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FR2081346A1 - 1-benzamidoalkyl-4-camphorsulphonyl- - piperazines - Google Patents

1-benzamidoalkyl-4-camphorsulphonyl- - piperazines

Info

Publication number
FR2081346A1
FR2081346A1 FR7044685A FR7044685A FR2081346A1 FR 2081346 A1 FR2081346 A1 FR 2081346A1 FR 7044685 A FR7044685 A FR 7044685A FR 7044685 A FR7044685 A FR 7044685A FR 2081346 A1 FR2081346 A1 FR 2081346A1
Authority
FR
France
Prior art keywords
benzamidoalkyl
camphorsulphonyl
piperazines
cpds
inotropic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7044685A
Other languages
French (fr)
Other versions
FR2081346B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liade SA
Original Assignee
Laboratorios Liade SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Liade SA filed Critical Laboratorios Liade SA
Publication of FR2081346A1 publication Critical patent/FR2081346A1/en
Application granted granted Critical
Publication of FR2081346B1 publication Critical patent/FR2081346B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

1-Benzamidoalkyl-4-camphorsulphonyl-piperazines. Processes for preparing new cpds. of formula (I) (where X is -CH2-, -CH2CH2- or -CH2,CH(OH)CH2- and R is o-, m- or p- chloro, 3,4,5,-trimethoxy, p-methoxy or m-trifluoromethyl) are claimed. The cpds. have coronary vasodilating, inotropic, negative chronotropic antiepileptic and local-anaesthetic activity.
FR7044685A 1969-12-12 1970-12-11 1-benzamidoalkyl-4-camphorsulphonyl- - piperazines Granted FR2081346A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES374515A ES374515A1 (en) 1969-12-12 1969-12-12 Procedure for obtaining new compounds with cardiovascular actions. (Machine-translation by Google Translate, not legally binding)

Publications (2)

Publication Number Publication Date
FR2081346A1 true FR2081346A1 (en) 1971-12-03
FR2081346B1 FR2081346B1 (en) 1974-06-21

Family

ID=8454556

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7044685A Granted FR2081346A1 (en) 1969-12-12 1970-12-11 1-benzamidoalkyl-4-camphorsulphonyl- - piperazines

Country Status (3)

Country Link
DE (1) DE2061377A1 (en)
ES (1) ES374515A1 (en)
FR (1) FR2081346A1 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2292477A1 (en) * 1974-11-27 1976-06-25 Liade Sa Lab DERIVATIVES OF 1-AMIDOALKYL-4-SULFONYL-PIPERAZINE, THEIR PROCESS FOR OBTAINING THEM AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533241A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
US5665719A (en) * 1993-07-16 1997-09-09 Merck & Co., Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
US5686454A (en) * 1993-07-16 1997-11-11 Merck & Co., Inc. Camphorcarbonyl

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2292477A1 (en) * 1974-11-27 1976-06-25 Liade Sa Lab DERIVATIVES OF 1-AMIDOALKYL-4-SULFONYL-PIPERAZINE, THEIR PROCESS FOR OBTAINING THEM AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
US5648352A (en) * 1991-09-13 1997-07-15 Merck & Co., Inc. Piperazinylcamphorsulfonyl oxytocin antagonists
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533241A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted alkyl derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
EP0533240A3 (en) * 1991-09-16 1993-09-29 Merck & Co. Inc. Substituted amine derivatives of piperazinylcamphorsulfonyl oxytocin antagonists
US5665719A (en) * 1993-07-16 1997-09-09 Merck & Co., Inc. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists
US5686454A (en) * 1993-07-16 1997-11-11 Merck & Co., Inc. Camphorcarbonyl
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5756504A (en) * 1994-03-24 1998-05-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists

Also Published As

Publication number Publication date
DE2061377A1 (en) 1971-06-16
FR2081346B1 (en) 1974-06-21
ES374515A1 (en) 1972-01-01

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Legal Events

Date Code Title Description
ST Notification of lapse