | 2008-07-31 | Oncomed Pharmaceuticals, Inc. | Compositions et procedes utilises pour le diagnostic et le traitement du cancer |
| CL2008002085A1 (es) | 2007-07-16 | 2008-11-21 | Genentech Inc | Anticuerpo humanizado anti-cd79b/igbeta/b29; polinucleotido codificacnte, vector, celula huesped; metodo de fabricacion; inmunoconjugado; composicion farmaceutica; uso para tratar cancer; metodo in vitro para determinar presencia de cd79b, oinhibir crecimiento de celulas quqe expresa cd79b; ensayo in vitro para detectar celulas b |
| EP2641618A3 (fr) * | 2007-07-16 | 2013-10-23 | Genentech, Inc. | Anticorps anti-CD79B humanisés et immuno-conjugués et procédés dýutilisation |
| CN101835803B (zh) * | 2007-10-19 | 2016-05-25 | 健泰科生物技术公司 | 半胱氨酸改造的抗tenb2抗体和抗体药物偶联物 |
| CN104650230A (zh) | 2008-01-31 | 2015-05-27 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| US20100092495A1 (en) * | 2008-04-30 | 2010-04-15 | Immunogen Inc. | Potent cell-binding agent drug conjugates |
| CN102316897B (zh) | 2008-07-08 | 2014-11-05 | 昂考梅德药品有限公司 | Notch结合剂和拮抗剂及其应用方法 |
| US9132189B2 (en) | 2008-07-08 | 2015-09-15 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| WO2010126552A1 (fr) * | 2009-04-30 | 2010-11-04 | Immunogen, Inc. | Conjugués de médicament d'agent de liaison cellulaire puissant |
| RU2011149798A (ru) | 2009-05-08 | 2013-06-20 | Дженентек, Инк. | Гуманизированные анти-egfl7-антитела и способы их применения |
| KR101962476B1 (ko) * | 2009-07-03 | 2019-03-26 | 아비펩 피티와이 리미티트 | 면역성 접합체 및 그 제조방법 |
| CN102666583B (zh) | 2009-07-15 | 2015-11-25 | Aimm医疗股份公司 | 革兰氏阳性细菌特异性结合化合物 |
| US9315581B2 (en) | 2009-12-23 | 2016-04-19 | A Vipep Pty Limited | Immuno-conjugates and methods for producing them |
| AU2011205316B2 (en) | 2010-01-13 | 2015-05-28 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| EP2554669B1 (fr) * | 2010-03-26 | 2018-09-19 | Kyowa Hakko Kirin Co., Ltd. | Nouvel anticorps ayant un site de modification introduit dans celui-ci, et fragment d'anticorps |
| WO2011156328A1 (fr) | 2010-06-08 | 2011-12-15 | Genentech, Inc. | Anticorps et conjugués modifiés par la cystéine |
| WO2012054748A2 (fr) | 2010-10-22 | 2012-04-26 | Seattle Genetics, Inc. | Effets synergiques entre des conjugués d'anticorps et de médicament à base d'auristatine et des inhibiteurs de la voie pi3k-akt-mtor |
| US20130101628A1 (en) * | 2011-04-29 | 2013-04-25 | Northwestern University | Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use |
| BR112014006822B1 (pt) | 2011-09-22 | 2021-05-18 | Amgen Inc. | Proteína de ligação ao antígeno cd27l, composição compreendendo uma proteína de ligação ao antígeno cd27l, ácido nucleico isolado, vetor de expressão, célula hospedeira recombinante procariótica, método de preparação de um conjugado de droga e anticorpo cd27l e uso de uma proteína de ligação ao antígeno cd27l |
| EP2788020A4 (fr) | 2011-12-05 | 2015-04-29 | Immunomedics Inc | Utilisation thérapeutique d'anticorps anti-cd22 pour induire une trogocytose |
| EP2793949B1 (fr) | 2011-12-23 | 2018-08-22 | Innate Pharma | Conjugaison enzymatique d'anticorps |
| AR091069A1 (es) | 2012-05-18 | 2014-12-30 | Amgen Inc | Proteinas de union a antigeno dirigidas contra el receptor st2 |
| SG11201500087VA (en) | 2012-07-09 | 2015-02-27 | Genentech Inc | Immunoconjugates comprising anti-cd22 antibodies |
| AR091701A1 (es) | 2012-07-09 | 2015-02-25 | Genentech Inc | Anticuerpos anti-cd22 e inmunoconjugados |
| AU2013288930A1 (en) * | 2012-07-09 | 2014-12-04 | Genentech, Inc. | Immunoconjugates comprising anti-CD79b antibodies |
| KR20150030698A (ko) | 2012-07-09 | 2015-03-20 | 제넨테크, 인크. | 항-cd79b 항체를 포함하는 면역접합체 |
| EP2872894B1 (fr) | 2012-07-13 | 2019-04-17 | Innate Pharma | Criblage d'anticorps conjugués |
| US9493562B2 (en) | 2012-07-19 | 2016-11-15 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| EP3722320A3 (fr) | 2012-10-25 | 2020-12-30 | Bioverativ USA Inc. | Anticorps c1s anti-complément et leurs utilisations |
| GB2509260B (en) | 2012-11-02 | 2016-05-04 | True North Therapeutics Inc | Anti-complement C1s antibodies and uses thereof |
| EP2916872B1 (fr) | 2012-11-09 | 2019-02-27 | Innate Pharma | Etiquettes de reconnaissance pour la conjugaison à médiation par la tgase |
| KR20240063172A (ko) * | 2012-11-20 | 2024-05-09 | 사노피 | 항-ceacam5 항체 및 이의 용도 |
| WO2014089177A2 (fr) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Composés, conjugués et compositions d'épipolythiodicétopipérazines et de polythiodicétopipérazines |
| TW201425336A (zh) | 2012-12-07 | 2014-07-01 | Amgen Inc | Bcma抗原結合蛋白質 |
| US9920121B2 (en) | 2013-01-25 | 2018-03-20 | Amgen Inc. | Antibodies targeting CDH19 for melanoma |
| SI2953976T1 (sl) * | 2013-02-08 | 2021-08-31 | Novartis Ag | Specifična mesta z modificiranje protiteles za izdelavo imunokonjugatov |
| JP6423804B2 (ja) * | 2013-02-28 | 2018-11-14 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
| EP2968582B1 (fr) | 2013-03-15 | 2020-07-01 | Innate Pharma | Conjugaison d'anticorps en phase solide médiée par la tgase |
| CN105189558A (zh) * | 2013-05-02 | 2015-12-23 | 豪夫迈·罗氏有限公司 | 无岩藻糖基化CD20抗体与CD79b抗体-药物缀合物的组合疗法 |
| MY199321A (en) | 2013-05-30 | 2023-10-24 | Kiniksa Pharmaceuticals Ltd | Oncostatin m receptor antigen binding proteins |
| WO2014202773A1 (fr) | 2013-06-20 | 2014-12-24 | Innate Pharma | Conjugaison enzymatique de polypeptides |
| CA2914189C (fr) | 2013-06-21 | 2023-03-14 | Innate Pharma | Conjugaison enzymatique de polypeptides |
| KR20160023725A (ko) | 2013-07-03 | 2016-03-03 | 서울대학교산학협력단 | 시스테인으로 변형된 닭의 항체 및 이를 이용한 부위-특이적 접합 |
| TW201605896A (zh) | 2013-08-30 | 2016-02-16 | 安美基股份有限公司 | Gitr抗原結合蛋白 |
| GB201409558D0 (en) | 2014-05-29 | 2014-07-16 | Ucb Biopharma Sprl | Method |
| GB201412658D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| GB201412659D0 (en) | 2014-07-16 | 2014-08-27 | Ucb Biopharma Sprl | Molecules |
| WO2016014360A1 (fr) * | 2014-07-24 | 2016-01-28 | Genentech, Inc. | Procédés de conjugaison d'un agent à une fraction thiol dans une protéine qui contient au moins une liaison trisulfure |
| MA40321A (fr) | 2014-08-06 | 2021-04-14 | Astellas Pharma Inc | Nouvelle anticorp anti-ig(beta) humain |
| TW201609152A (zh) | 2014-09-03 | 2016-03-16 | 免疫原公司 | 包含細胞結合劑及細胞毒性劑之偶聯物 |
| MX2017003123A (es) | 2014-09-12 | 2017-05-12 | Genentech Inc | Anticuerpos y conjugados modificados geneticamente con cisteina. |
| EP3262071B8 (fr) | 2014-09-23 | 2022-05-18 | F. Hoffmann-La Roche AG | Procédé d'utilisation d'immunoconjugués anti-cd79b |
| GB201419108D0 (en) * | 2014-10-27 | 2014-12-10 | Glythera Ltd | Materials and methods relating to linkers for use in antibody drug conjugates |
| SG11201704449VA (en) | 2014-12-05 | 2017-06-29 | Genentech Inc | ANTI-CD79b ANTIBODIES AND METHODS OF USE |
| HK1259251A1 (zh) | 2015-04-06 | 2019-11-29 | Bioverativ Usa Inc. | 人源化抗c1s抗体及其使用方法 |
| EP3307780A1 (fr) | 2015-06-15 | 2018-04-18 | Genentech, Inc. | Anticorps et immunoconjugués |
| GB201601077D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibody molecule |
| GB201601075D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies molecules |
| GB201601073D0 (en) | 2016-01-20 | 2016-03-02 | Ucb Biopharma Sprl | Antibodies |
| CA2997444A1 (fr) | 2015-09-29 | 2017-04-06 | Amgen Inc. | Inhibiteur d'asgr destine a reduire les taux de cholesterol |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| GB201521382D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521389D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Method |
| GB201521393D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| GB201521383D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl And Ucb Celltech | Method |
| GB201521391D0 (en) | 2015-12-03 | 2016-01-20 | Ucb Biopharma Sprl | Antibodies |
| WO2017197045A1 (fr) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Synthèse totale convergente et énantiosélective d'analogues de la communesine |
| MY198182A (en) | 2016-10-12 | 2023-08-09 | Bioverativ Usa Inc | Anti-C1s Antibodies and Methods of use Thereof |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| WO2018209239A1 (fr) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Dérivés d'agélastatine puissants en tant que modulateurs de l'invasion et de la métastase du cancer |
| DE102017004751A1 (de) * | 2017-05-18 | 2018-11-22 | Forschungszentrum Jülich GmbH | Pyruvatcarboxylase und für die Pyruvatcarboxylase kodierende DNA, Plasmid enthaltend die DNA, sowie Mikroorganismus zur Produktion und verfahren zur Herstellung von Produkten, deren Bioynthese Oxalacetat als Vorstufe beeinhaltet und Chromosom |
| CN110799640B (zh) * | 2017-06-07 | 2024-11-12 | 综合医院公司 | 表达嵌合抗原受体的t细胞 |
| NZ762376A (en) | 2017-09-19 | 2022-08-26 | Scherrer Inst Paul | Transglutaminase conjugation method and linker |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| CR20250325A (es) * | 2018-04-13 | 2025-08-29 | Genentech Inc | Formulaciones inmunoconjugadas anti-cd79b estables (divisional expediente 2020-0550) |
| GB201807870D0 (en) * | 2018-05-15 | 2018-06-27 | Autolus Ltd | A CD79-specific chimeric antigen receptor |
| KR20210071987A (ko) * | 2018-10-03 | 2021-06-16 | 네펜쓰 바이오사이언스, 엘엘씨 | 항-cd79 항체 및 이들의 용도 |
| CN111116753A (zh) * | 2018-10-30 | 2020-05-08 | 上海泰因生物技术有限公司 | 一种双特异性抗体的制备方法 |
| CN111116745B (zh) * | 2018-11-01 | 2022-10-14 | 上海新理念生物医药科技有限公司 | 抗CD79b抗体、其药物偶联物及其应用 |
| JP7451520B2 (ja) | 2018-11-15 | 2024-03-18 | ビョンディス・ビー.ブイ. | ヒト化抗SIRPα抗体 |
| KR20210100668A (ko) | 2018-12-06 | 2021-08-17 | 제넨테크, 인크. | 항-CD79b 면역접합체, 알킬화제 및 항-CD20 항체를 포함하는 미만성 큰 B-세포 림프종의 조합 요법 |
| CN109493915B (zh) * | 2018-12-12 | 2021-05-07 | 桂林电子科技大学 | 一种基于不确定图模型侦测蛋白质复合物的方法 |
| US20220047636A1 (en) * | 2018-12-13 | 2022-02-17 | The General Hospital Corporation | Chimeric antigen receptors targeting cd79b and cd19 |
| PH12021551487A1 (en) | 2018-12-21 | 2022-04-11 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
| US12365730B2 (en) | 2019-01-28 | 2025-07-22 | Tuojie Biotech (Shanghai) Co., Ltd. | Anti-CD79B antibody, antigen-binding fragment thereof, and pharmaceutical use thereof |
| AU2020236015B9 (en) | 2019-03-14 | 2024-11-28 | Genentech, Inc. | Treatment of cancer with HER2XCD3 bispecific antibodies in combination with anti-HER2 MAB |
| CN111825742B (zh) * | 2019-04-18 | 2024-01-30 | 陈铭 | Ctpa作为特种偶合剂用于氨基酸离子液体的多肽固相合成 |
| EP3968993A1 (fr) * | 2019-05-14 | 2022-03-23 | F. Hoffmann-La Roche AG | Procédés d'utilisation d'immunoconjugués anti-cd79b pour traiter un lymphome folliculaire |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
| CR20220166A (es) | 2019-10-18 | 2022-06-15 | Genentech Inc | Métodos para usar inmunoconjugados anti-cd79b para tratar linfoma difuso de linfocitos b grandes |
| US11086075B2 (en) * | 2019-10-30 | 2021-08-10 | Alliance Fiber Optic Products, Inc. | Fiber array units with mode-field diameter conversion, and fabrication method |
| CN111560383A (zh) * | 2020-03-14 | 2020-08-21 | 天津大学青岛海洋技术研究院 | 促进枯草芽孢杆菌合成甲萘醌-7的重组菌及其基因修饰方法 |
| BR112022021441A2 (pt) | 2020-04-24 | 2022-12-13 | Genentech Inc | Métodos para tratar linfoma folicular e linfoma difuso de grandes células b e kits |
| BR112022021992A2 (pt) * | 2020-04-30 | 2023-01-03 | Arch Oncology Inc | Método de tratamento de câncer em um sujeito em necessidade do mesmo |
| WO2021225954A1 (fr) | 2020-05-04 | 2021-11-11 | The Regents Of The University Of California | Anticorps anti-enpp1 inhibiteurs |
| CN111961136B (zh) * | 2020-07-13 | 2022-07-08 | 厦门医学院 | 一种全人源化中和破伤风毒素的三价特异性抗体及其制备方法 |
| CN113940995A (zh) * | 2020-07-16 | 2022-01-18 | 西安迪赛生物药业有限责任公司 | 高三尖杉酯碱靶向治疗剂的应用 |
| CN116390947A (zh) | 2020-08-17 | 2023-07-04 | Atb治疗公司 | 包含核糖体毒素或RNAse的重组免疫毒素 |
| CN114249832B (zh) * | 2020-09-24 | 2023-11-10 | 博源润生医药(杭州)有限公司 | 一种靶向cpsg4的人源化嵌合抗原受体及表达该嵌合抗原受体的免疫效应细胞及其应用 |
| AU2021357841A1 (en) | 2020-10-08 | 2023-06-15 | Affimed Gmbh | Trispecific binders |
| AU2021366341A1 (en) | 2020-10-25 | 2023-06-22 | Araris Biotech Ag | Means and methods for producing antibody-linker conjugates |
| IL302396A (en) | 2020-11-04 | 2023-06-01 | Genentech Inc | Dosage for treatment with bispecific anti-CD20/anti-CD3 antibodies |
| IL302217A (en) * | 2020-11-04 | 2023-06-01 | Genentech Inc | Dosage for treatment with bispecific anti-CD20/anti-CD3 antibodies and anti-CD79B drug antibody conjugates |
| JP7716473B2 (ja) | 2020-11-04 | 2025-07-31 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体の皮下投薬 |
| WO2022182415A1 (fr) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Dérivés d'himastatine, leurs procédés de préparation et leurs utilisations |
| TW202243689A (zh) | 2021-04-30 | 2022-11-16 | 瑞士商赫孚孟拉羅股份公司 | 抗cd20/抗cd3雙特異性抗體及抗cd78b抗體藥物結合物的組合治療之給藥 |
| AU2022273063A1 (en) | 2021-05-12 | 2023-11-23 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| AU2022273541A1 (en) | 2021-05-14 | 2023-11-30 | Genentech, Inc. | Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin |
| CN113185572B (zh) * | 2021-05-24 | 2023-03-17 | 江南大学 | 一种虎奶菇细胞壁糖蛋白的提取方法 |
| AU2022320948A1 (en) | 2021-07-30 | 2024-01-18 | Affimed Gmbh | Duplexbodies |
| US20240336697A1 (en) | 2021-08-07 | 2024-10-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| CN114137203A (zh) * | 2021-10-21 | 2022-03-04 | 广州万孚生物技术股份有限公司 | 抗原与碱性磷酸酶结合物的制备方法 |
| EP4426439A1 (fr) | 2021-11-03 | 2024-09-11 | Affimed GmbH | Liants de cd16a bispécifiques |
| AU2023204801A1 (en) * | 2022-01-06 | 2024-07-11 | PTM Therapeutics, Inc. | Methods of treating solid tumors and compositions thereof |
| KR20240150768A (ko) | 2022-02-17 | 2024-10-16 | 에이티비 테라퓨틱스 | 리보솜 불활성화 단백질을 포함하는 재조합 면역독소 |
| MX2024011468A (es) | 2022-03-23 | 2024-09-25 | Hoffmann La Roche | Tratamiento conjunto de un anticuerpo biespecifico anti-cd20/anti-cd3 y quimioterapia. |
| CN119677542A (zh) * | 2022-06-03 | 2025-03-21 | Ube株式会社 | 抗体-多药物缀合物前体及其合成中间体 |
| CN119630430A (zh) * | 2022-06-03 | 2025-03-14 | Ube株式会社 | 抗体多药物缀合物 |
| CN115349490B (zh) * | 2022-07-14 | 2024-01-12 | 成都中医药大学 | 一种卵巢储备功能低下动物模型的建立方法 |
| KR20250049549A (ko) | 2022-08-08 | 2025-04-11 | 에이티비 테라퓨틱스 | CD79b에 대한 인간화된 항체 |
| CN115651881B (zh) * | 2022-12-27 | 2023-03-28 | 广州傲农生物科技有限公司 | 一种益生菌复合菌液、制备方法及其应用 |
| WO2024254455A1 (fr) | 2023-06-08 | 2024-12-12 | Genentech, Inc. | Signatures de macrophages pour méthodes diagnostiques et thérapeutiques pour un lymphome |
| CN116535509B (zh) * | 2023-06-28 | 2023-11-03 | 上海偌妥生物科技有限公司 | 抗CD79b抗体、其制备方法及其应用 |
| WO2025085781A1 (fr) | 2023-10-19 | 2025-04-24 | Genentech, Inc. | Combinaisons de protéines de fusion fc hétérodimères il15/il15r alpha et d'anticorps bispécifiques her2xcd3 pour traiter des cancers her2-positifs |
| CN117783524B (zh) * | 2024-02-26 | 2024-05-03 | 中国医学科学院医学生物学研究所 | 一种双抗体夹心法间接定量检测柯萨奇a10型病毒抗原的建立与应用 |
| CN118542230B (zh) * | 2024-05-24 | 2025-01-28 | 内蒙古农业大学 | 一种基于培养皿的农杆菌侵染苜蓿根系体系及其建立方法 |
| CN119859189B (zh) * | 2025-03-21 | 2025-05-23 | 四川省肿瘤医院 | 一种抗cd79b蛋白单克隆抗体及其相关产品和用途 |
Family Cites Families (360)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US633410A (en) | 1898-09-22 | 1899-09-19 | George A Ames | Ice-cutter. |
| US3445518A (en) | 1966-05-06 | 1969-05-20 | Warner Lambert Pharmaceutical | P-acylphenylethylamines |
| US3720760A (en) | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
| US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| EP0028683A1 (fr) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotique C-15003 PHO et sa préparation |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| WO1981001145A1 (fr) | 1979-10-18 | 1981-04-30 | Univ Illinois | Medicaments "pro-drugs" pouvant etre actives par des enzymes hydrolytiques |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| WO1982001188A1 (fr) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | Composes 4,5-deoxymaytansinoide et leur procede de preparation |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4414205A (en) | 1981-08-28 | 1983-11-08 | University Patents, Inc. | Cell growth inhibitory substances |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4943529A (en) | 1982-05-19 | 1990-07-24 | Gist-Brocades Nv | Kluyveromyces as a host strain |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| AU3145184A (en) | 1983-08-16 | 1985-02-21 | Zymogenetics Inc. | High expression of foreign genes in schizosaccharomyces pombe |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| WO1985003357A1 (fr) | 1984-01-30 | 1985-08-01 | Icrf Patents Ltd. | Ameliorations relatives aux facteurs de croissance |
| US5169774A (en) | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4764368A (en) | 1984-08-29 | 1988-08-16 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US5342606A (en) | 1984-10-18 | 1994-08-30 | Board Of Regents, The University Of Texas System | Polyazamacrocyclic compounds for complexation of metal ions |
| US5316757A (en) | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| EP0206448B1 (fr) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hémoglobine liée à un poly(oxyde d'alkylène) |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| WO1987005330A1 (fr) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Procede pour ameliorer la stabilite des glycoproteines |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US4946783A (en) | 1987-01-30 | 1990-08-07 | President And Fellows Of Harvard College | Periplasmic protease mutants of Escherichia coli |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US4816444A (en) | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US5010182A (en) | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| GB8724885D0 (en) | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5053394A (en) | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| JPH04501201A (ja) | 1987-12-21 | 1992-03-05 | ジ・アップジョン・カンパニー | 発芽植物種子類のアグロバクテリウム媒介形質転換 |
| WO1989006692A1 (fr) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Procede de traitement de cellules tumorales par inhibition de la fonction receptrice du facteur de croissance |
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| US4943628A (en) | 1988-06-13 | 1990-07-24 | Ortho Pharmaceutical Corporation | HIV peptide-inducted T cell stimulation |
| AU4005289A (en) | 1988-08-25 | 1990-03-01 | Smithkline Beecham Corporation | Recombinant saccharomyces |
| DE68925971T2 (de) | 1988-09-23 | 1996-09-05 | Cetus Oncology Corp | Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US4978744A (en) | 1989-01-27 | 1990-12-18 | Arizona Board Of Regents | Synthesis of dolastatin 10 |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| DE68927344T2 (de) | 1989-04-28 | 1997-02-20 | Rhein Biotech Proz & Prod Gmbh | Hefezellen der Gattung-Schwanniomyces |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US4879278A (en) | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| EP0402226A1 (fr) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Vecteurs de transformation de la levure yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| DE69029036T2 (de) | 1989-06-29 | 1997-05-22 | Medarex Inc | Bispezifische reagenzien für die aids-therapie |
| FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
| US5286637A (en) | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| EP0494135B1 (fr) | 1989-09-29 | 1996-04-10 | Oncogene Science, Inc. | Protéine humaine "neu" p100 et son utilisation pour la détection de cellules prénéoplasiques ou néoplasiques chez l'homme |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| CA2026147C (fr) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Agents cytotoxiques comprenant des maytansinoides et leur usage therapeutique |
| US5165923A (en) | 1989-11-20 | 1992-11-24 | Imperial Cancer Research Technology | Methods and compositions for the treatment of hodgkin's disease |
| US6075181A (en) * | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5767236A (en) | 1990-05-09 | 1998-06-16 | Biomeasure, Inc. | Linear therapeutic peptides |
| US5179774A (en) | 1990-05-24 | 1993-01-19 | Ford Motor Company | Apparatus and method for mechanically applying a sealing strip |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| WO1992000373A1 (fr) | 1990-06-29 | 1992-01-09 | Biosource Genetics Corporation | Production de melanines a l'aide de microorganismes transformes |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| AU8507191A (en) | 1990-08-29 | 1992-03-30 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| US5508192A (en) | 1990-11-09 | 1996-04-16 | Board Of Regents, The University Of Texas System | Bacterial host strains for producing proteolytically sensitive polypeptides |
| US5264365A (en) | 1990-11-09 | 1993-11-23 | Board Of Regents, The University Of Texas System | Protease-deficient bacterial strains for production of proteolytically sensitive polypeptides |
| CA2095633C (fr) | 1990-12-03 | 2003-02-04 | Lisa J. Garrard | Methode d'enrichissement de proteines variantes aux proprietes liantes alterees |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| WO1992018619A1 (fr) | 1991-04-10 | 1992-10-29 | The Scripps Research Institute | Banques de recepteurs heterodimeres utilisant des phagemides |
| EP0586505A1 (fr) | 1991-05-14 | 1994-03-16 | Repligen Corporation | Anticorps d'heteroconjugues pour le traitement des infections a l'hiv |
| EP0940468A1 (fr) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Domaine variable d'un anticorps humanisé |
| WO1994004679A1 (fr) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Procede pour fabriquer des anticorps humanises |
| JP3050424B2 (ja) | 1991-07-12 | 2000-06-12 | 塩野義製薬株式会社 | ヒトエンドセリンリセプター |
| ATE190983T1 (de) | 1991-08-09 | 2000-04-15 | Teikoku Hormone Mfg Co Ltd | Neue tetrapeptidderivate |
| CA2078539C (fr) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Procede de fabrication de chimere d'anticorps humain |
| EP0604580A1 (fr) | 1991-09-19 | 1994-07-06 | Genentech, Inc. | EXPRESSION DANS L'E. COLI DE FRAGMENTS D'ANTICORPS POSSEDANT AU MOINS UNE CYSTEINE PRESENTE SOUS FORME D'UN THIOL LIBRE, ET LEUR UTILISATION DANS LA PRODUCTION D'ANTICORPS BIFONCTIONNELS F(ab') 2? |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5362852A (en) | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1993008829A1 (fr) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions induisant la destruction de cellules infectees par l'hiv |
| EP0617706B1 (fr) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Proteines multivalentes de fixation aux antigenes |
| US5428139A (en) | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
| US5739294A (en) | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
| US5480990A (en) | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| DE69334255D1 (de) | 1992-02-06 | 2009-02-12 | Novartis Vaccines & Diagnostic | Marker für Krebs und biosynthetisches Bindeprotein dafür |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| EP0646178A1 (fr) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | Cassette d'expression avec des regious regulatrices fonctionnelles chez le mammifere hote |
| JPH08500017A (ja) | 1992-08-17 | 1996-01-09 | ジェネンテク,インコーポレイテッド | 二特異的免疫アドヘジン |
| DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| US6569834B1 (en) | 1992-12-03 | 2003-05-27 | George R. Pettit | Elucidation and synthesis of antineoplastic tetrapeptide w-aminoalkyl-amides |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US6034065A (en) | 1992-12-03 | 2000-03-07 | Arizona Board Of Regents | Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10 |
| CA2109861C (fr) | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | Paclitaxels modifies en 6,7 |
| DK0672142T3 (da) | 1992-12-04 | 2001-06-18 | Medical Res Council | Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse |
| US5644033A (en) * | 1992-12-22 | 1997-07-01 | Health Research, Inc. | Monoclonal antibodies that define a unique antigen of human B cell antigen receptor complex and methods of using same for diagnosis and treatment |
| US5410024A (en) | 1993-01-21 | 1995-04-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| JPH06234790A (ja) | 1993-02-09 | 1994-08-23 | Teikoku Hormone Mfg Co Ltd | 新規テトラペプチドアミド誘導体 |
| US5869445A (en) | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| DK0616812T3 (da) | 1993-03-24 | 2000-04-25 | Berlex Biosciences | Kombination af antihormonforbindelser og bindingsmolekyler til behandling af cancer |
| US5385893A (en) | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| US5462725A (en) | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| JPH0719832A (ja) * | 1993-06-21 | 1995-01-20 | Canon Inc | 複数画像の対応点抽出方法 |
| US5767237A (en) | 1993-10-01 | 1998-06-16 | Teikoku Hormone Mfg. Co., Ltd. | Peptide derivatives |
| US5553097A (en) | 1994-06-01 | 1996-09-03 | International Business Machines Corporation | System and method for transporting high-bandwidth signals over electrically conducting transmission lines |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| US5504191A (en) | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5521284A (en) | 1994-08-01 | 1996-05-28 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide amides and esters |
| US5530097A (en) | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5554725A (en) | 1994-09-14 | 1996-09-10 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis of dolastatin 15 |
| US5639635A (en) | 1994-11-03 | 1997-06-17 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US5599902A (en) | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| JPH10511085A (ja) | 1994-12-02 | 1998-10-27 | カイロン コーポレイション | 二重特異性抗体を用いる免疫応答を促進する方法 |
| US5663149A (en) | 1994-12-13 | 1997-09-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides |
| ATE186745T1 (de) | 1995-01-18 | 1999-12-15 | Roche Diagnostics Gmbh | Antikörper gegen cd30, die proteolytische spaltung und abgabe des membrangebundenen cd30 antigens verhindern |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| PT831100E (pt) | 1995-04-21 | 2001-01-31 | Teikoku Hormone Mfg Co Ltd | Novos derivados de peptido |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| FR2737588B1 (fr) | 1995-08-01 | 2001-11-02 | Kodak Pathe | Nouveau produit pour radiographie industrielle |
| JPH0977791A (ja) | 1995-09-08 | 1997-03-25 | Nippon Kayaku Co Ltd | ペプチド誘導体及びその用途 |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| AU703769B2 (en) | 1996-01-05 | 1999-04-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Mesothelium antigen and methods and kits for targeting it |
| US5834456A (en) | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| US6027888A (en) | 1996-04-05 | 2000-02-22 | Board Of Regents, The University Of Texas System | Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| US5741892A (en) | 1996-07-30 | 1998-04-21 | Basf Aktiengesellschaft | Pentapeptides as antitumor agents |
| WO1998036765A1 (fr) | 1997-02-25 | 1998-08-27 | Arizona Board Of Regents | Isolement et analyse de la structure des depsipeptides cytostatiques lineaires et des cyclo-depsipeptides cytostatiques dolastatine 16, dolastatine 17, dolastatine 18 |
| US5965537A (en) | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| US6183744B1 (en) | 1997-03-24 | 2001-02-06 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| US6319688B1 (en) | 1997-04-28 | 2001-11-20 | Smithkline Beecham Corporation | Polynucleotide encoding human sodium dependent phosphate transporter (IPT-1) |
| US6184105B1 (en) | 1997-05-22 | 2001-02-06 | Advanced Micro Devices | Method for post transistor isolation |
| US6083715A (en) | 1997-06-09 | 2000-07-04 | Board Of Regents, The University Of Texas System | Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells |
| US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US6143721A (en) | 1997-07-18 | 2000-11-07 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| US6248564B1 (en) * | 1997-08-29 | 2001-06-19 | Harvard University | Mutant MHC class I molecules |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| CN1277632A (zh) | 1997-10-03 | 2000-12-20 | 中外制药株式会社 | 天然人源化抗体 |
| JP2002500233A (ja) | 1998-01-09 | 2002-01-08 | アリゾナ ボード オブ リーゼンツ | 抗−クリプトコッカルペプチド類 |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| US6162930A (en) | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| PT1068241E (pt) | 1998-04-02 | 2007-11-19 | Genentech Inc | Variantes de anticorpos e respectivos fragmentos |
| DK1086223T3 (da) | 1998-06-01 | 2009-11-30 | Agensys Inc | Nye serpentintransmembranantigener udtrykt i humane cancerformer og anvendelser deraf |
| US5985837A (en) | 1998-07-08 | 1999-11-16 | Basf Aktiengesellschaft | Dolastatin 15 derivatives |
| WO2000012130A1 (fr) | 1998-08-27 | 2000-03-09 | Smithkline Beecham Corporation | Agonistes et antagonistes de rp105 |
| WO2001057188A2 (fr) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Nouveaux acides nucleiques et polypeptides |
| KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| US20040141983A1 (en) | 1999-03-15 | 2004-07-22 | Protein Design Labs, Inc. | Compositions against cancer antigen LIV-1 and uses thereof |
| WO2000064946A2 (fr) | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions et procedes de traitement du cancer par inhibition selective de vegf |
| KR100850389B1 (ko) | 1999-06-25 | 2008-08-04 | 제넨테크, 인크. | 인간화 항-ErbB2 항체 및 항-ErbB2 항체를 사용한치료 방법 |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6346249B1 (en) | 1999-10-22 | 2002-02-12 | Ludwig Institute For Cancer Research | Methods for reducing the effects of cancers that express A33 antigen using A33 antigen specific immunoglobulin products |
| US6372907B1 (en) | 1999-11-03 | 2002-04-16 | Apptera Corporation | Water-soluble rhodamine dye peptide conjugates |
| DE60043784D1 (de) | 1999-12-06 | 2010-03-18 | Agensys Inc | Serpentinetransmembranrezeptoren exprimiert in menschlichem prostatakrebs und ihre verwendungen |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| JP2003518075A (ja) | 1999-12-24 | 2003-06-03 | ジェネンテック・インコーポレーテッド | 生理活性化合物の消失半減期延長のための方法及び組成物 |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| NO20001182L (no) | 2000-03-08 | 2001-09-10 | Per Gunnar Werner | Implanteringsmetode og apparat for hartransplantasjon |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| IL151873A0 (en) | 2000-03-24 | 2003-04-10 | Micromet Ag | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| KR20020091170A (ko) | 2000-03-31 | 2002-12-05 | 아이덱 파마슈티칼즈 코포레이션 | B 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-cd20의 조합된 사용 |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| US20020150573A1 (en) * | 2000-11-10 | 2002-10-17 | The Rockefeller University | Anti-Igalpha-Igbeta antibody for lymphoma therapy |
| US7090843B1 (en) | 2000-11-28 | 2006-08-15 | Seattle Genetics, Inc. | Recombinant anti-CD30 antibodies and uses thereof |
| US20040018194A1 (en) | 2000-11-28 | 2004-01-29 | Francisco Joseph A. | Recombinant anti-CD30 antibodies and uses thereof |
| US20070258987A1 (en) | 2000-11-28 | 2007-11-08 | Seattle Genetics, Inc. | Recombinant Anti-Cd30 Antibodies and Uses Thereof |
| RU2285541C2 (ru) | 2000-12-22 | 2006-10-20 | Байоджен Айдек Инк. | Комбинированная терапия для лечения аутоиммунных заболеваний с использованием комбинации элиминирующего в-клетки/иммунорегуляторного антител |
| US6790952B2 (en) | 2001-02-13 | 2004-09-14 | Cincinnati Children's Hospital Research Foundation | Quantitative epstein barr virus PCR rapid assay |
| JP5232350B2 (ja) | 2001-04-17 | 2013-07-10 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | Ca125遺伝子のリピート配列並びに診断および治療的介入のためのその使用 |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US20030083263A1 (en) | 2001-04-30 | 2003-05-01 | Svetlana Doronina | Pentapeptide compounds and uses related thereto |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US20050107595A1 (en) | 2001-06-20 | 2005-05-19 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US7803915B2 (en) | 2001-06-20 | 2010-09-28 | Genentech, Inc. | Antibody compositions for the diagnosis and treatment of tumor |
| US6881557B2 (en) | 2001-07-12 | 2005-04-19 | Arrowsmith Technologies Llp | Super humanized antibodies |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| US20040235068A1 (en) | 2001-09-05 | 2004-11-25 | Levinson Arthur D. | Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders |
| US7098305B2 (en) | 2001-09-06 | 2006-08-29 | Ardana Bioscience Limited | Sustained release of microcrystalline peptide suspensions |
| CA2459318C (fr) | 2001-09-06 | 2017-09-26 | Agensys, Inc. | Acide nucleique et proteine correspondante designes par steap-1 utiles dans le traitement et la detection du cancer |
| JP2005536439A (ja) | 2001-09-18 | 2005-12-02 | ジェネンテック・インコーポレーテッド | 腫瘍の診断及び治療のための組成物と方法 |
| US7091186B2 (en) | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
| WO2003026577A2 (fr) | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-aminobenzyl ether dans des agents d'administration de medicaments |
| US20050238650A1 (en) * | 2002-04-17 | 2005-10-27 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20110045005A1 (en) * | 2001-10-19 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20050123925A1 (en) | 2002-11-15 | 2005-06-09 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP2360169B1 (fr) | 2001-10-23 | 2015-10-14 | Psma Development Company, L.L.C. | Anticorps contre le PSMA |
| AU2002363939A1 (en) | 2001-11-20 | 2003-06-10 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
| EP1485130A4 (fr) | 2002-02-21 | 2006-11-22 | Univ Duke | Reactifs et methodes therapeutiques de maladies auto-immunes |
| JP4472351B2 (ja) | 2002-03-01 | 2010-06-02 | イミューノメディクス、インコーポレイテッド | インターナライジング抗cd74抗体およびその使用方法 |
| SI1572087T1 (sl) | 2002-03-08 | 2008-10-31 | Pdl Biopharma Inc | Protitelesa proti antigenu tmeff2 raka in njihovauporaba |
| EP1576169B1 (fr) | 2002-03-19 | 2016-08-10 | Celldex Therapeutics, Inc. | Polypeptides therapeutiques et methodes d'utilisation associees |
| US20070207142A1 (en) * | 2002-05-08 | 2007-09-06 | Genentech, Inc. | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US20090068178A1 (en) | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| AU2003245441A1 (en) | 2002-06-12 | 2003-12-31 | Avalon Pharmaceuticals, Inc. | Cancer-linked gene as target for chemotherapy |
| EP1516433B1 (fr) | 2002-06-20 | 2012-04-04 | Snaptrack Incorporated | Reduction du brouillage croise dans un recepteur gps et un systeme de communication combine |
| EP2365004B1 (fr) | 2002-06-21 | 2016-01-06 | Johns Hopkins University School of Medicine | Marqueurs associés à la membrane d'endothélium tumoral |
| JP2006502110A (ja) | 2002-07-03 | 2006-01-19 | イミュノジェン・インコーポレーテッド | 非放出Muc1およびMuc16に対する抗体、およびその使用 |
| WO2004032828A2 (fr) | 2002-07-31 | 2004-04-22 | Seattle Genetics, Inc. | Conjugues anticorps anti-cd20-medicament pour le traitement du cancer et des troubles immunitaires |
| SI2357006T1 (sl) | 2002-07-31 | 2016-01-29 | Seattle Genetics, Inc. | Konjugati zdravil in njihova uporaba za zdravljenje raka, avtoimunske bolezni ali infekcijske bolezni |
| ES2361739T3 (es) | 2002-08-16 | 2011-06-21 | Immunogen, Inc. | Reticulantes con elevada reactividad y solubilidad y su uso en la preparación de conjugados para el suministro dirigido de fármacos de molécula pequeña. |
| KR20050048615A (ko) | 2002-08-19 | 2005-05-24 | 제넨테크, 인크. | 종양의 진단 및 치료를 위한 조성물 및 방법 |
| EP1391213A1 (fr) | 2002-08-21 | 2004-02-25 | Boehringer Ingelheim International GmbH | Compositions et méthodes pour le traitement du cancer en utilisant un conjugué d'un anticorps contre le CD44 avec un maytansinoide et des agents chimiothérapeutiques |
| US7608429B2 (en) | 2002-10-31 | 2009-10-27 | Genentech, Inc. | Methods and compositions for increasing antibody production |
| AU2003282624A1 (en) | 2002-11-14 | 2004-06-03 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| AU2003298794A1 (en) | 2002-12-02 | 2004-06-23 | Us Gov Health & Human Serv | Recombinant immunotoxin and use in treating tumors |
| JP4898120B2 (ja) | 2002-12-20 | 2012-03-14 | アボット バイオセラピューティクス コーポレイション | Gpr64に対する抗体とその利用法 |
| JPWO2004060919A1 (ja) | 2002-12-26 | 2006-05-11 | 中外製薬株式会社 | ヘテロ受容体に対するアゴニスト抗体 |
| AU2004205684A1 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
| US20080025989A1 (en) | 2003-02-20 | 2008-01-31 | Seattle Genetics, Inc. | Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders |
| EP1594542B1 (fr) | 2003-02-20 | 2010-06-30 | Seattle Genetics, Inc. | Conjugues de medicaments anticorps anti-cd70, utilisation desdits conjugues dans le traitement du cancer |
| DK1613750T3 (en) | 2003-03-19 | 2016-01-18 | Amgen Fremont Inc | ANTIBODIES TO T CELL AND MUCINDO immunoglobulin-binding domain 1 (TIM-1) antigen and uses thereof |
| US20110042260A1 (en) * | 2003-04-10 | 2011-02-24 | Craig Crowley | Compositions and methods for the treatment of tumor of hematopoietic origin |
| US7755007B2 (en) | 2003-04-17 | 2010-07-13 | K&H Manufacturing, Inc | Heated pet mat |
| US7432088B2 (en) | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| BRPI0416262B1 (pt) | 2003-11-05 | 2022-04-12 | Roche Glycart Ag | Anticorpo anti-cd20 humano tipo ii humanizado, seu método de produção, seus usos, bem como polinucleotídeo isolado, vetor de expressão e composição farmacêutica |
| BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| ATE453405T1 (de) | 2003-11-17 | 2010-01-15 | Genentech Inc | Zusammensetzungen und verfahren zur behandlung von tumoren hämatopoetischen ursprungs |
| US20060204496A1 (en) | 2003-11-28 | 2006-09-14 | Tetsuo Kojima | Agonist antibody against heteroreceptor |
| AU2005216251B2 (en) | 2004-02-23 | 2011-03-10 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| AU2005218642B2 (en) | 2004-03-02 | 2011-04-28 | Seagen Inc. | Partially loaded antibodies and methods of their conjugation |
| US7399469B2 (en) | 2004-03-26 | 2008-07-15 | Pdl Biopharma, Inc. | Anti-LFL2 antibodies for the diagnosis, prognosis and treatment of cancer |
| EP1740954B1 (fr) | 2004-04-07 | 2015-08-19 | Genentech, Inc. | Spectrometrie de masse de conjugues d'anticorps |
| BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
| KR20070020060A (ko) | 2004-06-02 | 2007-02-16 | 에프. 호프만-라 로슈 아게 | 아미노-알콕시-헵탄산 알킬 에스테르의 합성 |
| JP2008503498A (ja) | 2004-06-17 | 2008-02-07 | マンカインド コーポレイション | 癌の診断及び免疫療法における腫瘍関連抗原プロファイル |
| KR20070036089A (ko) * | 2004-07-02 | 2007-04-02 | 제넨테크, 인크. | 비호지킨 림프종의 치료 방법 및 치료 조성물 |
| CA2573293A1 (fr) | 2004-07-10 | 2006-02-16 | Alexion Pharmaceuticals, Inc. | Techniques de recherche d'anticorps specifiques des cellules cancereuses et anticorps decouverts par ces techniques |
| ME01803B (fr) | 2004-08-05 | 2010-12-31 | Genentech Inc | Antagonistes anti-cmet humanises |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| CN101065151B (zh) | 2004-09-23 | 2014-12-10 | 健泰科生物技术公司 | 半胱氨酸改造的抗体和偶联物 |
| KR20070073886A (ko) | 2004-10-05 | 2007-07-10 | 제넨테크, 인크. | 독성이 감소된 치료제 |
| EP1817336B1 (fr) | 2004-11-12 | 2019-01-09 | Seattle Genetics, Inc. | Auristatines comportant une unite d'acide aminobenzoique au n-terminal |
| WO2006071441A2 (fr) | 2004-11-30 | 2006-07-06 | Curagen Corporation | Anticorps dirigés contre la gpnmb et leurs utilisations |
| EP1817059A2 (fr) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Conjugues medicament anticorps et procedes correspondants |
| US7947839B2 (en) | 2004-12-01 | 2011-05-24 | Genentech, Inc. | Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use |
| US20070134243A1 (en) | 2004-12-01 | 2007-06-14 | Gazzard Lewis J | Antibody drug conjugates and methods |
| KR20070086128A (ko) | 2004-12-13 | 2007-08-27 | 에프. 호프만-라 로슈 아게 | 3-피롤리딘-2-일-프로피온산 유도체의 신규 제조 방법 |
| MX2007008017A (es) | 2004-12-31 | 2007-09-12 | Genentech Inc | Polipeptidos que se ligan a br3 y usos de los mismos. |
| US7301019B2 (en) | 2005-01-21 | 2007-11-27 | Immunogen, Inc. | Method for the preparation of maytansinoid esters |
| JP2008537673A (ja) | 2005-01-31 | 2008-09-25 | ジェネンテック・インコーポレーテッド | 抗ephb2抗体とその使用方法 |
| JP2008535823A (ja) | 2005-03-25 | 2008-09-04 | キュラジェン コーポレイション | テネイシンの主要な抗原に対する抗体 |
| ES2373080T3 (es) | 2005-06-20 | 2012-01-31 | Genentech, Inc. | Anticuerpos que se unen al antígeno tat10772 asociado a tumores para el diagnóstico y tratamiento de un tumor. |
| KR20150126978A (ko) | 2005-06-20 | 2015-11-13 | 피에스엠에이 디벨롭먼트 캄파니, 엘엘씨 | Psma 항체-약물 접합체 |
| ES2585357T3 (es) | 2005-07-07 | 2016-10-05 | Seattle Genetics, Inc. | Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C |
| US8871720B2 (en) | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| SI3248613T1 (sl) | 2005-07-18 | 2022-04-29 | Seagen Inc. | Konjugati beta-glukuronidni linker-zdravilo |
| CA2617953C (fr) | 2005-08-09 | 2013-12-17 | Millennium Pharmaceuticals, Inc. | Procede d'acylation de maytansinol a l'aide d'aminoacides chiraux |
| WO2007030642A2 (fr) | 2005-09-07 | 2007-03-15 | Medimmune, Inc. | Anticorps anti-recepteur eph conjugues a des toxines |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| US20090226465A1 (en) | 2005-10-31 | 2009-09-10 | Jackson David Y | Macrocyclic depsipeptide antibody-drug conjugates and methods |
| JP2009515897A (ja) | 2005-11-10 | 2009-04-16 | キュラジェン コーポレイション | T細胞の免疫グロブリンドメインおよびムチンドメイン1(tim−1)抗原に対する抗体を用いて卵巣癌および腎臓癌を処置する方法 |
| US20100040637A1 (en) | 2005-11-23 | 2010-02-18 | Karen Van Orden | Methods and Composition for Treating Diseases Targeting Prominin-1 (CD133) |
| CN105859886A (zh) | 2005-12-02 | 2016-08-17 | 健泰科生物技术公司 | 牵涉与il-22和il-22r结合的抗体的组合物和方法 |
| DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| AR059900A1 (es) | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| US8263038B2 (en) | 2006-04-18 | 2012-09-11 | Delta-Energy Holdings, Llc | Method of devolatilizing recycled carbon black and associated method |
| HRP20140172T1 (hr) | 2006-05-30 | 2014-03-28 | Genentech, Inc. | Protutijela i imunokonjugati kao i njihove uporabe |
| US9382327B2 (en) | 2006-10-10 | 2016-07-05 | Vaccinex, Inc. | Anti-CD20 antibodies and methods of use |
| CA2699837C (fr) | 2006-12-01 | 2017-06-13 | Seattle Genetics, Inc. | Agent se liant a une cible de variant et ses utilisations |
| EP2641618A3 (fr) | 2007-07-16 | 2013-10-23 | Genentech, Inc. | Anticorps anti-CD79B humanisés et immuno-conjugués et procédés dýutilisation |
| CL2008002085A1 (es) | 2007-07-16 | 2008-11-21 | Genentech Inc | Anticuerpo humanizado anti-cd79b/igbeta/b29; polinucleotido codificacnte, vector, celula huesped; metodo de fabricacion; inmunoconjugado; composicion farmaceutica; uso para tratar cancer; metodo in vitro para determinar presencia de cd79b, oinhibir crecimiento de celulas quqe expresa cd79b; ensayo in vitro para detectar celulas b |
| AU2008310908B2 (en) | 2007-10-12 | 2014-01-09 | Seagen Inc. | Combination therapy with antibody-drug conjugates |
| SI2211904T1 (sl) | 2007-10-19 | 2016-12-30 | Seattle Genetics, Inc. | CD19 vezavna sredstva in njihove uporabe |
| CN104650230A (zh) | 2008-01-31 | 2015-05-27 | 健泰科生物技术公司 | 抗cd79b抗体和免疫偶联物及使用方法 |
| US8742076B2 (en) | 2008-02-01 | 2014-06-03 | Genentech, Inc. | Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods |
| TWI409079B (zh) | 2009-08-14 | 2013-09-21 | Roche Glycart Ag | 非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法 |
| JP2013505944A (ja) | 2009-09-24 | 2013-02-21 | シアトル ジェネティックス, インコーポレイテッド | Dr5リガンド薬物結合体 |
| EA201890869A3 (ru) | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| AU2013288930A1 (en) | 2012-07-09 | 2014-12-04 | Genentech, Inc. | Immunoconjugates comprising anti-CD79b antibodies |
| CN111481552A (zh) | 2012-09-07 | 2020-08-04 | 吉宁特有限公司 | II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗 |
| US10314842B2 (en) | 2013-12-02 | 2019-06-11 | Cornell University | Methods for treating B cell proliferative disorders |
| US20140134405A1 (en) | 2014-01-22 | 2014-05-15 | Sung-Yun Yang | Textile having an integral underlying layer of hook and loop fabric |
| EP3262071B8 (fr) | 2014-09-23 | 2022-05-18 | F. Hoffmann-La Roche AG | Procédé d'utilisation d'immunoconjugués anti-cd79b |
| SG11201704449VA (en) | 2014-12-05 | 2017-06-29 | Genentech Inc | ANTI-CD79b ANTIBODIES AND METHODS OF USE |
| BR102016018430A2 (pt) | 2016-08-10 | 2018-02-27 | Fundação Oswaldo Cruz | Cassete de expressão heteróloga, constructo de dna e composição vacinal para imunizar contra flavivírus e/ou outros patógenos. |
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